O42422
SS
Gene name |
EPHA7 (CEK11) |
Protein name |
Ephrin type-A receptor 7 |
Names |
EC 2.7.10.1 , EPH-like kinase 11 , EK11 , cEK11 , Tyrosine-protein kinase receptor CEPHA7 |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:395967 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Ephrin type-B receptor 2 is a membrane-associated protein that mediates axon guidance, cell migration and morphogenesis. The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. The structure, supported by mutagenesis data, reveals that the juxtamembrane segment adopts a helical conformation that distorts the small lobe of the kinase domain, and blocks the activation segment from attaining an activated conformation. Phosphorylation of the conserved juxtamembrane tyrosines would relieve this autoinhibition by disturbing the association of the juxtamembrane segment with the kinase domain, while liberating phosphotyrosine sites for binding SH2 domains of target proteins.
Autoinhibitory domains (AIDs)
Target domain |
628-889 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
770-796 (Activation loop from InterPro)
Target domain |
628-885 (Tyrosine-protein kinase, catalytic domain) |
Relief mechanism |
|
Assay |
|
References
Autoinhibited structure
Activated structure
1 structures for O42422
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O42422-F1 | Predicted | AlphaFoldDB |
No variants for O42422
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O42422 | |||||
No associated diseases with O42422
14 regional properties for O42422
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 628 - 889 | IPR000719 |
| domain | Ephrin receptor ligand binding domain | 32 - 210 | IPR001090 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 628 - 883 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class V, conserved site | 186 - 206 | IPR001426-1 |
| conserved_site | Tyrosine-protein kinase, receptor class V, conserved site | 250 - 270 | IPR001426-2 |
| domain | Sterile alpha motif domain | 915 - 982 | IPR001660 |
| domain | Fibronectin type III | 331 - 441 | IPR003961-1 |
| domain | Fibronectin type III | 442 - 537 | IPR003961-2 |
| active_site | Tyrosine-protein kinase, active site | 749 - 761 | IPR008266 |
| domain | Tyrosine-protein kinase ephrin type A/B receptor-like | 271 - 309 | IPR011641 |
| binding_site | Protein kinase, ATP binding site | 634 - 660 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 628 - 885 | IPR020635 |
| domain | Ephrin receptor, transmembrane domain | 555 - 625 | IPR027936 |
| domain | Ephrin type-A receptor 7, ligand binding domain | 30 - 206 | IPR034283 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| axon guidance receptor activity | Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance. |
| GPI-linked ephrin receptor activity | Combining with a GPI-anchored ephrin to initiate a change in cell activity. |
| protein tyrosine kinase activity | Catalysis of the reaction |
| transmembrane-ephrin receptor activity | Combining with a transmembrane ephrin to initiate a change in cell activity. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| ephrin receptor signaling pathway | The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| regulation of cell-cell adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process | Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis. |
| regulation of ERK1 and ERK2 cascade | Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| regulation of peptidyl-tyrosine phosphorylation | Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. |
| regulation of protein autophosphorylation | Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues. |
52 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q07494 | EPHB1 | Ephrin type-B receptor 1 | Gallus gallus (Chicken) | SS |
| Q07496 | EPHA4 | Ephrin type-A receptor 4 | Gallus gallus (Chicken) | SS |
| P29318 | EPHA3 | Ephrin type-A receptor 3 | Gallus gallus (Chicken) | SS |
| Q07497 | EPHB5 | Ephrin type-B receptor 5 | Gallus gallus (Chicken) | PR |
| P28693 | EPHB2 | Ephrin type-B receptor 2 | Gallus gallus (Chicken) | PR |
| P54755 | EPHA5 | Ephrin type-A receptor 5 | Gallus gallus (Chicken) | SS |
| Q07498 | EPHB3 | Ephrin type-B receptor 3 | Gallus gallus (Chicken) | SS |
| P0C0K6 | EPHB6 | Ephrin type-B receptor 6 | Pan troglodytes (Chimpanzee) | SS |
| P29322 | EPHA8 | Ephrin type-A receptor 8 | Homo sapiens (Human) | SS |
| P21709 | EPHA1 | Ephrin type-A receptor 1 | Homo sapiens (Human) | SS |
| P54764 | EPHA4 | Ephrin type-A receptor 4 | Homo sapiens (Human) | SS |
| P54753 | EPHB3 | Ephrin type-B receptor 3 | Homo sapiens (Human) | SS |
| P29320 | EPHA3 | Ephrin type-A receptor 3 | Homo sapiens (Human) | PR |
| P54760 | EPHB4 | Ephrin type-B receptor 4 | Homo sapiens (Human) | SS |
| P29317 | EPHA2 | Ephrin type-A receptor 2 | Homo sapiens (Human) | SS |
| Q5JZY3 | EPHA10 | Ephrin type-A receptor 10 | Homo sapiens (Human) | SS |
| P29323 | EPHB2 | Ephrin type-B receptor 2 | Homo sapiens (Human) | EV |
| Q9UF33 | EPHA6 | Ephrin type-A receptor 6 | Homo sapiens (Human) | SS |
| P54762 | EPHB1 | Ephrin type-B receptor 1 | Homo sapiens (Human) | SS |
| P54756 | EPHA5 | Ephrin type-A receptor 5 | Homo sapiens (Human) | SS |
| O15197 | EPHB6 | Ephrin type-B receptor 6 | Homo sapiens (Human) | SS |
| Q15375 | EPHA7 | Ephrin type-A receptor 7 | Homo sapiens (Human) | SS |
| P54754 | Ephb3 | Ephrin type-B receptor 3 | Mus musculus (Mouse) | SS |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q03137 | Epha4 | Ephrin type-A receptor 4 | Mus musculus (Mouse) | SS |
| O09127 | Epha8 | Ephrin type-A receptor 8 | Mus musculus (Mouse) | SS |
| Q8CBF3 | Ephb1 | Ephrin type-B receptor 1 | Mus musculus (Mouse) | SS |
| Q8BYG9 | Epha10 | Ephrin type-A receptor 10 | Mus musculus (Mouse) | SS |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| P29319 | Epha3 | Ephrin type-A receptor 3 | Mus musculus (Mouse) | SS |
| Q62413 | Epha6 | Ephrin type-A receptor 6 | Mus musculus (Mouse) | SS |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P54763 | Ephb2 | Ephrin type-B receptor 2 | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| O08644 | Ephb6 | Ephrin type-B receptor 6 | Mus musculus (Mouse) | PR |
| Q61772 | Epha7 | Ephrin type-A receptor 7 | Mus musculus (Mouse) | SS |
| P54757 | Epha5 | Ephrin type-A receptor 5 | Rattus norvegicus (Rat) | SS |
| P09759 | Ephb1 | Ephrin type-B receptor 1 | Rattus norvegicus (Rat) | SS |
| P0C0K7 | Ephb6 | Ephrin type-B receptor 6 | Rattus norvegicus (Rat) | SS |
| O08680 | Epha3 | Ephrin type-A receptor 3 | Rattus norvegicus (Rat) | SS |
| P54759 | Epha7 | Ephrin type-A receptor 7 | Rattus norvegicus (Rat) | SS |
| O61460 | vab-1 | Ephrin receptor 1 | Caenorhabditis elegans | SS |
| Q7X8C5 | WAKL2 | Wall-associated receptor kinase-like 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9S9M2 | WAKL4 | Wall-associated receptor kinase-like 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LMN7 | WAK5 | Wall-associated receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C9L5 | WAKL9 | Wall-associated receptor kinase-like 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VYA3 | WAKL10 | Wall-associated receptor kinase-like 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M092 | WAKL17 | Wall-associated receptor kinase-like 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WNY5 | WAKL18 | Wall-associated receptor kinase-like 18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O13147 | ephb3 | Ephrin type-B receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73878 | ephb4b | Ephrin type-B receptor 4b | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVLRSRLPPW | IMLCSVWLLR | FAHTGEAQAA | KEVILLDSKA | QQTELEWISS | PPNGWEEISG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LDENYTPIRT | YQVCQVMESN | QNNWLRTNWI | AKSNAQRIFV | ELKFTLRDCN | SLPGVLGTCK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ETFNLYYYET | DYDTGRNIRE | NQYVKIDTIA | ADESFTQGDL | GERKMKLNTE | VREIGPLSKK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GFYLAFQDVG | ACIALVSVKV | YYKKCWSIIE | NLAIFPDTVT | GSEFSSLVEV | RGTCVSSAEE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EAENSPKMHC | SAEGEWLVPI | GKCICKAGYQ | QKGDTCEPCG | RGFYKSSSQD | LQCSRCPTHS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FSDKEGSSRC | DCEDSYYRAP | SDPPYVACTR | PPSAPQNLIF | NINQTTVSLE | WSPPADNGGR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NDVTYRILCK | RCSWEQGECV | PCGSNIGYMP | QQTGLVDNYV | TVMDLLAHAN | YTFEVEAVNG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VSDLSRSQRL | FAAVSITTGQ | AAPSQVSGVM | KERVLQRSVE | LSWQEPEHPN | GVITEYEIKY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YEKDQRERTY | STVKTKSTSA | SINNLKPGTV | YVFQIRAFTA | AGYGNYSPRL | DVATLEEATA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TAVSSEQNPV | IIIAVVAVAG | TIILVFMVFG | FIIGRRHCGY | SKADQEGDEE | LYFHFKFPGT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KTYIDPETYE | DPNRAVHQFA | KELDASCIKI | ERVIGAGEFG | EVCSGRLKLP | GKRDVAVAIK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TLKVGYTEKQ | RRDFLCEASI | MGQFDHPNVV | HLEGVVTRGK | PVMIVIEYME | NGALDAFLRK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| HDGQFTVIQL | VGMLRGIAAG | MRYLADMGYV | HRDLAARNIL | VNSNLVCKVS | DFGLSRVIED |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DPEAVYTTTG | GKIPVRWTAP | EAIQYRKFTS | ASDVWSYGIV | MWEVMSYGER | PYWDMSNQDV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IKAIEEGYRL | PAPMDCPAGL | HQLMLDCWQK | ERGERPKFEQ | IVGILDKMIR | NPNSLKTPLG |
| 910 | 920 | 930 | 940 | 950 | 960 |
| TCSRPISPLL | DQNTPDFTTF | CSVGEWLQAI | KMERYKDNFT | AAGYNSLESV | ARMTIEDVMS |
| 970 | 980 | 990 | |||
| LGITLVGHQK | KIMSSIQTMR | AQMLHLHGTG | IQV |