O17583

SS
Gene name
lin-10 (C09H6.2)
Protein name
Protein lin-10
Names
Abnormal cell lineage protein 10
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C09H6.2
EC number
Protein Class

Descriptions

Mint adaptor proteins bind to the amyloid precursor protein (APP) and regulate APP processing associated with Alzheimer’s disease. The Mint1 phosphotyrosine binding (PTB) domain that binds to APP is intramolecularly inhibited by the adjacent C-terminal linker region (the autoinhibitory helix) that folds back onto the core structure of the PTB domain and sterically hinders the APP binding site. This intramolecular interaction is disrupted by mutation of Tyr633 within Mint1 autoinhibitory helix, enhancing APP binding and β-amyloid production. As a result, Mint1 undergoes a conformational transition between a closed state that does not bind APP and an open state that involves APP binding and its proteolytic processing.

Autoinhibitory domains (AIDs)

778-786 (Autoinhibitory helix) SS

Target domain

597-778 (PTB domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O17583

Entry ID Method Resolution Chain Position Source
AF-O17583-F1 Predicted AlphaFoldDB

No variants for O17583

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O17583

No associated diseases with O17583

3 regional properties for O17583

Type Name Position InterPro Accession
domain PDZ domain 800 - 888 IPR001478-1
domain PDZ domain 890 - 968 IPR001478-2
domain PTB/PI domain 602 - 788 IPR006020

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein
  • Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein
  • Cytoplasm
  • Synapse
  • Perikaryon
  • In trans cisternae of Golgi or trans-Golgi network (PubMed:10359617)
  • Localizes to Golgi-associated structures (PubMed:22213799)
  • Partially co-localizes with glr-1 at the synapse (PubMed:17671168)
  • Localizes in endosome-like structures in ventral cord dendrites
  • During hypoxia, diffused cytoplasmic localization
  • Localization in the ventral nerve cord is regulated by egl-9 isoform e and cdk-5 (PubMed:22252129)
  • Co-localizes with rab-6
  • 2 in neuronal cell bodies (PubMed:22213799)
  • Co-localizes with rme-8 in puntate structures in neuronal cell bodies and in the intestine (PubMed:22213799)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

12 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi cisterna membrane The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex.
Golgi trans cisterna The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
trans-Golgi network transport vesicle A vesicle that mediates transport between the trans-Golgi network and other parts of the cell.

2 GO annotations of molecular function

Name Definition
amyloid-beta binding Binding to an amyloid-beta peptide/protein.
small GTPase binding Binding to a small monomeric GTPase.

12 GO annotations of biological process

Name Definition
chemical synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
neuron-neuron synaptic transmission The process of synaptic transmission from a neuron to another neuron across a synapse.
positive regulation of backward locomotion Any process that activates or increases the frequency, rate or extent of backward locomotion.
positive regulation of vulval development Any process that activates or increases the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
protein localization Any process in which a protein is transported to, or maintained in, a specific location.
protein localization to basolateral plasma membrane Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane.
protein localization to early endosome A process in which a protein is transported to, or maintained in, a location within an early endosome.
receptor localization to synapse Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
regulation of backward locomotion Any process that modulates the speed, mechanical force, or rhythm of the posterior movement of an organism.
response to mechanical stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
sensory perception of touch The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach).

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q99767 APBA2 Amyloid-beta A4 precursor protein-binding family A member 2 Homo sapiens (Human) SS
Q02410 APBA1 Amyloid-beta A4 precursor protein-binding family A member 1 Homo sapiens (Human) SS
B2RUJ5 Apba1 Amyloid-beta A4 precursor protein-binding family A member 1 Mus musculus (Mouse) SS
P98084 Apba2 Amyloid-beta A4 precursor protein-binding family A member 2 Mus musculus (Mouse) SS
O35431 Apba2 Amyloid-beta A4 precursor protein-binding family A member 2 Rattus norvegicus (Rat) SS
O35430 Apba1 Amyloid-beta A4 precursor protein-binding family A member 1 Rattus norvegicus (Rat) EV
10 20 30 40 50 60
MSSEAVAQAT AATTSPEHGV PTSSATPTPP PSKGGGAGGG GGGEQQQVPF QMIPPGHFFA
70 80 90 100 110 120
NPFLNPYIPT AGAPAQEGEA QPQMVFSPAQ YQEVMHHYFQ QMMAASGAQF PIPFPMQFQP
130 140 150 160 170 180
ALQQPRPSSQ ASSSHRSEDD NGRQTAGSVV SSNVSPNHRE VRPAEDSTET SGVVQNNDEL
190 200 210 220 230 240
LVPTSTSSDV TIGDVIEKSD SPENSQESAG GEEKSEEKRK LSGDRTDSLI RKQMSEMEKE
250 260 270 280 290 300
ITRRSQNKNI KTIDDDGLAE LIGGSSTRTV ADDFSPFVDK SGLSYTAPAP PSTEKSAPKE
310 320 330 340 350 360
SLNQLRSSFN LPDDSTTVGP VGPSTVPQQS QQFANNSMFM ANAGNFVQNA FPIGVTMTPQ
370 380 390 400 410 420
ATFGAAPGFQ MMQPHQHNLF MQQPNPTFVN NGTNPFLQTQ ATLPNFVQNG TAPLVPTVSA
430 440 450 460 470 480
QQFTPEQLAA AFAQQQIAQS AAPTPFDSPP PSMPSTSSGP SGALAPPPPP SHPIPRRVSG
490 500 510 520 530 540
NGWPEENKEN GTSTSTTNGA QSVPAAAGTD DPVWVLRDSY LKKMQREQRT SEEEEMSWQE
550 560 570 580 590 600
AATAAQEAAE NGGGDDQEEQ ETDRLLNGGT TGASTKGAER RGSVDKKKNS KETMVHEPAV
610 620 630 640 650 660
LIEGVLFRAR YLGSTQMLCE SRGSKAARMA QAQEAVARVK APEGDVQPST EIDLFISTEK
670 680 690 700 710 720
IMVLNTDLQR ISDTDVRQDI LMDHALRTIS YIADIGDLVV LMARRMSTSH SDESCSDGDS
730 740 750 760 770 780
SGGGVRKTPK VICHVFESDE ASFIAQSIGQ AFQVAYVEFL RANGIDDPSY LRQIDYQEVL
790 800 810 820 830 840
NSQELLGDEL EMFAKKETQK EVVVPKKAGE PLGIVVVESG WGSMLPTVVL AHMNPVGPAA
850 860 870 880 890 900
HSNKLNIGDQ IININGISLV GLPLSAAQTQ IKNMKTATAV RMTVVSTPPV VEVRIRRPDT
910 920 930 940 950 960
KYQLGFSVQN GVICSLLRGG IAERGGIRVG HRIIEINGTS VVAVAHDRIV NMLATAVGEI
970 980
HMKTMPTSMF RLLTGQEQPQ YI