O35465

SS
Gene name
Fkbp8 (Fkbp38, Sam11)
Protein name
Peptidyl-prolyl cis-trans isomerase FKBP8
Names
PPIase FKBP8 , EC 5.2.1.8 , 38 kDa FK506-binding protein , 38 kDa FKBP , FKBP-38 , mFKBP38 , FK506-binding protein 8 , FKBP-8 , FKBPR38 , Rotamase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:14232
EC number
5.2.1.8: Cis-trans isomerases
Protein Class

Descriptions

FK506 binding protein 38 (FKBP38) is a multi-domain protein containing a peptidyl-prolyl cis-trans isomerase domain (PPlase) domain followed by tetratricopeptide repeats (TPR), and transmembrane domain. FKBP38 regulates apoptosis through unique interactions with multiple regulators including Bcl-2. The N-terminal extension preceding the catalytic domain of FKBP38 has an autoinhibitory activity. The core isomerase activity of FKBP38 is inhibited by transient interactions involving the flexible N-terminal extension that precedes the catalytic domain. CaM/Ca2+ binds to the N-terminal extension and thereby releases the autoinhibitory contacts between the N-terminal extension and the catalytic domain.

Autoinhibitory domains (AIDs)

1-32 (N-terminal extension) SS

Target domain

105-194 (Peptidyl-prolyl cis-trans isomerase domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O35465

Entry ID Method Resolution Chain Position Source
AF-O35465-F1 Predicted AlphaFoldDB

13 variants for O35465

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388965222 46 E>V No EVA
rs3398792321 154 D>A No EVA
rs3399224373 156 G>S No EVA
rs3388980250 165 S>F No EVA
rs3388981106 205 Q>* No EVA
rs3399224425 243 S>F No EVA
rs3399221519 290 E>Q No EVA
rs3399224408 292 Q>L No EVA
rs3388975262 322 A>V No EVA
rs3388965203 349 T>I No EVA
rs3388965204 350 E>D No EVA
rs3388985693 355 R>L No EVA
rs3388939710 367 K>M No EVA

No associated diseases with O35465

4 regional properties for O35465

Type Name Position InterPro Accession
domain FKBP-type peptidyl-prolyl cis-trans isomerase domain 105 - 194 IPR001179
repeat Tetratricopeptide repeat 211 - 244 IPR019734-1
repeat Tetratricopeptide repeat 262 - 295 IPR019734-2
repeat Tetratricopeptide repeat 296 - 329 IPR019734-3

Functions

Description
EC Number 5.2.1.8 Cis-trans isomerases
Subcellular Localization
  • Mitochondrion membrane ; Single-pass membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

5 GO annotations of molecular function

Name Definition
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
disordered domain specific binding Binding to a disordered domain of a protein.
identical protein binding Binding to an identical protein or proteins.
peptidyl-prolyl cis-trans isomerase activity Catalysis of the reaction
protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process.

18 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
BMP signaling pathway The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
camera-type eye development The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
cell fate specification The cellular developmental process involved in cell fate commitment in which the cell is designated to follow a developmental path, unless they receive extrinsic cues that direct an alternative fate.
dorsal/ventral neural tube patterning The process in which the neural tube is regionalized in the dorsoventral axis.
dorsal/ventral pattern formation The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
multicellular organism growth The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of protein phosphorylation Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
neural tube development The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
neuron fate specification The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.
positive regulation of BMP signaling pathway Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein localization to mitochondrion A process in which a protein is transported to, or maintained in, a location within the mitochondrion.
regulation of BMP signaling pathway Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.
regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of mitophagy Any process that modulates the frequency, rate or extent of macromitophagy.
smoothened signaling pathway The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6QQ71 FKBP6 Inactive peptidyl-prolyl cis-trans isomerase FKBP6 Bos taurus (Bovine) PR
Q9W1I9 shu Inactive peptidyl-prolyl cis-trans isomerase shutdown Drosophila melanogaster (Fruit fly) PR
Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4 Homo sapiens (Human) PR
Q14318 FKBP8 Peptidyl-prolyl cis-trans isomerase FKBP8 Homo sapiens (Human) EV
Q3B7U9 Fkbp8 Peptidyl-prolyl cis-trans isomerase FKBP8 Rattus norvegicus (Rat) SS
Q7DMA9 PAS1 Peptidyl-prolyl cis-trans isomerase PASTICCINO1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MASWAEPSEP AALRLPGAPL LEGFEVLDGV DDAEEEDDLS GLPPLEDMGQ PTVEEAEQPG
70 80 90 100 110 120
ALAREFLAAT EPEPAPAPAP EEWLDILGNG LLRMKTLVPG PKGSSRPLKG QVVTVHLQMS
130 140 150 160 170 180
LENGTRVQEE PELAFTLGDC DVIQALDLSV PLMDVGETAM VTADSKYCYG PQGRSPYIPP
190 200 210 220 230 240
HAALCLEVTL KTAEDGPDLE MLSGQERVAL ANRKRECGNA HYQRADFVLA ANSYDLAIKA
250 260 270 280 290 300
ITSNTKVDMT CEEEEELLQL KVKCLNNLAA SQLKLDHYRA ALRSCSQVLE HQPDNIKALF
310 320 330 340 350 360
RKGKVLAQQG EYSEAIPILR AALKLEPSNK TIHAELSKLV KKRAAQRSTE TALYRKMLGN
370 380 390 400
PSRLPAKCPG KGAWSIPWKW LFGATAVALG GVALSVVIAA RN