AiPD: Autoinhibited Protein Database

O15370

Gene name	SOX12 (SOX22)
Protein name	Transcription factor SOX-12
Names	Protein SOX-22
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6666
EC number
Protein Class

Descriptions

Sox11 acts as a transcriptional activator of TEAD2 by binding to its gene promoter. This protein possesses intrinsically disordered regions (IDRs) with large negative charge, some of which involve a consecutive sequence of aspartate (D) or glutamate (E) residues, known as D/E repeats. These D/E repeats can cause autoinhibition through intramolecular electrostatic interaction with HMG boxes and modulate binding to DNA. This autoinhibited state can transition into the uninhibited complex with DNA through an electrostatically driven induced-fit process, which accelerates the target DNA search kinetics in the presence of non-functional high-affinity ligands ('decoys').

Autoinhibitory domains (AIDs)

162-173 (D/E repeat) SS

Target domain	29-120 (HMG box domain)
Relief mechanism
Assay

AID

162-173 (D/E repeat)

Target domain

29-120 (HMG box domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O15370

Entry ID	Method	Resolution	Chain	Position	Source
AF-O15370-F1	Predicted				AlphaFoldDB

346 variants for O15370

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs2122429332	2	V>G		No	Ensembl
rs1568504498	7	A>G		No	TOPMed
rs1568504498	7	A>V		No	TOPMed
rs1317086166	10	K>N		No	TOPMed gnomAD
rs2013079754	10	K>R		No	TOPMed
rs1335656897	13	G>D		No	TOPMed gnomAD
rs1215815120	14	G>A		No	TOPMed gnomAD
rs1046439261	15	P>S		No	TOPMed gnomAD
rs772171052	16	P>L		No	ExAC TOPMed gnomAD
rs2122429513	17	P>L		No	Ensembl
rs1183055643	17	P>S		No	gnomAD
rs1322496549	18	P>L		No	gnomAD
rs1322496549	18	P>R		No	gnomAD
rs1235093477	18	P>S		No	gnomAD
rs1471897239	19	G>R		No	TOPMed gnomAD
rs1417978895	20	P>H		No	TOPMed gnomAD
rs1417978895	20	P>L		No	TOPMed gnomAD
rs2122429594	21	G>R		No	Ensembl
rs2013080675	22	P>L		No	gnomAD
rs1427986253	23	A>T		No	TOPMed gnomAD
rs747028249	23	A>V		No	ExAC TOPMed gnomAD
rs527827665	24	E>K		No	1000Genomes gnomAD
rs2013080917	25	E>*		No	Ensembl
rs940668358	26	G>R		No	TOPMed
rs1410310750	29	E>D		No	gnomAD
rs1473422417	30	P>T		No	Ensembl
rs775530498	31	G>C		No	ExAC TOPMed gnomAD
rs775530498	31	G>R		No	ExAC TOPMed gnomAD
rs775530498	31	G>S		No	ExAC TOPMed gnomAD
rs1409153342	33	C>W		No	gnomAD
rs762847089	34	K>R		No	ExAC gnomAD
TCGA novel	35	T>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs375905724	36	P>L		No	ExAC gnomAD
rs375905724	36	P>R		No	ExAC gnomAD
rs1600206723	40	I>V		No	Ensembl
rs2013081671	43	P>S		No	Ensembl
rs2122429852	44	M>I		No	Ensembl
rs866924860	46	A>S		No	Ensembl
rs761598365	49	V>G		No	ExAC gnomAD
rs2122429883	50	W>*		No	Ensembl
rs767050311	51	S>*		No	ExAC
rs1268459677	51	S>P		No	gnomAD
rs1205112667	52	Q>R		No	gnomAD
rs1358188637	53	H>Y		No	TOPMed
rs1169375494	59	M>I		No	gnomAD
rs1475540637	59	M>T		No	gnomAD
rs2013082426	62	W>G		No	TOPMed
COSM3673098	63	P>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2122429993	64	D>E		No	Ensembl
rs1428985618	68	A>S		No	gnomAD
rs1157480305	69	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs2013082832	71	S>F		No	Ensembl
rs2122430039	71	S>P		No	Ensembl
rs2013082885	72	K>R		No	Ensembl
rs1028803326	73	R>C		No	TOPMed gnomAD
rs1332273974	75	G>A		No	gnomAD
rs2013083061 COSM4923376	75	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed
rs2013083153	76	R>C		No	Ensembl
rs779303375	76	R>H		No	ExAC gnomAD
rs1272249801	77	R>H		No	gnomAD
rs753056440	77	R>S		No	ExAC gnomAD
rs2013083418	80	L>R		No	Ensembl
rs1048176849	80	L>V		No	Ensembl
rs758686415	83	D>G		No	ExAC gnomAD
rs2013083574	84	S>A		No	TOPMed
rs747132284	84	S>L		No	ExAC TOPMed gnomAD
rs747132284	84	S>W		No	ExAC TOPMed gnomAD
rs2013083730	85	E>D		No	Ensembl
rs2122430206 COSM3799422	86	K>M	Variant assessed as Somatic; MODERATE impact. urinary_tract [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs55875126	86	K>N		No	Ensembl
rs2013083830 COSM4134426	87	I>M	thyroid [Cosmic]	No	cosmic curated TOPMed
rs1198161731	88	P>A		No	gnomAD
rs2013083934	89	F>L		No	TOPMed gnomAD
rs2013083999	90	V>L		No	TOPMed
rs2013084044	91	R>L		No	Ensembl
rs770850889	92	E>Q		No	ExAC gnomAD
rs780154689	94	E>D		No	ExAC TOPMed gnomAD
rs2122430296	97	R>P		No	Ensembl
rs761494795	101	M>I		No	ExAC gnomAD
rs2013084438	101	M>T		No	Ensembl
rs1464492090	102	A>E		No	TOPMed gnomAD
rs1464492090	102	A>V		No	TOPMed gnomAD
rs2122430351	103	D>Y		No	Ensembl
rs2122430365	105	P>S		No	Ensembl
rs2013084704	106	D>N		No	TOPMed
rs1344511263	107	Y>C		No	gnomAD
rs2122430390	108	K>M		No	Ensembl
rs760233296	108	K>N		No	ExAC gnomAD
rs2122430408	110	R>G		No	Ensembl
rs765814571	110	R>Q		No	ExAC gnomAD
rs35462946	112	R>C		No	Ensembl
COSM1410894 rs867428648	112	R>H	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl NCI-TCGA
rs2122430471	113	K>E		No	Ensembl
rs2122430495	113	K>N		No	Ensembl
rs2013085141	113	K>R		No	Ensembl
rs2122430509	114	K>Q		No	Ensembl
rs2122430527	115	S>G		No	Ensembl
rs2122430534	115	S>R		No	Ensembl
rs866311137	116	K>M		No	Ensembl
rs866311137	116	K>R		No	Ensembl
rs556205020	117	G>A		No	1000Genomes ExAC TOPMed gnomAD
rs556205020	117	G>E		No	1000Genomes ExAC TOPMed gnomAD
rs1008567981	117	G>R		No	TOPMed
rs556205020	117	G>V		No	1000Genomes ExAC TOPMed gnomAD
rs978436990	118	A>E		No	TOPMed gnomAD
rs753152460	118	A>S		No	ExAC TOPMed gnomAD
rs978436990	118	A>V		No	TOPMed gnomAD
rs1254868779	120	A>D		No	gnomAD
rs1254868779	120	A>V		No	gnomAD
rs2013085759	121	K>R		No	gnomAD
rs2013085908	124	P>R		No	Ensembl
rs2013085865	124	P>S		No	TOPMed
rs2013086249	126	P>H		No	gnomAD
rs1459142259	126	P>T		No	TOPMed gnomAD
rs1413082555	127	P>S		No	TOPMed
rs758639743	128	G>C		No	1000Genomes ExAC TOPMed gnomAD
rs939858413	128	G>D		No	TOPMed gnomAD
rs758639743	128	G>S		No	1000Genomes ExAC TOPMed gnomAD
rs1345087091	128	G>V	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs764383462	129	G>C		No	ExAC TOPMed gnomAD
rs764383462	129	G>S		No	ExAC TOPMed gnomAD
rs1046190720	129	G>V		No	Ensembl
rs751675521	130	S>G		No	ExAC gnomAD
rs1361604306	130	S>I		No	gnomAD
rs991407227	131	G>D		No	TOPMed gnomAD
rs1198043967	134	S>C		No	gnomAD
rs2013087641	135	R>G		No	TOPMed
rs1002103858	135	R>P		No	Ensembl
rs2122430926	136	L>P		No	Ensembl
rs2013087766	137	K>N		No	gnomAD
rs916714328	138	P>A		No	TOPMed gnomAD
rs916714328	138	P>S		No	TOPMed gnomAD
rs982230130	139	G>R		No	TOPMed gnomAD
rs1248945894	140	P>L		No	TOPMed gnomAD
rs1248945894	140	P>Q		No	TOPMed gnomAD
rs535111667	140	P>S		No	1000Genomes ExAC TOPMed gnomAD
rs1310646290	141	Q>*		No	TOPMed
rs1011981897	141	Q>L		No	1000Genomes
rs1011981897	141	Q>R		No	1000Genomes
rs1386644328	143	P>H		No	TOPMed gnomAD
rs1386644328	143	P>L		No	TOPMed gnomAD
rs1318633194	144	G>A		No	TOPMed gnomAD
rs745915966	145	R>C		No	ExAC TOPMed gnomAD
rs1326943752	145	R>L		No	TOPMed gnomAD
rs745915966	145	R>S		No	ExAC TOPMed gnomAD
rs1600206857	146	G>V		No	Ensembl
rs1336429146	147	G>D		No	TOPMed gnomAD
rs2013089118	147	G>S		No	TOPMed
rs2013089326	149	R>P		No	Ensembl
rs2122431112	150	A>P		No	1000Genomes
rs1600206868	151	A>T		No	Ensembl
rs1385494921	152	G>A		No	TOPMed gnomAD
rs1385494921	152	G>E		No	TOPMed gnomAD
rs1177872142	152	G>R		No	TOPMed gnomAD
rs2013089785	154	P>S		No	Ensembl
rs1451204049	155	L>F		No	TOPMed gnomAD
rs755018354	156	G>R		No	ExAC TOPMed gnomAD
rs2013090234	156	G>V		No	gnomAD
rs755018354	156	G>W		No	ExAC TOPMed gnomAD
rs1796309196	157	G>D		No	TOPMed
rs2013090310	157	G>S		No	TOPMed
rs1482193457	158	G>R		No	TOPMed gnomAD
rs967433229	159	A>T		No	Ensembl
rs778948503	160	A>T		No	ExAC TOPMed gnomAD
rs1341725060	160	A>V		No	TOPMed gnomAD
rs1213961891	161	A>T		No	TOPMed gnomAD
rs1487369311	162	P>L		No	TOPMed gnomAD
rs2013091052	162	P>S		No	Ensembl
rs748008617	164	D>Y		No	ExAC gnomAD
rs770657048	165	D>G		No	Ensembl
rs1161177069	165	D>Y		No	gnomAD
rs2013091756	166	D>A		No	gnomAD
rs890248293	166	D>E		No	TOPMed gnomAD
rs1364548001	166	D>N		No	gnomAD
rs1462227838	168	D>H		No	TOPMed gnomAD
rs1008682476	169	D>E		No	TOPMed
rs1466196308	169	D>V		No	TOPMed
rs554982419	170	D>E		No	1000Genomes TOPMed gnomAD
TCGA novel	171	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1166153415	171	E>K		No	TOPMed
rs2013092448	172	E>A		No	TOPMed
rs1431151377	172	E>Q		No	TOPMed gnomAD
rs1600206904	175	E>D		No	Ensembl
rs1041476189	175	E>G		No	TOPMed gnomAD
rs1165889458	176	V>A		No	gnomAD
rs1257926884	176	V>M		No	TOPMed gnomAD
rs1456704983	177	R>C		No	TOPMed gnomAD
rs1456704983	177	R>G		No	TOPMed gnomAD
rs1019825613	177	R>H		No	TOPMed gnomAD
rs1019825613	177	R>P		No	TOPMed gnomAD
rs372611150	178	L>Q		No	Ensembl
rs1207342389	179	V>A		No	TOPMed gnomAD
rs1000287490	180	E>K		No	TOPMed gnomAD
rs1000287490	180	E>Q		No	TOPMed gnomAD
rs2122431637	181	T>I		No	Ensembl
rs1265356388	182	P>L		No	Ensembl
rs1393977546	184	R>P		No	TOPMed gnomAD
rs746695082	185	E>A		No	ExAC TOPMed gnomAD
rs1390618405	186	L>P		No	gnomAD
rs1314417108	190	V>A		No	TOPMed gnomAD
rs866806497	190	V>I		No	Ensembl
rs975730143	192	A>V		No	TOPMed gnomAD
rs2013094672	193	G>*		No	Ensembl
rs1251689087	193	G>V		No	gnomAD
rs2013094770	194	R>W		No	TOPMed
rs1483968030	195	A>V		No	TOPMed gnomAD
rs1370570444	196	A>S		No	TOPMed
rs2013094901	196	A>V		No	TOPMed
rs1251044891	197	R>G		No	TOPMed gnomAD
rs931003404	197	R>P		No	gnomAD
rs931003404	197	R>Q		No	gnomAD
rs1251044891	197	R>W		No	TOPMed gnomAD
rs1422294179	200	A>E		No	TOPMed gnomAD
rs1422294179	200	A>G		No	TOPMed gnomAD
rs1416141473	200	A>T		No	gnomAD
rs1422294179	200	A>V		No	TOPMed gnomAD
TCGA novel	201	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1374021367	202	R>C		No	gnomAD
rs1374021367	202	R>G		No	gnomAD
rs1432059218	202	R>H		No	gnomAD
rs557418764	203	A>T		No	1000Genomes ExAC TOPMed gnomAD
rs958538885	204	Q>L		No	TOPMed gnomAD
rs958538885	204	Q>R		No	TOPMed gnomAD
rs1483508318	205	G>E		No	TOPMed
rs1304086424	206	P>R		No	gnomAD
rs1395115403	207	S>P		No	TOPMed gnomAD
rs2013095957	208	G>R		No	gnomAD
rs1797079049	209	E>K		No	Ensembl
rs1797079049	209	E>Q		No	Ensembl
rs1273814862	210	G>V		No	gnomAD
rs2013096242	211	A>S		No	TOPMed gnomAD
rs2013096242	211	A>T		No	TOPMed gnomAD
rs1210831415	211	A>V		No	gnomAD
rs562098614	212	A>T		No	1000Genomes ExAC TOPMed gnomAD
rs2013096707	213	A>T		No	TOPMed gnomAD
rs2013096753	213	A>V		No	gnomAD
rs906397602	214	A>S		No	TOPMed gnomAD
rs906397602	214	A>T		No	TOPMed gnomAD
rs2013097001	215	A>S		No	TOPMed
rs1055083034	216	A>T		No	Ensembl
rs1181198696	216	A>V		No	gnomAD
rs1456494948	218	S>F		No	TOPMed gnomAD
rs1384138545	219	P>R		No	gnomAD
rs181303084	220	T>I		No	1000Genomes ESP ExAC TOPMed gnomAD
rs181303084	220	T>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs866230814	221	P>L		No	TOPMed
rs866230814	221	P>Q		No	TOPMed
rs866230814	221	P>R		No	TOPMed
rs1390027264	221	P>S		No	gnomAD
rs2013097662	224	D>E		No	gnomAD
rs2013097612	224	D>G		No	TOPMed
rs2122432293	224	D>N		No	Ensembl
rs1177544531	225	E>Q		No	TOPMed gnomAD
rs757594648	226	E>Q		No	ExAC
rs2013097907	227	P>L		No	TOPMed
rs2013097907	227	P>R		No	TOPMed
rs1446707122	228	E>G		No	TOPMed gnomAD
rs1337191150	228	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1289066635	230	E>A		No	gnomAD
rs1600207027	230	E>K		No	Ensembl
rs1296612131	232	E>K		No	TOPMed gnomAD
rs750556965	233	E>A		No	1000Genomes ExAC TOPMed gnomAD
rs2013098833	233	E>K		No	gnomAD
rs2013099071	234	A>S		No	TOPMed gnomAD
rs1229415912	234	A>V		No	gnomAD
rs1276461508	235	A>T		No	gnomAD
rs1019709029	236	A>V		No	TOPMed gnomAD
rs527670259	237	A>S		No	1000Genomes ExAC gnomAD
rs527670259	237	A>T		No	1000Genomes ExAC gnomAD
rs1350911968	237	A>V		No	TOPMed gnomAD
rs778917309	238	E>A		No	ExAC TOPMed gnomAD
rs778917309	238	E>G		No	ExAC TOPMed gnomAD
rs747974957	239	E>G		No	ExAC gnomAD
rs758339680	240	G>A		No	ExAC TOPMed gnomAD
rs1423746067	243	E>D		No	gnomAD
rs73574574 RCV000905791	243	E>G		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1386391522	243	E>K		No	TOPMed gnomAD
rs1386391522	243	E>Q		No	TOPMed gnomAD
rs983816506	244	T>M		No	gnomAD
rs983816506	244	T>R		No	gnomAD
rs1401767358	244	T>S		No	Ensembl
rs776214890	246	A>P		No	ExAC TOPMed gnomAD
rs776214890	246	A>S		No	ExAC TOPMed gnomAD
rs776214890	246	A>T		No	ExAC TOPMed gnomAD
rs1188037724	247	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs961007431	248	G>R		No	TOPMed gnomAD
rs1394903386	249	E>Q		No	gnomAD
rs369677394	251	S>L		No	ESP ExAC TOPMed gnomAD
rs369677394	251	S>W		No	ESP ExAC TOPMed gnomAD
rs1366903638	252	L>P		No	gnomAD
rs2013101753	253	G>V		No	Ensembl
rs2013101992	255	L>V		No	TOPMed
rs1346687941	256	S>F		No	Ensembl
rs1243213478	257	R>W		No	TOPMed gnomAD
rs1485880682	258	L>M		No	gnomAD
rs2013102518	259	P>L		No	TOPMed
rs764632747	259	P>T		No	ExAC TOPMed gnomAD
rs1207094435	260	P>S		No	TOPMed gnomAD
rs774631945	261	G>D		No	ExAC TOPMed gnomAD
rs1015072676	261	G>R		No	TOPMed gnomAD
rs2013102864	262	P>S		No	TOPMed
TCGA novel	263	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs532985023	264	G>V		No	1000Genomes
rs2013103198	265	L>P		No	Ensembl
rs144343937	265	L>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs767885882	266	D>E		No	ExAC
rs1376314168	266	D>G		No	TOPMed
rs1416339129	266	D>H		No	Ensembl
rs1182204068	267	C>R		No	gnomAD
rs1427947620	270	L>V		No	TOPMed
rs766425276	271	D>E		No	ExAC gnomAD
rs1391073787	272	R>C		No	gnomAD
rs1349172414	273	D>E		No	gnomAD
rs758304545	273	D>H		No	ExAC TOPMed gnomAD
rs758304545	273	D>N		No	ExAC TOPMed gnomAD
rs569739469	274	P>A		No	1000Genomes
rs569739469	274	P>T		No	1000Genomes
rs1187675741	275	D>A		No	TOPMed gnomAD
rs1442865208	277	Q>R		No	gnomAD
rs777743090	278	P>A		No	ExAC TOPMed gnomAD
rs1352381281	278	P>L		No	TOPMed gnomAD
rs1352381281	278	P>R		No	TOPMed gnomAD
rs777743090	278	P>S		No	ExAC TOPMed gnomAD
rs751377586	279	P>L		No	ExAC TOPMed gnomAD
rs1357408940	281	G>D		No	gnomAD
rs1230324812	282	T>M		No	gnomAD
rs2013104714	283	S>*		No	TOPMed
rs2013104714	283	S>L		No	TOPMed
rs2013104659	283	S>T		No	TOPMed
rs2013104956	286	E>D		No	Ensembl
rs1451494563	288	P>T		No	gnomAD
COSM6159436	294	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	294	E>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1180909485	297	E>A		No	TOPMed gnomAD
rs2013105465	299	I>T		No	Ensembl
rs2122433258	300	A>G		No	Ensembl
rs774885244	301	G>R		No	ExAC gnomAD
rs1430211953	302	D>E		No	gnomAD
rs1368695880	305	P>L		No	TOPMed gnomAD
rs1368695880	305	P>R		No	TOPMed gnomAD
rs2076676163	306	S>P		No	Ensembl
rs1307509025	307	S>T		No	gnomAD
rs2013106069	308	I>V		No	Ensembl
rs2122433342	309	A>T		No	Ensembl
rs2122433352	310	D>E		No	Ensembl
rs201221995	315	Y>N		No	1000Genomes ExAC gnomAD

No associated diseases with O15370

2 regional properties for O15370

Type	Name	Position	InterPro Accession
repeat	Leucine-rich repeat	89 - 110	IPR001611-1
repeat	Leucine-rich repeat	114 - 135	IPR001611-2

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription activator activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
transcription cis-regulatory region binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

7 GO annotations of biological process

Name	Definition
anatomical structure morphogenesis	The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
brain development	The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
neuron differentiation	The process in which a relatively unspecialized cell acquires specialized features of a neuron.
positive regulation of regulatory T cell differentiation	Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
spinal cord development	The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.

14 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P48435	SOX11	Transcription factor SOX-11	Gallus gallus (Chicken)	SS
P48436	SOX9	Transcription factor SOX-9	Homo sapiens (Human)	PR
O94993	SOX30	Transcription factor SOX-30	Homo sapiens (Human)	PR
P35716	SOX11	Transcription factor SOX-11	Homo sapiens (Human)	EV
Q04888	Sox10	Transcription factor SOX-10	Mus musculus (Mouse)	PR
Q05738	Sry	Sex-determining region Y protein	Mus musculus (Mouse)	SS
Q04886	Sox8	Transcription factor SOX-8	Mus musculus (Mouse)	SS
Q04887	Sox9	Transcription factor SOX-9	Mus musculus (Mouse)	PR
Q7M6Y2	Sox11	Transcription factor SOX-11	Mus musculus (Mouse)	SS
Q04890	Sox12	Transcription factor SOX-12	Mus musculus (Mouse)	SS
P0C1G9	Sox11	Transcription factor SOX-11	Rattus norvegicus (Rat)	SS
Q8T3B9	sem-2	Transcription factor sem-2	Caenorhabditis elegans	SS
Q6GLH8	sox17b.2	Transcription factor Sox-17-beta.2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q8AWH2	sox17b.1	Transcription factor Sox-17-beta.1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MVQQRGARAK	RDGGPPPPGP	GPAEEGAREP	GWCKTPSGHI	KRPMNAFMVW	SQHERRKIMD
70	80	90	100	110	120
QWPDMHNAEI	SKRLGRRWQL	LQDSEKIPFV	REAERLRLKH	MADYPDYKYR	PRKKSKGAPA
130	140	150	160	170	180
KARPRPPGGS	GGGSRLKPGP	QLPGRGGRRA	AGGPLGGGAA	APEDDDEDDD	EELLEVRLVE
190	200	210	220	230	240
TPGRELWRMV	PAGRAARGQA	ERAQGPSGEG	AAAAAAASPT	PSEDEEPEEE	EEEAAAAEEG
250	260	270	280	290	300
EEETVASGEE	SLGFLSRLPP	GPAGLDCSAL	DRDPDLQPPS	GTSHFEFPDY	CTPEVTEMIA
310
GDWRPSSIAD	LVFTY