AiPD: Autoinhibited Protein Database

O15539

Gene name	RGS5
Protein name	Regulator of G-protein signaling 5
Names	RGS5
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8490
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

7-79 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

7-79 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for O15539

Entry ID	Method	Resolution	Chain	Position	Source
2CRP	NMR	-	A	44-180	PDB
AF-O15539-F1	Predicted				AlphaFoldDB

145 variants for O15539

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	4	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754269659 CA343466193	4	G>A		No	ClinGen ExAC TOPMed gnomAD
CA1218846 rs754269659	4	G>E		No	ClinGen ExAC TOPMed gnomAD
rs867715021 CA31998105	6	A>S		No	ClinGen Ensembl
CA343466182 rs1439478729	6	A>V		No	ClinGen TOPMed gnomAD
rs778098929 CA1218845	7	A>P		No	ClinGen ExAC gnomAD
CA31998104 rs908862104	11	S>*		No	ClinGen TOPMed gnomAD
TCGA novel	13	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	14	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1161225071 CA343466134	14	E>G		No	ClinGen gnomAD
CA1218840 rs762320638	14	E>K		No	ClinGen ExAC gnomAD
rs753504362 CA1218817	16	A>T		No	ClinGen ExAC gnomAD
rs1276294311 CA343419838	16	A>V		No	ClinGen gnomAD
rs760440634 CA1218815	18	E>G		No	ClinGen ExAC TOPMed gnomAD
CA343419800 rs1270633977	19	I>T		No	ClinGen gnomAD
CA31847821 rs145871235	20	K>N		No	ClinGen ESP TOPMed
rs775325062 CA1218814	21	I>F		No	ClinGen ExAC gnomAD
rs1346060751 CA343419758	22	K>N		No	ClinGen gnomAD
rs1571231174 CA343419698	27	L>P		No	ClinGen Ensembl
TCGA novel	28	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA343419688 rs1282619058	28	Q>R		No	ClinGen gnomAD
CA1218812 rs759505895	31	D>A		No	ClinGen ExAC TOPMed gnomAD
CA343419613 rs1300065405	34	G>C		No	ClinGen gnomAD
CA343419564 rs1462700441	38	I>F		No	ClinGen gnomAD
CA1218810 rs774429422	39	P>L		No	ClinGen ExAC gnomAD
CA343419526 rs35968905	41	N>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs35968905 CA1218808	41	N>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1218807 rs374711151	41	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1474045884 CA343419512	42	E>Q		No	ClinGen gnomAD
CA31847767 rs759477959	44	P>A		No	ClinGen gnomAD
rs759477959 CA343419481	44	P>S		No	ClinGen gnomAD
CA343419442 rs1253367758	47	P>T		No	ClinGen gnomAD
rs1187670218 CA343419414	49	K>T		No	ClinGen TOPMed gnomAD
rs747544052 CA1218785	53	T>S		No	ClinGen ExAC gnomAD
rs1239832135 CA343419031	54	S>L		No	ClinGen gnomAD
rs1183349685 CA343419035	54	S>P		No	ClinGen TOPMed
rs777324995 CA343419020	56	D>E		No	ClinGen ExAC TOPMed gnomAD
CA1218782 rs748874557	56	D>H		No	ClinGen ExAC TOPMed gnomAD
rs755737266 CA1218780	57	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	57	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1218779 rs752330335	58	A>G		No	ClinGen ExAC TOPMed gnomAD
rs767246365 CA1218778	62	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1218777 rs754717880	62	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1380159437 CA343418979	63	D>H		No	ClinGen TOPMed
CA343418967 rs1324830436	64	S>Y		No	ClinGen gnomAD
CA31843105 rs369125258	65	L>P		No	ClinGen ESP TOPMed gnomAD
rs1452385815 CA343418955	66	D>E		No	ClinGen gnomAD
rs1251394136 CA343418962	66	D>N		No	ClinGen TOPMed
rs1361587373 CA343418944	68	L>F		No	ClinGen gnomAD
rs751332579 CA1218776	70	Q>R		No	ClinGen ExAC
TCGA novel	72	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1044247757 CA31843097	72	N>S		No	ClinGen TOPMed
rs750306051 CA1218754	73	Y>C		No	ClinGen ExAC gnomAD
COSM400882 CA343418117 rs866971353	74	G>*	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
COSM1663917 rs866971353 CA31837898	74	G>R	kidney [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1018911732 CA31837892	77	S>N		No	ClinGen Ensembl
rs1404998460 CA343418033	79	K>E		No	ClinGen gnomAD
rs375964318 CA1218752	79	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA343417995 rs1557880075	80	S>N		No	ClinGen Ensembl
CA343417983 rs753832247	80	S>R		No	ClinGen ExAC gnomAD
CA343417991 rs1557880075	80	S>T		No	ClinGen Ensembl
CA1218749 rs201830771	87	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA31837872 rs1027034349	88	E>K		No	ClinGen TOPMed gnomAD
rs1266978669 CA343417765	90	N>D		No	ClinGen TOPMed
CA1218747 rs143682816	90	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	90	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200762280 CA1218745	92	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1218746 rs772501697	92	E>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	93	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1036136629 CA31837856	94	W>R		No	ClinGen TOPMed gnomAD
CA1218744 rs148930012	95	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA343417648 rs1251592440	97	C>F		No	ClinGen gnomAD
rs1251592440 CA343417650	97	C>Y		No	ClinGen gnomAD
CA1218743 rs771316827	99	D>H		No	ClinGen ExAC gnomAD
rs1316489572 CA343417600	100	Y>D		No	ClinGen gnomAD
CA1218742 rs747730118	102	K>T		No	ClinGen ExAC gnomAD
CA343417547 rs1386893999	103	I>N		No	ClinGen TOPMed
CA31837840 rs906463602	104	K>R		No	ClinGen Ensembl
rs141283960 CA1218741	105	S>A		No	ClinGen ExAC TOPMed gnomAD
rs1392771881 CA343417476	108	K>E		No	ClinGen TOPMed
rs1280808730 CA343417452	109	M>I		No	ClinGen gnomAD
TCGA novel	110	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746606578 CA1218738	110	A>S		No	ClinGen ExAC TOPMed gnomAD
CA1218737 rs779826661	110	A>V		No	ClinGen ExAC gnomAD
rs1334596366 CA343417438	112	K>E		No	ClinGen TOPMed
rs190048374 CA1218736	112	K>N		No	ClinGen 1000Genomes ExAC gnomAD
CA343417409 rs1389428885	116	I>V		No	ClinGen gnomAD
rs757138090 CA343417397	117	Y>*		No	ClinGen ExAC gnomAD
rs144088608 CA1218734	117	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs144088608 CA343417399	117	Y>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA1218732 rs754008466	122	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs764215537 CA343417355	123	T>K		No	ClinGen ExAC TOPMed gnomAD
rs764215537 CA1218731	123	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs768014429 CA1218728	125	A>P		No	ClinGen ExAC gnomAD
TCGA novel	125	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1218727 rs759991833	127	K>E		No	ClinGen ExAC TOPMed gnomAD
rs755146862 CA1218707	129	V>M		No	ClinGen ExAC gnomAD
CA1218706 rs752015607	131	I>V		No	ClinGen ExAC gnomAD
rs1557877821 CA343415973	132	D>G		No	ClinGen Ensembl
rs1291024162 CA343415906	135	T>A		No	ClinGen TOPMed
rs1315372347 CA343415852	137	D>N		No	ClinGen TOPMed gnomAD
CA343415840 rs1434786120	137	D>V		No	ClinGen TOPMed
rs766595377 CA1218705	138	I>T		No	ClinGen ExAC gnomAD
CA31835278 rs1052965505	140	M>R		No	ClinGen Ensembl
CA343415774 rs1295762998	140	M>V		No	ClinGen TOPMed
CA1218704 rs148613695	141	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA1218703 rs773667539	142	N>S		No	ClinGen ExAC gnomAD
rs763615294 CA1218702	144	V>A		No	ClinGen ExAC gnomAD
rs1367658247 CA343415597	146	P>H		No	ClinGen gnomAD
rs760220434 CA1218701	146	P>T		No	ClinGen ExAC gnomAD
CA1218700 rs774978465	147	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1412104524 CA343415543	148	L>R		No	ClinGen gnomAD
TCGA novel	149	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA343415526 rs1476025671	149	S>N		No	ClinGen gnomAD
rs1311567901 CA343415541	149	S>R		No	ClinGen TOPMed
CA31835258 rs1007594231	149	S>R		No	ClinGen TOPMed
rs1262386674 CA343415484	151	F>S		No	ClinGen TOPMed
CA1218697 rs774205323	153	M>I		No	ClinGen ExAC gnomAD
rs745454274 CA1218698	153	M>K		No	ClinGen ExAC TOPMed gnomAD
CA343415391 rs1242366596	155	Q>E		No	ClinGen Ensembl
rs1490710140 CA343415386	155	Q>R		No	ClinGen gnomAD
CA343415366 rs1477897678	156	K>E		No	ClinGen TOPMed gnomAD
CA31835244 rs770595330	157	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1218696 rs770595330	157	R>K		No	ClinGen ExAC TOPMed gnomAD
CA343415315 rs1247708336	158	I>S		No	ClinGen gnomAD
rs1221312842 CA343415305	159	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs777909194 CA1218694	160	A>V		No	ClinGen ExAC gnomAD
CA1218693 rs756084760	162	M>T		No	ClinGen ExAC gnomAD
CA1218692 rs748302072	164	K>E		No	ClinGen ExAC gnomAD
TCGA novel	164	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	165	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA343415139 rs1398193231	166	S>P		No	ClinGen gnomAD
CA1218690 rs755241558	167	L>V		No	ClinGen ExAC gnomAD
CA1218688 rs751665168	168	P>R		No	ClinGen ExAC gnomAD
CA1218687 rs192189511	169	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs758639664 CA1218686 COSM1335818	169	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	170	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1205978249 CA343415000	171	V>G		No	ClinGen gnomAD
CA1218684 rs1457102023	171	V>L		No	ClinGen TOPMed
COSM369226 CA1218683 rs112323155	172	R>C	lung kidney [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
COSM530240 rs147130564 CA1218682	172	R>H	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA31835186 rs147130564	172	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA343414922 rs1571205111	175	F>V		No	ClinGen Ensembl
CA1218681 rs762295521	182	K>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1218680 rs774994927	182	K>W		No	ClinGen ExAC gnomAD

No associated diseases with O15539

2 regional properties for O15539

Type	Name	Position	InterPro Accession
domain	RGS domain	61 - 180	IPR016137
domain	Regulator of G-protein signalling 5, RGS domain	65 - 178	IPR034956

Functions

		Description
EC Number
Subcellular Localization	[Isoform 1]: Cytoplasm Membrane ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name	Definition
GTPase activator activity	Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

3 GO annotations of biological process

Name	Definition
G protein-coupled receptor signaling pathway	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
negative regulation of signal transduction	Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
regulation of G protein-coupled receptor signaling pathway	Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.

8 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O46471	RGS16	Regulator of G-protein signaling 16	Bos taurus (Bovine)	PR
Q3T0T8	RGS5	Regulator of G-protein signaling 5	Bos taurus (Bovine)	PR
P49802	RGS7	Regulator of G-protein signaling 7	Homo sapiens (Human)	PR
Q9Z2H1	Rgs11	Regulator of G-protein signaling 11	Mus musculus (Mouse)	PR
O54829	Rgs7	Regulator of G-protein signaling 7	Mus musculus (Mouse)	PR
Q0QWG9	Grid2ip	Delphilin	Mus musculus (Mouse)	PR
Q18312	rgs-3	Regulator of G-protein signaling rgs-3	Caenorhabditis elegans	PR
Q8H1F2	RGS1	Regulator of G-protein signaling 1	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MCKGLAALPH	SCLERAKEIK	IKLGILLQKP	DSVGDLVIPY	NEKPEKPAKT	QKTSLDEALQ
70	80	90	100	110	120
WRDSLDKLLQ	NNYGLASFKS	FLKSEFSEEN	LEFWIACEDY	KKIKSPAKMA	EKAKQIYEEF
130	140	150	160	170	180
IQTEAPKEVN	IDHFTKDITM	KNLVEPSLSS	FDMAQKRIHA	LMEKDSLPRF	VRSEFYQELI

K