O23304
Gene name |
BLUS1 (At4g14480, dl3280c) |
Protein name |
Serine/threonine-protein kinase BLUS1 |
Names |
Protein BLUE LIGHT SIGNALING 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G14480 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
156-189 (Activation loop from InterPro)
Target domain |
15-293 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for O23304
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O23304-F1 | Predicted | AlphaFoldDB |
46 variants for O23304
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_8331537_C_T | 3 | R>Q | No | 1000Genomes | |
| tmp_4_8331531_T_G | 5 | K>T | No | 1000Genomes | |
| tmp_4_8331511_C_G | 12 | A>P | No | 1000Genomes | |
| tmp_4_8331507_T_C | 13 | E>G | No | 1000Genomes | |
| tmp_4_8331448_T_G | 33 | I>L | No | 1000Genomes | |
| ENSVATH00503921 | 84 | D>A | No | 1000Genomes | |
| ENSVATH06662975 | 125 | N>S | No | 1000Genomes | |
| ENSVATH14190495 | 149 | S>A | No | 1000Genomes | |
| ENSVATH06662970 | 241 | R>S | No | 1000Genomes | |
| ENSVATH14190484 | 250 | N>S | No | 1000Genomes | |
| tmp_4_8330785_T_A | 254 | S>C | No | 1000Genomes | |
| ENSVATH06662966 | 257 | K>N | No | 1000Genomes | |
| tmp_4_8330584_G_T | 321 | Q>K | No | 1000Genomes | |
| ENSVATH14190482 | 323 | L>S | No | 1000Genomes | |
| ENSVATH02831653 | 329 | D>A | No | 1000Genomes | |
| ENSVATH06662963 | 332 | E>D | No | 1000Genomes | |
| ENSVATH14190481 | 333 | E>D | No | 1000Genomes | |
| ENSVATH11726297 | 337 | E>D | No | 1000Genomes | |
| ENSVATH06662962 | 338 | D>E | No | 1000Genomes | |
| ENSVATH15002322 | 338 | D>G | No | 1000Genomes | |
| ENSVATH06662960 | 345 | R>T | No | 1000Genomes | |
| tmp_4_8330433_G_A | 371 | S>F | No | 1000Genomes | |
| ENSVATH02831652 | 372 | E>D | No | 1000Genomes | |
| ENSVATH02831651 | 378 | E>K | No | 1000Genomes | |
| tmp_4_8330403_G_A | 381 | S>L | No | 1000Genomes | |
| ENSVATH14190477 | 382 | K>Q | No | 1000Genomes | |
| tmp_4_8330395_T_G,C | 384 | K>E | No | 1000Genomes | |
| tmp_4_8330395_T_G,C | 384 | K>Q | No | 1000Genomes | |
| tmp_4_8330386_C_T | 387 | D>N | No | 1000Genomes | |
| ENSVATH00503918 | 398 | G>D | No | 1000Genomes | |
| ENSVATH06662959 | 400 | G>A | No | 1000Genomes | |
| ENSVATH00503917 | 412 | E>D | No | 1000Genomes | |
| tmp_4_8330279_T_G | 422 | L>F | No | 1000Genomes | |
| tmp_4_8330278_C_G | 423 | E>Q | No | 1000Genomes | |
| tmp_4_8330267_T_A | 426 | K>N | No | 1000Genomes | |
| tmp_4_8330266_C_G | 427 | V>L | No | 1000Genomes | |
| tmp_4_8330248_C_T | 433 | E>K | No | 1000Genomes | |
| tmp_4_8330221_T_C | 442 | I>V | No | 1000Genomes | |
| tmp_4_8330138_T_G | 469 | E>D | No | 1000Genomes | |
| ENSVATH06662957 | 472 | T>A | No | 1000Genomes | |
| ENSVATH14190475 | 472 | T>N | No | 1000Genomes | |
| ENSVATH14190475 | 472 | T>S | No | 1000Genomes | |
| ENSVATH06662956 | 473 | E>K | No | 1000Genomes | |
| tmp_4_8330121_A_C | 475 | L>R | No | 1000Genomes | |
| tmp_4_8330096_A_C | 483 | D>E | No | 1000Genomes | |
| ENSVATH06662955 | 484 | S>T | No | 1000Genomes |
No associated diseases with O23304
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| metal ion binding | Binding to a metal ion. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of stomatal opening | Any process that modulates the frequency, rate or extent of stomatal opening. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9UEW8 | STK39 | STE20/SPS1-related proline-alanine-rich protein kinase | Homo sapiens (Human) | PR |
| O95747 | OXSR1 | Serine/threonine-protein kinase OSR1 | Homo sapiens (Human) | PR |
| O95819 | MAP4K4 | Mitogen-activated protein kinase kinase kinase kinase 4 | Homo sapiens (Human) | PR |
| Q9C0K7 | STRADB | STE20-related kinase adapter protein beta | Homo sapiens (Human) | PR |
| Q7RTN6 | STRADA | STE20-related kinase adapter protein alpha | Homo sapiens (Human) | PR |
| Q6P9R2 | Oxsr1 | Serine/threonine-protein kinase OSR1 | Mus musculus (Mouse) | PR |
| Q9Z1W9 | Stk39 | STE20/SPS1-related proline-alanine-rich protein kinase | Mus musculus (Mouse) | PR |
| Q9JM52 | Mink1 | Misshapen-like kinase 1 | Mus musculus (Mouse) | PR |
| P83510 | Tnik | Traf2 and NCK-interacting protein kinase | Mus musculus (Mouse) | PR |
| P97820 | Map4k4 | Mitogen-activated protein kinase kinase kinase kinase 4 | Mus musculus (Mouse) | PR |
| Q8K4T3 | Stradb | STE20-related kinase adapter protein beta | Mus musculus (Mouse) | PR |
| Q3UUJ4 | Strada | STE20-related kinase adapter protein alpha | Mus musculus (Mouse) | PR |
| Q863I2 | OXSR1 | Serine/threonine-protein kinase OSR1 | Sus scrofa (Pig) | PR |
| O88506 | Stk39 | STE20/SPS1-related proline-alanine-rich protein kinase | Rattus norvegicus (Rat) | PR |
| Q7TNZ6 | Strada | STE20-related kinase adapter protein alpha | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARNKLEFPL | DAEAYEIICK | IGVGVSASVY | KAICIPMNSM | VVAIKAIDLD | QSRADFDSLR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RETKTMSLLS | HPNILNAYCS | FTVDRCLWVV | MPFMSCGSLH | SIVSSSFPSG | LPENCISVFL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KETLNAISYL | HDQGHLHRDI | KAGNILVDSD | GSVKLADFGV | SASIYEPVTS | SSGTTSSSLR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LTDIAGTPYW | MAPEVVHSHT | GYGFKADIWS | FGITALELAH | GRPPLSHLPP | LKSLLMKITK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RFHFSDYEIN | TSGSSKKGNK | KFSKAFREMV | GLCLEQDPTK | RPSAEKLLKH | PFFKNCKGLD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FVVKNVLHSL | SNAEQMFMES | QILIKSVGDD | DEEEEEEDEE | IVKNRRISGW | NFREDDLQLS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PVFPATESDS | SESSPREEDQ | SKDKKEDDNV | TITGYELGLG | LSNEEAKNQE | GEVVGFDKDL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VLEKLKVLKK | SLEHQRARVS | IIIEALSGDK | EEKSREEELL | EMVEKLKIEL | ETEKLKTLRA |
| DKDSVLG |