O35963

PR
Gene name
Rab33b
Protein name
Ras-related protein Rab-33B
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:19338
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for O35963

Entry ID Method Resolution Chain Position Source
1Z06 X-ray 181 A A 30-202 PDB
2G77 X-ray 226 A B 14-202 PDB
6SUR X-ray 347 A A/B/C/D/E/F 30-202 PDB
AF-O35963-F1 Predicted AlphaFoldDB

11 variants for O35963

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388612571 9 L>Q No EVA
rs3393039623 65 T>A No EVA
rs3393039625 66 I>V No EVA
rs3393039627 68 V>E No EVA
rs3388612589 94 R>G No EVA
rs3388633609 110 V>I No EVA
rs3388625271 169 T>I No EVA
rs3388617838 172 M>I No EVA
rs3388612578 179 A>V No EVA
rs3388630159 185 N>T No EVA
rs3388625684 186 D>H No EVA

No associated diseases with O35963

1 regional properties for O35963

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 33 - 181 IPR005225

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus membrane ; Lipid-anchor
  • Golgi apparatus, cis-Golgi network
  • Under starvation conditions punctate RAB33B-positive structures are often observed in the cytoplasm (PubMed:18448665)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
endosome A vacuole to which materials ingested by endocytosis are delivered.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi lumen The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
presynapse The part of a synapse that is part of the presynaptic cell.

2 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

10 GO annotations of biological process

Name Definition
autophagosome assembly The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
intra-Golgi vesicle-mediated transport The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).
negative regulation of constitutive secretory pathway Any process that stops, prevents or reduces the frequency, rate or extent of constitutive secretory pathway.
protein localization to Golgi apparatus A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Rab protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state.
regulation of exocytosis Any process that modulates the frequency, rate or extent of exocytosis.
regulation of Golgi organization Any process that modulates the frequency, rate or extent of Golgi organization.
regulation of retrograde vesicle-mediated transport, Golgi to ER Any process that modulates the frequency, rate or extent of retrograde vesicle-mediated transport, Golgi to ER.
skeletal system morphogenesis The process in which the anatomical structures of the skeleton are generated and organized.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3ZC27 RAB19 Ras-related protein Rab-19 Bos taurus (Bovine) PR
Q5ZHV1 RAB33B Ras-related protein Rab-33B Gallus gallus (Chicken) PR
A4D1S5 RAB19 Ras-related protein Rab-19 Homo sapiens (Human) PR
Q9H082 RAB33B Ras-related protein Rab-33B Homo sapiens (Human) PR
P35294 Rab19 Ras-related protein Rab-19 Mus musculus (Mouse) PR
Q9JKM7 Rab37 Ras-related protein Rab-37 Mus musculus (Mouse) PR
Q5M7U5 Rab19 Ras-related protein Rab-19 Rattus norvegicus (Rat) PR
P25766 RGP1 Ras-related protein RGP1 Oryza sativa subsp japonica (Rice) PR
Q20365 rab-33 Ras-related protein Rab-33 Caenorhabditis elegans PR
Q9LNK1 RABA3 Ras-related protein RABA3 Arabidopsis thaliana (Mouse-ear cress) PR
O04486 RABA2A Ras-related protein RABA2a Arabidopsis thaliana (Mouse-ear cress) PR
Q9LNW1 RABA2B Ras-related protein RABA2b Arabidopsis thaliana (Mouse-ear cress) PR
Q9LH50 RABA4D Ras-related protein RABA4d Arabidopsis thaliana (Mouse-ear cress) PR
Q9FE79 RABA4C Ras-related protein RABA4c Arabidopsis thaliana (Mouse-ear cress) PR
Q9SJZ5 RABA4E Putative Ras-related protein RABA4e Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MTSEMESSLE VSFSSSCAVS GASGCLPPAR SRIFKIIVIG DSNVGKTCLT YRFCAGRFPD
70 80 90 100 110 120
RTEATIGVDF RERAVDIDGE RIKIQLWDTA GQERFRKSMV QHYYRNVHAV VFVYDMTNMA
130 140 150 160 170 180
SFHSLPAWIE ECKQHLLAND IPRILVGNKC DLRSAIQVPT DLAQKFADTH SMPLFETSAK
190 200 210 220
NPNDNDHVEA IFMTLAHKLK SHKPLMLSQL PDNRISLKPE TKPAVTCWC