O15264
SS
Gene name |
MAPK13 (PRKM13, SAPK4) |
Protein name |
Mitogen-activated protein kinase 13 |
Names |
MAP kinase 13 , MAPK 13 , EC 2.7.11.24 , Mitogen-activated protein kinase p38 delta , MAP kinase p38 delta , Stress-activated protein kinase 4 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:5603 |
EC number |
2.7.11.24: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
MAPK1 encodes Mitogen-activated protein kinase 1, and is involved in diverse cellular responses by phosphorylating cytoplasmic and nuclear proteins. Unlike other MAP kinases, MAPK1 activates via dual phosphorylation of Thr-186 and Tyr-193 within the activation lip, and mutations at Q105 alone were sufficient for autoactivation. Additionally, in the inactive form, L76, Q10 and I87 form a structural unit that restrains intramolecular autophosphorylation by preventing interactions between activation lip residues and the catalytic base (D149) needed for phosphoryl transfer. Mutations at L76, I87 and additionally S153 increased basal specific activity via autophosphorylation of Thr-186 and Tyr-193.
Autoinhibitory domains (AIDs)
Target domain |
25-308 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
167-187 (Activation loop from InterPro)
Target domain |
25-308 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
167-187 (Activation loop from InterPro)
Target domain |
25-308 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100
- Emrick MA et al. (2006) "The gatekeeper residue controls autoactivation of ERK2 via a pathway of intramolecular connectivity", Proceedings of the National Academy of Sciences of the United States of America, 103, 18101-6
- Emrick MA et al. (2001) "Constitutive activation of extracellular signal-regulated kinase 2 by synergistic point mutations", The Journal of biological chemistry, 276, 46469-79
Autoinhibited structure
Activated structure
9 structures for O15264
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3COI | X-ray | 209 A | A | 2-352 | PDB |
| 4EYJ | X-ray | 210 A | A | 1-352 | PDB |
| 4EYM | X-ray | 235 A | A | 1-352 | PDB |
| 4MYG | X-ray | 259 A | A/B | 1-352 | PDB |
| 4YNO | X-ray | 170 A | A | 1-352 | PDB |
| 5EKN | X-ray | 259 A | A | 1-352 | PDB |
| 5EKO | X-ray | 200 A | A | 1-352 | PDB |
| 8X23 | X-ray | 150 A | A | 1-352 | PDB |
| AF-O15264-F1 | Predicted | AlphaFoldDB |
322 variants for O15264
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1485272672 CA363804372 |
2 | S>R | No |
ClinGen gnomAD |
|
|
rs772574143 CA3776343 |
3 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA363804385 rs200726449 |
4 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA363804388 rs1476538162 |
5 | R>Q | No |
ClinGen gnomAD |
|
|
CA3776345 rs761126232 |
6 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA363804403 rs1174315147 |
7 | K>N | No |
ClinGen gnomAD |
|
|
COSM1312144 rs766704073 CA3776346 COSM1312143 |
7 | K>R | urinary_tract [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs200978679 CA137330507 |
8 | G>S | No |
ClinGen 1000Genomes TOPMed |
|
|
rs1435949223 CA363804416 |
9 | F>L | No |
ClinGen gnomAD |
|
|
CA363804428 rs1358741796 |
11 | K>* | No |
ClinGen gnomAD |
|
|
rs759180926 CA3776348 |
12 | Q>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1364272384 CA363804442 |
13 | D>H | No |
ClinGen gnomAD |
|
|
rs1364272384 CA363804443 |
13 | D>Y | No |
ClinGen gnomAD |
|
|
CA3776349 rs560599111 |
14 | V>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA363804476 rs1282354733 |
18 | A>P | No |
ClinGen TOPMed gnomAD |
|
|
CA363804478 rs1282354733 |
18 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA3776351 rs757938099 |
18 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1317883609 CA363804487 |
19 | W>* | No |
ClinGen TOPMed |
|
|
CA363804482 rs1214407248 |
19 | W>R | No |
ClinGen gnomAD |
|
|
rs1397181580 CA363804494 |
20 | E>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1581877501 CA363804505 |
22 | P>S | No |
ClinGen Ensembl |
|
|
rs151226715 CA3776352 |
25 | Y>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs371857533 CA3776354 |
26 | V>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs751593993 CA3776353 |
26 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA3776357 rs780913488 |
27 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3776356 rs780913488 |
27 | S>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3776359 rs779041093 |
29 | T>S | No |
ClinGen ExAC gnomAD |
|
|
rs772092887 CA3776361 |
32 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs1347031517 CA363804578 |
34 | G>W | No |
ClinGen TOPMed gnomAD |
|
|
rs773255782 CA3776362 |
35 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3776363 rs761129055 |
36 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA363804591 rs761129055 |
36 | Y>F | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 37 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs771466675 CA3776364 |
38 | S>A | No |
ClinGen ExAC gnomAD |
|
|
rs140256527 CA3776366 |
39 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3776367 rs140256527 |
39 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA363804611 rs1478239766 |
40 | C>G | No |
ClinGen TOPMed |
|
|
CA3776368 rs561092120 |
40 | C>Y | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1362221011 CA363804630 |
41 | S>A | No |
ClinGen gnomAD |
|
|
COSM3697818 COSM3697817 VAR_042267 RCV000955175 CA3776411 rs55776345 |
41 | S>L | large_intestine [Cosmic] | No |
ClinGen cosmic curated ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs1373786271 CA363804644 |
43 | I>T | No |
ClinGen TOPMed |
|
|
rs758681137 CA3776412 |
46 | R>Q | No |
ClinGen ExAC |
|
|
CA363804671 rs1275889575 |
47 | S>L | No |
ClinGen gnomAD |
|
|
rs1420330282 CA363804675 |
48 | G>E | No |
ClinGen TOPMed |
|
|
CA363804682 rs1425474731 |
49 | E>G | No |
ClinGen TOPMed |
|
|
rs138132800 CA3776413 |
49 | E>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs138132800 CA363804678 |
49 | E>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1581878387 CA363804686 |
50 | K>E | No |
ClinGen Ensembl |
|
|
CA363804690 rs1581878400 |
50 | K>M | No |
ClinGen Ensembl |
|
|
CA363804696 rs1581878418 |
51 | V>A | No |
ClinGen Ensembl |
|
|
CA3776415 rs757309624 |
51 | V>L | No |
ClinGen ExAC gnomAD |
|
|
COSM1444068 rs1275730417 COSM1444067 CA363804703 |
52 | A>V | Variant assessed as Somatic; 0.0 impact. large_intestine haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs1256797127 CA363804710 |
53 | I>M | No |
ClinGen TOPMed |
|
|
CA137331480 rs977481810 |
56 | L>M | No |
ClinGen Ensembl |
|
|
rs1417842444 CA363804729 |
56 | L>P | No |
ClinGen gnomAD |
|
|
CA363804741 rs1210779465 |
58 | R>Q | No |
ClinGen gnomAD |
|
|
CA3776417 rs746424319 |
59 | P>H | No |
ClinGen ExAC gnomAD |
|
|
CA363804777 rs1191833181 |
63 | E>D | No |
ClinGen gnomAD |
|
|
rs373125773 CA3776418 |
64 | I>N | No |
ClinGen ESP ExAC TOPMed |
|
|
CA3776419 COSM2150636 rs776053641 COSM2150637 |
66 | A>T | Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA3776420 rs749605342 |
67 | K>N | No |
ClinGen ExAC gnomAD |
|
|
rs1474977102 CA363804801 |
67 | K>T | No |
ClinGen gnomAD |
|
|
CA3776422 rs774015147 |
69 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3776423 rs761251686 |
70 | Y>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA363804816 rs761251686 |
70 | Y>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs149104977 CA3776424 |
71 | R>Q | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1375578753 CA363804824 |
71 | R>W | No |
ClinGen gnomAD |
|
|
rs772566843 CA3776426 |
73 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3776427 rs143141487 |
79 | M>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1272345792 CA363804873 |
79 | M>K | No |
ClinGen gnomAD |
|
|
rs1272345792 CA363804874 |
79 | M>T | No |
ClinGen gnomAD |
|
|
rs766292303 CA3776428 |
80 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA363804889 rs1395767902 |
81 | H>R | No |
ClinGen TOPMed |
|
|
CA3776429 rs753649504 |
81 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs764257506 CA3776431 |
82 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754705455 CA3776430 |
82 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA3776432 rs751852929 |
83 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs933817377 CA137331652 |
83 | N>T | No |
ClinGen Ensembl |
|
|
rs756221881 CA363804924 |
85 | I>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs756221881 CA3776457 |
85 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA363804922 rs1274357133 |
85 | I>V | No |
ClinGen TOPMed |
|
|
CA363804933 rs918806990 |
87 | L>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs918806990 CA137332636 |
87 | L>I | No |
ClinGen TOPMed gnomAD |
|
|
CA3776458 rs780728892 |
88 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3776459 rs780728892 |
88 | L>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 89 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA3776460 rs755410159 |
91 | F>S | No |
ClinGen ExAC |
|
|
CA3776461 rs779402785 |
92 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 93 | P>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA363804970 rs1390210391 |
93 | P>L | No |
ClinGen gnomAD |
|
|
CA3776462 rs748450780 |
93 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs141255553 CA137332695 |
95 | S>A | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs777227831 CA3776464 |
96 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs551991367 CA3776465 |
98 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs752598428 CA3776466 |
98 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs551991367 CA363804992 |
98 | R>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA3776468 rs759533532 |
100 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA137332738 rs759533532 |
100 | F>V | No |
ClinGen ExAC gnomAD |
|
|
CA3776469 rs769602431 |
101 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA3776471 rs762587584 |
102 | D>G | No |
ClinGen ExAC gnomAD |
|
|
CA3776470 rs775367734 |
102 | D>H | No |
ClinGen ExAC gnomAD |
|
|
CA363805024 rs1183258202 |
103 | F>L | No |
ClinGen gnomAD |
|
|
CA363805027 rs1415224311 |
103 | F>S | No |
ClinGen TOPMed gnomAD |
|
|
CA3776492 rs774256716 |
105 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761045728 CA3776493 |
106 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761045728 CA363805697 |
106 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs267600997 CA137335278 |
108 | P>L | No |
ClinGen Ensembl |
|
|
CA3776494 rs766696837 |
108 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3776495 rs776866585 |
111 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs11554013 CA3776496 |
111 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
COSM1165650 COSM1165651 CA3776497 rs765793199 |
112 | T>M | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA363805773 rs1307852986 |
113 | D>H | No |
ClinGen gnomAD |
|
|
rs764504921 CA3776500 |
118 | M>T | No |
ClinGen ExAC gnomAD |
|
|
rs751919900 CA3776501 |
119 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs1238856390 CA363805866 |
120 | M>I | No |
ClinGen gnomAD |
|
|
rs1484722828 CA363805898 |
123 | S>N | No |
ClinGen gnomAD |
|
|
CA3776503 rs756909803 |
125 | E>A | No |
ClinGen ExAC gnomAD |
|
|
rs1262920565 CA363805923 |
125 | E>K | No |
ClinGen gnomAD |
|
|
CA3776504 rs780767262 |
132 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs780767262 CA3776505 |
132 | Y>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1237732603 CA363805999 |
132 | Y>H | No |
ClinGen TOPMed |
|
|
CA3776506 rs147237748 |
133 | Q>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3776507 rs779585719 |
135 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA363806069 rs1362430272 |
138 | L>V | No |
ClinGen gnomAD |
|
|
CA363806152 rs1469697874 |
141 | I>M | No |
ClinGen gnomAD |
|
|
rs754969233 CA3776528 |
144 | A>P | No |
ClinGen ExAC gnomAD |
|
|
rs778934266 CA3776529 COSM1621581 COSM1621582 |
144 | A>V | liver [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA3776533 rs544518831 |
147 | V>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 149 | R>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 149 | R>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1221936044 CA363806781 |
150 | D>Y | No |
ClinGen TOPMed |
|
|
CA3776557 rs774392687 |
153 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA3776558 rs374179700 |
154 | G>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1191298624 CA363806877 |
159 | N>S | No |
ClinGen gnomAD |
|
|
rs772628857 CA3776559 |
163 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1302560874 CA363806997 |
166 | I>V | No |
ClinGen gnomAD |
|
|
rs772469045 CA3776580 |
167 | L>P | No |
ClinGen ExAC |
|
|
CA363807010 rs1164754308 |
167 | L>V | No |
ClinGen TOPMed |
|
|
CA363807036 rs1236920989 |
169 | F>L | No |
ClinGen gnomAD |
|
|
CA3776582 rs747361731 |
169 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA363807045 rs1351747744 |
170 | G>R | No |
ClinGen gnomAD |
|
|
rs771364241 CA3776583 |
172 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs199612050 CA3776585 |
173 | R>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA3776586 rs773875976 |
173 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1452840871 CA363807097 |
175 | A>E | No |
ClinGen gnomAD |
|
|
rs762479045 CA3776588 |
176 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs149860912 CA3776590 |
177 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs866170089 CA137336710 |
178 | E>K | No |
ClinGen TOPMed |
|
|
rs1160882051 CA363807149 |
179 | M>I | No |
ClinGen gnomAD |
|
|
CA363807141 rs1221580965 |
179 | M>V | No |
ClinGen TOPMed |
|
|
rs1325286855 CA363807164 |
181 | G>S | No |
ClinGen gnomAD |
|
|
CA3776594 rs200103514 |
183 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1581884182 CA363807204 |
184 | V>G | No |
ClinGen Ensembl |
|
| TCGA novel | 185 | T>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA137336761 rs942023313 |
185 | T>I | No |
ClinGen TOPMed |
|
|
CA3776596 rs370006071 |
186 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs376384508 CA3776597 |
186 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs370006071 CA137336819 |
186 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs747597727 CA3776599 |
187 | W>L | No |
ClinGen ExAC gnomAD |
|
|
rs1230517034 CA363807228 |
187 | W>R | No |
ClinGen gnomAD |
|
|
rs771324880 CA3776600 |
188 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
CA363807244 rs1581884236 |
188 | Y>D | No |
ClinGen Ensembl |
|
|
CA3776601 rs148572287 |
189 | R>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs769204580 CA137336853 |
189 | R>Q | No |
ClinGen Ensembl |
|
|
rs769596675 CA3776603 |
190 | A>D | No |
ClinGen ExAC TOPMed |
|
|
rs746180228 CA3776602 |
190 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs775245798 CA3776604 |
191 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs763710785 CA3776606 |
192 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA3776605 COSM1444074 rs762484290 COSM1444073 |
192 | E>K | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs1581884285 CA363807299 |
193 | V>G | No |
ClinGen Ensembl |
|
|
CA363807304 rs1364274433 |
194 | I>L | No |
ClinGen TOPMed |
|
|
CA363807375 rs1561790203 |
199 | H>R | No |
ClinGen Ensembl |
|
|
rs773721437 CA3776607 |
201 | N>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1212572650 CA363807418 |
202 | Q>H | No |
ClinGen gnomAD |
|
|
rs1465731041 CA363807415 |
202 | Q>R | No |
ClinGen TOPMed gnomAD |
|
|
CA363807473 rs1396156463 |
204 | V>A | No |
ClinGen TOPMed |
|
|
rs756669245 CA3776608 |
204 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs200671231 CA137337046 |
205 | D>G | No |
ClinGen 1000Genomes |
|
|
rs1380272521 CA363807475 |
205 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1561790308 CA363807496 |
206 | I>M | No |
ClinGen Ensembl |
|
|
CA3776629 rs772019230 |
206 | I>S | No |
ClinGen ExAC |
|
|
rs1365764093 CA363807504 |
207 | W>* | No |
ClinGen TOPMed gnomAD |
|
|
rs1365764093 CA363807507 |
207 | W>L | No |
ClinGen TOPMed gnomAD |
|
|
CA3776631 rs773092204 |
208 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA363807524 rs1300680070 |
209 | V>G | No |
ClinGen gnomAD |
|
|
CA363807544 rs1257358596 |
212 | I>V | No |
ClinGen gnomAD |
|
|
rs763299038 CA3776635 |
213 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA3776634 rs201346595 |
213 | M>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1176044716 CA363807584 |
214 | A>V | No |
ClinGen TOPMed |
|
| TCGA novel | 215 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1451948949 CA363807621 |
216 | M>I | No |
ClinGen gnomAD |
|
|
rs1249024848 CA363807615 |
216 | M>K | No |
ClinGen gnomAD |
|
|
rs1249024848 CA363807619 COSM1546452 COSM1546451 |
216 | M>T | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA137337082 rs866584286 |
219 | G>R | No |
ClinGen Ensembl |
|
|
CA3776638 rs751686942 |
221 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751686942 CA137337115 |
221 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA363807693 rs1581884553 |
223 | F>L | No |
ClinGen Ensembl |
|
|
CA3776640 rs781392976 |
224 | K>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 225 | G>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA3776655 rs774478541 |
230 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA363807999 rs1294848772 |
231 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
CA3776656 rs762108258 |
232 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs767764804 CA3776657 |
234 | Q>P | No |
ClinGen ExAC gnomAD |
|
|
CA363808119 rs1561790960 |
239 | T>S | No |
ClinGen Ensembl |
|
|
COSM1187021 rs530516205 CA3776660 COSM1187020 |
240 | G>R | lung [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs146698142 CA3776662 |
244 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs747846767 CA363808205 |
245 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3776665 rs747846767 |
245 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3776666 rs758029820 |
246 | F>I | No |
ClinGen ExAC gnomAD |
|
|
rs777329553 CA3776667 |
246 | F>S | No |
ClinGen ExAC gnomAD |
|
|
rs1405928203 CA363808277 |
249 | K>R | No |
ClinGen gnomAD |
|
|
CA3776668 rs746445436 |
250 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3776669 rs770864557 |
251 | N>D | No |
ClinGen ExAC gnomAD |
|
|
CA3776671 rs201112625 |
251 | N>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA3776673 rs371922245 |
252 | D>E | No |
ClinGen ESP ExAC gnomAD |
|
|
CA3776672 rs769528395 COSM240598 |
252 | D>N | prostate [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA137338785 rs1036649507 |
254 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA363808973 rs1464493128 |
255 | A>T | No |
ClinGen TOPMed |
|
|
rs1476732952 CA363809021 |
258 | Y>* | No |
ClinGen gnomAD |
|
|
rs1171646319 CA363809046 |
260 | Q>P | No |
ClinGen gnomAD |
|
|
rs1415810843 CA363809065 |
261 | S>P | No |
ClinGen gnomAD |
|
|
CA3776701 rs760023880 |
264 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1436531436 CA363809140 |
265 | T>N | No |
ClinGen TOPMed gnomAD |
|
|
rs764413376 CA3776704 |
270 | F>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1288830739 CA363809263 |
271 | T>I | No |
ClinGen TOPMed |
|
|
CA3776706 rs756924582 |
271 | T>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs111986227 CA137339271 |
272 | Q>* | No |
ClinGen Ensembl |
|
|
rs903363847 CA137339274 |
274 | F>L | No |
ClinGen TOPMed |
|
|
rs1054573809 CA137339285 |
276 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA3776708 rs749882773 |
276 | R>W | No |
ClinGen ExAC |
|
|
rs756019824 CA3776709 |
277 | A>S | No |
ClinGen ExAC gnomAD |
|
|
rs893132693 CA137339290 |
278 | S>R | No |
ClinGen gnomAD |
|
|
CA137339320 rs996888500 |
279 | P>H | No |
ClinGen TOPMed |
|
|
rs780093040 CA3776710 |
280 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA137339534 rs1052378549 |
281 | A>G | No |
ClinGen TOPMed gnomAD |
|
|
rs55990045 CA3776732 VAR_042268 |
282 | A>V | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs745962868 CA3776734 |
283 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA363809533 rs1325318451 |
283 | D>N | No |
ClinGen TOPMed |
|
|
CA3776737 rs749864730 |
286 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA3776739 rs35287268 |
288 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs769087916 CA3776738 |
288 | M>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3776741 rs767109473 |
293 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs760221733 CA3776743 |
294 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA3776742 rs772959134 |
294 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs766044738 CA3776744 |
296 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs766044738 CA137339616 |
296 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs370476051 CA3776745 |
296 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA363809781 rs370476051 |
296 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3776747 rs201152233 |
298 | T>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
VAR_042269 rs41270090 CA3776750 |
300 | A>T | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA137339701 rs138408572 |
300 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP NCI-TCGA gnomAD |
|
CA363809884 rs1342222692 |
301 | Q>L | No |
ClinGen gnomAD |
|
|
rs1342222692 CA363809881 |
301 | Q>R | No |
ClinGen gnomAD |
|
|
rs746162553 CA363809900 |
302 | A>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746162553 CA3776754 |
302 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs756329405 CA3776755 |
303 | L>F | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 307 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA363810035 rs1346683715 |
309 | E>D | No |
ClinGen TOPMed gnomAD |
|
|
rs769173599 CA3776759 |
309 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA3776758 rs763985653 |
309 | E>P | No |
ClinGen ExAC |
|
|
CA137339765 rs372731935 |
310 | P>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA137339767 rs372731935 |
310 | P>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA3776760 rs372731935 |
310 | P>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA363810040 rs1188463612 |
310 | P>T | No |
ClinGen gnomAD |
|
|
CA3776762 rs143894874 |
312 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3776761 rs779750672 |
312 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs773433371 CA3776763 |
314 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs3179150 CA137339823 |
315 | E>* | No |
ClinGen Ensembl |
|
|
CA137339830 rs549299964 |
316 | E>K | No |
ClinGen Ensembl |
|
|
CA3776765 rs376241274 |
318 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA363810177 rs1478522978 |
319 | E>G | No |
ClinGen TOPMed |
|
|
CA363810186 rs1319749038 |
320 | A>T | No |
ClinGen gnomAD |
|
|
rs1191935739 CA363810198 |
321 | Q>E | No |
ClinGen TOPMed |
|
|
rs1459286086 CA363810213 |
321 | Q>R | No |
ClinGen TOPMed |
|
|
CA3776769 rs752717013 |
323 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs765115824 CA3776768 |
323 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs1561791455 CA363810275 |
324 | F>L | No |
ClinGen Ensembl |
|
|
CA3776771 rs764018811 |
324 | F>S | Variant assessed as Somatic; 4.631e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA3776772 rs751249979 |
326 | D>G | No |
ClinGen ExAC gnomAD |
|
|
CA363810295 rs1233482764 |
326 | D>N | No |
ClinGen gnomAD |
|
|
rs1233482764 CA363810300 |
326 | D>Y | No |
ClinGen gnomAD |
|
|
CA3776774 rs756346015 CA137339898 |
330 | H>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1208689264 CA363810365 |
330 | H>Y | No |
ClinGen gnomAD |
|
|
CA3776777 rs778837321 |
331 | E>D | No |
ClinGen ExAC gnomAD |
|
|
rs753950475 CA3776776 |
331 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA3776775 rs753950475 |
331 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA363810419 rs1434021367 |
334 | T>K | No |
ClinGen gnomAD |
|
|
rs1178474815 CA363810422 |
335 | V>M | No |
ClinGen gnomAD |
|
|
CA3776779 rs566531410 |
336 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA363810469 rs1158340714 |
338 | W>R | No |
ClinGen TOPMed gnomAD |
|
|
CA363810505 rs1343959443 |
340 | Q>* | No |
ClinGen TOPMed |
|
|
CA363810502 rs1343959443 |
340 | Q>K | No |
ClinGen TOPMed |
|
|
CA363810588 rs1466702692 |
341 | H>Y | No |
ClinGen TOPMed |
|
|
CA363810613 rs775083164 |
342 | I>M | No |
ClinGen ExAC gnomAD |
|
|
rs147268021 CA137340265 |
343 | Y>H | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs111849509 CA137340267 |
345 | E>D | No |
ClinGen gnomAD |
|
|
rs1180046466 CA363810689 |
347 | V>M | No |
ClinGen gnomAD |
|
|
CA137340270 rs768847631 |
348 | N>D | No |
ClinGen Ensembl |
|
|
rs1412900333 CA363810706 |
348 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1412900333 CA363810704 |
348 | N>T | No |
ClinGen TOPMed gnomAD |
|
|
rs141183489 CA363810749 |
350 | S>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA3776810 rs202042434 |
352 | I>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA3776812 rs148306220 |
354 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3776811 rs761718374 |
354 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3776813 rs750212778 |
355 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs866546471 CA363810868 |
356 | D>G | No |
ClinGen TOPMed gnomAD |
|
|
rs866546471 CA137340335 |
356 | D>V | No |
ClinGen TOPMed gnomAD |
|
|
CA137340331 rs61730658 |
356 | D>Y | No |
ClinGen Ensembl |
|
|
rs200916556 CA3776815 |
358 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA3776814 rs759807867 |
358 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs141413397 CA3776816 |
359 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA gnomAD |
|
COSM1078475 COSM1596324 rs368211065 CA3776817 |
359 | R>H | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA gnomAD |
|
CA3776820 rs150915766 |
360 | R>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA3776819 rs150915766 |
360 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs183038663 COSM1078477 COSM1596323 CA3776818 |
360 | R>W | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA363810960 rs1275296124 |
361 | S>N | No |
ClinGen gnomAD |
|
|
CA363810961 rs1275296124 |
361 | S>T | No |
ClinGen gnomAD |
|
|
CA363810983 rs1236680459 |
362 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
rs546224704 CA3776821 |
362 | G>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1434618391 CA363810993 |
363 | M>L | No |
ClinGen TOPMed |
|
|
rs1434618391 CA363810994 |
363 | M>V | No |
ClinGen TOPMed |
|
| rs1185326213 | 366 | L>= | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
No associated diseases with O15264
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.24 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| MAP kinase activity | Catalysis of the reaction |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cellular response to anisomycin | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus. |
| cellular response to hydrogen peroxide | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
| cellular response to interleukin-1 | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. |
| cellular response to sodium arsenite | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus. |
| cellular response to sorbitol | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus. |
| cellular response to UV | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| positive regulation of inflammatory response | Any process that activates or increases the frequency, rate or extent of the inflammatory response. |
| positive regulation of interleukin-6 production | Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. |
| response to osmotic stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. |
| stress-activated MAPK cascade | The series of molecular signals in which a stress-activated MAP kinase cascade relays a signal; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase. |
91 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32485 | HOG1 | Mitogen-activated protein kinase HOG1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| A5PKJ4 | MAPK7 | Mitogen-activated protein kinase 7 | Bos taurus (Bovine) | SS |
| P46196 | MAPK1 | Mitogen-activated protein kinase 1 | Bos taurus (Bovine) | SS |
| Q3T0N5 | MAPK13 | Mitogen-activated protein kinase 13 | Bos taurus (Bovine) | SS |
| Q5F3W3 | MAPK6 | Mitogen-activated protein kinase 6 | Gallus gallus (Chicken) | SS |
| Q95NE7 | MAPK14 | Mitogen-activated protein kinase 14 | Pan troglodytes (Chimpanzee) | SS |
| Q9N272 | MAPK13 | Mitogen-activated protein kinase 13 | Pan troglodytes (Chimpanzee) | SS |
| Q9W354 | Erk7 | Extracellular signal-regulated kinase 7 | Drosophila melanogaster (Fruit fly) | SS |
| P40417 | rl | Mitogen-activated protein kinase ERK-A | Drosophila melanogaster (Fruit fly) | SS |
| P83100 | p38c | Putative mitogen-activated protein kinase 14C | Drosophila melanogaster (Fruit fly) | SS |
| O62618 | p38a | Mitogen-activated protein kinase p38a | Drosophila melanogaster (Fruit fly) | SS |
| O61443 | p38b | Mitogen-activated protein kinase p38b | Drosophila melanogaster (Fruit fly) | SS |
| P20794 | MAK | Serine/threonine-protein kinase MAK | Homo sapiens (Human) | PR |
| Q9UQ07 | MOK | MAPK/MAK/MRK overlapping kinase | Homo sapiens (Human) | PR |
| Q8TD08 | MAPK15 | Mitogen-activated protein kinase 15 | Homo sapiens (Human) | SS |
| P45984 | MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens (Human) | SS |
| P45983 | MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens (Human) | EV |
| P53779 | MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens (Human) | EV |
| Q9UBE8 | NLK | Serine/threonine-protein kinase NLK | Homo sapiens (Human) | SS |
| P27361 | MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens (Human) | SS |
| P28482 | MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens (Human) | EV |
| P31152 | MAPK4 | Mitogen-activated protein kinase 4 | Homo sapiens (Human) | SS |
| Q16659 | MAPK6 | Mitogen-activated protein kinase 6 | Homo sapiens (Human) | SS |
| Q13164 | MAPK7 | Mitogen-activated protein kinase 7 | Homo sapiens (Human) | SS |
| P53778 | MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens (Human) | SS |
| Q15759 | MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens (Human) | SS |
| Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens (Human) | SS |
| P47811 | Mapk14 | Mitogen-activated protein kinase 14 | Mus musculus (Mouse) | SS |
| Q61532 | Mapk6 | Mitogen-activated protein kinase 6 | Mus musculus (Mouse) | SS |
| Q63844 | Mapk3 | Mitogen-activated protein kinase 3 | Mus musculus (Mouse) | SS |
| P63085 | Mapk1 | Mitogen-activated protein kinase 1 | Mus musculus (Mouse) | SS |
| Q9WVS8 | Mapk7 | Mitogen-activated protein kinase 7 | Mus musculus (Mouse) | SS |
| Q9WUI1 | Mapk11 | Mitogen-activated protein kinase 11 | Mus musculus (Mouse) | SS |
| O08911 | Mapk12 | Mitogen-activated protein kinase 12 | Mus musculus (Mouse) | SS |
| Q80Y86 | Mapk15 | Mitogen-activated protein kinase 15 | Mus musculus (Mouse) | SS |
| Q6P5G0 | Mapk4 | Mitogen-activated protein kinase 4 | Mus musculus (Mouse) | SS |
| Q9Z1B7 | Mapk13 | Mitogen-activated protein kinase 13 | Mus musculus (Mouse) | SS |
| P70618 | Mapk14 | Mitogen-activated protein kinase 14 | Rattus norvegicus (Rat) | SS |
| P63086 | Mapk1 | Mitogen-activated protein kinase 1 | Rattus norvegicus (Rat) | SS |
| Q9Z2A6 | Mapk15 | Mitogen-activated protein kinase 15 | Rattus norvegicus (Rat) | SS |
| P27704 | Mapk6 | Mitogen-activated protein kinase 6 | Rattus norvegicus (Rat) | SS |
| P21708 | Mapk3 | Mitogen-activated protein kinase 3 | Rattus norvegicus (Rat) | SS |
| Q63538 | Mapk12 | Mitogen-activated protein kinase 12 | Rattus norvegicus (Rat) | SS |
| Q63454 | Mapk4 | Mitogen-activated protein kinase 4 | Rattus norvegicus (Rat) | SS |
| P0C865 | Mapk7 | Mitogen-activated protein kinase 7 | Rattus norvegicus (Rat) | SS |
| Q9WTY9 | Mapk13 | Mitogen-activated protein kinase 13 | Rattus norvegicus (Rat) | SS |
| Q5ZCI1 | MPK10 | Mitogen-activated protein kinase 10 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5VP69 | MPK16 | Mitogen-activated protein kinase 16 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5SN53 | MPK8 | Mitogen-activated protein kinase 8 | Oryza sativa subsp. japonica (Rice) | SS |
| Q0E459 | MPK13 | Mitogen-activated protein kinase 13 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6Z437 | MPK3 | Mitogen-activated protein kinase 3 | Oryza sativa subsp. japonica (Rice) | SS |
| Q75KK8 | MPK14 | Mitogen-activated protein kinase 14 | Oryza sativa subsp. japonica (Rice) | SS |
| Q67C40 | MPK7 | Mitogen-activated protein kinase 7 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6L5F7 | MPK17 | Mitogen-activated protein kinase 17 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5VN19 | MPK11 | Mitogen-activated protein kinase 11 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5Z859 | MPK4 | Mitogen-activated protein kinase 4 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5Z9J0 | MPK12 | Mitogen-activated protein kinase 12 | Oryza sativa subsp. japonica (Rice) | SS |
| Q53N72 | MPK15 | Mitogen-activated protein kinase 15 | Oryza sativa subsp. japonica (Rice) | SS |
| Q336X9 | MPK6 | Mitogen-activated protein kinase 6 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5J4W4 | MPK2 | Mitogen-activated protein kinase 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q84UI5 | MPK1 | Mitogen-activated protein kinase 1 | Oryza sativa subsp. japonica (Rice) | SS |
| Q10N20 | MPK5 | Mitogen-activated protein kinase 5 | Oryza sativa subsp. japonica (Rice) | SS |
| Q11179 | mapk-15 | Mitogen-activated protein kinase 15 | Caenorhabditis elegans | SS |
| O44514 | pmk-3 | Mitogen-activated protein kinase pmk-3 | Caenorhabditis elegans | PR |
| P39745 | mpk-1 | Mitogen-activated protein kinase mpk-1 | Caenorhabditis elegans | SS |
| G5EBT1 | sma-5 | Mitogen-activated protein kinase sma-5 | Caenorhabditis elegans | SS |
| Q8MXI4 | pmk-2 | Mitogen-activated protein kinase pmk-2 | Caenorhabditis elegans | SS |
| Q17446 | pmk-1 | Mitogen-activated protein kinase pmk-1 | Caenorhabditis elegans | SS |
| Q39021 | MPK1 | Mitogen-activated protein kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LM33 | MPK8 | Mitogen-activated protein kinase 8 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9C5C0 | MPK18 | Mitogen-activated protein kinase 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39022 | MPK2 | Mitogen-activated protein kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9C9U4 | MPK15 | Mitogen-activated protein kinase 15 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84M93 | MPK17 | Mitogen-activated protein kinase 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39027 | MPK7 | Mitogen-activated protein kinase 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SJG9 | MPK20 | Mitogen-activated protein kinase 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LUC3 | MPK19 | Mitogen-activated protein kinase 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LV37 | MPK9 | Mitogen-activated protein kinase 9 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23236 | MPK14 | Mitogen-activated protein kinase 14 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8W4J2 | MPK16 | Mitogen-activated protein kinase 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39023 | MPK3 | Mitogen-activated protein kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39026 | MPK6 | Mitogen-activated protein kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39025 | MPK5 | Mitogen-activated protein kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39024 | MPK4 | Mitogen-activated protein kinase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M1Z5 | MPK10 | Mitogen-activated protein kinase 10 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GYQ5 | MPK12 | Mitogen-activated protein kinase 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LMM5 | MPK11 | Mitogen-activated protein kinase 11 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LQQ9 | MPK13 | Mitogen-activated protein kinase 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O42376 | mapk12 | Mitogen-activated protein kinase 12 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DGE1 | mapk14b | Mitogen-activated protein kinase 14B | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DGE2 | mapk14a | Mitogen-activated protein kinase 14A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLIRKKGFY | KQDVNKTAWE | LPKTYVSPTH | VGSGAYGSVC | SAIDKRSGEK | VAIKKLSRPF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QSEIFAKRAY | RELLLLKHMQ | HENVIGLLDV | FTPASSLRNF | YDFYLVMPFM | QTDLQKIMGM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EFSEEKIQYL | VYQMLKGLKY | IHSAGVVHRD | LKPGNLAVNE | DCELKILDFG | LARHADAEMT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GYVVTRWYRA | PEVILSWMHY | NQTVDIWSVG | CIMAEMLTGK | TLFKGKDYLD | QLTQILKVTG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VPGTEFVQKL | NDKAAKSYIQ | SLPQTPRKDF | TQLFPRASPQ | AADLLEKMLE | LDVDKRLTAA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QALTHPFFEP | FRDPEEETEA | QQPFDDSLEH | EKLTVDEWKQ | HIYKEIVNFS | PIARKDSRRR |
| SGMKL |