O22265
PR
Gene name |
CAO (CPSRP43, At2g47450, T30B22.25) |
Protein name |
Signal recognition particle 43 kDa protein, chloroplastic |
Names |
Chromo protein SRP43, CpSRP43 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G47450 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
11 structures for O22265
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1X32 | NMR | - | A | 84-128 | PDB |
| 1X3P | NMR | - | A | 320-373 | PDB |
| 1X3Q | NMR | - | A | 265-319 | PDB |
| 2HUG | NMR | - | A | 265-319 | PDB |
| 2N88 | NMR | - | A | 316-373 | PDB |
| 3DEO | X-ray | 150 A | A | 85-267 | PDB |
| 3DEP | X-ray | 270 A | A | 85-267 | PDB |
| 3UI2 | X-ray | 318 A | A | 84-327 | PDB |
| 5E4W | X-ray | 280 A | C/D | 265-369 | PDB |
| 5E4X | X-ray | 275 A | A | 319-368 | PDB |
| AF-O22265-F1 | Predicted | AlphaFoldDB |
29 variants for O22265
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_2_19472795_C_A | 5 | F>L | No | 1000Genomes | |
| ENSVATH05735252 | 11 | C>G | No | 1000Genomes | |
| ENSVATH05735253 | 21 | R>S | No | 1000Genomes | |
| ENSVATH05735254 | 26 | P>T | No | 1000Genomes | |
| ENSVATH13668340 | 41 | S>F | No | 1000Genomes | |
| ENSVATH01998470 | 50 | C>Y | No | 1000Genomes | |
| tmp_2_19472952_G_T | 58 | A>S | No | 1000Genomes | |
| tmp_2_19472980_C_T | 67 | T>I | No | 1000Genomes | |
| ENSVATH05735257 | 70 | V>A | No | 1000Genomes | |
| ENSVATH05735256 | 70 | V>M | No | 1000Genomes | |
| ENSVATH13668342 | 82 | S>L | No | 1000Genomes | |
| tmp_2_19473085_A_C | 102 | Y>S | No | 1000Genomes | |
| ENSVATH01998472 | 115 | V>I | No | 1000Genomes | |
| tmp_2_19473133_G_A | 118 | S>N | No | 1000Genomes | |
| ENSVATH13668357 | 150 | D>N | No | 1000Genomes | |
| tmp_2_19473267_G_T | 163 | A>S | No | 1000Genomes | |
| tmp_2_19473318_G_A | 180 | A>T | No | 1000Genomes | |
| tmp_2_19473336_C_T | 186 | L>F | No | 1000Genomes | |
| ENSVATH05735259 | 189 | R>L | No | 1000Genomes | |
| ENSVATH01998476 | 212 | A>V | No | 1000Genomes | |
| ENSVATH01998477 | 215 | E>K | No | 1000Genomes | |
| ENSVATH14624671 | 221 | E>G | No | 1000Genomes | |
| ENSVATH13668372 | 257 | K>N | No | 1000Genomes | |
| ENSVATH14624672 | 257 | K>R | No | 1000Genomes | |
| ENSVATH14624673 | 276 | V>E | No | 1000Genomes | |
| tmp_2_19473690_C_G | 304 | H>D | No | 1000Genomes | |
| ENSVATH05735265 | 341 | V>I | No | 1000Genomes | |
| tmp_2_19473842_G_C | 354 | Q>H | No | 1000Genomes | |
| tmp_2_19473876_C_A | 366 | Q>K | No | 1000Genomes |
No associated diseases with O22265
1 regional properties for O22265
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | TATA-box binding protein, conserved site | 263 - 312 | IPR030491 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast envelope | The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. |
| chloroplast stroma | The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. |
| chloroplast thylakoid membrane | The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| signal recognition particle, chloroplast targeting | A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to the chloroplast. |
| signal recognition particle, endoplasmic reticulum targeting | A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| disordered domain specific binding | Binding to a disordered domain of a protein. |
| identical protein binding | Binding to an identical protein or proteins. |
| metal ion binding | Binding to a metal ion. |
| protein domain specific binding | Binding to a specific domain of a protein. |
| protein-macromolecule adaptor activity | The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| protein heterotrimerization | The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical. |
| protein import into chloroplast thylakoid membrane | The import of proteins into the chloroplast thylakoid membranes. Proteins that are destined for the thylakoid lumen require two uptake-targeting sequences: the first targets the protein to the stroma, and the second targets the protein from the stroma to the thylakoid lumen. Four separate thylakoid-import systems deal with the proteins once they are in the stroma. |
| response to high light intensity | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q04861 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Gallus gallus (Chicken) | SS |
| P98150 | NFKB2 | Nuclear factor NF-kappa-B p100 subunit | Gallus gallus (Chicken) | SS |
| Q94527 | Rel | Nuclear factor NF-kappa-B p110 subunit | Drosophila melanogaster (Fruit fly) | EV |
| P19838 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Homo sapiens (Human) | SS |
| Q99549 | MPHOSPH8 | M-phase phosphoprotein 8 | Homo sapiens (Human) | PR |
| Q00653 | NFKB2 | Nuclear factor NF-kappa-B p100 subunit | Homo sapiens (Human) | SS |
| Q8N9B4 | ANKRD42 | Ankyrin repeat domain-containing protein 42 | Homo sapiens (Human) | PR |
| Q6ZVZ8 | ASB18 | Ankyrin repeat and SOCS box protein 18 | Homo sapiens (Human) | PR |
| Q9CZK6 | Anks3 | Ankyrin repeat and SAM domain-containing protein 3 | Mus musculus (Mouse) | PR |
| P25799 | Nfkb1 | Nuclear factor NF-kappa-B p105 subunit [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] | Mus musculus (Mouse) | EV |
| Q8VHA6 | Asb18 | Ankyrin repeat and SOCS box protein 18 | Mus musculus (Mouse) | PR |
| Q9WTK5 | Nfkb2 | Nuclear factor NF-kappa-B p100 subunit [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | Mus musculus (Mouse) | EV |
| Q9TZM3 | lrk-1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Caenorhabditis elegans | SS |
| Q9SZI3 | NPR2 | Regulatory protein NPR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQKVFLAMDT | CALVIHQSLS | RIKLSPPKSS | SSSSSAFSPE | SLPIRRIELC | FRGAICAAVQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RNYEETTSSV | EEAEEDDESS | SSYGEVNKII | GSRTAGEGAM | EYLIEWKDGH | SPSWVPSSYI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AADVVSEYET | PWWTAARKAD | EQALSQLLED | RDVDAVDENG | RTALLFVAGL | GSDKCVRLLA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EAGADLDHRD | MRGGLTALHM | AAGYVRPEVV | EALVELGADI | EVEDERGLTA | LELAREILKT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TPKGNPMQFG | RRIGLEKVIN | VLEGQVFEYA | EVDEIVEKRG | KGKDVEYLVR | WKDGGDCEWV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KGVHVAEDVA | KDYEDGLEYA | VAESVIGKRV | GDDGKTIEYL | VKWTDMSDAT | WEPQDNVDST |
| 370 | |||||
| LVLLYQQQQP | MNE |