AiPD: Autoinhibited Protein Database

O43298

Gene name	ZBTB43 (KIAA0414, ZBTB22B, ZNF297B)
Protein name	Zinc finger and BTB domain-containing protein 43
Names	Zinc finger and BTB domain-containing protein 22B, Zinc finger protein 297B, ZnF-x
Species	Homo sapiens (Human)
KEGG Pathway	hsa:23099
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

148-221 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

148-221 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for O43298

Entry ID	Method	Resolution	Chain	Position	Source
2CSH	NMR	-	A	370-466	PDB
AF-O43298-F1	Predicted				AlphaFoldDB

247 variants for O43298

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs903396679 CA200210709	2	E>K		No	ClinGen Ensembl
TCGA novel	3	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1223468690 CA375162282	4	G>E		No	ClinGen gnomAD
rs999126833 CA200210710	5	T>A		No	ClinGen TOPMed gnomAD
rs1318869135 CA375162287	5	T>K		No	ClinGen gnomAD
rs1280244543 CA375162303	7	S>C		No	ClinGen gnomAD
rs1484952180 CA375162305	8	F>L		No	ClinGen gnomAD
rs578000038 CA5242624	9	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA375162313 rs1420179710	9	R>W		No	ClinGen TOPMed
CA5242625 rs771744088	10	V>I		No	ClinGen ExAC gnomAD
rs777753960 CA5242626	19	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1429790446 CA375162437	27	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA375162496 rs1388119939	35	V>I		No	ClinGen gnomAD
rs1296941920 CA375162507	37	I>V		No	ClinGen TOPMed
TCGA novel	41	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375162541 rs1353774514	42	H>Y		No	ClinGen TOPMed gnomAD
rs775595302 CA5242632	44	F>C		No	ClinGen ExAC
CA5242635 rs573779320	45	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs373620611 COSM1105220 CA5242634	45	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs768016149 CA5242637	50	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA375162634 rs1237201643	56	P>L		No	ClinGen gnomAD
CA200210714 rs113316414	61	Q>R		No	ClinGen Ensembl
CA375162676 rs1564207872	62	V>L		No	ClinGen Ensembl
rs1202798321 CA375162715	68	R>G		No	ClinGen TOPMed gnomAD
rs984736251 CA200210716	69	R>K		No	ClinGen TOPMed
TCGA novel	72	L>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	72	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375162762 rs1234261699	75	V>M		No	ClinGen gnomAD
rs778532844 CA5242640	79	R>I		No	ClinGen ExAC TOPMed gnomAD
CA375162793 rs778532844	79	R>T		No	ClinGen ExAC TOPMed gnomAD
COSM1674835 CA5242643 rs777694326	92	R>C	lung Variant assessed as Somatic; 0.0 impact. central_nervous_system [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs138321525 CA5242644	92	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs781313323 CA5242646	97	A>T		No	ClinGen ExAC TOPMed gnomAD
CA375162914 rs778029601	98	P>A		No	ClinGen ExAC TOPMed gnomAD
CA5242647 rs778029601	98	P>S		No	ClinGen ExAC TOPMed gnomAD
CA5242648 rs769741963	106	A>E		No	ClinGen ExAC TOPMed gnomAD
rs769741963 CA375162979	106	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1330100730 CA375162993	108	S>G		No	ClinGen TOPMed
rs112254303 CA200210718	111	Q>R		No	ClinGen Ensembl
rs1339227748 CA375163066	114	H>Y		No	ClinGen gnomAD
TCGA novel	117	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375163115 rs1275496361	118	K>R		No	ClinGen gnomAD
CA375163136 rs1245318630	120	T>A		No	ClinGen gnomAD
rs1270867863 CA375163186	124	E>A		No	ClinGen gnomAD
CA375163226 rs1263695362	128	T>A		No	ClinGen gnomAD
rs1469428870 CA375163233	129	V>F		No	ClinGen gnomAD
CA200210720 rs979110718	131	C>Y		No	ClinGen TOPMed gnomAD
CA200210721 rs950117472	133	K>M		No	ClinGen Ensembl
CA5242654 rs767961190	135	N>K		No	ClinGen ExAC gnomAD
rs773685519 CA375163317	136	H>P		No	ClinGen ExAC TOPMed gnomAD
rs773685519 CA5242655	136	H>R		No	ClinGen ExAC TOPMed gnomAD
CA375163338 rs1564208008	138	S>G		No	ClinGen Ensembl
rs1259665074 CA375163348	139	D>N		No	ClinGen Ensembl
rs1045900921 CA200210722	140	H>R		No	ClinGen TOPMed
rs1427792663 CA375163377	141	Q>R		No	ClinGen TOPMed
rs1377013341 CA375163457	147	S>N		No	ClinGen TOPMed
rs764645703 CA5242657	150	G>V		No	ClinGen ExAC TOPMed gnomAD
CA5242658 rs145932561	151	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs763847462 CA5242660	152	V>A		No	ClinGen ExAC TOPMed gnomAD
CA200210725 rs763847462	152	V>G		No	ClinGen ExAC TOPMed gnomAD
CA5242659 rs757926402	152	V>I		No	ClinGen ExAC gnomAD
CA375163546 rs1251398443	155	F>I		No	ClinGen TOPMed
rs1341583507 CA375163576 COSM1460059	158	G>D	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA5242665 rs756144687	159	S>C		No	ClinGen ExAC gnomAD
rs549957286 CA5242664	159	S>P		No	ClinGen ExAC TOPMed gnomAD
rs549957286 CA375163584	159	S>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	161	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1344754454 CA375163606	161	G>V		No	ClinGen TOPMed
TCGA novel	162	H>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5242667 rs749399898	163	T>A		No	ClinGen ExAC
COSM3780648 CA375163662 rs1449605182	166	P>L	pancreas [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1253879598 CA375163682	168	A>G		No	ClinGen TOPMed
CA5242668 rs368266946	169	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA200210729 rs564215950	171	L>P		No	ClinGen 1000Genomes
rs1242621571 CA375163733	173	D>G		No	ClinGen gnomAD
CA200210730 rs532992128	175	E>G		No	ClinGen 1000Genomes
rs774577774 CA5242669	179	E>G		No	ClinGen ExAC TOPMed gnomAD
CA200210731 rs916668341	179	E>K		No	ClinGen TOPMed
rs779334745 CA5242670	180	S>N		No	ClinGen ExAC TOPMed gnomAD
CA375163826 rs1164027560	181	T>P		No	ClinGen gnomAD
rs1384431357 CA375163840	182	K>R		No	ClinGen gnomAD
rs1320866014 CA375163862	184	E>K		No	ClinGen gnomAD
CA375163899 rs1361658048	187	S>P		No	ClinGen gnomAD
rs1361658048 CA375163897	187	S>T		No	ClinGen gnomAD
TCGA novel	190	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA200210733 rs746081284	190	T>P		No	ClinGen Ensembl
rs1171018072 CA375163960 COSM3780649	192	H>Y	pancreas [Cosmic]	No	ClinGen cosmic curated TOPMed
CA375163972 rs1357731816	193	E>*		No	ClinGen gnomAD
CA5242674 rs766919021	194	Y>H		No	ClinGen ExAC gnomAD
CA375163985 rs1588369531	194	Y>S		No	ClinGen Ensembl
CA200210735 rs868178594	195	L>V		No	ClinGen Ensembl
rs1286662747 CA375164043	199	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs763793863 CA5242677	204	D>N		No	ClinGen ExAC gnomAD
CA5242678 rs372523361	205	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA200210736 rs372523361	205	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs146199686 CA5242679	205	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs146199686 COSM3664105 CA5242680	205	R>L	liver [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA5242681 rs750291521	208	T>M		No	ClinGen ExAC TOPMed gnomAD
CA375164164 rs1160330406	209	E>Q		No	ClinGen gnomAD
rs566607178 CA375164837	210	M>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs566607178 CA5242683	210	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5242684 rs749278622	211	A>T		No	ClinGen ExAC TOPMed gnomAD
CA5242685 rs755027598	215	G>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	217	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200047024 CA5242688	219	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5242691 rs771306645	221	D>A		No	ClinGen ExAC gnomAD
rs747400108 CA5242690	221	D>N		No	ClinGen ExAC gnomAD
CA200210737 rs915923825	223	A>T		No	ClinGen gnomAD
CA375165037 rs1260332530	224	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs768252006 CA5242694	226	H>R		No	ClinGen ExAC gnomAD
CA375165094 rs1327608591	227	Y>C		No	ClinGen gnomAD
CA200210738 rs981569746	227	Y>N		No	ClinGen Ensembl
rs774073992 CA5242695	228	T>S		No	ClinGen ExAC gnomAD
rs924714975 CA375165108	229	R>P		No	ClinGen TOPMed gnomAD
rs924714975 CA200210739	229	R>Q	Variant assessed as Somatic; 4.754e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA5242696 rs761546236	229	R>W		No	ClinGen ExAC gnomAD
CA5242697 rs140871297	231	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA5242698 rs750118615	234	K>N		No	ClinGen ExAC gnomAD
rs760541582 CA5242699	239	A>T		No	ClinGen ExAC gnomAD
CA5242700 rs766135175	239	A>V		No	ClinGen ExAC gnomAD
rs768683304 CA5242701	240	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1393908989 CA375165231	240	H>Y		No	ClinGen TOPMed gnomAD
CA375165244 rs1331573609	241	K>R		No	ClinGen gnomAD
CA375165252 rs754972509	242	R>C		No	ClinGen ExAC gnomAD
CA5242702 rs754972509	242	R>G		No	ClinGen ExAC gnomAD
rs1438006963 CA375165253	242	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA375165270 rs776414476	244	I>L		No	ClinGen gnomAD
CA200210741 rs776414476	244	I>V		No	ClinGen gnomAD
CA5242704 rs752784579	249	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA375165342 rs1200826753	250	R>C		No	ClinGen gnomAD
CA5242705 rs758545202	250	R>H		No	ClinGen ExAC gnomAD
rs1468104366 CA375165372	253	Q>K		No	ClinGen gnomAD
CA5242708 rs771307216	256	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1434213454 CA375165409	256	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA375165425 rs1467507425	257	G>D		No	ClinGen gnomAD
CA5242709 rs781452123	257	G>S		No	ClinGen ExAC gnomAD
rs943626112 CA200210742	258	M>I		No	ClinGen Ensembl
CA5242710 rs746374838	258	M>T		No	ClinGen ExAC gnomAD
CA5242712 rs147671798	259	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA5242711 rs201825288	259	D>V		No	ClinGen 1000Genomes ExAC
CA375165455 rs1327272029	260	V>M		No	ClinGen gnomAD
rs142327112 CA5242714	262	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA375165502 rs1328036935	264	Y>C		No	ClinGen TOPMed gnomAD
CA5242716 rs199994042	265	D>N		No	ClinGen ExAC TOPMed gnomAD
rs753688302 CA5242718	266	E>K		No	ClinGen ExAC TOPMed gnomAD
rs759408694 CA5242719	267	H>R		No	ClinGen ExAC TOPMed gnomAD
CA375165558 rs1475856690	268	Q>H		No	ClinGen Ensembl
TCGA novel	271	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1404858172 CA375165581	271	E>Q		No	ClinGen TOPMed
CA5242722 rs758532444	272	S>A		No	ClinGen ExAC gnomAD
CA5242724 rs369755467	273	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA5242723 rs777768927	273	I>V		No	ClinGen ExAC gnomAD
rs1588369915 CA375165608	274	N>H		No	ClinGen Ensembl
rs757490602 CA5242725	274	N>S		No	ClinGen ExAC gnomAD
rs1350028724 CA375165628	275	T>I		No	ClinGen gnomAD
rs781610126 CA5242726	275	T>P		No	ClinGen ExAC TOPMed gnomAD
CA5242728 rs191588058	276	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5242730 rs749857953	281	T>K		No	ClinGen ExAC gnomAD
CA5242731 rs749857953	281	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA375165700 rs1231731132	282	V>M		No	ClinGen gnomAD
CA375165718 rs1197480077	283	Q>P		No	ClinGen TOPMed
rs1315106681 CA375165741	285	S>L		No	ClinGen TOPMed gnomAD
CA375165768 rs1259514573	287	V>A		No	ClinGen gnomAD
CA5242734 rs770501160	287	V>M		No	ClinGen ExAC gnomAD
rs148991528 CA5242736	290	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA375165824 rs1272259007	292	H>Y		No	ClinGen TOPMed
rs376271351 CA375165839	293	I>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA5242740 rs762841686	293	I>S		No	ClinGen ExAC gnomAD
CA5242739 rs762841686	293	I>T		No	ClinGen ExAC gnomAD
CA5242738 rs376271351	293	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA200210751 rs934780939	294	G>E		No	ClinGen Ensembl
CA375165842 CA200210750 rs924712879	294	G>R		No	ClinGen gnomAD
rs754413999 CA200210752	296	K>N		No	ClinGen Ensembl
CA5242742 rs143042822	296	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1430997618 CA375165885	298	V>M		No	ClinGen TOPMed
rs780606036 CA5242746	301	E>D		No	ClinGen ExAC gnomAD
rs756524331 CA5242745	301	E>K		No	ClinGen ExAC gnomAD
CA5242747 rs749795591	302	F>L		No	ClinGen ExAC gnomAD
rs755494192 CA5242748	305	Q>R		No	ClinGen ExAC gnomAD
rs1305020334 CA375165985	309	S>G		No	ClinGen gnomAD
CA5242750 rs746503099	309	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs371000662 CA5242752	313	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA5242754 rs769550533	315	V>E		No	ClinGen ExAC gnomAD
CA5242755 rs577845855	319	G>S		No	ClinGen 1000Genomes ExAC gnomAD
CA375166075 rs1564208673	321	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs762937475 CA5242756	322	M>T		No	ClinGen ExAC gnomAD
CA375166096 rs1480081170	324	E>G		No	ClinGen gnomAD
rs943594820 CA200210753	327	G>R		No	ClinGen Ensembl
CA5242758 rs540500967	329	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1172999539 CA375166137	330	S>L		No	ClinGen gnomAD
rs761830141 CA5242759	332	G>R		No	ClinGen ExAC gnomAD
rs902126317 CA375166159	333	N>K		No	ClinGen gnomAD
CA200210755 rs764711346	334	L>I		No	ClinGen Ensembl
CA5242762 rs202118678	335	I>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs766834854 CA5242763	338	R>I		No	ClinGen ExAC gnomAD
CA375166188 rs76038996	338	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM165667 rs1329551313 CA375166206	341	A>T	NS [Cosmic]	No	ClinGen cosmic curated gnomAD
rs755444046 CA5242765	342	A>V		No	ClinGen ExAC gnomAD
TCGA novel	344	A>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5242767 rs141489057	344	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA375166232 rs1369377073	345	A>G		No	ClinGen gnomAD
rs1279846301 CA375166239	346	G>A		No	ClinGen gnomAD
TCGA novel	350	N>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1192390758 CA375166275	351	I>T		No	ClinGen gnomAD
CA5242772 rs779841894	351	I>V		No	ClinGen ExAC gnomAD
rs749043675 CA5242773	352	E>A		No	ClinGen ExAC gnomAD
rs1478995170 CA375166286	353	M>V		No	ClinGen gnomAD
rs774179189 CA5242775	356	G>V		No	ClinGen ExAC gnomAD
rs1168808589 CA375166313	357	I>L		No	ClinGen TOPMed gnomAD
rs1168808589 CA375166312	357	I>V		No	ClinGen TOPMed gnomAD
rs531958155 CA5242777	360	E>A		No	ClinGen 1000Genomes ExAC gnomAD
rs772274175 CA5242778	361	A>T		No	ClinGen ExAC gnomAD
rs1275957515 CA375166421	363	H>Q		No	ClinGen gnomAD
CA5242780 rs760920518	365	G>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel CA5242781 rs376108916 COSM176863	366	F>L	Variant assessed as Somatic; impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs754188610 CA5242782	368	A>V		No	ClinGen ExAC gnomAD
CA5242783 rs759837410	369	T>A		No	ClinGen ExAC gnomAD
rs1270768769 CA375166496	370	D>N		No	ClinGen gnomAD
rs1241387506 CA375166721	384	K>R		No	ClinGen gnomAD
CA375166780 rs1345349049	388	D>E		No	ClinGen gnomAD
CA375166804 rs1474304839	392	S>G		No	ClinGen gnomAD
rs1012112533 CA200210758	401	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs780669266 CA5242787	401	G>V		No	ClinGen ExAC gnomAD
CA5242788 rs118027417	402	C>W		No	ClinGen Ensembl
CA375166887 rs1588370364	404	V>G		No	ClinGen Ensembl
CA5242793 rs144022095	406	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs149938715 CA5242792	406	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	416	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1460060 CA375166977 rs1300483453	417	G>S	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1236725758 CA375167036	425	I>V		No	ClinGen TOPMed
rs1357859604 CA375167088	432	I>V		No	ClinGen gnomAD
rs1229011643 CA375167167	442	S>G		No	ClinGen TOPMed
rs1481775873 CA375167188	444	H>Q		No	ClinGen gnomAD
CA375167191 rs1228325362	445	R>Q		No	ClinGen gnomAD
CA5242799 rs760867054	448	T>I		No	ClinGen ExAC gnomAD
CA375167246 rs1263687281	453	S>F		No	ClinGen gnomAD
rs776691831 CA375167253	454	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA5242800 rs771223974	454	Y>C		No	ClinGen ExAC
CA5242802 rs759846609	455	E>K		No	ClinGen ExAC gnomAD
rs1488069217 CA375167261	456	A>T		No	ClinGen gnomAD
rs1235888711 CA375167266	456	A>V		No	ClinGen TOPMed gnomAD
CA375167287 rs973993831	460	E>*		No	ClinGen TOPMed gnomAD
CA200210762 rs973993831	460	E>K		No	ClinGen TOPMed gnomAD
TCGA novel	461	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375167322 rs1407319320	465	E>K		No	ClinGen gnomAD
CA375167331 rs753166344	466	A>P		No	ClinGen ExAC TOPMed gnomAD
CA5242804 rs753166344	466	A>T		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with O43298

4 regional properties for O43298

Type	Name	Position	InterPro Accession
domain	BTB/POZ domain	23 - 127	IPR000210
domain	Zinc finger C2H2-type	373 - 399	IPR013087-1
domain	Zinc finger C2H2-type	400 - 427	IPR013087-2
domain	Zinc finger C2H2-type	428 - 457	IPR013087-3

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name	Definition
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
metal ion binding	Binding to a metal ion.
RNA polymerase II transcription regulatory region sequence-specific DNA binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
RNA polymerase III general transcription initiation factor binding	Binding to an RNA polymerase III transcription factor, a protein required to initiate or regulate transcription by RNA polymerase III.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

1 GO annotations of biological process

Name	Definition
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

178 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q08DS3	OSR1	Protein odd-skipped-related 1	Bos taurus (Bovine)	PR
Q2VWH6	FEZF2	Fez family zinc finger protein 2	Bos taurus (Bovine)	PR
A6QNZ0	ZSCAN26	Zinc finger and SCAN domain-containing protein 26	Bos taurus (Bovine)	PR
A7MBI1	ZFP69	Zinc finger protein 69 homolog	Bos taurus (Bovine)	PR
Q08705	CTCF	Transcriptional repressor CTCF	Gallus gallus (Chicken)	PR
O42409	GFI1B	Zinc finger protein Gfi-1b	Gallus gallus (Chicken)	PR
A2T6W2	ZNF449	Zinc finger protein 449	Pan troglodytes (Chimpanzee)	PR
Q9U405	grau	Transcription factor grauzone	Drosophila melanogaster (Fruit fly)	PR
Q7K0S9	sug	Zinc finger protein GLIS2 homolog	Drosophila melanogaster (Fruit fly)	PR
P20385	Cf2	Chorion transcription factor Cf2	Drosophila melanogaster (Fruit fly)	PR
Q86P48	ATbp	AT-rich binding protein	Drosophila melanogaster (Fruit fly)	PR
P28698	MZF1	Myeloid zinc finger 1	Homo sapiens (Human)	PR
Q9NTW7	ZFP64	Zinc finger protein 64	Homo sapiens (Human)	PR
O14978	ZNF263	Zinc finger protein 263	Homo sapiens (Human)	PR
O60304	ZNF500	Zinc finger protein 500	Homo sapiens (Human)	PR
P08151	GLI1	Zinc finger protein GLI1	Homo sapiens (Human)	PR
Q9UFB7	ZBTB47	Zinc finger and BTB domain-containing protein 47	Homo sapiens (Human)	PR
P18146	EGR1	Early growth response protein 1	Homo sapiens (Human)	PR
Q9Y5W3	KLF2	Krueppel-like factor 2	Homo sapiens (Human)	PR
Q9UNY5	ZNF232	Zinc finger protein 232	Homo sapiens (Human)	PR
Q96SZ4	ZSCAN10	Zinc finger and SCAN domain-containing protein 10	Homo sapiens (Human)	PR
P17028	ZNF24	Zinc finger protein 24	Homo sapiens (Human)	PR
P57682	KLF3	Krueppel-like factor 3	Homo sapiens (Human)	PR
P25490	YY1	Transcriptional repressor protein YY1	Homo sapiens (Human)	SS
O43296	ZNF264	Zinc finger protein 264	Homo sapiens (Human)	PR
P49711	CTCF	Transcriptional repressor CTCF	Homo sapiens (Human)	PR
Q9NQX1	PRDM5	PR domain zinc finger protein 5	Homo sapiens (Human)	PR
Q9HBE1	PATZ1	POZ-, AT hook-, and zinc finger-containing protein 1	Homo sapiens (Human)	PR
Q8TAX0	OSR1	Protein odd-skipped-related 1	Homo sapiens (Human)	PR
Q9UL58	ZNF215	Zinc finger protein 215	Homo sapiens (Human)	PR
Q8TBJ5	FEZF2	Fez family zinc finger protein 2	Homo sapiens (Human)	PR
Q96SR6	ZNF382	Zinc finger protein 382	Homo sapiens (Human)	PR
Q96IT1	ZNF496	Zinc finger protein 496	Homo sapiens (Human)	PR
Q96N95	ZNF396	Zinc finger protein 396	Homo sapiens (Human)	PR
Q9ULJ3	ZBTB21	Zinc finger and BTB domain-containing protein 21	Homo sapiens (Human)	PR
O75840	KLF7	Krueppel-like factor 7	Homo sapiens (Human)	PR
Q9H9D4	ZNF408	Zinc finger protein 408	Homo sapiens (Human)	PR
Q13127	REST	RE1-silencing transcription factor	Homo sapiens (Human)	PR
Q8IZM8	ZNF654	Zinc finger protein 654	Homo sapiens (Human)	PR
Q14526	HIC1	Hypermethylated in cancer 1 protein	Homo sapiens (Human)	PR
P17022	ZNF18	Zinc finger protein 18	Homo sapiens (Human)	PR
Q86XF7	ZNF575	Zinc finger protein 575	Homo sapiens (Human)	PR
Q06889	EGR3	Early growth response protein 3	Homo sapiens (Human)	PR
Q8NAM6	ZSCAN4	Zinc finger and SCAN domain-containing protein 4	Homo sapiens (Human)	PR
Q08ER8	ZNF543	Zinc finger protein 543	Homo sapiens (Human)	PR
P17029	ZKSCAN1	Zinc finger protein with KRAB and SCAN domains 1	Homo sapiens (Human)	PR
Q8N680	ZBTB2	Zinc finger and BTB domain-containing protein 2	Homo sapiens (Human)	PR
O95625	ZBTB11	Zinc finger and BTB domain-containing protein 11	Homo sapiens (Human)	PR
Q9NPC7	MYNN	Myoneurin	Homo sapiens (Human)	PR
Q96BV0	ZNF775	Zinc finger protein 775	Homo sapiens (Human)	PR
Q8NF99	ZNF397	Zinc finger protein 397	Homo sapiens (Human)	PR
Q63HK3	ZKSCAN2	Zinc finger protein with KRAB and SCAN domains 2	Homo sapiens (Human)	PR
Q5FWF6	ZNF789	Zinc finger protein 789	Homo sapiens (Human)	PR
Q15776	ZKSCAN8	Zinc finger protein with KRAB and SCAN domains 8	Homo sapiens (Human)	PR
Q53GI3	ZNF394	Zinc finger protein 394	Homo sapiens (Human)	PR
O95125	ZNF202	Zinc finger protein 202	Homo sapiens (Human)	PR
Q05516	ZBTB16	Zinc finger and BTB domain-containing protein 16	Homo sapiens (Human)	PR
Q9H116	GZF1	GDNF-inducible zinc finger protein 1	Homo sapiens (Human)	PR
Q8N0Y2	ZNF444	Zinc finger protein 444	Homo sapiens (Human)	PR
Q6P9G9	ZNF449	Zinc finger protein 449	Homo sapiens (Human)	PR
Q8IW36	ZNF695	Zinc finger protein 695	Homo sapiens (Human)	PR
Q5VTD9	GFI1B	Zinc finger protein Gfi-1b	Homo sapiens (Human)	PR
Q6PG37	ZNF790	Zinc finger protein 790	Homo sapiens (Human)	PR
Q9NQV6	PRDM10	PR domain zinc finger protein 10	Homo sapiens (Human)	PR
Q9Y2D9	ZNF652	Zinc finger protein 652	Homo sapiens (Human)	PR
Q5TC79	ZBTB37	Zinc finger and BTB domain-containing protein 37	Homo sapiens (Human)	PR
Q9Y4E5	ZNF451	E3 SUMO-protein ligase ZNF451	Homo sapiens (Human)	PR
Q8ND82	ZNF280C	Zinc finger protein 280C	Homo sapiens (Human)	PR
Q49AA0	ZFP69	Zinc finger protein 69 homolog	Homo sapiens (Human)	PR
Q13105	ZBTB17	Zinc finger and BTB domain-containing protein 17	Homo sapiens (Human)	PR
P51508	ZNF81	Zinc finger protein 81	Homo sapiens (Human)	PR
Q5JNZ3	ZNF311	Zinc finger protein 311	Homo sapiens (Human)	PR
Q9BRR0	ZKSCAN3	Zinc finger protein with KRAB and SCAN domains 3	Homo sapiens (Human)	PR
Q969J2	ZKSCAN4	Zinc finger protein with KRAB and SCAN domains 4	Homo sapiens (Human)	PR
P49910	ZNF165	Zinc finger protein 165	Homo sapiens (Human)	PR
Q9Y4X4	KLF12	Krueppel-like factor 12	Homo sapiens (Human)	PR
P10074	ZBTB48	Telomere zinc finger-associated protein	Homo sapiens (Human)	PR
P17010	ZFX	Zinc finger X-chromosomal protein	Homo sapiens (Human)	PR
Q9H5H4	ZNF768	Zinc finger protein 768	Homo sapiens (Human)	PR
Q6NSZ9	ZSCAN25	Zinc finger and SCAN domain-containing protein 25	Homo sapiens (Human)	PR
Q9Y2L8	ZKSCAN5	Zinc finger protein with KRAB and SCAN domains 5	Homo sapiens (Human)	PR
Q86UZ6	ZBTB46	Zinc finger and BTB domain-containing protein 46	Homo sapiens (Human)	PR
Q9NX65	ZSCAN32	Zinc finger and SCAN domain-containing protein 32	Homo sapiens (Human)	PR
O14771	ZNF213	Zinc finger protein 213	Homo sapiens (Human)	PR
Q8IWY8	ZSCAN29	Zinc finger and SCAN domain-containing protein 29	Homo sapiens (Human)	PR
Q8NCP5	ZBTB44	Zinc finger and BTB domain-containing protein 44	Homo sapiens (Human)	PR
P41182	BCL6	B-cell lymphoma 6 protein	Homo sapiens (Human)	PR
Q9NQX0	PRDM6	Putative histone-lysine N-methyltransferase PRDM6	Homo sapiens (Human)	PR
Q9BU19	ZNF692	Zinc finger protein 692	Homo sapiens (Human)	PR
Q08AG5	ZNF844	Zinc finger protein 844	Homo sapiens (Human)	PR
Q6R2W3	ZBED9	SCAN domain-containing protein 3	Homo sapiens (Human)	PR
P98182	ZNF200	Zinc finger protein 200	Homo sapiens (Human)	PR
Q9UK11	ZNF223	Zinc finger protein 223	Homo sapiens (Human)	PR
Q6ZMS7	ZNF783	Zinc finger protein 783	Homo sapiens (Human)	PR
P59923	ZNF445	Zinc finger protein 445	Homo sapiens (Human)	PR
Q8N859	ZNF713	Zinc finger protein 713	Homo sapiens (Human)	PR
Q99612	KLF6	Krueppel-like factor 6	Homo sapiens (Human)	PR
Q8TD17	ZNF398	Zinc finger protein 398	Homo sapiens (Human)	PR
P52739	ZNF131	Zinc finger protein 131	Homo sapiens (Human)	PR
A6NGD5	ZSCAN5C	Zinc finger and SCAN domain-containing protein 5C	Homo sapiens (Human)	PR
Q05215	EGR4	Early growth response protein 4	Homo sapiens (Human)	PR
Q7Z398	ZNF550	Zinc finger protein 550	Homo sapiens (Human)	PR
Q9Y2K1	ZBTB1	Zinc finger and BTB domain-containing protein 1	Homo sapiens (Human)	PR
Q96N20	ZNF75A	Zinc finger protein 75A	Homo sapiens (Human)	PR
A6NJL1	ZSCAN5B	Zinc finger and SCAN domain-containing protein 5B	Homo sapiens (Human)	PR
Q9NWS9	ZNF446	Zinc finger protein 446	Homo sapiens (Human)	PR
P24278	ZBTB25	Zinc finger and BTB domain-containing protein 25	Homo sapiens (Human)	PR
Q96N38	ZNF714	Zinc finger protein 714	Homo sapiens (Human)	PR
Q86YH2	ZNF280B	Zinc finger protein 280B	Homo sapiens (Human)	PR
Q9Y330	ZBTB12	Zinc finger and BTB domain-containing protein 12	Homo sapiens (Human)	PR
A1YPR0	ZBTB7C	Zinc finger and BTB domain-containing protein 7C	Homo sapiens (Human)	PR
O15156	ZBTB7B	Zinc finger and BTB domain-containing protein 7B	Homo sapiens (Human)	PR
O08584	Klf6	Krueppel-like factor 6	Mus musculus (Mouse)	PR
Q61164	Ctcf	Transcriptional repressor CTCF	Mus musculus (Mouse)	PR
Q810A1	Znf18	Zinc finger protein 18	Mus musculus (Mouse)	PR
Q8BGS3	Zkscan1	Zinc finger protein with KRAB and SCAN domains 1	Mus musculus (Mouse)	PR
Q00899	Yy1	Transcriptional repressor protein YY1	Mus musculus (Mouse)	PR
P41183	Bcl6	B-cell lymphoma 6 protein homolog	Mus musculus (Mouse)	PR
O70237	Gfi1b	Zinc finger protein Gfi-1b	Mus musculus (Mouse)	PR
Q99KZ6	Znf639	Zinc finger protein 639	Mus musculus (Mouse)	PR
Q9Z1D9	Znf394	Zinc finger protein 394	Mus musculus (Mouse)	PR
Q9CXE0	Prdm5	PR domain zinc finger protein 5	Mus musculus (Mouse)	PR
P43300	Egr3	Early growth response protein 3	Mus musculus (Mouse)	PR
Q9DAU9	Znf654	Zinc finger protein 654	Mus musculus (Mouse)	PR
Q9R1Y5	Hic1	Hypermethylated in cancer 1 protein	Mus musculus (Mouse)	PR
Q8R0T2	Znf768	Zinc finger protein 768	Mus musculus (Mouse)	PR
Q9WVG7	Osr1	Protein odd-skipped-related 1	Mus musculus (Mouse)	PR
Q8BI73	Znf775	Zinc finger protein 775	Mus musculus (Mouse)	PR
Q8VCZ7	Zbtb7c	Zinc finger and BTB domain-containing protein 7C	Mus musculus (Mouse)	PR
Q91VN1	Znf24	Zinc finger protein 24	Mus musculus (Mouse)	PR
Q9DB38	Znf580	Zinc finger protein 580	Mus musculus (Mouse)	PR
A7KBS4	Zscan4d	Zinc finger and SCAN domain containing protein 4D	Mus musculus (Mouse)	PR
Q91VW9	Zkscan3	Zinc finger protein with KRAB and SCAN domains 3	Mus musculus (Mouse)	PR
P10925	Zfy1	Zinc finger Y-chromosomal protein 1	Mus musculus (Mouse)	PR
P08046	Egr1	Early growth response protein 1	Mus musculus (Mouse)	PR
Q3TTC2	Yy2	Transcription factor YY2	Mus musculus (Mouse)	PR
Q3UTQ7	Prdm10	PR domain zinc finger protein 10	Mus musculus (Mouse)	PR
Q6P3Y5	Znf280c	Zinc finger protein 280C	Mus musculus (Mouse)	PR
Q9ERU3	Znf22	Zinc finger protein 22	Mus musculus (Mouse)	PR
Q8VIG1	Rest	RE1-silencing transcription factor	Mus musculus (Mouse)	PR
Q9Z1D8	Zkscan5	Zinc finger protein with KRAB and SCAN domains 5	Mus musculus (Mouse)	PR
Q8BID6	Zbtb46	Zinc finger and BTB domain-containing protein 46	Mus musculus (Mouse)	PR
P17012	Zfx	Zinc finger X-chromosomal protein	Mus musculus (Mouse)	PR
Q9WUK6	Zbtb18	Zinc finger and BTB domain-containing protein 18	Mus musculus (Mouse)	PR
O35738	Klf12	Krueppel-like factor 12	Mus musculus (Mouse)	PR
B2RXC5	Znf382	Zinc finger protein 382	Mus musculus (Mouse)	PR
O08900	Ikzf3	Zinc finger protein Aiolos	Mus musculus (Mouse)	PR
Q5DU09	Znf652	Zinc finger protein 652	Mus musculus (Mouse)	PR
Q5RJ54	Zscan26	Zinc finger and SCAN domain-containing protein 26	Mus musculus (Mouse)	PR
Q8BLM0	Klf8	Krueppel-like factor 8	Mus musculus (Mouse)	PR
Q99JB0	Klf7	Krueppel-like factor 7	Mus musculus (Mouse)	PR
Q8R0A2	Zbtb44	Zinc finger and BTB domain-containing protein 44	Mus musculus (Mouse)	PR
P20662	Zfy2	Zinc finger Y-chromosomal protein 2	Mus musculus (Mouse)	PR
Q80VJ6	Zscan4c	Zinc finger and SCAN domain containing protein 4C	Mus musculus (Mouse)	PR
Q3URS2	Zscan4f	Zinc finger and SCAN domain containing protein 4F	Mus musculus (Mouse)	PR
Q60980	Klf3	Krueppel-like factor 3	Mus musculus (Mouse)	PR
Q8K3J5	Znf131	Zinc finger protein 131	Mus musculus (Mouse)	PR
Q9DAI4	Zbtb43	Zinc finger and BTB domain-containing protein 43	Mus musculus (Mouse)	PR
Q9Z2K3	Znf394	Zinc finger protein 394	Rattus norvegicus (Rat)	PR
Q642B9	Znf18	Zinc finger protein 18	Rattus norvegicus (Rat)	PR
B0K011	Osr1	Protein odd-skipped-related 1	Rattus norvegicus (Rat)	PR
D3ZUU2	Gzf1	GDNF-inducible zinc finger protein 1	Rattus norvegicus (Rat)	PR
B1WBU4	Zbtb8a	Zinc finger and BTB domain-containing protein 8A	Rattus norvegicus (Rat)	PR
Q7TNK3	Znf24	Zinc finger protein 24	Rattus norvegicus (Rat)	PR
O35819	Klf6	Krueppel-like factor 6	Rattus norvegicus (Rat)	PR
Q9R1D1	Ctcf	Transcriptional repressor CTCF	Rattus norvegicus (Rat)	PR
P43301	Egr3	Early growth response protein 3	Rattus norvegicus (Rat)	PR
P08154	Egr1	Early growth response protein 1	Rattus norvegicus (Rat)	PR
A0JPL0	Znf382	Zinc finger protein 382	Rattus norvegicus (Rat)	PR
Q4KLI1	Zkscan1	Zinc finger protein with KRAB and SCAN domains 1	Rattus norvegicus (Rat)	PR
A1L1J6	Znf652	Zinc finger protein 652	Rattus norvegicus (Rat)	PR
Q9SHD0	ZAT4	Zinc finger protein ZAT4	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LFU0	DOT3	BTB/POZ domain-containing protein DOT3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0P4X6	zbtb44	Zinc finger and BTB domain-containing protein 44	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
A4II20	egr1	Early growth response protein 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6P882	zbtb8a.2	Zinc finger and BTB domain-containing protein 8A.2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q567C6	znf367	Zinc finger protein 367	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
A7Y7X5	znf711	Zinc finger protein 711	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MEPGTNSFRV	EFPDFSSTIL	QKLNQQRQQG	QLCDVSIVVQ	GHIFRAHKAV	LAASSPYFCD
70	80	90	100	110	120
QVLLKNSRRI	VLPDVMNPRV	FENILLSSYT	GRLVMPAPEI	VSYLTAASFL	QMWHVVDKCT
130	140	150	160	170	180
EVLEGNPTVL	CQKLNHGSDH	QSPSSSSYNG	LVESFELGSG	GHTDFPKAQE	LRDGENEEES
190	200	210	220	230	240
TKDELSSQLT	EHEYLPSNSS	TEHDRLSTEM	ASQDGEEGAS	DSAEFHYTRP	MYSKPSIMAH
250	260	270	280	290	300
KRWIHVKPER	LEQACEGMDV	HATYDEHQVT	ESINTVQTEH	TVQPSGVEED	FHIGEKKVEA
310	320	330	340	350	360
EFDEQADESN	YDEQVDFYGS	SMEEFSGERS	DGNLIGHRQE	AALAAGYSEN	IEMVTGIKEE
370	380	390	400	410	420
ASHLGFSATD	KLYPCQCGKS	FTHKSQRDRH	MSMHLGLRPY	GCGVCGKKFK	MKHHLVGHMK
430	440	450	460
IHTGIKPYEC	NICAKRFMWR	DSFHRHVTSC	TKSYEAAKAE	QNTTEAN