O23447

SS
Gene name
PME43 (ARATH43, At4g15980, dl4030c, FCAALL.248)
Protein name
Putative pectinesterase/pectinesterase inhibitor 43
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G15980
EC number
3.1.1.11: Carboxylic ester hydrolases
Protein Class

Descriptions

(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.

Autoinhibitory domains (AIDs)

46-195 (PMEI region) SS

Target domain

391-688 (Pectinesterase domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O23447

Entry ID Method Resolution Chain Position Source
AF-O23447-F1 Predicted AlphaFoldDB

174 variants for O23447

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH02848418 2 N>K No 1000Genomes
ENSVATH06683405 4 Y>S No 1000Genomes
tmp_4_9059966_C_T,G 6 L>F No 1000Genomes
tmp_4_9059968_A_C 6 L>V No 1000Genomes
tmp_4_9059955_G_A 10 T>M No 1000Genomes
ENSVATH14210937 11 A>V No 1000Genomes
ENSVATH14210936 15 A>E No 1000Genomes
ENSVATH14210936 15 A>G No 1000Genomes
tmp_4_9059919_G_T 22 A>D No 1000Genomes
tmp_4_9059915_G_T 23 N>K No 1000Genomes
tmp_4_9059907_T_C 26 N>S No 1000Genomes
tmp_4_9059888_C_T 32 M>I No 1000Genomes
ENSVATH02848417 38 E>K No 1000Genomes
ENSVATH06683402 38 E>V No 1000Genomes
tmp_4_9059851_T_A 45 K>* No 1000Genomes
ENSVATH06683401 45 K>T No 1000Genomes
ENSVATH11820897 54 S>F No 1000Genomes
tmp_4_9059813_G_T 57 Y>* No 1000Genomes
ENSVATH06683399 62 T>I No 1000Genomes
ENSVATH06683398 66 A>T No 1000Genomes
ENSVATH02848416 67 T>A No 1000Genomes
tmp_4_9059755_T_A 77 I>L No 1000Genomes
tmp_4_9059737_G_T 83 L>I No 1000Genomes
tmp_4_9059727_A_G 86 I>T No 1000Genomes
tmp_4_9059728_T_C 86 I>V No 1000Genomes
tmp_4_9059718_C_T 89 R>Q No 1000Genomes
ENSVATH06683395 91 G>R No 1000Genomes
ENSVATH06683394 96 M>I No 1000Genomes
ENSVATH06683393 100 K>N No 1000Genomes
ENSVATH11820895 108 H>Y No 1000Genomes
ENSVATH06683390 112 A>S No 1000Genomes
ENSVATH06683390 112 A>T No 1000Genomes
ENSVATH06683389 112 A>V No 1000Genomes
ENSVATH06683388 115 T>I No 1000Genomes
tmp_4_9059620_C_T 122 D>N No 1000Genomes
tmp_4_9059611_C_G 125 D>H No 1000Genomes
ENSVATH06683386 137 F>Y No 1000Genomes
ENSVATH02848415 140 T>S No 1000Genomes
tmp_4_9059562_C_T 141 R>K No 1000Genomes
tmp_4_9059528_C_G 152 W>C No 1000Genomes
tmp_4_9059479_C_G 169 G>R No 1000Genomes
ENSVATH00510189 177 M>I No 1000Genomes
tmp_4_9059433_T_C 184 K>R No 1000Genomes
ENSVATH02848414 185 G>A No 1000Genomes
ENSVATH06683382 194 A>G No 1000Genomes
tmp_4_9059398_C_T 196 A>T No 1000Genomes
tmp_4_9059372_C_G,T 204 K>N No 1000Genomes
tmp_4_9059347_G_A 213 L>F No 1000Genomes
ENSVATH00510185 216 R>K No 1000Genomes
tmp_4_9059193_A_T 223 L>* No 1000Genomes
ENSVATH14210883 224 G>R No 1000Genomes
tmp_4_9059184_C_G 226 G>A No 1000Genomes
ENSVATH06683375 227 S>T No 1000Genomes
ENSVATH00510184 231 E>Q No 1000Genomes
tmp_4_9059166_G_A 232 S>L No 1000Genomes
tmp_4_9059157_G_A 235 S>F No 1000Genomes
ENSVATH02848405 239 S>Y No 1000Genomes
ENSVATH06683374 246 S>F No 1000Genomes
tmp_4_9059112_G_C 250 P>R No 1000Genomes
ENSVATH00510181 251 S>I No 1000Genomes
ENSVATH06683372 254 D>E No 1000Genomes
ENSVATH11820797 256 S>L No 1000Genomes
tmp_4_9059080_C_A 261 V>L No 1000Genomes
tmp_4_9059070_G_C 264 S>* No 1000Genomes
tmp_4_9059068_A_C 265 S>A No 1000Genomes
tmp_4_9059067_G_A 265 S>L No 1000Genomes
ENSVATH06683371 266 E>G No 1000Genomes
tmp_4_9059059_G_T 268 Q>K No 1000Genomes
tmp_4_9059058_T_A 268 Q>L No 1000Genomes
ENSVATH00510179 269 S>P No 1000Genomes
ENSVATH06683369 273 S>L No 1000Genomes
ENSVATH06683370 273 S>P No 1000Genomes
ENSVATH06683368 274 N>D No 1000Genomes
ENSVATH06683367 274 N>S No 1000Genomes
ENSVATH06683366 277 P>Q No 1000Genomes
tmp_4_9059032_G_T 277 P>T No 1000Genomes
tmp_4_9058998_G_T 288 S>Y No 1000Genomes
tmp_4_9058995_G_A 289 S>F No 1000Genomes
ENSVATH06683365 290 E>Q No 1000Genomes
ENSVATH06683364 291 D>N No 1000Genomes
tmp_4_9058983_G_C 293 P>R No 1000Genomes
tmp_4_9058979_T_G 294 K>N No 1000Genomes
ENSVATH06683361 295 K>N No 1000Genomes
ENSVATH06683362 295 K>R No 1000Genomes
tmp_4_9058975_A_T 296 S>T No 1000Genomes
ENSVATH00510177 298 F>S No 1000Genomes
tmp_4_9058965_G_A 299 S>L No 1000Genomes
ENSVATH00510176 300 G>E No 1000Genomes
tmp_4_9058954_G_T 303 P>T No 1000Genomes
ENSVATH06683359 305 D>N No 1000Genomes
tmp_4_9058919_T_A 314 K>N No 1000Genomes
ENSVATH00510175 315 S>P No 1000Genomes
ENSVATH06683358 316 T>S No 1000Genomes
ENSVATH11820783 318 S>C No 1000Genomes
ENSVATH11820784 318 S>T No 1000Genomes
ENSVATH00510174 320 N>I No 1000Genomes
tmp_4_9058899_T_C 321 Q>R No 1000Genomes
ENSVATH06683355 322 P>Q No 1000Genomes
ENSVATH06683354 323 L>F No 1000Genomes
ENSVATH06683353 324 D>N No 1000Genomes
tmp_4_9058884_G_A 326 S>F No 1000Genomes
ENSVATH11820781 327 E>D No 1000Genomes
ENSVATH11820780 328 N>K No 1000Genomes
ENSVATH11820779 329 P>L No 1000Genomes
ENSVATH11820778 330 P>L No 1000Genomes
tmp_4_9058864_A_T 333 S>T No 1000Genomes
tmp_4_9058857_G_A 335 S>F No 1000Genomes
tmp_4_9058831_G_C 344 L>V No 1000Genomes
ENSVATH11820760 345 R>C No 1000Genomes
tmp_4_9058827_C_T 345 R>H No 1000Genomes
tmp_4_9058820_C_G 347 L>F No 1000Genomes
ENSVATH02848404 351 N>K No 1000Genomes
ENSVATH02848404 351 N>K No 1000Genomes
tmp_4_9058807_T_G 352 K>Q No 1000Genomes
tmp_4_9058802_C_A 353 L>F No 1000Genomes
tmp_4_9058800_T_C 354 D>G No 1000Genomes
ENSVATH06683351 363 E>K No 1000Genomes
ENSVATH06683351 363 E>Q No 1000Genomes
ENSVATH11820759 364 E>A No 1000Genomes
ENSVATH11820758 373 P>S No 1000Genomes
tmp_4_9058734_C_T 376 R>Q No 1000Genomes
tmp_4_9058731_C_T 377 R>K No 1000Genomes
ENSVATH00510172 384 R>K No 1000Genomes
ENSVATH00510172 384 R>T No 1000Genomes
ENSVATH11820757 387 G>E No 1000Genomes
tmp_4_9058695_T_C 389 K>R No 1000Genomes
tmp_4_9058692_G_C 390 A>G No 1000Genomes
ENSVATH06683350 395 A>T No 1000Genomes
ENSVATH06683349 398 G>R No 1000Genomes
tmp_4_9058662_C_T 400 G>D No 1000Genomes
tmp_4_9058644_G_A 406 A>V No 1000Genomes
tmp_4_9058642_G_A 407 Q>* No 1000Genomes
tmp_4_9058611_G_A 417 T>I No 1000Genomes
tmp_4_9058604_C_G 419 K>N No 1000Genomes
tmp_4_9058591_T_G 424 I>L No 1000Genomes
tmp_4_9058561_C_G 434 E>Q No 1000Genomes
tmp_4_9058551_T_C 437 K>R No 1000Genomes
ENSVATH06683348 440 L>V No 1000Genomes
tmp_4_9058512_G_T 450 T>K No 1000Genomes
tmp_4_9058504_C_T 453 V>I No 1000Genomes
ENSVATH11820755 466 G>S No 1000Genomes
tmp_4_9058458_T_A 468 Y>F No 1000Genomes
tmp_4_9058456_G_A,C 469 R>C No 1000Genomes
tmp_4_9058456_G_A,C 469 R>G No 1000Genomes
ENSVATH00510168 473 V>F No 1000Genomes
tmp_4_9058228_A_G 479 Y>H No 1000Genomes
ENSVATH11820728 481 M>I No 1000Genomes
tmp_4_9058208_T_C 485 I>M No 1000Genomes
tmp_4_9058147_C_A 506 D>Y No 1000Genomes
tmp_4_9058143_A_G 507 F>S No 1000Genomes
ENSVATH11820726 527 H>N No 1000Genomes
ENSVATH14210878 530 F>L No 1000Genomes
tmp_4_9058056_A_T 536 V>D No 1000Genomes
ENSVATH14210877 538 G>S No 1000Genomes
ENSVATH06683341 553 N>K No 1000Genomes
ENSVATH00510162 557 V>I No 1000Genomes
tmp_4_9057985_G_A 560 R>C No 1000Genomes
ENSVATH06683340 564 H>N No 1000Genomes
tmp_4_9057971_G_C,A 564 H>Q No 1000Genomes
ENSVATH06683340 564 H>Y No 1000Genomes
ENSVATH00510161 566 Q>R No 1000Genomes
ENSVATH06683338 577 R>W No 1000Genomes
ENSVATH11820674 591 T>I No 1000Genomes
tmp_4_9057889_C_T 592 G>S No 1000Genomes
tmp_4_9057880_A_C 595 S>A No 1000Genomes
ENSVATH11820671 631 E>K No 1000Genomes
tmp_4_9057671_A_G 634 L>S No 1000Genomes
tmp_4_9057609_G_C 655 R>G No 1000Genomes
tmp_4_9057590_C_A 661 R>L No 1000Genomes
tmp_4_9057575_C_A 666 R>I No 1000Genomes
ENSVATH06683330 669 K>E No 1000Genomes
tmp_4_9057542_C_G 677 R>T No 1000Genomes
ENSVATH00510157 689 T>I No 1000Genomes
ENSVATH06683328 693 Q>H No 1000Genomes

No associated diseases with O23447

4 regional properties for O23447

Type Name Position InterPro Accession
domain Pectinesterase, catalytic 391 - 688 IPR000070
domain Pectinesterase inhibitor domain 43 - 199 IPR006501
active_site Pectinesterase, Tyr active site 416 - 435 IPR018040
active_site Pectinesterase, Asp active site 536 - 545 IPR033131

Functions

Description
EC Number 3.1.1.11 Carboxylic ester hydrolases
Subcellular Localization
  • Secreted, cell wall
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.

3 GO annotations of molecular function

Name Definition
aspartyl esterase activity Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue.
pectinesterase activity Catalysis of the reaction: pectin + n H2O = n methanol + pectate.
pectinesterase inhibitor activity Binds to and stops, prevents or reduces the activity of pectinesterase.

2 GO annotations of biological process

Name Definition
cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly.
pectin catabolic process The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.

42 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3E8Z8 PME28 Putative pectinesterase/pectinesterase inhibitor 28 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GX86 PME21 Probable pectinesterase/pectinesterase inhibitor 21 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SRX4 PME7 Probable pectinesterase/pectinesterase inhibitor 7 Arabidopsis thaliana (Mouse-ear cress) SS
Q1JPL7 PME18 Pectinesterase/pectinesterase inhibitor 18 Arabidopsis thaliana (Mouse-ear cress) SS
Q84JX1 PME19 Probable pectinesterase/pectinesterase inhibitor 19 Arabidopsis thaliana (Mouse-ear cress) SS
O49298 PME6 Probable pectinesterase/pectinesterase inhibitor 6 Arabidopsis thaliana (Mouse-ear cress) SS
Q42534 PME2 Pectinesterase 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q43867 PME1 Pectinesterase 1 Arabidopsis thaliana (Mouse-ear cress) SS
O48711 PME12 Probable pectinesterase/pectinesterase inhibitor 12 Arabidopsis thaliana (Mouse-ear cress) SS
Q7Y201 PME13 Probable pectinesterase/pectinesterase inhibitor 13 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SKX2 PME16 Probable pectinesterase/pectinesterase inhibitor 16 Arabidopsis thaliana (Mouse-ear cress) SS
O22149 PME17 Probable pectinesterase/pectinesterase inhibitor 17 Arabidopsis thaliana (Mouse-ear cress) SS
O80722 PME4 Pectinesterase 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV8 PME5 Pectinesterase 5 Arabidopsis thaliana (Mouse-ear cress) SS
O22256 PME20 Probable pectinesterase/pectinesterase inhibitor 20 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M9W7 PME22 Putative pectinesterase/pectinesterase inhibitor 22 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GXA1 PME23 Probable pectinesterase/pectinesterase inhibitor 23 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SG77 PME24 Putative pectinesterase/pectinesterase inhibitor 24 Arabidopsis thaliana (Mouse-ear cress) SS
O49006 PME3 Pectinesterase/pectinesterase inhibitor 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q9STY3 PME33 Probable pectinesterase/pectinesterase inhibitor 33 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LYT5 PME35 Probable pectinesterase/pectinesterase inhibitor 35 Arabidopsis thaliana (Mouse-ear cress) SS
Q84R10 PME36 Probable pectinesterase/pectinesterase inhibitor 36 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV6 VGDH2 Probable pectinesterase/pectinesterase inhibitor VGDH2 Arabidopsis thaliana (Mouse-ear cress) SS
O81320 PME38 Putative pectinesterase/pectinesterase inhibitor 38 Arabidopsis thaliana (Mouse-ear cress) SS
O81415 PME39 Probable pectinesterase/pectinesterase inhibitor 39 Arabidopsis thaliana (Mouse-ear cress) SS
O81301 PME40 Probable pectinesterase/pectinesterase inhibitor 40 Arabidopsis thaliana (Mouse-ear cress) SS
Q8RXK7 PME41 Probable pectinesterase/pectinesterase inhibitor 41 Arabidopsis thaliana (Mouse-ear cress) SS
Q1PEC0 PME42 Probable pectinesterase/pectinesterase inhibitor 42 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY7 PME44 Probable pectinesterase/pectinesterase inhibitor 44 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY6 PME45 Putative pectinesterase/pectinesterase inhibitor 45 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF78 PME46 Probable pectinesterase/pectinesterase inhibitor 46 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF77 PME47 Probable pectinesterase/pectinesterase inhibitor 47 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXD9 PME51 Probable pectinesterase/pectinesterase inhibitor 51 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E989 PME54 Probable pectinesterase/pectinesterase inhibitor 54 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FJ21 PME58 Probable pectinesterase/pectinesterase inhibitor 58 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHN5 PME59 Probable pectinesterase/pectinesterase inhibitor 59 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHN4 PME60 Probable pectinesterase/pectinesterase inhibitor 60 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FK05 PME61 Probable pectinesterase/pectinesterase inhibitor 61 Arabidopsis thaliana (Mouse-ear cress) SS
Q8L7Q7 PME64 Probable pectinesterase/pectinesterase inhibitor 64 Arabidopsis thaliana (Mouse-ear cress) SS
Q94CB1 PME25 Probable pectinesterase/pectinesterase inhibitor 25 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXK7 PME32 Probable pectinesterase/pectinesterase inhibitor 32 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M3B0 PME34 Probable pectinesterase/pectinesterase inhibitor 34 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MNKYVLLGVT ALIMAMVICV EANDGNSPSR KMEEVHRESK LMITKTTVSI ICASTDYKQD
70 80 90 100 110 120
CTTSLATVRS PDPRNLIRSA FDLAIISIRS GIDRGMIDLK SRADADMHTR EALNTCRELM
130 140 150 160 170 180
DDAIDDLRKT RDKFRGFLFT RLSDFVEDLC VWLSGSITYQ QTCIDGFEGI DSEAAVMMER
190 200 210 220 230 240
VMRKGQHLTS NGLAIAANLD KLLKAFRIPF PFLRSRRGRL GILGSGSSRD ESVGSSQDSP
250 260 270 280 290 300
PNEDSSDDSP STVDSSENQP VDSSSENQSS DSSNNRPLDS SKNQQMESSE DTPKKSAFSG
310 320 330 340 350 360
NQPLDDSSDK LPQKSTSSEN QPLDSSENPP QKSTSSENRP LDPLRKLNPL NKLDSLKDRH
370 380 390 400 410 420
LSEEGEFPPW VTPHSRRLLA RRPRNNGIKA NVVVAKDGSG KCKTIAQALA MVPMKNTKKF
430 440 450 460 470 480
VIHIKEGVYK EKVEVTKKML HVMFVGDGPT KTVITGDIAF LPDQVGTYRT ASVAVNGDYF
490 500 510 520 530 540
MAKDIGFENT AGAARHQAVA LRVSADFAVF FNCHMNGYQD TLYVHTHRQF YRNCRVSGTI
550 560 570 580 590 600
DFVFGDAKAV FQNCEFVIRR PMEHQQCIVT AQGRKDRRET TGIVIHNSRI TGDASYLPVK
610 620 630 640 650 660
AKNRAFLGRP WKEFSRTIIM NTEIDDVIDP EGWLKWNETF ALNTLFYTEY RNRGRGSGQG
670 680 690 700
RRVRWRGIKR ISDRAAREFA PGNFLRGNTW IPQTRIPYNA N