O22042
Gene name |
ANP3 (At3g06030, F24F17.1, F2O10.1) |
Protein name |
Mitogen-activated protein kinase kinase kinase 3 |
Names |
Arabidopsis NPK1-related protein kinase 3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G06030 |
EC number |
2.7.11.25: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
213-222 (Activation loop from InterPro)
Target domain |
68-330 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
233-238 (Activation loop from InterPro)
Target domain |
68-330 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for O22042
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O22042-F1 | Predicted | AlphaFoldDB |
48 variants for O22042
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_1822696_T_G | 4 | I>L | No | 1000Genomes | |
| tmp_3_1822633_T_C | 25 | S>G | No | 1000Genomes | |
| tmp_3_1822627_C_T | 27 | G>R | No | 1000Genomes | |
| tmp_3_1822616_G_T | 30 | S>R | No | 1000Genomes | |
| tmp_3_1822591_T_C | 39 | S>G | No | 1000Genomes | |
| tmp_3_1822590_C_G | 39 | S>T | No | 1000Genomes | |
| tmp_3_1822567_G_T | 47 | L>I | No | 1000Genomes | |
| tmp_3_1822564_A_G | 48 | F>L | No | 1000Genomes | |
| ENSVATH05780475 | 49 | S>T | No | 1000Genomes | |
| ENSVATH00308604 | 76 | C>S | No | 1000Genomes | |
| ENSVATH05780454 | 233 | M>I | No | 1000Genomes | |
| tmp_3_1821450_C_A | 241 | A>S | No | 1000Genomes | |
| tmp_3_1821059_C_T | 283 | V>I | No | 1000Genomes | |
| ENSVATH05780444 | 308 | M>L | No | 1000Genomes | |
| tmp_3_1820810_C_T | 321 | A>T | No | 1000Genomes | |
| ENSVATH00308600 | 337 | P>S | No | 1000Genomes | |
| ENSVATH13876721 | 346 | T>P | No | 1000Genomes | |
| tmp_3_1820506_C_A | 360 | R>L | No | 1000Genomes | |
| ENSVATH05780418 | 367 | I>T | No | 1000Genomes | |
| ENSVATH05780416 | 375 | L>F | No | 1000Genomes | |
| ENSVATH05780415 | 378 | V>L | No | 1000Genomes | |
| ENSVATH05780414 | 379 | C>Y | No | 1000Genomes | |
| tmp_3_1820324_T_A | 390 | Y>F | No | 1000Genomes | |
| ENSVATH05780413 | 393 | K>M | No | 1000Genomes | |
| ENSVATH05780406 | 447 | N>K | No | 1000Genomes | |
| tmp_3_1820058_G_T | 449 | S>Y | No | 1000Genomes | |
| ENSVATH00308598 | 450 | C>Y | No | 1000Genomes | |
| ENSVATH00308597 | 457 | K>E | No | 1000Genomes | |
| ENSVATH05780405 | 472 | Q>E | No | 1000Genomes | |
| tmp_3_1819989_T_A | 472 | Q>L | No | 1000Genomes | |
| ENSVATH13876719 | 486 | T>I | No | 1000Genomes | |
| ENSVATH05780403 | 502 | E>G | No | 1000Genomes | |
| tmp_3_1819445_G_T | 528 | H>N | No | 1000Genomes | |
| tmp_3_1819383_T_A | 548 | L>F | No | 1000Genomes | |
| tmp_3_1819381_G_A | 549 | P>L | No | 1000Genomes | |
| tmp_3_1819382_G_A | 549 | P>S | No | 1000Genomes | |
| tmp_3_1819366_A_T | 554 | I>K | No | 1000Genomes | |
| tmp_3_1819331_G_A | 566 | L>F | No | 1000Genomes | |
| ENSVATH05780385 | 577 | L>F | No | 1000Genomes | |
| ENSVATH05780384 | 578 | K>R | No | 1000Genomes | |
| ENSVATH00308596 | 592 | S>P | No | 1000Genomes | |
| ENSVATH02117715 | 596 | P>L | No | 1000Genomes | |
| ENSVATH00308595 | 606 | G>E | No | 1000Genomes | |
| ENSVATH05780383 | 611 | R>H | No | 1000Genomes | |
| ENSVATH13876717 | 612 | C>R | No | 1000Genomes | |
| tmp_3_1819096_T_A | 616 | I>L | No | 1000Genomes | |
| tmp_3_1818911_G_A | 647 | S>L | No | 1000Genomes | |
| ENSVATH00308593 | 648 | G>A | No | 1000Genomes |
No associated diseases with O22042
3 regional properties for O22042
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | 14-3-3 protein, conserved site | 41 - 51 | IPR023409-1 |
| conserved_site | 14-3-3 protein, conserved site | 211 - 230 | IPR023409-2 |
| domain | 14-3-3 domain | 3 - 242 | IPR023410 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.25 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| apoplast | The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| MAP kinase kinase kinase activity | Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cortical microtubule organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q95UN8 | slpr | Mitogen-activated protein kinase kinase kinase | Drosophila melanogaster (Fruit fly) | EV |
| Q99759 | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3 | Homo sapiens (Human) | PR |
| Q9Y2U5 | MAP3K2 | Mitogen-activated protein kinase kinase kinase 2 | Homo sapiens (Human) | PR |
| Q61084 | Map3k3 | Mitogen-activated protein kinase kinase kinase 3 | Mus musculus (Mouse) | PR |
| Q61083 | Map3k2 | Mitogen-activated protein kinase kinase kinase 2 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQDILGSVRR | SLVFRSSLAG | DDGTSGGGLS | GFVGKINSSI | RSSRIGLFSK | PPPGLPAPRK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EEAPSIRWRK | GELIGCGAFG | RVYMGMNLDS | GELLAIKQVL | IAPSSASKEK | TQGHIRELEE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EVQLLKNLSH | PNIVRYLGTV | RESDSLNILM | EFVPGGSISS | LLEKFGSFPE | PVIIMYTKQL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LLGLEYLHNN | GIMHRDIKGA | NILVDNKGCI | RLADFGASKK | VVELATVNGA | KSMKGTPYWM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| APEVILQTGH | SFSADIWSVG | CTVIEMATGK | PPWSEQYQQF | AAVLHIGRTK | AHPPIPEDLS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PEAKDFLMKC | LHKEPSLRLS | ATELLQHPFV | TGKRQEPYPA | YRNSLTECGN | PITTQGMNVR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SSINSLIRRS | TCSGLKDVCE | LGSLRSSIIY | PQKSNNSGFG | WRDGDSDDLC | QTDMDDLCNI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ESVRNNVLSQ | STDLNKSFNP | MCDSTDNWSC | KFDESPKVMK | SKSNLLSYQA | SQLQTGVPCD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EETSLTFAGG | SSVAEDDYKG | TELKIKSFLD | EKAQDLKRLQ | TPLLEEFHNA | MNPGIPQGAL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GDTNIYNLPN | LPSISKTPKR | LPSRRLSAIS | DAMPSPLKSS | KRTLNTSRVM | QSGTEPTQVN |
| 610 | 620 | 630 | 640 | 650 | |
| ESTKKGVNNS | RCFSEIRRKW | EEELYEELER | HRENLRHAGA | GGKTPLSGHK | G |