O35381

SS
Gene name
Anp32a (Anp32, Lanp)
Protein name
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Names
Acidic nuclear phosphoprotein pp32 , Leucine-rich acidic nuclear protein , LANP , Potent heat-stable protein phosphatase 2A inhibitor I1PP2A
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:11737
EC number
Protein Class

Descriptions

ANP32A(I1<sup>PP2A</sup>) regulates PP2A activity by functioning as a non-competitive inhibitor of this enzyme. PP2A is a major regulator of the phosphorylation of Tau. The activity of PP2A is compromised in Alzheimer's disease brain. ANP32A has an autoinhibitory domain that negatively affects the interaction of ANP32A with PP2Ac and its ability to modulate the PP2A activity, which lies within amino acid residues 121-163. The inhibitory role of the autoinhibitory region might be regulated through the phosphorylation of Ser-158 or both Ser-158 and Ser-204 by casein kinase II. The autoinhibition is disrupted by C-terminal region.

Autoinhibitory domains (AIDs)

121-163 (Autoinhibitory domain) SS

Target domain

1-163 (Leucine-rich region)

Relief mechanism

PTM, Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for O35381

Entry ID Method Resolution Chain Position Source
2JQD NMR - A 1-164 PDB
AF-O35381-F1 Predicted AlphaFoldDB

10 variants for O35381

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389049021 38 T>M No EVA
rs3389044388 45 E>K No EVA
rs3389031583 102 D>N No EVA
rs3389049260 134 N>K No EVA
rs3402644589 151 D>Y No EVA
rs3389018919 164 V>M No EVA
rs3389059298 169 E>K No EVA
rs230191403 189 E>D No EVA
rs3389053508 211 G>D No EVA
rs3389054503 232 S>I No EVA

No associated diseases with O35381

1 regional properties for O35381

Type Name Position InterPro Accession
repeat Leucine-rich repeat 89 - 110 IPR001611

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Endoplasmic reticulum
  • Shuttles between nucleus and cytoplasm
  • Translocates to the cytoplasm during the process of neuritogenesis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
nuclear matrix The dense fibrillar network lying on the inner side of the nuclear membrane.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

1 GO annotations of molecular function

Name Definition
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.

2 GO annotations of biological process

Name Definition
nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm.
regulation of apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process.

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SZC6 ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B Bos taurus (Bovine) SS
P51122 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A Bos taurus (Bovine) SS
Q5F4A3 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E Gallus gallus (Chicken) SS
Q5ZMN0 ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B Gallus gallus (Chicken) SS
Q8HY67 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A Canis lupus familiaris (Dog) (Canis familiaris) SS
Q9V895 Anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Drosophila melanogaster (Fruit fly) SS
Q92688 ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B Homo sapiens (Human) SS
Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E Homo sapiens (Human) SS
P39687 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A Homo sapiens (Human) EV
O43423 ANP32CP Putative uncharacterized protein ANP32CP Homo sapiens (Human) SS
P97822 Anp32e Acidic leucine-rich nuclear phosphoprotein 32 family member E Mus musculus (Mouse) SS
Q9EST5 Anp32b Acidic leucine-rich nuclear phosphoprotein 32 family member B Mus musculus (Mouse) SS
Q9EST6 Anp32b Acidic leucine-rich nuclear phosphoprotein 32 family member B Rattus norvegicus (Rat) SS
Q5XIE0 Anp32e Acidic leucine-rich nuclear phosphoprotein 32 family member E Rattus norvegicus (Rat) SS
P49911 Anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Rattus norvegicus (Rat) SS
Q7Y180 Os03g0668900 Acidic leucine-rich nuclear phosphoprotein 32-related protein 2 Oryza sativa subsp. japonica (Rice) SS
Q9SCQ7 At3g50690 Acidic leucine-rich nuclear phosphoprotein 32-related protein Arabidopsis thaliana (Mouse-ear cress) SS
Q6P1U7 anp32b Acidic leucine-rich nuclear phosphoprotein 32 family member B Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q6NUW5 anp32e Acidic leucine-rich nuclear phosphoprotein 32 family member E Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q7ZUP0 anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MEMDKRIYLE LRNRTPSDVK ELVLDNCKSI EGKIEGLTDE FEELEFLSTI NVGLTSISNL
70 80 90 100 110 120
PKLNKLKKLE LSENRISGDL EVLAEKCPNL KHLNLSGNKI KDLSTIEPLK KLENLKSLDL
130 140 150 160 170 180
FNCEVTNLNA YRENVFKLLP QVMYLDGYDR DNKEAPDSDV EGYVEDDDEE DEDEEEYDEY
190 200 210 220 230 240
AQLVEDEEEE DEEEEGEEED VSGEEEEDEE GYNDGEVDDE EDEEEAGEEE GSQKRKREPD
DEGEEDD