O22558

PR
Gene name
STY8
Protein name
Serine/threonine-protein kinase STY8
Names
Serine/threonine/tyrosine-protein kinase 8
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G17700
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-307 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

424-446 (Activation loop from InterPro)

Target domain

286-539 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for O22558

Entry ID Method Resolution Chain Position Source
AF-O22558-F1 Predicted AlphaFoldDB

10 variants for O22558

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_2_7689088_C_A 64 R>L No 1000Genomes
ENSVATH13243825 113 A>D No 1000Genomes
ENSVATH01830322 166 T>I No 1000Genomes
ENSVATH05516657 209 V>A No 1000Genomes
ENSVATH00235260 231 R>K No 1000Genomes
ENSVATH14511184 260 S>L No 1000Genomes
tmp_2_7687463_T_A 273 T>S No 1000Genomes
ENSVATH05516630 510 V>L No 1000Genomes
ENSVATH05516629 516 R>K No 1000Genomes
ENSVATH13243643 524 Q>E No 1000Genomes

No associated diseases with O22558

3 regional properties for O22558

Type Name Position InterPro Accession
conserved_site Heat shock protein 70, conserved site 9 - 16 IPR018181-1
conserved_site Heat shock protein 70, conserved site 197 - 210 IPR018181-2
conserved_site Heat shock protein 70, conserved site 334 - 348 IPR018181-3

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

2 GO annotations of biological process

Name Definition
chloroplast organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast.
protein phosphorylation The process of introducing a phosphate group on to a protein.

90 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A2VDU3 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Bos taurus (Bovine) SS
Q4TVR5 DSTYK Dual serine/threonine and tyrosine protein kinase Bos taurus (Bovine) PR
Q3SZJ2 RIPK2 Receptor-interacting serine/threonine-protein kinase 2 Bos taurus (Bovine) PR
A7E3S4 RAF1 RAF proto-oncogene serine/threonine-protein kinase Bos taurus (Bovine) SS
Q6XUX0 DSTYK Dual serine/threonine and tyrosine protein kinase Gallus gallus (Chicken) PR
P00523 SRC Proto-oncogene tyrosine-protein kinase Src Gallus gallus (Chicken) EV
Q02977 YRK Proto-oncogene tyrosine-protein kinase Yrk Gallus gallus (Chicken) SS
P09324 YES1 Tyrosine-protein kinase Yes Gallus gallus (Chicken) SS
F1N9Y5 SYK Tyrosine-protein kinase SYK Gallus gallus (Chicken) SS
Q05876 FYN Tyrosine-protein kinase Fyn Gallus gallus (Chicken) SS
Q95UN8 slpr Mitogen-activated protein kinase kinase kinase Drosophila melanogaster (Fruit fly) EV
P83104 Takl1 Putative mitogen-activated protein kinase kinase kinase 7-like Drosophila melanogaster (Fruit fly) PR
O43353 RIPK2 Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens (Human) PR
Q02779 MAP3K10 Mitogen-activated protein kinase kinase kinase 10 Homo sapiens (Human) SS
Q8NB16 MLKL Mixed lineage kinase domain-like protein Homo sapiens (Human) EV
Q16584 MAP3K11 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens (Human) EV
P00540 MOS Proto-oncogene serine/threonine-protein kinase mos Homo sapiens (Human) PR
Q5TCX8 MAP3K21 Mitogen-activated protein kinase kinase kinase 21 Homo sapiens (Human) PR
Q6XUX3 DSTYK Dual serine/threonine and tyrosine protein kinase Homo sapiens (Human) PR
Q9NYL2 MAP3K20 Mitogen-activated protein kinase kinase kinase 20 Homo sapiens (Human) PR
Q38SD2 LRRK1 Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens (Human) EV
P80192 MAP3K9 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens (Human) SS
O43318 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Homo sapiens (Human) SS
P06239 LCK Tyrosine-protein kinase Lck Homo sapiens (Human) EV
P06241 FYN Tyrosine-protein kinase Fyn Homo sapiens (Human) SS
P07948 LYN Tyrosine-protein kinase Lyn Homo sapiens (Human) SS
P08631 HCK Tyrosine-protein kinase HCK Homo sapiens (Human) EV
P12931 SRC Proto-oncogene tyrosine-protein kinase Src Homo sapiens (Human) EV
P42685 FRK Tyrosine-protein kinase FRK Homo sapiens (Human) EV
P43403 ZAP70 Tyrosine-protein kinase ZAP-70 Homo sapiens (Human) EV
Q13882 PTK6 Protein-tyrosine kinase 6 Homo sapiens (Human) EV
P51451 BLK Tyrosine-protein kinase Blk Homo sapiens (Human) SS
P09769 FGR Tyrosine-protein kinase Fgr Homo sapiens (Human) SS
P07947 YES1 Tyrosine-protein kinase Yes Homo sapiens (Human) SS
Q13418 ILK Integrin-linked protein kinase Homo sapiens (Human) PR
Q80XI6 Map3k11 Mitogen-activated protein kinase kinase kinase 11 Mus musculus (Mouse) PR
Q8VDG6 Map3k21 Mitogen-activated protein kinase kinase kinase 21 Mus musculus (Mouse) PR
P58801 Ripk2 Receptor-interacting serine/threonine-protein kinase 2 Mus musculus (Mouse) PR
Q62073 Map3k7 Mitogen-activated protein kinase kinase kinase 7 Mus musculus (Mouse) EV
Q3U1V8 Map3k9 Mitogen-activated protein kinase kinase kinase 9 Mus musculus (Mouse) SS
Q9D2Y4 Mlkl Mixed lineage kinase domain-like protein Mus musculus (Mouse) SS
Q9ESL4 Map3k20 Mitogen-activated protein kinase kinase kinase 20 Mus musculus (Mouse) PR
P00536 Mos Proto-oncogene serine/threonine-protein kinase mos Mus musculus (Mouse) PR
Q66L42 Map3k10 Mitogen-activated protein kinase kinase kinase 10 Mus musculus (Mouse) SS
P08103 Hck Tyrosine-protein kinase HCK Mus musculus (Mouse) SS
P25911 Lyn Tyrosine-protein kinase Lyn Mus musculus (Mouse) EV
P28028 Braf Serine/threonine-protein kinase B-raf Mus musculus (Mouse) SS
P39688 Fyn Tyrosine-protein kinase Fyn Mus musculus (Mouse) SS
P41242 Matk Megakaryocyte-associated tyrosine-protein kinase Mus musculus (Mouse) SS
P43404 Zap70 Tyrosine-protein kinase ZAP-70 Mus musculus (Mouse) SS
Q99N57 Raf1 RAF proto-oncogene serine/threonine-protein kinase Mus musculus (Mouse) SS
P04627 Araf Serine/threonine-protein kinase A-Raf Mus musculus (Mouse) PR
P16277 Blk Tyrosine-protein kinase Blk Mus musculus (Mouse) SS
Q64434 Ptk6 Protein-tyrosine kinase 6 Mus musculus (Mouse) SS
P05480 Src Proto-oncogene tyrosine-protein kinase Src Mus musculus (Mouse) EV
P14234 Fgr Tyrosine-protein kinase Fgr Mus musculus (Mouse) SS
P41241 Csk Tyrosine-protein kinase CSK Mus musculus (Mouse) EV
P06240 Lck Proto-oncogene tyrosine-protein kinase LCK Mus musculus (Mouse) SS
Q04736 Yes1 Tyrosine-protein kinase Yes Mus musculus (Mouse) SS
P48025 Syk Tyrosine-protein kinase SYK Mus musculus (Mouse) SS
Q922K9 Frk Tyrosine-protein kinase FRK Mus musculus (Mouse) SS
O55222 Ilk Integrin-linked protein kinase Mus musculus (Mouse) PR
Q62270 Srms Tyrosine-protein kinase Srms Mus musculus (Mouse) SS
Q00655 SYK Tyrosine-protein kinase SYK Sus scrofa (Pig) SS
Q66HA1 Map3k11 Mitogen-activated protein kinase kinase kinase 11 Rattus norvegicus (Rat) PR
D3ZG83 Map3k10 Mitogen-activated protein kinase kinase kinase 10 Rattus norvegicus (Rat) SS
P00539 Mos Proto-oncogene serine/threonine-protein kinase mos Rattus norvegicus (Rat) PR
P0C8E4 Map3k7 Mitogen-activated protein kinase kinase kinase 7 Rattus norvegicus (Rat) SS
P50545 Hck Tyrosine-protein kinase HCK Rattus norvegicus (Rat) SS
Q07014 Lyn Tyrosine-protein kinase Lyn Rattus norvegicus (Rat) SS
Q64725 Syk Tyrosine-protein kinase SYK Rattus norvegicus (Rat) SS
Q9WUD9 Src Proto-oncogene tyrosine-protein kinase Src Rattus norvegicus (Rat) SS
Q62662 Frk Tyrosine-protein kinase FRK Rattus norvegicus (Rat) SS
Q62844 Fyn Tyrosine-protein kinase Fyn Rattus norvegicus (Rat) SS
Q6P6U0 Fgr Tyrosine-protein kinase Fgr Rattus norvegicus (Rat) SS
F1LM93 Yes1 Tyrosine-protein kinase Yes Rattus norvegicus (Rat) SS
Q01621 Lck Proto-oncogene tyrosine-protein kinase LCK Rattus norvegicus (Rat) SS
Q9TZM3 lrk-1 Leucine-rich repeat serine/threonine-protein kinase 1 Caenorhabditis elegans SS
O45539 src-2 Tyrosine protein-kinase src-2 Caenorhabditis elegans SS
O01798 spe-8 Spermatocyte protein spe-8 Caenorhabditis elegans PR
Q9TZC4 pat-4 Integrin-linked protein kinase homolog pat-4 Caenorhabditis elegans PR
G5ECJ6 csk-1 Tyrosine-protein kinase csk-1 Caenorhabditis elegans SS
G5EE56 src-1 Tyrosine protein-kinase src-1 Caenorhabditis elegans SS
Q9FPR3 EDR1 Serine/threonine-protein kinase EDR1 Arabidopsis thaliana (Mouse-ear cress) PR
Q2MHE4 HT1 Serine/threonine/tyrosine-protein kinase HT1 Arabidopsis thaliana (Mouse-ear cress) PR
F4JTP5 STY46 Serine/threonine-protein kinase STY46 Arabidopsis thaliana (Mouse-ear cress) PR
Q05609 CTR1 Serine/threonine-protein kinase CTR1 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWL6 STY17 Serine/threonine-protein kinase STY17 Arabidopsis thaliana (Mouse-ear cress) PR
Q67E00 dstyk Dual serine/threonine and tyrosine protein kinase Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
O13147 ephb3 Ephrin type-B receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MTIKDESESC GSRAVVASPS QENPRHYRMK LDVYSEVLQR LQESNYEEAT LPDFEDQLWL
70 80 90 100 110 120
HFNRLPARYA LDVKVERAED VLTHQRLLKL AADPATRPVF EVRSVQVSPR ISADSDPAVE
130 140 150 160 170 180
EDAQSSHQPS GPGVLAPPTF GSSPNFEAIT QGSKIVEDVD SVVNATLSTR PMHEITFSTI
190 200 210 220 230 240
DKPKLLSQLT SLLGELGLNI QEAHAFSTVD GFSLDVFVVD GWSQEETDGL RDALSKEILK
250 260 270 280 290 300
LKDQPGSKQK SISFFEHDKS SNELIPACIE IPTDGTDEWE IDVTQLKIEK KVASGSYGDL
310 320 330 340 350 360
HRGTYCSQEV AIKFLKPDRV NNEMLREFSQ EVFIMRKVRH KNVVQFLGAC TRSPTLCIVT
370 380 390 400 410 420
EFMARGSIYD FLHKQKCAFK LQTLLKVALD VAKGMSYLHQ NNIIHRDLKT ANLLMDEHGL
430 440 450 460 470 480
VKVADFGVAR VQIESGVMTA ETGTYRWMAP EVIEHKPYNH KADVFSYAIV LWELLTGDIP
490 500 510 520 530 540
YAFLTPLQAA VGVVQKGLRP KIPKKTHPKV KGLLERCWHQ DPEQRPLFEE IIEMLQQIMK
EVNVVV