O15197
SS
Gene name |
EPHB6 |
Protein name |
Ephrin type-B receptor 6 |
Names |
HEP , Tyrosine-protein kinase-defective receptor EPH-6 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:2051 |
EC number |
|
Protein Class |
|
Descriptions
Ephrin type-B receptor 2 is a membrane-associated protein that mediates axon guidance, cell migration and morphogenesis. The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. The structure, supported by mutagenesis data, reveals that the juxtamembrane segment adopts a helical conformation that distorts the small lobe of the kinase domain, and blocks the activation segment from attaining an activated conformation. Phosphorylation of the conserved juxtamembrane tyrosines would relieve this autoinhibition by disturbing the association of the juxtamembrane segment with the kinase domain, while liberating phosphotyrosine sites for binding SH2 domains of target proteins.
Autoinhibitory domains (AIDs)
Target domain |
670-919 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
2 structures for O15197
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7K7J | X-ray | 300 A | A | 33-578 | PDB |
| AF-O15197-F1 | Predicted | AlphaFoldDB |
18 variants for O15197
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs8177173 VAR_019139 |
122 | G>S | No |
UniProt dbSNP |
|
| VAR_042190 | 170 | S>T | No | UniProt | |
| VAR_042191 | 221 | A>V | No | UniProt | |
| VAR_042192 | 282 | P>H | No | UniProt | |
|
VAR_019140 rs8177143 |
282 | P>R | No |
UniProt dbSNP |
|
|
VAR_042193 rs55728646 |
309 | R>Q | No |
UniProt dbSNP |
|
|
VAR_019141 rs8177146 |
324 | S>A | No |
UniProt dbSNP |
|
|
VAR_042194 rs35189999 |
332 | S>L | No |
UniProt dbSNP |
|
| VAR_036091 | 360 | D>N | a colorectal cancer sample; somatic mutation [UniProt] | No | UniProt |
|
VAR_019142 rs8177175 |
499 | R>Q | No |
UniProt dbSNP |
|
| VAR_036092 | 603 | A>P | a colorectal cancer sample; somatic mutation [UniProt] | No | UniProt |
|
VAR_042195 rs35984674 |
662 | A>V | No |
UniProt dbSNP |
|
| VAR_036093 | 719 | R>Q | a colorectal cancer sample; somatic mutation [UniProt] | No | UniProt |
| VAR_042196 | 743 | P>S | an ovarian mucinous carcinoma sample; somatic mutation [UniProt] | No | UniProt |
| VAR_042197 | 813 | R>H | No | UniProt | |
| VAR_042198 | 875 | E>K | a glioblastoma multiforme sample; somatic mutation [UniProt] | No | UniProt |
| VAR_036094 | 930 | D>G | a colorectal cancer sample; somatic mutation [UniProt] | No | UniProt |
| VAR_042199 | 993 | I>V | No | UniProt |
No associated diseases with O15197
10 regional properties for O15197
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 670 - 919 | IPR000719 |
| domain | Ephrin receptor ligand binding domain | 33 - 237 | IPR001090 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 670 - 914 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class V, conserved site | 213 - 233 | IPR001426-1 |
| conserved_site | Tyrosine-protein kinase, receptor class V, conserved site | 286 - 306 | IPR001426-2 |
| domain | Sterile alpha motif domain | 945 - 1012 | IPR001660 |
| domain | Fibronectin type III | 369 - 486 | IPR003961-1 |
| domain | Fibronectin type III | 487 - 582 | IPR003961-2 |
| domain | Tyrosine-protein kinase ephrin type A/B receptor-like | 306 - 345 | IPR011641 |
| domain | Ephrin receptor, transmembrane domain | 596 - 667 | IPR027936 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ephrin receptor activity | Combining with an ephrin receptor ligand to initiate a change in cell activity. |
| signaling receptor activity | Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. |
| transmembrane-ephrin receptor activity | Combining with a transmembrane ephrin to initiate a change in cell activity. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| ephrin receptor signaling pathway | The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
49 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P28693 | EPHB2 | Ephrin type-B receptor 2 | Gallus gallus (Chicken) | PR |
| Q07496 | EPHA4 | Ephrin type-A receptor 4 | Gallus gallus (Chicken) | SS |
| Q07494 | EPHB1 | Ephrin type-B receptor 1 | Gallus gallus (Chicken) | SS |
| Q07497 | EPHB5 | Ephrin type-B receptor 5 | Gallus gallus (Chicken) | PR |
| P29318 | EPHA3 | Ephrin type-A receptor 3 | Gallus gallus (Chicken) | SS |
| O42422 | EPHA7 | Ephrin type-A receptor 7 | Gallus gallus (Chicken) | SS |
| P54755 | EPHA5 | Ephrin type-A receptor 5 | Gallus gallus (Chicken) | SS |
| Q07498 | EPHB3 | Ephrin type-B receptor 3 | Gallus gallus (Chicken) | SS |
| P0C0K6 | EPHB6 | Ephrin type-B receptor 6 | Pan troglodytes (Chimpanzee) | SS |
| P21709 | EPHA1 | Ephrin type-A receptor 1 | Homo sapiens (Human) | SS |
| P54760 | EPHB4 | Ephrin type-B receptor 4 | Homo sapiens (Human) | SS |
| P29317 | EPHA2 | Ephrin type-A receptor 2 | Homo sapiens (Human) | SS |
| Q15375 | EPHA7 | Ephrin type-A receptor 7 | Homo sapiens (Human) | SS |
| P54756 | EPHA5 | Ephrin type-A receptor 5 | Homo sapiens (Human) | SS |
| Q9UF33 | EPHA6 | Ephrin type-A receptor 6 | Homo sapiens (Human) | SS |
| P54762 | EPHB1 | Ephrin type-B receptor 1 | Homo sapiens (Human) | SS |
| P29322 | EPHA8 | Ephrin type-A receptor 8 | Homo sapiens (Human) | SS |
| P29320 | EPHA3 | Ephrin type-A receptor 3 | Homo sapiens (Human) | PR |
| P54764 | EPHA4 | Ephrin type-A receptor 4 | Homo sapiens (Human) | SS |
| P54753 | EPHB3 | Ephrin type-B receptor 3 | Homo sapiens (Human) | SS |
| Q5JZY3 | EPHA10 | Ephrin type-A receptor 10 | Homo sapiens (Human) | SS |
| P29323 | EPHB2 | Ephrin type-B receptor 2 | Homo sapiens (Human) | EV |
| P54754 | Ephb3 | Ephrin type-B receptor 3 | Mus musculus (Mouse) | SS |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q03137 | Epha4 | Ephrin type-A receptor 4 | Mus musculus (Mouse) | SS |
| Q61772 | Epha7 | Ephrin type-A receptor 7 | Mus musculus (Mouse) | SS |
| O09127 | Epha8 | Ephrin type-A receptor 8 | Mus musculus (Mouse) | SS |
| Q8CBF3 | Ephb1 | Ephrin type-B receptor 1 | Mus musculus (Mouse) | SS |
| Q8BYG9 | Epha10 | Ephrin type-A receptor 10 | Mus musculus (Mouse) | SS |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| P29319 | Epha3 | Ephrin type-A receptor 3 | Mus musculus (Mouse) | SS |
| Q62413 | Epha6 | Ephrin type-A receptor 6 | Mus musculus (Mouse) | SS |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P54763 | Ephb2 | Ephrin type-B receptor 2 | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| O08644 | Ephb6 | Ephrin type-B receptor 6 | Mus musculus (Mouse) | PR |
| P54757 | Epha5 | Ephrin type-A receptor 5 | Rattus norvegicus (Rat) | SS |
| P54759 | Epha7 | Ephrin type-A receptor 7 | Rattus norvegicus (Rat) | SS |
| P09759 | Ephb1 | Ephrin type-B receptor 1 | Rattus norvegicus (Rat) | SS |
| O08680 | Epha3 | Ephrin type-A receptor 3 | Rattus norvegicus (Rat) | SS |
| P0C0K7 | Ephb6 | Ephrin type-B receptor 6 | Rattus norvegicus (Rat) | SS |
| O61460 | vab-1 | Ephrin receptor 1 | Caenorhabditis elegans | SS |
| Q8RWZ5 | SD25 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AG2 | SERK1 | Somatic embryogenesis receptor kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E991 | PRK6 | Pollen receptor-like kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FXF2 | RKF1 | Probable LRR receptor-like serine/threonine-protein kinase RFK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O13147 | ephb3 | Ephrin type-B receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73878 | ephb4b | Ephrin type-B receptor 4b | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATEGAAQLG | NRVAGMVCSL | WVLLLVSSVL | ALEEVLLDTT | GETSEIGWLT | YPPGGWDEVS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VLDDQRRLTR | TFEACHVAGA | PPGTGQDNWL | QTHFVERRGA | QRAHIRLHFS | VRACSSLGVS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GGTCRETFTL | YYRQAEEPDS | PDSVSSWHLK | RWTKVDTIAA | DESFPSSSSS | SSSSSSAAWA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VGPHGAGQRA | GLQLNVKERS | FGPLTQRGFY | VAFQDTGACL | ALVAVRLFSY | TCPAVLRSFA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SFPETQASGA | GGASLVAAVG | TCVAHAEPEE | DGVGGQAGGS | PPRLHCNGEG | KWMVAVGGCR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CQPGYQPARG | DKACQACPRG | LYKSSAGNAP | CSPCPARSHA | PNPAAPVCPC | LEGFYRASSD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PPEAPCTGPP | SAPQELWFEV | QGSALMLHWR | LPRELGGRGD | LLFNVVCKEC | EGRQEPASGG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GGTCHRCRDE | VHFDPRQRGL | TESRVLVGGL | RAHVPYILEV | QAVNGVSELS | PDPPQAAAIN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VSTSHEVPSA | VPVVHQVSRA | SNSITVSWPQ | PDQTNGNILD | YQLRYYDQAE | DESHSFTLTS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ETNTATVTQL | SPGHIYGFQV | RARTAAGHGP | YGGKVYFQTL | PQGELSSQLP | ERLSLVIGSI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LGALAFLLLA | AITVLAVVFQ | RKRRGTGYTE | QLQQYSSPGL | GVKYYIDPST | YEDPCQAIRE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LAREVDPAYI | KIEEVIGTGS | FGEVRQGRLQ | PRGRREQTVA | IQALWAGGAE | SLQMTFLGRA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| AVLGQFQHPN | ILRLEGVVTK | SRPLMVLTEF | MELGPLDSFL | RQREGQFSSL | QLVAMQRGVA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| AAMQYLSSFA | FVHRSLSAHS | VLVNSHLVCK | VARLGHSPQG | PSCLLRWAAP | EVIAHGKHTT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SSDVWSFGIL | MWEVMSYGER | PYWDMSEQEV | LNAIEQEFRL | PPPPGCPPGL | HLLMLDTWQK |
| 910 | 920 | 930 | 940 | 950 | 960 |
| DRARRPHFDQ | LVAAFDKMIR | KPDTLQAGGD | PGERPSQALL | TPVALDFPCL | DSPQAWLSAI |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| GLECYQDNFS | KFGLCTFSDV | AQLSLEDLPA | LGITLAGHQK | KLLHHIQLLQ | QHLRQQGSVE |
| V |