Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for O35368

Entry ID Method Resolution Chain Position Source
AF-O35368-F1 Predicted AlphaFoldDB

No variants for O35368

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O35368

1 associated diseases with O35368

Without disease ID

3 regional properties for O35368

Type Name Position InterPro Accession
domain Protein kinase domain 64 - 325 IPR000719
active_site Serine/threonine-protein kinase, active site 186 - 198 IPR008271
binding_site Protein kinase, ATP binding site 70 - 93 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
double-stranded DNA binding Binding to double-stranded DNA.
identical protein binding Binding to an identical protein or proteins.

2 GO annotations of biological process

Name Definition
activation of innate immune response Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
cellular response to interferon-beta Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O14862 AIM2 Interferon-inducible protein AIM2 Homo sapiens (Human) EV
P41218 MNDA Myeloid cell nuclear differentiation antigen Homo sapiens (Human) PR
Q91VJ1 Aim2 Interferon-inducible protein AIM2 Mus musculus (Mouse) SS
10 20 30 40 50 60
MAEYKNIVLL KGLENMEDYQ FRTVKSLLRK ELKLTKKMQE DYDRIQLADW MEDKFPKDAG
70 80 90 100 110 120
LDKLIKVCEH IKDLKDLAKK LKTEKAKVQE KKKGKCKTAG KKKGQDELSS SESLFINKES
130 140 150 160 170 180
YKSVPSSKKK RKQITKTEGG KKKKLTQEQA QLPETSGTNI KKEEDCLQNP HKSPPTPSSS
190 200 210 220 230 240
SSNKAPRRGT VPKEPSREEG HHQGPKQVMV LKVTEPFTYD FEETKRMFHA TVATETEFFR
250 260 270 280 290 300
VKVFDTALMS KFIPGKIIAI SHYIGCNGFL EIYRASCVSD VNINPTMIIS NTLSESAIAT
310 320 330 340 350 360
PKISYLLSQA KGTFVNGEFV VFKKSERHEC ICYGIGDDTG KMAVVVYGRL TNVRCEPGSK
370 380 390 400
LRLVCFELTS TKDVCLLRSV RHSYMQVINE GKPLNPDSVR RNSLEPYF