O35984
PR
Gene name |
Pbx2 |
Protein name |
Pre-B-cell leukemia transcription factor 2 |
Names |
Homeobox protein PBX2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:18515 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O35984
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O35984-F1 | Predicted | AlphaFoldDB |
8 variants for O35984
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389455239 | 41 | S>R | No | EVA | |
| rs3389455572 | 148 | G>D | No | EVA | |
| rs3389405870 | 161 | Y>C | No | EVA | |
| rs3389415191 | 358 | G>R | No | EVA | |
| rs3389450525 | 415 | T>I | No | EVA | |
| rs3406618365 | 417 | P>L | No | EVA | |
| rs3389459013 | 424 | V>A | No | EVA | |
| rs3389405830 | 430 | N>I | No | EVA |
No associated diseases with O35984
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| transcription regulator complex | A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor binding | Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| animal organ morphogenesis | Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. |
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| embryonic limb morphogenesis | The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. |
| embryonic organ development | Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. |
| eye development | The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. |
| neuron development | The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| proximal/distal pattern formation | The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end). |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P40424 | PBX1 | Pre-B-cell leukemia transcription factor 1 | Homo sapiens (Human) | PR |
| P40425 | PBX2 | Pre-B-cell leukemia transcription factor 2 | Homo sapiens (Human) | PR |
| P97367 | Meis2 | Homeobox protein Meis2 | Mus musculus (Mouse) | SS |
| P97368 | Meis3 | Homeobox protein Meis3 | Mus musculus (Mouse) | PR |
| Q75LX9 | Os03g0673500 | Putative homeobox protein knotted-1-like 5 | Oryza sativa subsp japonica (Rice) | PR |
| Q75LX7 | OSH10 | Homeobox protein knotted-1-like 4 | Oryza sativa subsp japonica (Rice) | PR |
| Q19503 | ceh-40 | Homeobox protein ceh-40 | Caenorhabditis elegans | PR |
| Q1PFD1 | BLH11 | BEL1-like homeodomain protein 11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SIW1 | BLH7 | BEL1-like homeodomain protein 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDERLLGPPP | PGGGRGGLGL | VGAEPGGPGE | PPGGGDPGGG | SGGVPGGRGK | QDIGDILQQI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MTITDQSLDE | AQAKKHALNC | HRMKPALFSV | LCEIKEKTGL | SIRSSQEEEP | VDPQLMRLDN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MLLAEGVAGP | EKGGGSAAAA | AAAAASGGGV | SPDNSIEHSD | YRSKLAQIRH | IYHSELEKYE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QACNEFTTHV | MNLLREQSRT | RPVAPKEMER | MVSIIHRKFS | AIQMQLKQST | CEAVMILRSR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FLDARRKRRN | FSKQATEVLN | EYFYSHLSNP | YPSEEAKEEL | AKKCGITVSQ | VSNWFGNKRI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RYKKNIGKFQ | EEANIYAVKT | AVSVAQGGHS | RTSSPTPPSS | AGSGGSFNLS | GSGDMFLGMP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GLNGDSYPAS | QVESLRHSMG | PGSYGDNIGG | GQIYSPREIR | ANGGWQEAVT | PSSVTSPTEG |
| PGSVHSDTSN |