O35379

PR
Gene name
Abcc1
Protein name
Multidrug resistance-associated protein 1
Names
ATP-binding cassette sub-family C member 1, Glutathione-S-conjugate-translocating ATPase ABCC1, Leukotriene C(4) transporter, LTC4 transporter
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:17250
EC number
7.6.2.2: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

242-329 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O35379

Entry ID Method Resolution Chain Position Source
AF-O35379-F1 Predicted AlphaFoldDB

87 variants for O35379

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389402121 22 W>S No EVA
rs3389404331 40 W>* No EVA
rs3389350980 41 V>M No EVA
rs3406361357 67 M>K No EVA
rs3406681476 68 T>P No EVA
rs3406747307 70 L>P No EVA
rs3389399594 79 F>I No EVA
rs3389406981 79 F>L No EVA
rs3389407011 129 R>S No EVA
rs3389417294 147 L>I No EVA
rs3389392029 162 K>* No EVA
rs49103284 166 H>Q No EVA
rs3389317754 187 V>L No EVA
rs3389404354 195 S>L No EVA
rs3389351006 198 F>I No EVA
rs3389402061 240 D>E No EVA
rs3389317760 256 V>E No EVA
rs3389380697 281 K>Q No EVA
rs258330447 284 S>T No EVA
rs3389395310 290 S>F No EVA
rs3389317750 298 V>M No EVA
rs3389400004 312 P>R No EVA
rs3389395573 328 M>V No EVA
rs3389361567 355 N>D No EVA
rs8268231 357 R>T No EVA
rs3389404336 399 A>T No EVA
rs3389392034 409 L>F No EVA
rs3389370171 414 A>T No EVA
rs3405811186 425 V>D No EVA
rs3406681461 429 S>T No EVA
rs3389399626 455 A>T No EVA
rs3406851014 461 L>M No EVA
rs3405737258 461 L>R No EVA
rs3389417236 525 F>V No EVA
rs3389404369 539 V>M No EVA
rs3389417285 569 F>V No EVA
rs3412161849 616 R>H No EVA
rs3389407057 663 G>D No EVA
rs3389391969 668 I>T No EVA
rs3389407017 687 L>M No EVA
rs3389395611 708 V>L No EVA
rs224515317 723 R>Q No EVA
rs3389411767 761 I>F No EVA
rs3389407051 869 Y>F No EVA
rs3389370164 883 V>A No EVA
rs3406635112 891 K>M No EVA
rs3405738296 892 P>A No EVA
rs8260197 928 I>T No EVA
rs3389417233 933 K>M No EVA
rs3389399550 934 A>V No EVA
rs8260198 935 G>E No EVA
rs3389370232 965 A>V No EVA
rs3406682093 1007 A>P No EVA
rs213125277 1027 I>V No EVA
rs3389395641 1029 G>S No EVA
rs3389361637 1037 G>A No EVA
rs3389411746 1037 G>R No EVA
rs3389402073 1038 G>D No EVA
rs3389318944 1045 L>F No EVA
rs3389404377 1213 L>I No EVA
rs3389404372 1215 A>V No EVA
rs3389395652 1218 S>T No EVA
rs3389351492 1235 L>V No EVA
rs3389351502 1282 S>G No EVA
rs3389370149 1282 S>R No EVA
rs3389351450 1285 P>S No EVA
rs3389351451 1338 F>I No EVA
rs3389370187 1356 A>P No EVA
rs3389395585 1362 N>S No EVA
rs3389395348 1403 A>T No EVA
rs3389407065 1408 F>L No EVA
rs3405811182 1419 E>Y No EVA
rs3407018152 1420 C>R No EVA
rs3406682110 1422 E>* No EVA
rs3389351436 1423 G>A No EVA
rs3405042864 1436 C>S No EVA
rs3405042822 1436 C>W No EVA
rs3405042837 1438 A>P No EVA
rs3407018149 1439 R>Q No EVA
rs3389351480 1440 A>G No EVA
rs3412891137 1452 E>* No EVA
rs3389318884 1460 E>K No EVA
rs3389361604 1476 C>* No EVA
rs3389351438 1489 M>L No EVA
rs3413020207 1505 C>R No EVA
rs3389402116 1513 Q>L No EVA
rs3389395309 1527 L>* No EVA

No associated diseases with O35379

1 regional properties for O35379

Type Name Position InterPro Accession
domain High mobility group box domain 4 - 74 IPR009071

Functions

Description
EC Number 7.6.2.2 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
basal plasma membrane The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
lateral plasma membrane The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

14 GO annotations of molecular function

Name Definition
ABC-type glutathione S-conjugate transporter activity Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out).
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ABC-type vitamin B12 transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: vitamin B12(out) + ATP + H2O = ADP + an vitamin B12(in) + H+ + phosphate. Vitamin B12 is alkylcob(III)alamin.
ABC-type xenobiotic transporter activity Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
amide transmembrane transporter activity Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled lipid transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out).
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
carboxylic acid transmembrane transporter activity Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).
efflux transmembrane transporter activity Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
glutathione transmembrane transporter activity Enables the transfer of glutathione, the tripeptide glutamylcysteinylglycine, from one side of a membrane to the other.
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
long-chain fatty acid transporter activity Enables the transfer of long-chain fatty acids from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
xenobiotic transmembrane transporter activity Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

22 GO annotations of biological process

Name Definition
carboxylic acid transmembrane transport The process in which carboxylic acid is transported across a membrane.
cell chemotaxis The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
cellular response to amyloid-beta Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.
cobalamin transport The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
export across plasma membrane The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region.
glutathione transmembrane transport A process in which glutathione is transported across a membrane.
leukotriene transport The directed movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups.
long-chain fatty acid import across plasma membrane The directed movement of long-chain fatty acids from outside of a cell, across the plasma membrane and into the cytosol. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
negative regulation of cell death Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
negative regulation of neuron death Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
phospholipid efflux The directed movement of a phospholipid out of a cell or organelle.
phospholipid translocation The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of inflammatory response Any process that activates or increases the frequency, rate or extent of the inflammatory response.
response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
sphingolipid translocation The movement of a sphingolipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
transepithelial transport The directed movement of a substance from one side of an epithelium to the other.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
xenobiotic detoxification by transmembrane export across the plasma membrane A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.
xenobiotic transport The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
xenobiotic transport across blood-brain barrier The directed movement of a xenobiotic through the blood-brain barrier.

26 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P14772 BPT1 Bile pigment transporter 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q8HXQ5 ABCC1 Multidrug resistance-associated protein 1 Bos taurus (Bovine) PR
Q2QLE5 CFTR Cystic fibrosis transmembrane conductance regulator Pan troglodytes (Chimpanzee) PR
Q6UR05 ABCC1 Multidrug resistance-associated protein 1 Canis lupus familiaris (Dog) (Canis familiaris) PR
P91660 Rh5 Probable multidrug resistance-associated protein lethal(2)03659 Drosophila melanogaster (Fruit fly) PR
P13569 CFTR Cystic fibrosis transmembrane conductance regulator Homo sapiens (Human) PR
O15439 ABCC4 ATP-binding cassette sub-family C member 4 Homo sapiens (Human) PR
Q96J66 ABCC11 ATP-binding cassette sub-family C member 11 Homo sapiens (Human) PR
O15438 ABCC3 ATP-binding cassette sub-family C member 3 Homo sapiens (Human) PR
O95255 ABCC6 ATP-binding cassette sub-family C member 6 Homo sapiens (Human) PR
Q92887 ABCC2 ATP-binding cassette sub-family C member 2 Homo sapiens (Human) SS
P33527 ABCC1 Multidrug resistance-associated protein 1 Homo sapiens (Human) PR
B2RX12 Abcc3 ATP-binding cassette sub-family C member 3 Mus musculus (Mouse) PR
Q8VI47 Abcc2 ATP-binding cassette sub-family C member 2 Mus musculus (Mouse) SS
Q80WJ6 Abcc12 ATP-binding cassette sub-family C member 12 Mus musculus (Mouse) PR
P26361 Cftr Cystic fibrosis transmembrane conductance regulator Mus musculus (Mouse) PR
Q6PQZ2 CFTR Cystic fibrosis transmembrane conductance regulator Sus scrofa (Pig) PR
Q6Y306 Abcc12 ATP-binding cassette sub-family C member 12 Rattus norvegicus (Rat) PR
Q63120 Abcc2 ATP-binding cassette sub-family C member 2 Rattus norvegicus (Rat) EV
Q8CG09 Abcc1 Multidrug resistance-associated protein 1 Rattus norvegicus (Rat) PR
Q00553 CFTR Cystic fibrosis transmembrane conductance regulator Macaca mulatta (Rhesus macaque) PR
Q9SKX0 ABCC13 ABC transporter C family member 13 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VZZ4 ABCC6 ABC transporter C family member 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M1C7 ABCC9 ABC transporter C family member 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C8G9 ABCC1 ABC transporter C family member 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C8H0 ABCC12 ABC transporter C family member 12 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MALRSFCSAD GSDPLWDWNV TWHTSNPDFT KCFQNTVLTW VPCFYLWSCF PLYFFYLSRH
70 80 90 100 110 120
DRGYIQMTHL NKTKTALGFF LWIICWADLF YSFWERSQGV LRAPVLLVSP TLLGITMLLA
130 140 150 160 170 180
TFLIQLERRK GVQSSGIMLT FWLVALLCAL AILRSKIISA LKKDAHVDVF RDSTFYLYFT
190 200 210 220 230 240
LVLVQLVLSC FSDCSPLFSE TVHDRNPCPE SSASFLSRIT FWWITGMMVH GYRQPLESSD
250 260 270 280 290 300
LWSLNKEDTS EEVVPVLVNN WKKECDKSRK QPVRIVYAPP KDPSKPKGSS QLDVNEEVEA
310 320 330 340 350 360
LIVKSPHKDR EPSLFKVLYK TFGPYFLMSF LYKALHDLMM FAGPKILELI INFVNDREAP
370 380 390 400 410 420
DWQGYFYTAL LFVSACLQTL ALHQYFHICF VSGMRIKTAV VGAVYRKALL ITNAARKSST
430 440 450 460 470 480
VGEIVNLMSV DAQRFMDLAT YINMIWSAPL QVILALYFLW LSLGPSVLAG VAVMILMVPL
490 500 510 520 530 540
NAVMAMKTKT YQVAHMKSKD NRIKLMNEIL NGIKVLKLYA WELAFQDKVM SIRQEELKVL
550 560 570 580 590 600
KKSAYLAAVG TFTWVCTPFL VALSTFAVFV TVDERNILDA KKAFVSLALF NILRFPLNIL
610 620 630 640 650 660
PMVISSIVQA SVSLKRLRIF LSHEELEPDS IERRSIKSGE GNSITVKNAT FTWARGEPPT
670 680 690 700 710 720
LNGITFSIPE GALVAVVGQV GCGKSSLLSA LLAEMDKVEG HVTLKGSVAY VPQQAWIQND
730 740 750 760 770 780
SLRENILFGH PLQENYYKAV MEACALLPDL EILPSGDRTE IGEKGVNLSG GQKQRVSLAR
790 800 810 820 830 840
AVYSNSDIYL FDDPLSAVDA HVGKHIFEKV VGPMGLLKNK TRILVTHGIS YLPQVDVIIV
850 860 870 880 890 900
MSGGKISEMG SYQELLDRDG AFAEFLRTYA NAEQDLASED DSVSGSGKES KPVENGMLVT
910 920 930 940 950 960
DTVGKHLQRH LSNSSSHSGD TSQQHSSIAE LQKAGAKEET WKLMEADKAQ TGQVQLSVYW
970 980 990 1000 1010 1020
NYMKAIGLFI TFLSIFLFLC NHVSALASNY WLSLWTDDPP VVNGTQANRN FRLSVYGALG
1030 1040 1050 1060 1070 1080
ILQGAAIFGY SMAVSIGGIF ASRRLHLDLL YNVLRSPMSF FERTPSGNLV NRFSKELDTV
1090 1100 1110 1120 1130 1140
DSMIPQVIKM FMGSLFSVIG AVIIILLATP IAAVIIPPLG LVYFFVQRFY VASSRQLKRL
1150 1160 1170 1180 1190 1200
ESVSRSPVYS HFNETLLGVS VIRAFEEQER FIHQSDLKVD ENQKAYYPSI VANRWLAVRL
1210 1220 1230 1240 1250 1260
ECVGNCIVLF AALFAVISRH SLSAGLVGLS VSYSLQITAY LNWLVRMSSE METNIVAVER
1270 1280 1290 1300 1310 1320
LKEYSETEKE APWQIQETAP PSTWPHSGRV EFRDYCLRYR EDLDLVLKHI NVTIEGGEKV
1330 1340 1350 1360 1370 1380
GIVGRTGAGK SSLTLGLFRI NESAEGEIII DGVNIAKIGL HNLRFKITII PQDPVLFSGS
1390 1400 1410 1420 1430 1440
LRMNLDPFSQ YSDEEVWMAL ELAHLKGFVS ALPDKLNHEC AEGGENLSVG QRQLVCLARA
1450 1460 1470 1480 1490 1500
LLRKTKILVL DEATAAVDLE TDNLIQSTIR TQFEDCTVLT IAHRLNTIMD YTRVIVLDKG
1510 1520
EVRECGAPSE LLQQRGIFYS MAKDAGLV