O35904
PR
Gene name |
Pik3cd |
Protein name |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform |
Names |
PI3-kinase subunit delta, PI3K-delta, PI3Kdelta, PtdIns-3-kinase subunit delta, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta, PtdIns-3-kinase subunit p110-delta, p110delta |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:18707 |
EC number |
2.7.1.137: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
908-934 (Activation loop from InterPro)
Target domain |
675-1041 (Catalytic domain of Class IA Phosphoinositide 3-kinase delta) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
45 structures for O35904
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2WXF | X-ray | 190 A | A | 106-1043 | PDB |
| 2WXG | X-ray | 200 A | A | 106-1043 | PDB |
| 2WXH | X-ray | 190 A | A | 106-1043 | PDB |
| 2WXI | X-ray | 280 A | A | 106-1043 | PDB |
| 2WXJ | X-ray | 260 A | A | 106-1043 | PDB |
| 2WXK | X-ray | 290 A | A | 106-1043 | PDB |
| 2WXL | X-ray | 199 A | A | 106-1043 | PDB |
| 2WXM | X-ray | 280 A | A | 106-1043 | PDB |
| 2WXN | X-ray | 260 A | A | 106-1043 | PDB |
| 2WXO | X-ray | 249 A | A | 106-1043 | PDB |
| 2WXP | X-ray | 230 A | A | 106-1043 | PDB |
| 2WXQ | X-ray | 270 A | A | 106-1043 | PDB |
| 2WXR | X-ray | 250 A | A | 106-1043 | PDB |
| 2X38 | X-ray | 220 A | A | 106-1043 | PDB |
| 4AJW | X-ray | 280 A | A/B | 110-1043 | PDB |
| 4V0I | X-ray | 254 A | A/B | 106-1043 | PDB |
| 4XE0 | X-ray | 243 A | A | 106-1043 | PDB |
| 5AE8 | X-ray | 242 A | A | 106-1043 | PDB |
| 5AE9 | X-ray | 244 A | A | 106-1043 | PDB |
| 5I4U | X-ray | 237 A | A | 106-1043 | PDB |
| 5I6U | X-ray | 284 A | A | 106-1043 | PDB |
| 5IS5 | X-ray | 285 A | A | 1-1043 | PDB |
| 5L72 | X-ray | 306 A | A | 106-1043 | PDB |
| 5NCY | X-ray | 190 A | PDB | ||
| 5NCZ | X-ray | 194 A | A | 106-1043 | PDB |
| 5NGB | X-ray | 290 A | A | 1-1043 | PDB |
| 5O83 | X-ray | 290 A | A | 106-1043 | PDB |
| 5T27 | X-ray | 260 A | A | 106-1043 | PDB |
| 5T28 | X-ray | 280 A | PDB | ||
| 5T2B | X-ray | 230 A | A | 106-1043 | PDB |
| 5T2D | X-ray | 290 A | A | 106-1043 | PDB |
| 5T2G | X-ray | 255 A | A | 106-1043 | PDB |
| 5T2I | X-ray | 230 A | A | 106-1043 | PDB |
| 5T2L | X-ray | 255 A | A | 106-1043 | PDB |
| 5T2M | X-ray | 280 A | A | 106-1043 | PDB |
| 5T7F | X-ray | 260 A | A/B | 106-1043 | PDB |
| 5T8I | X-ray | 260 A | A | 106-1043 | PDB |
| 6DGT | X-ray | 260 A | A | 106-1043 | PDB |
| 6EYZ | X-ray | 220 A | A | 1-1043 | PDB |
| 6EZ6 | X-ray | 204 A | A | 1-1043 | PDB |
| 6GY0 | X-ray | 255 A | A | 106-1043 | PDB |
| 6HI9 | X-ray | 208 A | A | 106-1043 | PDB |
| 6MUL | X-ray | 309 A | A/B | 106-1043 | PDB |
| 6MUM | X-ray | 306 A | A/B | 106-1043 | PDB |
| AF-O35904-F1 | Predicted | AlphaFoldDB |
50 variants for O35904
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388732041 | 7 | C>W | No | EVA | |
| rs3388709294 | 28 | T>I | No | EVA | |
| rs3388729057 | 36 | V>M | No | EVA | |
| rs3388725616 | 44 | T>I | No | EVA | |
| rs3388733790 | 55 | Y>C | No | EVA | |
| rs3412982928 | 69 | V>M | No | EVA | |
| rs3388735911 | 107 | D>N | No | EVA | |
| rs3388735844 | 170 | Q>P | No | EVA | |
| rs3388735580 | 189 | A>V | No | EVA | |
| rs3395116003 | 264 | S>* | No | EVA | |
| rs3395151952 | 264 | S>R | No | EVA | |
| rs3395086887 | 276 | M>L | No | EVA | |
| rs3388719458 | 335 | A>G | No | EVA | |
| rs3413075890 | 336 | D>E | No | EVA | |
| rs3388719497 | 359 | S>T | No | EVA | |
| rs3388736095 | 378 | D>V | No | EVA | |
| rs3395065936 | 419 | A>G | No | EVA | |
| rs3395091690 | 420 | W>* | No | EVA | |
| rs3395140451 | 420 | W>* | No | EVA | |
| rs3388729134 | 444 | S>P | No | EVA | |
| rs3388728701 | 465 | T>K | No | EVA | |
| rs3388733624 | 506 | E>D | No | EVA | |
| rs3388731967 | 520 | G>W | No | EVA | |
| rs3388736031 | 532 | K>N | No | EVA | |
| rs3388733848 | 563 | M>K | No | EVA | |
| rs3388736077 | 566 | L>M | No | EVA | |
| rs3388728712 | 584 | F>Y | No | EVA | |
| rs3388736026 | 585 | S>N | No | EVA | |
| rs3388735838 | 607 | L>P | No | EVA | |
| rs3388721624 | 644 | H>L | No | EVA | |
| rs3388741019 | 666 | I>T | No | EVA | |
| rs3388725611 | 692 | K>N | No | EVA | |
| rs3388741033 | 706 | T>A | No | EVA | |
| rs3388733855 | 714 | M>K | No | EVA | |
| rs3388732080 | 748 | C>Y | No | EVA | |
| rs3388728697 | 752 | D>V | No | EVA | |
| rs3388738136 | 817 | T>I | No | EVA | |
| rs3388725617 | 883 | V>L | No | EVA | |
| rs3388729088 | 884 | A>T | No | EVA | |
| rs3388721638 | 889 | G>D | No | EVA | |
| rs3388732083 | 900 | I>N | No | EVA | |
| rs3388728698 | 902 | E>V | No | EVA | |
| rs3388733604 | 904 | G>D | No | EVA | |
| rs3388740935 | 905 | Q>K | No | EVA | |
| rs3388733876 | 907 | F>L | No | EVA | |
| rs3395152017 | 943 | Q>K | No | EVA | |
| rs3388733680 | 943 | Q>R | No | EVA | |
| rs3388727211 | 947 | N>I | No | EVA | |
| rs3388729096 | 963 | Y>F | No | EVA | |
| rs3388733613 | 1016 | V>M | No | EVA |
No associated diseases with O35904
1 regional properties for O35904
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RGS domain | 62 - 181 | IPR016137 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.137 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| phosphatidylinositol 3-kinase complex | A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too. |
| phosphatidylinositol 3-kinase complex, class IA | A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-phosphatidylinositol-3-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+). |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+). |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| phosphatidylinositol kinase activity | Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. |
| phosphatidylinositol-3,4-bisphosphate 5-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+). |
| phosphatidylinositol-4,5-bisphosphate 3-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+). |
26 GO annotations of biological process
| Name | Definition |
|---|---|
| adaptive immune response | An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). |
| B cell activation | The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. |
| B cell homeostasis | The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. |
| cell surface receptor signaling pathway | The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| chemotaxis | The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
| defense response to fungus | Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. |
| homeostasis of number of cells | Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| negative regulation of gene expression | Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| phosphatidylinositol 3-kinase signaling | A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions. |
| phosphatidylinositol phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. |
| phosphatidylinositol-3-phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position. |
| phosphatidylinositol-mediated signaling | The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| positive regulation of angiogenesis | Any process that activates or increases angiogenesis. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| positive regulation of cell migration by vascular endothelial growth factor signaling pathway | The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to its receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another. |
| positive regulation of endothelial cell migration | Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. |
| positive regulation of endothelial cell proliferation | Any process that activates or increases the rate or extent of endothelial cell proliferation. |
| positive regulation of epithelial tube formation | Any process that activates or increases the frequency, rate or extent of epithelial tube formation. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of neutrophil apoptotic process | Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process. |
| positive regulation of protein kinase B signaling | Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32871 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Bos taurus (Bovine) | PR |
| P42336 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Homo sapiens (Human) | PR |
| P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Homo sapiens (Human) | PR |
| P48736 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Homo sapiens (Human) | PR |
| O00329 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | Homo sapiens (Human) | PR |
| Q8BKC8 | Pi4kb | Phosphatidylinositol 4-kinase beta | Mus musculus (Mouse) | PR |
| Q61194 | Pik3c2a | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha | Mus musculus (Mouse) | PR |
| Q9JHG7 | Pik3cg | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Mus musculus (Mouse) | PR |
| P42337 | Pik3ca | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Mus musculus (Mouse) | PR |
| Q8BTI9 | Pik3cb | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Mus musculus (Mouse) | PR |
| O02697 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Sus scrofa (Pig) | PR |
| Q9Z1L0 | Pik3cb | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Rattus norvegicus (Rat) | PR |
| Q94125 | age-1 | Phosphatidylinositol 3-kinase age-1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPPGVDCPME | FWTKEESQSV | VVDFLLPTGV | YLNFPVSRNA | NLSTIKQVLW | HRAQYEPLFH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MLSDPEAYVF | TCVNQTAEQQ | ELEDEQRRLC | DIQPFLPVLR | LVAREGDRVK | KLINSQISLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IGKGLHEFDS | LRDPEVNDFR | TKMRQFCEEA | AAHRQQLGWV | EWLQYSFPLQ | LEPSARGWRA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GLLRVSNRAL | LVNVKFEGSE | ESFTFQVSTK | DMPLALMACA | LRKKATVFRQ | PLVEQPEEYA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LQVNGRHEYL | YGNYPLCHFQ | YICSCLHSGL | TPHLTMVHSS | SILAMRDEQS | NPAPQVQKPR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AKPPPIPAKK | PSSVSLWSLE | QPFSIELIEG | RKVNADERMK | LVVQAGLFHG | NEMLCKTVSS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SEVNVCSEPV | WKQRLEFDIS | VCDLPRMARL | CFALYAVVEK | AKKARSTKKK | SKKADCPIAW |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ANLMLFDYKD | QLKTGERCLY | MWPSVPDEKG | ELLNPAGTVR | GNPNTESAAA | LVIYLPEVAP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HPVYFPALEK | ILELGRHGER | GRITEEELQL | REILERRGSG | ELYEHEKDLV | WKMRHEVQEH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FPEALARLLL | VTKWNKHEDV | AQMLYLLCSW | PELPVLSALE | LLDFSFPDCY | VGSFAIKSLR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KLTDDELFQY | LLQLVQVLKY | ESYLDCELTK | FLLGRALANR | KIGHFLFWHL | RSEMHVPSVA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LRFGLIMEAY | CRGSTHHMKV | LMKQGEALSK | LKALNDFVKV | SSQKTTKPQT | KEMMHMCMRQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ETYMEALSHL | QSPLDPSTLL | EEVCVEQCTF | MDSKMKPLWI | MYSSEEAGSA | GNVGIIFKNG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DDLRQDMLTL | QMIQLMDVLW | KQEGLDLRMT | PYGCLPTGDR | TGLIEVVLHS | DTIANIQLNK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SNMAATAAFN | KDALLNWLKS | KNPGEALDRA | IEEFTLSCAG | YCVATYVLGI | GDRHSDNIMI |
| 910 | 920 | 930 | 940 | 950 | 960 |
| RESGQLFHID | FGHFLGNFKT | KFGINRERVP | FILTYDFVHV | IQQGKTNNSE | KFERFRGYCE |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| RAYTILRRHG | LLFLHLFALM | RAAGLPELSC | SKDIQYLKDS | LALGKTEEEA | LKHFRVKFNE |
| 1030 | 1040 | ||||
| ALRESWKTKV | NWLAHNVSKD | NRQ |