O43423

SS
Gene name
ANP32CP (PP32R1)
Protein name
Putative uncharacterized protein ANP32CP
Names
Acidic leucine-rich nuclear phosphoprotein 32 family member C , Phosphoprotein 32-related protein 1 , Tumorigenic protein pp32r1
Species
Homo sapiens (Human)
KEGG Pathway
EC number
Protein Class

Descriptions

ANP32A(I1<sup>PP2A</sup>) regulates PP2A activity by functioning as a non-competitive inhibitor of this enzyme. PP2A is a major regulator of the phosphorylation of Tau. The activity of PP2A is compromised in Alzheimer's disease brain. ANP32A has an autoinhibitory domain that negatively affects the interaction of ANP32A with PP2Ac and its ability to modulate the PP2A activity, which lies within amino acid residues 121-163. The inhibitory role of the autoinhibitory region might be regulated through the phosphorylation of Ser-158 or both Ser-158 and Ser-204 by casein kinase II. The autoinhibition is disrupted by C-terminal region.

Autoinhibitory domains (AIDs)

117-159 (Autoinhibitory domain) SS

Target domain

1-159 (Leucine-rich region)

Relief mechanism

PTM, Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O43423

Entry ID Method Resolution Chain Position Source
AF-O43423-F1 Predicted AlphaFoldDB

5 variants for O43423

Variant ID(s) Position Change Description Diseaes Association Provenance
rs2288674
VAR_026702
 23 A>V No UniProt
dbSNP
rs2288675
VAR_020419
 71 R>K No UniProt
dbSNP
rs17008716
VAR_048314
 105 L>P No UniProt
dbSNP
rs76372915
VAR_026703
 140 Y>H No UniProt
dbSNP
rs2288676
VAR_020420
 204 E>G No UniProt
dbSNP

No associated diseases with O43423

5 regional properties for O43423

Type Name Position InterPro Accession
domain Sec7 domain 643 - 834 IPR000904
domain Mon2/Sec7/BIG1-like, HDS 1174 - 1255 IPR015403
domain Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain 23 - 198 IPR032629
domain Mon2/Sec7/BIG1-like, HUS domain 378 - 536 IPR032691
domain Sec7/BIG1-like, C-terminal domain 1561 - 1766 IPR046455

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

1 GO annotations of molecular function

Name Definition
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.

2 GO annotations of biological process

Name Definition
nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm.
regulation of apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P51122 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A Bos taurus (Bovine) SS
Q8HY67 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A Canis lupus familiaris (Dog) (Canis familiaris) SS
Q9V895 Anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Drosophila melanogaster (Fruit fly) SS
Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E Homo sapiens (Human) SS
Q92688 ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B Homo sapiens (Human) SS
P39687 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A Homo sapiens (Human) EV
O35381 Anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Mus musculus (Mouse) SS
P49911 Anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Rattus norvegicus (Rat) SS
Q7Y180 Os03g0668900 Acidic leucine-rich nuclear phosphoprotein 32-related protein 2 Oryza sativa subsp. japonica (Rice) SS
Q9SCQ7 At3g50690 Acidic leucine-rich nuclear phosphoprotein 32-related protein Arabidopsis thaliana (Mouse-ear cress) SS
Q7ZUP0 anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MEMGRRIHSE LRNRAPSDVK ELALDNSRSN EGKLEALTDE FEELEFLSKI NGGLTSISDL
70 80 90 100 110 120
PKLKLRKLEL RVSGGLEVLA EKCPNLTHLY LSGNKIKDLS TIEPLKQLEN LKSLDLFNCE
130 140 150 160 170 180
VTNLNDYGEN VFKLLLQLTY LDSCYWDHKE APYSDIEDHV EGLDDEEEGE HEEEYDEDAQ
190 200 210 220 230
VVEDEEGEEE EEEGEEEDVS GGDEEDEEGY NDGEVDGEED EEELGEEERG QKRK