O19064
SS
Gene name |
JAK2 |
Protein name |
Tyrosine-protein kinase JAK2 |
Names |
EC 2.7.10.2 , Janus kinase 2 , JAK-2 |
Species |
Sus scrofa (Pig) |
KEGG Pathway |
ssc:397201 |
EC number |
2.7.10.2: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Jak2 is a member of the Janus (Jak) family of non-receptor protein tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) and is crucial in signaling through multiple cytokine receptors. Jak2 has a kinase domain (JH1) and pseudokinase domain (JH2). JH2 has three regions for autoinhibition of JH1: IR3 (758-807) directly inhibits JH1, and IR2 (725-757) and IR1 (619-670) enhances IR3-mediated inhibition of JH1.
Autoinhibitory domains (AIDs)
Target domain |
849-1130 (Protein kinase domain) |
Relief mechanism |
Partner binding |
Assay |
|
Target domain |
849-1130 (Protein kinase domain) |
Relief mechanism |
Partner binding |
Assay |
|
Target domain |
849-1130 (Protein kinase domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
698-717 (Activation loop from InterPro)
Target domain |
545-806 (Janus kinase 2, pseudokinase domain) |
Relief mechanism |
|
Assay |
|
993-1019 (Activation loop from InterPro)
Target domain |
844-1127 (Janus kinase 2, catalytic domain) |
Relief mechanism |
|
Assay |
|
References
- Saharinen P et al. (2003) "Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain", Molecular biology of the cell, 14, 1448-59
- Kershaw NJ et al. (2013) "SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition", Nature structural & molecular biology, 20, 469-76
- Ma W et al. (2009) "Mutation profile of JAK2 transcripts in patients with chronic myeloproliferative neoplasias", The Journal of molecular diagnostics : JMD, 11, 49-53
- Hubbard SR (2017) "Mechanistic Insights into Regulation of JAK2 Tyrosine Kinase", Frontiers in endocrinology, 8, 361
- Wang J et al. (2023) "Triple-action inhibitory mechanism of allosteric TYK2-specific inhibitors", bioRxiv : the preprint server for biology, ,
- Lupardus PJ et al. (2014) "Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition", Proceedings of the National Academy of Sciences of the United States of America, 111, 8025-30
Autoinhibited structure
Activated structure
1 structures for O19064
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O19064-F1 | Predicted | AlphaFoldDB |
13 variants for O19064
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs338800654 | 151 | S>Y | No | EVA | |
| rs703668127 | 242 | H>Q | No | EVA | |
| rs708027395 | 256 | I>T | No | EVA | |
| rs699893242 | 277 | R>S | No | EVA | |
| rs786810686 | 406 | M>I | No | EVA | |
| rs713726910 | 421 | G>R | No | EVA | |
| rs708028317 | 538 | H>N | No | EVA | |
| rs712402745 | 656 | Q>H | No | EVA | |
| rs692475555 | 689 | T>K | No | EVA | |
| rs704739797 | 804 | D>E | No | EVA | |
| rs713609215 | 842 | T>K | No | EVA | |
| rs703672921 | 862 | S>N | No | EVA | |
| rs708915476 | 1061 | F>S | No | EVA |
No associated diseases with O19064
19 regional properties for O19064
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | FERM domain | 37 - 380 | IPR000299 |
| domain | Protein kinase domain | 545 - 809 | IPR000719-1 |
| domain | Protein kinase domain | 849 - 1126 | IPR000719-2 |
| domain | SH2 domain | 397 - 501 | IPR000980 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 546 - 805 | IPR001245-1 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 849 - 1120 | IPR001245-2 |
| active_site | Tyrosine-protein kinase, active site | 972 - 984 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 855 - 883 | IPR017441 |
| domain | FERM central domain | 152 - 222 | IPR019748 |
| domain | Band 4.1 domain | 33 - 270 | IPR019749 |
| domain | Tyrosine-protein kinase, catalytic domain | 545 - 805 | IPR020635-1 |
| domain | Tyrosine-protein kinase, catalytic domain | 849 - 1123 | IPR020635-2 |
| domain | Janus kinase 2, pseudokinase domain | 545 - 806 | IPR035588 |
| domain | Janus kinase 2, catalytic domain | 844 - 1127 | IPR035589 |
| domain | Tyrosine-protein kinase JAK2, SH2 domain | 386 - 482 | IPR035860 |
| domain | JAK2, FERM domain C-lobe | 266 - 386 | IPR037838 |
| domain | JAK, FERM F2 lobe domain | 143 - 261 | IPR041046 |
| domain | FERM F1 lobe ubiquitin-like domain | 39 - 134 | IPR041155 |
| domain | JAK1-3/TYK2, pleckstrin homology-like domain | 302 - 381 | IPR041381 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.2 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| caveola | A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endomembrane system | A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. |
| extrinsic component of cytoplasmic side of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. |
| focal adhesion | A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). |
| granulocyte macrophage colony-stimulating factor receptor complex | The heterodimeric receptor for granulocyte macrophage colony-stimulating factor. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
12 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| growth hormone receptor binding | Binding to a growth hormone receptor. |
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| histone H3Y41 kinase activity | Catalysis of the reaction |
| identical protein binding | Binding to an identical protein or proteins. |
| interleukin-12 receptor binding | Binding to an interleukin-12 receptor. |
| metal ion binding | Binding to a metal ion. |
| non-membrane spanning protein tyrosine kinase activity | Catalysis of the reaction |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| protein tyrosine kinase activity | Catalysis of the reaction |
| SH2 domain binding | Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. |
48 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of Janus kinase activity | The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it. |
| adaptive immune response | An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). |
| cellular response to dexamethasone stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. |
| cellular response to interleukin-3 | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus. |
| cellular response to lipopolysaccharide | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. |
| collagen-activated signaling pathway | The series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| cytokine-mediated signaling pathway | The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| erythrocyte differentiation | The process in which a myeloid precursor cell acquires specializes features of an erythrocyte. |
| extrinsic apoptotic signaling pathway | The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. |
| granulocyte-macrophage colony-stimulating factor signaling pathway | The series of molecular signals initiated by the binding of the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. GM-CSF binds to a heterodimer receptor (CSF2R) consisting of an alpha ligand-binding subunit, and a common beta subunit that is shared with other cytokine receptors. |
| growth hormone receptor signaling pathway via JAK-STAT | The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| interleukin-12-mediated signaling pathway | The series of molecular signals initiated by interleukin-12 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| interleukin-3-mediated signaling pathway | The series of molecular signals initiated by interleukin-3 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| interleukin-5-mediated signaling pathway | The series of molecular signals initiated by interleukin-5 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| mammary gland epithelium development | The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. |
| microglial cell activation | The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| negative regulation of cell population proliferation | Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
| positive regulation of apoptotic signaling pathway | Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. |
| positive regulation of cell-substrate adhesion | Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. |
| positive regulation of cold-induced thermogenesis | Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. |
| positive regulation of growth hormone receptor signaling pathway | Any process that increases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand. |
| positive regulation of interleukin-1 beta production | Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. |
| positive regulation of MHC class II biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II. |
| positive regulation of natural killer cell proliferation | Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation. |
| positive regulation of nitric-oxide synthase biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme. |
| positive regulation of NK T cell proliferation | Any process that activates or increases the frequency, rate or extent of natural killer T cell proliferation. |
| positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
| positive regulation of platelet activation | Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. |
| positive regulation of platelet aggregation | Any process that activates or increases the frequency, rate or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. |
| positive regulation of SMAD protein signal transduction | Any process that increases the rate, frequency or extent of SMAD protein signal transduction. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| positive regulation of tumor necrosis factor production | Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production. |
| positive regulation of type II interferon production | Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. |
| positive regulation of tyrosine phosphorylation of STAT protein | Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. |
| post-embryonic hemopoiesis | The stages of blood cell formation that take place after completion of embryonic development. |
| post-translational protein modification | The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| receptor signaling pathway via JAK-STAT | Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins. |
| regulation of apoptotic process | Any process that modulates the occurrence or rate of cell death by apoptotic process. |
| regulation of inflammatory response | Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. |
| response to antibiotic | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| symbiont-induced defense-related programmed cell death | Cell death resulting from activation of endogenous cellular processes after interaction with a symbiont (defined as the smaller of two, or more, organisms engaged in symbiosis, a close interaction encompassing mutualism through parasitism). This can be triggered by direct interaction with the organism, for example, contact with penetrating hyphae of a fungus; or an indirect interaction such as symbiont-secreted molecules. |
| transcription by RNA polymerase II | The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). |
| tumor necrosis factor-mediated signaling pathway | The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
76 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A0JNB0 | FYN | Tyrosine-protein kinase Fyn | Bos taurus (Bovine) | SS |
| Q0VBZ0 | CSK | Tyrosine-protein kinase CSK | Bos taurus (Bovine) | SS |
| Q3ZC95 | BTK | Tyrosine-protein kinase | Bos taurus (Bovine) | EV SS |
| P42683 | LCK | Proto-oncogene tyrosine-protein kinase LCK | Gallus gallus (Chicken) | SS |
| P41239 | CSK | Tyrosine-protein kinase CSK | Gallus gallus (Chicken) | SS |
| P00523 | SRC | Proto-oncogene tyrosine-protein kinase Src | Gallus gallus (Chicken) | EV |
| Q02977 | YRK | Proto-oncogene tyrosine-protein kinase Yrk | Gallus gallus (Chicken) | SS |
| Q8JH64 | BTK | Tyrosine-protein kinase BTK | Gallus gallus (Chicken) | SS |
| P09324 | YES1 | Tyrosine-protein kinase Yes | Gallus gallus (Chicken) | SS |
| Q05876 | FYN | Tyrosine-protein kinase Fyn | Gallus gallus (Chicken) | SS |
| Q75R65 | JAK2 | Tyrosine-protein kinase JAK2 | Gallus gallus (Chicken) | SS |
| P08630 | Btk | Tyrosine-protein kinase Btk | Drosophila melanogaster (Fruit fly) | SS |
| Q9V9J3 | Src42A | Tyrosine-protein kinase Src42A | Drosophila melanogaster (Fruit fly) | SS |
| P00528 | Src64B | Tyrosine-protein kinase Src64B | Drosophila melanogaster (Fruit fly) | SS |
| Q24592 | hop | Tyrosine-protein kinase hopscotch | Drosophila melanogaster (Fruit fly) | PR |
| P41240 | CSK | Tyrosine-protein kinase CSK | Homo sapiens (Human) | SS |
| P51451 | BLK | Tyrosine-protein kinase Blk | Homo sapiens (Human) | SS |
| P06239 | LCK | Tyrosine-protein kinase Lck | Homo sapiens (Human) | EV |
| P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Homo sapiens (Human) | SS |
| P06241 | FYN | Tyrosine-protein kinase Fyn | Homo sapiens (Human) | SS |
| P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Homo sapiens (Human) | SS |
| P12931 | SRC | Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (Human) | EV |
| P09769 | FGR | Tyrosine-protein kinase Fgr | Homo sapiens (Human) | SS |
| P42680 | TEC | Tyrosine-protein kinase Tec | Homo sapiens (Human) | SS |
| P42679 | MATK | Megakaryocyte-associated tyrosine-protein kinase | Homo sapiens (Human) | SS |
| P52333 | JAK3 | Tyrosine-protein kinase JAK3 | Homo sapiens (Human) | SS |
| Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Homo sapiens (Human) | EV |
| P07948 | LYN | Tyrosine-protein kinase Lyn | Homo sapiens (Human) | SS |
| P29597 | TYK2 | Non-receptor tyrosine-protein kinase TYK2 | Homo sapiens (Human) | EV |
| Q13882 | PTK6 | Protein-tyrosine kinase 6 | Homo sapiens (Human) | EV |
| P08631 | HCK | Tyrosine-protein kinase HCK | Homo sapiens (Human) | EV |
| P07947 | YES1 | Tyrosine-protein kinase Yes | Homo sapiens (Human) | SS |
| P42685 | FRK | Tyrosine-protein kinase FRK | Homo sapiens (Human) | EV |
| Q06187 | BTK | Tyrosine-protein kinase BTK | Homo sapiens (Human) | EV |
| O60674 | JAK2 | Tyrosine-protein kinase JAK2 | Homo sapiens (Human) | EV |
| Q9R117 | Tyk2 | Non-receptor tyrosine-protein kinase TYK2 | Mus musculus (Mouse) | SS |
| P08103 | Hck | Tyrosine-protein kinase HCK | Mus musculus (Mouse) | SS |
| P16277 | Blk | Tyrosine-protein kinase Blk | Mus musculus (Mouse) | SS |
| Q62270 | Srms | Tyrosine-protein kinase Srms | Mus musculus (Mouse) | SS |
| Q64434 | Ptk6 | Protein-tyrosine kinase 6 | Mus musculus (Mouse) | SS |
| P05480 | Src | Proto-oncogene tyrosine-protein kinase Src | Mus musculus (Mouse) | EV |
| P14234 | Fgr | Tyrosine-protein kinase Fgr | Mus musculus (Mouse) | SS |
| P35991 | Btk | Tyrosine-protein kinase BTK | Mus musculus (Mouse) | EV |
| P41241 | Csk | Tyrosine-protein kinase CSK | Mus musculus (Mouse) | EV |
| P25911 | Lyn | Tyrosine-protein kinase Lyn | Mus musculus (Mouse) | EV |
| Q62137 | Jak3 | Tyrosine-protein kinase JAK3 | Mus musculus (Mouse) | SS |
| P06240 | Lck | Proto-oncogene tyrosine-protein kinase LCK | Mus musculus (Mouse) | SS |
| P24604 | Tec | Tyrosine-protein kinase Tec | Mus musculus (Mouse) | SS |
| Q04736 | Yes1 | Tyrosine-protein kinase Yes | Mus musculus (Mouse) | SS |
| P39688 | Fyn | Tyrosine-protein kinase Fyn | Mus musculus (Mouse) | SS |
| P52332 | Jak1 | Tyrosine-protein kinase JAK1 | Mus musculus (Mouse) | SS |
| Q03526 | Itk | Tyrosine-protein kinase ITK/TSK | Mus musculus (Mouse) | SS |
| P41242 | Matk | Megakaryocyte-associated tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q922K9 | Frk | Tyrosine-protein kinase FRK | Mus musculus (Mouse) | SS |
| Q62120 | Jak2 | Tyrosine-protein kinase JAK2 | Mus musculus (Mouse) | EV |
| A1Y2K1 | FYN | Tyrosine-protein kinase Fyn | Sus scrofa (Pig) | SS |
| Q62662 | Frk | Tyrosine-protein kinase FRK | Rattus norvegicus (Rat) | SS |
| Q62844 | Fyn | Tyrosine-protein kinase Fyn | Rattus norvegicus (Rat) | SS |
| Q07014 | Lyn | Tyrosine-protein kinase Lyn | Rattus norvegicus (Rat) | SS |
| P50545 | Hck | Tyrosine-protein kinase HCK | Rattus norvegicus (Rat) | SS |
| Q9WUD9 | Src | Proto-oncogene tyrosine-protein kinase Src | Rattus norvegicus (Rat) | SS |
| Q01621 | Lck | Proto-oncogene tyrosine-protein kinase LCK | Rattus norvegicus (Rat) | SS |
| Q6P6U0 | Fgr | Tyrosine-protein kinase Fgr | Rattus norvegicus (Rat) | SS |
| Q63272 | Jak3 | Tyrosine-protein kinase JAK3 | Rattus norvegicus (Rat) | SS |
| P32577 | Csk | Tyrosine-protein kinase CSK | Rattus norvegicus (Rat) | SS |
| P41243 | Matk | Megakaryocyte-associated tyrosine-protein kinase | Rattus norvegicus (Rat) | SS |
| F1LM93 | Yes1 | Tyrosine-protein kinase Yes | Rattus norvegicus (Rat) | SS |
| Q62689 | Jak2 | Tyrosine-protein kinase JAK2 | Rattus norvegicus (Rat) | SS |
| O45539 | src-2 | Tyrosine protein-kinase src-2 | Caenorhabditis elegans | SS |
| G5ECJ6 | csk-1 | Tyrosine-protein kinase csk-1 | Caenorhabditis elegans | SS |
| G5EE56 | src-1 | Tyrosine protein-kinase src-1 | Caenorhabditis elegans | SS |
| A1A5H8 | yes1 | Tyrosine-protein kinase yes | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| F1RDG9 | fynb | Tyrosine-protein kinase fynb | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O12990 | jak1 | Tyrosine-protein kinase JAK1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q1JPZ3 | src | Proto-oncogene tyrosine-protein kinase Src | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6EWH2 | fyna | Tyrosine-protein kinase fyna | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGMACLTMTE | MEGTSTSPVH | QNGDIPGNAN | SVKQIDPVLQ | VYLYHSLGKA | EGDYLKFPAG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EYVAEEICVA | ASKACGITPV | YHSMFALMNE | TERIWYPPNH | VFHVDESTRH | NVLYRIRFYF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PYWYCNGSNR | TYRHGISRGA | EAPLLDDFVM | SYLFAQWRHD | FLYGWVKIPV | THETQEECLG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MAVLDMMRIA | KEKDQTPLDI | YSSVSYKTFL | PKCVRAKIQD | YHILTRKRIR | YRFRRFIEQF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SHCKATARNL | KLKYLINLET | LQSAFYTEQF | EVKEPGRGPS | GEEIFATIII | TGNGGIQWSR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GKHKESETLT | EQDLQLYCDF | PDIIDVSIKQ | ANQEGSNESR | IVTIHKQDGK | SLEIELSSLR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EALSFVSLID | GYYRLTADAH | HYLCKEVAPP | MVLENIQSNC | HGPISMDFAI | SKLKKAGNQT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GLFVLRCSPK | DFNKYFLTFA | VERENVTEYK | HCLITKNENG | EYNLSGTRKN | FSNLKDLLNC |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YQMETVRSDS | IIFQFTKCCP | PKPKDKSNLL | VFRTNGISDV | PTSPTLQRHN | NVNQMVFHKI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RNEDLIFNES | LGQGTFTKIF | KGVRREVGDY | GQLHETEVLL | KVLDKAHRNY | SESFFEAASM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| MSQLSHKHLV | LNYGVCVCGE | ENILVQEFVK | FGSLDTYLKK | NKNSINILWK | LEVAKQLAWA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MHFLEEKTLI | HGNVCAKNIL | LIREEDRKTG | NPPFIKLSDP | GISITVLPKD | ILQERIPWVP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PECIENPKNL | NLATDKWSFG | TTLWEICSGG | DKPLNALDSQ | RKLQFYEDRH | QLPAPKWTEL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ANLINNCMDY | EPDFRPSFRA | IIRDLNSLFT | PDYELLTEND | MLPNMRIGAL | GFSGAFEDRD |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PTQFEERHLK | FLQQLGKGNF | GSVEMCRYDP | LQDNTGEVVA | VKKLQHSTEE | HLRDFEREIE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ILKSLQHDNI | VKYKGVCYSA | GRRNLRLIME | YLPYGSLRDY | LQKHKERIDH | KKLLQYTSQI |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| CKGMEYLGTK | RYIHRDLATR | NILVENENRV | KIGDFGLTKV | LPQDKEYYKV | KEPGESPIFW |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| YAPESLTESK | FSVASDVWSF | GVVLYELFTY | IEKSKSPPAE | FMRMIGNDKQ | GQMIVFHLIE |
| 1090 | 1100 | 1110 | 1120 | 1130 | |
| LLKNNGRLPR | PDGCPDEIYI | IMTECWNNNV | NQRPSFRDLA | LRVDQIRDSM | A |