O22149
SS
Gene name |
PME17 (ARATH17, At2g45220, F4L23.27) |
Protein name |
Probable pectinesterase/pectinesterase inhibitor 17 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G45220 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
206-497 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for O22149
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O22149-F1 | Predicted | AlphaFoldDB |
31 variants for O22149
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05720570 | 4 | F>S | No | 1000Genomes | |
| ENSVATH05720569 | 8 | I>V | No | 1000Genomes | |
| ENSVATH00275689 | 13 | I>F | No | 1000Genomes | |
| ENSVATH05720567 | 35 | S>N | No | 1000Genomes | |
| tmp_2_18646276_G_A | 40 | P>L | No | 1000Genomes | |
| tmp_2_18646270_G_A | 42 | P>L | No | 1000Genomes | |
| tmp_2_18646169_G_C | 76 | L>V | No | 1000Genomes | |
| ENSVATH05720566 | 80 | H>N | No | 1000Genomes | |
| tmp_2_18646120_C_A | 92 | R>L | No | 1000Genomes | |
| tmp_2_18646062_G_C | 111 | I>M | No | 1000Genomes | |
| ENSVATH13644640 | 112 | N>K | No | 1000Genomes | |
| ENSVATH00275688 | 118 | N>T | No | 1000Genomes | |
| tmp_2_18646002_G_C | 131 | S>R | No | 1000Genomes | |
| tmp_2_18645788_G_A | 203 | P>S | No | 1000Genomes | |
| ENSVATH05720564 | 220 | I>V | No | 1000Genomes | |
| ENSVATH13644604 | 286 | V>G | No | 1000Genomes | |
| ENSVATH14617228 | 290 | F>V | No | 1000Genomes | |
| ENSVATH14617223 | 342 | R>C | No | 1000Genomes | |
| tmp_2_18644669_C_T | 383 | R>K | No | 1000Genomes | |
| tmp_2_18644588_C_T | 410 | G>E | No | 1000Genomes | |
| tmp_2_18644589_C_T | 410 | G>R | No | 1000Genomes | |
| tmp_2_18644486_T_C | 444 | E>G | No | 1000Genomes | |
| ENSVATH13644599 | 466 | A>G | No | 1000Genomes | |
| ENSVATH05720550 | 477 | F>I | No | 1000Genomes | |
| tmp_2_18644384_C_T | 478 | R>Q | No | 1000Genomes | |
| tmp_2_18644379_G_A | 480 | L>F | No | 1000Genomes | |
| ENSVATH05720549 | 481 | G>A | No | 1000Genomes | |
| tmp_2_18644369_G_A | 483 | A>V | No | 1000Genomes | |
| ENSVATH13644598 | 492 | G>S | No | 1000Genomes | |
| tmp_2_18644331_C_A | 496 | A>S | No | 1000Genomes | |
| ENSVATH05720547 | 508 | T>N | No | 1000Genomes |
No associated diseases with O22149
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| defense response to Gram-negative bacterium | Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
| response to bacterium | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. |
| response to fungus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMAFRAYIIN | FVILCILVAS | TVSGYNQKDV | KAWCSQTPNP | KPCEYFLTHN | SNNEPIKSES |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EFLKISMKLV | LDRAILAKTH | AFTLGPKCRD | TREKAAWEDC | IKLYDLTVSK | INETMDPNVK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CSKLDAQTWL | STALTNLDTC | RAGFLELGVT | DIVLPLMSNN | VSNLLCNTLA | INKVPFNYTP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PEKDGFPSWV | KPGDRKLLQS | STPKDNAVVA | KDGSGNFKTI | KEAIDAASGS | GRFVIYVKQG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VYSENLEIRK | KNVMLRGDGI | GKTIITGSKS | VGGGTTTFNS | ATVAAVGDGF | IARGITFRNT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AGASNEQAVA | LRSGSDLSVF | YQCSFEAYQD | TLYVHSNRQF | YRDCDVYGTV | DFIFGNAAAV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LQNCNIFARR | PRSKTNTITA | QGRSDPNQNT | GIIIHNSRVT | AASDLRPVLG | STKTYLGRPW |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RQYSRTVFMK | TSLDSLIDPR | GWLEWDGNFA | LKTLFYAEFQ | NTGPGASTSG | RVTWPGFRVL |
| 490 | 500 | 510 | |||
| GSASEASKFT | VGTFLAGGSW | IPSSVPFTSG | L |