AiPD: Autoinhibited Protein Database

O15031

Gene name	PLXNB2 (KIAA0315)
Protein name	Plexin-B2
Names	MM1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:23654
EC number
Protein Class

Descriptions

Plexins are a large family of cell surface receptors for the axon guidance molecules semaphorins. Semaphorin-plexin signaling is essential for the regulation of neuronal development and other processes. Dysfunction in plexin pathways has been implicated in various diseases including neurological disorders and cancer. <br> Plexins are transmembrane proteins with a multidomain extracellular region that contains an N-terminal Sema domain. Before semaphorin binding, Plexin is an inactive monomer or dimer in which the RapGAP activity is autoinhibited. Binding of semaphorin to the Sema domain of plexin leads to activation of its cytoplasmic region, which relays the signal to downstream pathways. Mouse Plexin-A3 (P70208) possesses a segment preceding C1 domain and RDB domain as autoinhibitory elements.

Autoinhibitory domains (AIDs)

9-466 (Sema domain) SS

Target domain	1271-1805 (Plexin, cytoplasmic RasGAP domain)
Relief mechanism	Partner binding
Assay

AID

9-466 (Sema domain)

Target domain

1271-1805 (Plexin, cytoplasmic RasGAP domain)

Relief mechanism

Partner binding (Semaphorin-induced dimerization)

Assay

1448-1558 (RBD domain) SS

Target domain	1271-1805 (Plexin, cytoplasmic RasGAP domain)
Relief mechanism	Partner binding
Assay

AID

1448-1558 (RBD domain)

Target domain

1271-1805 (Plexin, cytoplasmic RasGAP domain)

Relief mechanism

Partner binding (Binding of Rho-family GTPase (Rac1 or Rnd1) in their GTP-bound active form to the RBD)

Assay

Accessory elements

No accessory elements

References

Wang Y et al. (2012) "Plexins are GTPase-activating proteins for Rap and are activated by induced dimerization", Science signaling, 5, ra6

He H et al. (2009) "Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration", Proceedings of the National Academy of Sciences of the United States of America, 106, 15610-5

Autoinhibited structure

Activated structure

2 structures for O15031

Entry ID	Method	Resolution	Chain	Position	Source
4E71	X-ray	226 A	A	1452-1562	PDB
AF-O15031-F1	Predicted				AlphaFoldDB

1857 variants for O15031

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1471417012	2	A>T		No	TOPMed gnomAD
rs542502824	4	Q>P		No	1000Genomes ExAC TOPMed gnomAD
rs755797039	5	L>F		No	ExAC TOPMed gnomAD
rs755797039	5	L>I		No	ExAC TOPMed gnomAD
rs755797039	5	L>V		No	ExAC TOPMed gnomAD
rs2066794331	7	A>T		No	TOPMed
rs752601544	7	A>V		No	ExAC gnomAD
rs1459764825	9	T>I		No	TOPMed gnomAD
rs1328015651	9	T>P		No	gnomAD
rs1328015651	9	T>S		No	gnomAD
rs907874054	11	L>V		No	TOPMed
rs1370982481	13	L>P		No	gnomAD
rs1476297870	13	L>V		No	gnomAD
COSM4105109 rs372428698	16	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs761933126	16	A>V		No	ExAC TOPMed gnomAD
rs764370385	17	G>D		No	ExAC TOPMed gnomAD
rs764370385	17	G>V		No	ExAC TOPMed gnomAD
rs954590766	18	A>D		No	gnomAD
rs954590766	18	A>V		No	gnomAD
rs2147537152	19	S>I		No	Ensembl
rs2066790896	20	L>P		No	Ensembl
rs2066790742	21	R>K		No	Ensembl
rs775938208	21	R>S		No	ExAC TOPMed gnomAD
COSM3694168 rs546928788	23	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs370518066	23	R>H		No	ESP ExAC TOPMed gnomAD
rs774670910	24	K>E		No	ExAC gnomAD
TCGA novel	25	L>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2066788765	26	D>A		No	TOPMed
TCGA novel	26	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs748847916	28	F>L		No	ExAC TOPMed gnomAD
rs777413113	29	R>C		No	ExAC TOPMed gnomAD
rs769625156	29	R>H		No	ExAC TOPMed gnomAD
rs769625156	29	R>L		No	ExAC TOPMed gnomAD
COSM479118	31	E>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs747741923 COSM1417085	31	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs199944521	32	K>T		No	ExAC TOPMed gnomAD
rs2066787228	33	E>V		No	TOPMed gnomAD
rs2066786554	34	L>P		No	Ensembl
rs1171178234	36	H>L		No	gnomAD
rs1171178234	36	H>P		No	gnomAD
rs1252912952	37	L>P		No	gnomAD
rs758332139	39	V>G		No	ExAC gnomAD
rs1248795262	41	E>D		No	gnomAD
rs372801431	42	A>V		No	ESP ExAC TOPMed gnomAD
rs1569175477	43	S>L		No	Ensembl
rs756335548	44	G>D		No	ExAC TOPMed gnomAD
rs1347160019	45	V>A		No	gnomAD
rs201675007	45	V>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1280225940	46	V>L		No	TOPMed gnomAD
rs1376885639	50	A>S		No	TOPMed gnomAD
rs774745979	50	A>V		No	ExAC TOPMed gnomAD
rs923222375	51	V>L		No	gnomAD
rs923222375	51	V>M		No	gnomAD
rs2066780796	53	A>T		No	Ensembl
rs772859230	54	L>V		No	ExAC gnomAD
rs1471417535	55	Y>*		No	gnomAD
rs1169738620	56	Q>H		No	Ensembl
rs747863495	57	L>M		No	ExAC gnomAD
rs1181507364	59	A>T		No	gnomAD
rs776198723	59	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs375360559	62	Q>E		No	1000Genomes ExAC TOPMed gnomAD
rs2147535142	62	Q>H		No	Ensembl
rs2147535179	62	Q>L		No	Ensembl
TCGA novel	63	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs536602240	64	E>K		No	1000Genomes ExAC TOPMed gnomAD
rs1601729637	67	V>G		No	Ensembl
rs758346334	67	V>M		No	ExAC TOPMed gnomAD
rs1225579986	68	A>T		No	gnomAD
rs2066777898	68	A>V		No	TOPMed gnomAD
rs745740476	69	T>K		No	ExAC TOPMed gnomAD
rs745740476	69	T>M		No	ExAC TOPMed gnomAD
COSM3065409 rs1233673658	71	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1212847385	72	A>G		No	TOPMed
rs1212847385	72	A>V		No	TOPMed
rs1310856490	73	L>V		No	TOPMed gnomAD
rs1413731587	74	D>E		No	TOPMed gnomAD
rs767671854	76	K>N		No	ExAC gnomAD
rs2147534649	76	K>Q		No	Ensembl
rs1349167729	76	K>R		No	Ensembl
TCGA novel	77	K>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2147534562	77	K>*		No	Ensembl
TCGA novel	77	K>Q	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs569631269	79	T>M		No	1000Genomes ExAC TOPMed gnomAD
COSM726727	80	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1475828872	81	P>R		No	gnomAD
rs773812866	82	I>M		No	ExAC TOPMed gnomAD
rs1420414767	82	I>V		No	gnomAD
rs1474985932	84	A>P		No	gnomAD
rs2066774409	85	S>G		No	TOPMed gnomAD
TCGA novel	85	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs765819450	86	Q>E		No	ExAC gnomAD
rs1218028526	88	H>Y		No	gnomAD
rs1283660890	90	A>V		No	gnomAD
rs1555925101	91	E>Q		No	Ensembl
rs1243486713	92	M>I		No	TOPMed
rs376633792	94	D>N		No	ESP ExAC TOPMed gnomAD
rs768254955	95	N>S		No	ExAC gnomAD
rs1569175137	99	L>Q		No	Ensembl
rs367645843	102	L>F		No	ESP ExAC
COSM4164977	103	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2147533807	103	D>Y		No	Ensembl
rs778869284	105	P>R		No	ExAC TOPMed gnomAD
rs1322525284	107	K>N		No	TOPMed gnomAD
rs1397375327	107	K>R		No	gnomAD
rs2066770846	108	R>C		No	TOPMed
rs770869553	108	R>H		No	ExAC TOPMed gnomAD
rs770869553	108	R>L		No	ExAC TOPMed gnomAD
rs2066770846	108	R>S		No	TOPMed
rs1405202944	110	V>M		No	gnomAD
TCGA novel	111	E>Q	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1601729395	112	C>G		No	Ensembl
rs200827623	113	G>A		No	ExAC gnomAD
rs200827623	113	G>D		No	ExAC gnomAD
rs1474555294	113	G>S		No	gnomAD
rs1006977673	114	S>R		No	Ensembl
rs1194371646	114	S>T		No	gnomAD
rs1601729342	117	K>Q		No	Ensembl
rs2147533272	119	I>T		No	Ensembl
rs755165035	121	A>S		No	ExAC TOPMed gnomAD
rs755165035	121	A>T		No	ExAC TOPMed gnomAD
rs1176764896	121	A>V		No	Ensembl
rs751734137	122	L>Q		No	ExAC gnomAD
TCGA novel	122	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1307927339	123	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1344834441	123	R>H		No	TOPMed gnomAD
rs766516184	124	A>S		No	ExAC TOPMed gnomAD
rs766516184	124	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1360874782	125	L>Q		No	gnomAD
rs1303463814	126	S>N		No	TOPMed gnomAD
rs750788046	126	S>R		No	ExAC gnomAD
rs2066766735	127	N>H		No	TOPMed gnomAD
rs765914980	128	I>V		No	ExAC gnomAD
rs762372626	129	S>C		No	ExAC gnomAD
COSM3555709	129	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1436402793	130	L>F		No	TOPMed gnomAD
rs753306834	130	L>H		No	ExAC TOPMed gnomAD
rs753306834	130	L>R		No	ExAC TOPMed gnomAD
rs756123018	131	R>C		No	ExAC TOPMed gnomAD
rs756123018	131	R>G		No	ExAC TOPMed gnomAD
rs368491965	131	R>H		No	ESP ExAC TOPMed gnomAD
rs368491965	131	R>L		No	ESP ExAC TOPMed gnomAD
COSM4105107	134	Y>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs774126870 COSM1417084	135	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs200224862	136	D>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs749186574	137	G>S		No	ExAC TOPMed gnomAD
rs781132198	138	S>N		No	ExAC TOPMed gnomAD
COSM4105106	139	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1035420	140	E>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1035421	140	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM4414567	141	K>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM4414571	141	K>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2066764509 COSM1035419	144	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs780465304	145	A>T		No	ExAC gnomAD
rs2066763762	148	D>N		No	Ensembl
COSM461055	149	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs368559599	150	G>D		No	ESP ExAC TOPMed gnomAD
rs374494862	151	V>L		No	ESP ExAC TOPMed gnomAD
rs374494862	151	V>M		No	ESP ExAC TOPMed gnomAD
rs1281599374	154	V>A		No	TOPMed gnomAD
rs2066762960	155	G>E		No	gnomAD
rs1386653254	156	L>R		No	gnomAD
rs1601729143	157	V>G		No	Ensembl
rs2066762124	158	S>N		No	TOPMed
rs1440523203	159	S>F		No	TOPMed gnomAD
rs763537846	160	T>M		No	ExAC TOPMed gnomAD
rs767220661	163	G>D		No	ExAC gnomAD
rs767220661	163	G>V		No	ExAC gnomAD
rs1410136351	164	G>D		No	TOPMed gnomAD
rs774141104	164	G>S		No	ExAC TOPMed gnomAD
rs201610707	166	R>C		No	ESP ExAC TOPMed gnomAD
rs201610707	166	R>G		No	ESP ExAC TOPMed gnomAD
rs199977078	166	R>H		No	ESP ExAC TOPMed gnomAD
rs201610707	166	R>S		No	ESP ExAC TOPMed gnomAD
rs775699976	167	V>L		No	ExAC TOPMed gnomAD
rs775699976 COSM4105105	167	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1484500987	170	V>M		No	gnomAD
rs772437014	174	N>D		No	ExAC gnomAD
rs1318021803	174	N>S		No	TOPMed gnomAD
TCGA novel	175	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1222418641	176	P>L		No	gnomAD
rs779180914	177	H>D		No	ExAC TOPMed gnomAD
rs370376989	177	H>Q		No	ESP ExAC TOPMed gnomAD
rs779180914	177	H>Y		No	ExAC TOPMed gnomAD
rs1033777280	179	N>D		No	gnomAD
rs201664331	179	N>S		No	1000Genomes ExAC TOPMed gnomAD
rs373060838	180	G>S		No	ESP ExAC TOPMed gnomAD
rs751172888	183	V>M		No	ExAC TOPMed gnomAD
TCGA novel	184	S>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1397038623	185	T>S		No	Ensembl
rs531070913 COSM5393895	186	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	189	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs377754571	190	R>G		No	ESP ExAC TOPMed gnomAD
rs765277978	190	R>L		No	ExAC TOPMed gnomAD
rs765277978	190	R>Q		No	ExAC TOPMed gnomAD
rs377754571	190	R>W		No	ESP ExAC TOPMed gnomAD
rs761785573	191	T>S		No	ExAC TOPMed gnomAD
rs775716596	192	D>N		No	ExAC gnomAD
rs1248287051	193	S>G		No	TOPMed gnomAD
rs1017134736	193	S>N		No	TOPMed
rs2066755387	194	R>S		No	TOPMed gnomAD
TCGA novel	194	R>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs374426305	195	E>D		No	ESP ExAC gnomAD
rs2147530555	196	A>V		No	Ensembl
rs1294258423	200	Y>C		No	TOPMed gnomAD
rs1294258423	200	Y>F		No	TOPMed gnomAD
rs368995795	200	Y>H		No	ESP ExAC TOPMed gnomAD
rs1007052945	201	T>K		No	TOPMed gnomAD
rs1007052945	201	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1601728895	202	D>A		No	Ensembl
rs563687885	203	H>Q		No	1000Genomes ExAC TOPMed gnomAD
rs777982464	204	A>T		No	ExAC gnomAD
rs780711806	206	Y>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs748583369	206	Y>F		No	ExAC gnomAD
rs2066753526	208	A>V		No	Ensembl
rs751009983	209	G>S		No	ExAC TOPMed gnomAD
TCGA novel	210	Y>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2066752897	211	L>V		No	gnomAD
rs1367523730	213	T>A		No	gnomAD
rs1367523730	213	T>P		No	gnomAD
rs376374684	214	N>S		No	ESP ExAC TOPMed gnomAD
TCGA novel	215	T>S	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2066751793	216	Q>R		No	Ensembl
rs921924761	217	Q>L		No	TOPMed
TCGA novel	218	F>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs775396375	219	V>M		No	1000Genomes ExAC TOPMed gnomAD
rs75911819	220	A>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2066751196	220	A>T		No	TOPMed
rs75911819	220	A>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs774293656	222	F>L		No	ExAC TOPMed gnomAD
rs771239742	223	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs763024214	224	D>N		No	ExAC gnomAD
rs376560284	225	G>D		No	ESP ExAC gnomAD
rs770104035	225	G>S		No	ExAC TOPMed gnomAD
TCGA novel	225	G>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs375502604	226	P>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs375502604	226	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1211334712	227	Y>S		No	TOPMed gnomAD
rs746589854	228	V>I		No	ExAC TOPMed gnomAD
rs374549222	229	F>V		No	ESP ExAC TOPMed gnomAD
TCGA novel	230	F>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1255737072	231	V>A		No	TOPMed
rs1191748765	231	V>L		No	gnomAD
rs758074370	232	F>S		No	ExAC TOPMed gnomAD
COSM4105104	232	F>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2093443075	233	N>I		No	gnomAD
rs778877074	236	D>H		No	ExAC gnomAD
rs2066747172	237	K>E		No	gnomAD
rs753658408	237	K>R		No	ExAC gnomAD
rs764196872	239	P>L		No	ExAC gnomAD
rs1454388486	239	P>S		No	gnomAD
rs1450418662	240	A>S		No	TOPMed gnomAD
rs201878905	241	R>Q		No	ExAC TOPMed gnomAD
rs766298920	241	R>W		No	ExAC TOPMed gnomAD
rs773373233	243	R>C		No	ExAC TOPMed gnomAD
rs1227754334	243	R>H		No	TOPMed gnomAD
rs372225867	244	T>M		No	ESP ExAC TOPMed gnomAD
rs1292732087	245	L>M		No	Ensembl
rs779647430	248	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs910158916	248	R>H		No	gnomAD
rs985664639	249	M>I		No	gnomAD
rs2066743127	249	M>V		No	Ensembl
rs771435200	250	C>Y		No	ExAC gnomAD
rs28561594	252	E>G		No	ESP ExAC TOPMed
rs1601728564	253	D>A		No	Ensembl
TCGA novel	253	D>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	253	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1255644373	254	P>L		No	Ensembl
rs1209152483	254	P>T		No	TOPMed gnomAD
rs1486280033	255	N>D		No	TOPMed
rs1207006502	258	S>A		No	TOPMed
rs577027165	260	L>M		No	1000Genomes ExAC TOPMed gnomAD
rs1324027168	262	M>I		No	gnomAD
rs2066740947	262	M>V		No	TOPMed
rs1601728521	263	D>A		No	Ensembl
rs1377601683	263	D>N		No	TOPMed gnomAD
rs2066740036	265	Q>E		No	Ensembl
COSM3555705 rs200109107	265	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC TOPMed gnomAD NCI-TCGA Cosmic
COSM1035417	266	C>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs756079656	267	R>P		No	ExAC TOPMed gnomAD
rs756079656	267	R>Q		No	ExAC TOPMed gnomAD
rs777651523	267	R>W		No	ExAC TOPMed gnomAD
rs374601429	268	D>A		No	ESP ExAC TOPMed gnomAD
rs374601429	268	D>G		No	ESP ExAC TOPMed gnomAD
TCGA novel	268	D>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs374601429	268	D>V		No	ESP ExAC TOPMed gnomAD
rs1569174092	269	P>A		No	Ensembl
rs1569174092	269	P>S		No	Ensembl
rs1020040133	270	D>A		No	Ensembl
rs750469859	270	D>N		No	ExAC gnomAD
rs750469859	270	D>Y		No	ExAC gnomAD
rs765508447	271	I>F		No	ExAC TOPMed gnomAD
rs765508447	271	I>V		No	ExAC TOPMed gnomAD
rs28523652	272	H>P		No	Ensembl
rs886582997	272	H>Q		No	TOPMed gnomAD
rs761966193	273	A>T		No	ExAC TOPMed gnomAD
rs377609672	274	A>T		No	ESP ExAC TOPMed gnomAD
rs761267538	276	F>L		No	ExAC TOPMed gnomAD
rs374654956	278	T>A		No	ESP ExAC TOPMed gnomAD
rs374654956	278	T>P		No	ESP ExAC TOPMed gnomAD
rs745439137	280	L>V		No	ExAC TOPMed gnomAD
rs1159582667	281	A>G		No	gnomAD
rs773988692	281	A>S		No	ExAC gnomAD
rs200815418	282	A>T		No	1000Genomes ExAC TOPMed gnomAD
COSM4105103	282	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs747951490	284	V>M		No	ExAC TOPMed gnomAD
rs1191011058	285	A>S		No	TOPMed
rs554117465 COSM3842937	286	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1441846538	287	P>S		No	gnomAD
rs2066734788	289	S>C		No	TOPMed
rs1206774356	290	G>D		No	gnomAD
rs571462806	290	G>S		No	1000Genomes ExAC TOPMed gnomAD
rs1569173910	291	R>K		No	Ensembl
rs1356955662	296	V>L		No	gnomAD
rs1468212585	298	S>C		No	Ensembl
rs775923722	300	D>E		No	ExAC TOPMed gnomAD
rs2066732977	300	D>V		No	TOPMed
rs1435614645	301	S>N		No	TOPMed gnomAD
rs1435614645	301	S>T		No	TOPMed gnomAD
rs760065938	302	R>Q		No	ExAC TOPMed gnomAD
rs767968899	302	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs770522658	303	S>I		No	ExAC gnomAD
rs769456290	305	G>R		No	ExAC TOPMed gnomAD
rs769456290	305	G>W		No	ExAC TOPMed gnomAD
TCGA novel	306	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1233981945	307	P>L		No	TOPMed gnomAD
TCGA novel	308	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1180279837	308	G>S		No	gnomAD
TCGA novel	308	G>V	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2066730528	308	G>V		No	Ensembl
rs1242732256	309	A>S		No	TOPMed gnomAD
rs1242732256	309	A>T		No	TOPMed gnomAD
rs754877775	309	A>V		No	ExAC TOPMed gnomAD
rs371292339	310	G>V		No	1000Genomes ExAC TOPMed gnomAD
rs772771317	313	L>P		No	TOPMed gnomAD
rs764294104	314	F>Y		No	ExAC gnomAD
rs756348985	315	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs369038951	315	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP NCI-TCGA TOPMed gnomAD
rs767853611	317	D>E		No	ExAC TOPMed gnomAD
rs1601728158	317	D>Y		No	Ensembl
rs28379706 VAR_050600	318	K>E		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1442300968	319	V>M		No	gnomAD
rs371959367	320	H>L		No	ESP ExAC gnomAD
rs375153131	321	A>T		No	ESP ExAC TOPMed gnomAD
rs769389095	326	N>K		No	ExAC gnomAD
rs1447810081	327	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs776323520	327	R>H		No	ExAC TOPMed gnomAD
rs776323520	327	R>L		No	ExAC TOPMed gnomAD
rs746784728	328	N>K		No	ExAC gnomAD
rs1220605772	329	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs780008242	331	Y>*		No	ExAC gnomAD
rs201390815	332	T>I		No	Ensembl
TCGA novel	332	T>K	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs112883077	334	T>P		No	Ensembl
rs749432150	335	R>Q		No	ExAC TOPMed gnomAD
rs771996791	335	R>W		No	ExAC TOPMed gnomAD
rs1303532696	336	E>K		No	TOPMed gnomAD
COSM726728	337	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs372336824	338	R>C		No	ESP ExAC TOPMed gnomAD
COSM1417080 rs530051710	338	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs530051710	338	R>L		No	1000Genomes ExAC TOPMed gnomAD
rs372336824	338	R>S		No	ESP ExAC TOPMed gnomAD
rs752921231	339	D>N		No	ExAC TOPMed gnomAD
rs1601728010	340	I>N		No	Ensembl
rs755439325	340	I>V		No	ExAC gnomAD
rs1169888392	343	K>E		No	gnomAD
COSM6018313 rs559951398	344	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs2066722204	345	F>L		No	TOPMed
rs1235380008	346	H>L		No	TOPMed
rs1389583451	346	H>Y		No	gnomAD
rs763538802	347	G>S		No	ExAC TOPMed gnomAD
rs764764946	348	D>G		No	ExAC gnomAD
rs2066721288	348	D>N		No	TOPMed gnomAD
rs1601727941	349	I>T		No	Ensembl
rs761396649	350	Q>R		No	ExAC TOPMed gnomAD
rs760534896	352	G>C		No	ExAC TOPMed gnomAD
rs760534896	352	G>S		No	ExAC TOPMed gnomAD
rs1020073040	353	G>S		No	TOPMed gnomAD
rs745754194	354	H>Q		No	ExAC TOPMed gnomAD
rs532708125	355	A>E		No	1000Genomes ExAC TOPMed gnomAD
rs777742714	355	A>T		No	ExAC TOPMed gnomAD
rs532708125	355	A>V		No	1000Genomes ExAC TOPMed gnomAD
rs755245449	356	P>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
rs565122764	356	P>L		No	1000Genomes ExAC TOPMed gnomAD
rs2147517945	357	G>S		No	Ensembl
rs1601725717	360	K>N		No	Ensembl
COSM1417079	361	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs768815439	361	S>R		No	ExAC gnomAD
COSM3800287	362	F>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1449257751	364	C>R		No	TOPMed
rs1569172847	366	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs1601725692	368	H>P		No	Ensembl
rs1464189618	370	P>L		No	Ensembl
rs779092516	372	P>L		No	ExAC gnomAD
rs2066681903	373	L>P		No	TOPMed
rs777290861	374	G>S		No	ExAC gnomAD
rs370637750	376	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs143051588	376	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs766018907	377	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
TCGA novel	377	D>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1384922122	378	G>R		No	TOPMed gnomAD
rs750436164	379	L>F		No	ExAC TOPMed gnomAD
rs750436164	379	L>I		No	ExAC TOPMed gnomAD
rs2147517192	379	L>P		No	Ensembl
rs2066679979	380	R>I		No	TOPMed
rs1368115644	381	G>S		No	TOPMed gnomAD
rs760906220	382	T>I		No	ExAC TOPMed gnomAD
rs772355652	383	A>P		No	ExAC gnomAD
rs573754705	384	V>L		No	1000Genomes ExAC TOPMed gnomAD
rs573754705	384	V>M		No	1000Genomes ExAC TOPMed gnomAD
rs770278125	386	Q>H		No	ExAC TOPMed gnomAD
rs747712044	387	R>C		No	ExAC TOPMed gnomAD
rs747712044	387	R>G		No	ExAC TOPMed gnomAD
rs754662011	387	R>H		No	ExAC TOPMed gnomAD
rs754662011	387	R>P		No	ExAC TOPMed gnomAD
rs751131363	388	G>V		No	ExAC gnomAD
rs758310101	393	T>M		No	ExAC TOPMed gnomAD
rs758310101	393	T>R		No	ExAC TOPMed gnomAD
COSM5549755	394	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs767458963	395	V>L		No	ExAC TOPMed gnomAD
rs767458963	395	V>M		No	ExAC TOPMed gnomAD
rs376982545	396	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1174766050	398	A>T		No	TOPMed gnomAD
rs547358862	399	A>P		No	1000Genomes ExAC TOPMed gnomAD
rs547358862	399	A>T		No	1000Genomes ExAC TOPMed gnomAD
rs1302596108	400	E>D		No	TOPMed gnomAD
COSM1035416 rs776234564	400	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs372964527	401	N>D		No	1000Genomes ESP ExAC TOPMed gnomAD
rs28591681	401	N>S		No	Ensembl
rs1181547336	404	T>A		No	gnomAD
rs746497917	404	T>I		No	ExAC gnomAD
TCGA novel	411	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs778786971	412	D>H		No	ExAC gnomAD
rs778786971	412	D>N		No	ExAC gnomAD
rs2066671814	413	G>S		No	Ensembl
rs145844372	414	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs757294277	414	R>W		No	ExAC TOPMed gnomAD
rs2066670990	416	L>F		No	Ensembl
rs1009594300	418	V>A		No	Ensembl
rs1354097895	418	V>L		No	TOPMed gnomAD
rs375132799	419	Y>*		No	ESP ExAC TOPMed gnomAD
rs775174241	420	L>I		No	ExAC TOPMed gnomAD
rs775174241	420	L>V		No	ExAC TOPMed gnomAD
rs147728569	421	T>I		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2066660744	421	T>S		No	gnomAD
rs1298989097	422	P>A		No	TOPMed
rs1416300554	422	P>L		No	TOPMed gnomAD
rs1416300554	422	P>Q		No	TOPMed gnomAD
rs770698601	423	D>E		No	ExAC gnomAD
rs2066659395	423	D>G		No	gnomAD
rs544468493	424	G>D		No	gnomAD
rs1390877190	424	G>S		No	gnomAD
rs544468493	424	G>V		No	gnomAD
rs777563259	425	T>I		No	ExAC TOPMed gnomAD
rs1005391338	426	S>F		No	TOPMed gnomAD
rs1208878874	428	E>G		No	gnomAD
rs1231209117	430	D>G		No	gnomAD
rs1299203677	430	D>N		No	TOPMed gnomAD
COSM3371955	431	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs750470230	432	I>V		No	ExAC TOPMed gnomAD
COSM3555703	433	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1269962777	434	V>L		No	gnomAD
TCGA novel	434	V>Y	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1437710944	435	E>A		No	gnomAD
rs2066656219	435	E>D		No	TOPMed gnomAD
rs905405369	438	K>E		No	Ensembl
rs1045647927	438	K>N		No	Ensembl
rs1351989403	438	K>R		No	TOPMed gnomAD
rs374592428	441	K>E		No	ESP ExAC TOPMed gnomAD
rs374592428	441	K>Q		No	ESP ExAC TOPMed gnomAD
rs1371194693	441	K>R		No	TOPMed gnomAD
rs1371194693	441	K>T		No	TOPMed gnomAD
rs1170606000	442	R>C		No	TOPMed gnomAD
rs754158572	442	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs2066653935	443	D>G		No	TOPMed
rs764481494	443	D>N		No	ExAC TOPMed gnomAD
rs2066653647	445	V>L		No	Ensembl
rs761110627	447	S>C		No	ExAC gnomAD
rs1056791152	447	S>P		No	Ensembl
rs376295504	448	G>R		No	ESP ExAC TOPMed gnomAD
rs1483197768	449	D>Y		No	gnomAD
rs2066652423	450	L>V		No	TOPMed
rs759187654	451	G>A		No	ExAC gnomAD
rs759187654	451	G>V		No	ExAC gnomAD
rs1202484286	452	S>I		No	gnomAD
rs1202484286	452	S>N		No	gnomAD
rs372467611	452	S>R		No	ESP ExAC TOPMed gnomAD
rs1346124430	453	L>V		No	TOPMed gnomAD
COSM6095526	454	Y>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs772909474	455	A>T		No	ExAC TOPMed gnomAD
TCGA novel	455	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM1417078	456	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1404533598	458	Q>*		No	gnomAD
rs747914479	459	D>N		No	ExAC gnomAD
rs2066650013	460	K>R		No	Ensembl
rs1226756894	461	V>A		No	gnomAD
TCGA novel	461	V>G	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs752061694	462	F>L		No	ExAC gnomAD
rs192965378	463	R>Q		No	1000Genomes ExAC TOPMed gnomAD
rs988685059	463	R>W		No	TOPMed gnomAD
rs370042051	465	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs370042051	465	P>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1174947935	466	V>M		No	TOPMed gnomAD
rs935182746	468	E>K		No	Ensembl
rs2066592364	469	C>R		No	TOPMed
rs1410165755	471	S>N		No	gnomAD
rs763829959	473	P>L		No	ExAC TOPMed gnomAD
rs763829959	473	P>R		No	ExAC TOPMed gnomAD
rs2066591285	474	T>I		No	TOPMed
rs2066591285	474	T>N		No	TOPMed
rs2147500956	474	T>P		No	Ensembl
rs2147500905	475	C>S		No	Ensembl
rs1298731036	477	Q>E		No	TOPMed gnomAD
rs1298731036	477	Q>K		No	TOPMed gnomAD
rs775541473	477	Q>R		No	ExAC gnomAD
rs1450674690	478	C>Y		No	gnomAD
rs770096187	479	R>C		No	ExAC TOPMed gnomAD
rs770096187	479	R>G		No	ExAC TOPMed gnomAD
rs773103653	479	R>H		No	ExAC TOPMed gnomAD
rs1266189940	480	D>N		No	TOPMed gnomAD
COSM1035415	481	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1224065571	481	S>T		No	gnomAD
rs866516626	482	Q>K		No	Ensembl
rs1244295436	482	Q>R		No	TOPMed gnomAD
rs781705361	486	C>Y		No	ExAC gnomAD
TCGA novel	487	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs747304123	489	C>G		No	ExAC gnomAD
rs749954299	490	V>A		No	ExAC gnomAD
rs758817773	490	V>F		No	ExAC TOPMed gnomAD
rs758817773	490	V>I		No	ExAC TOPMed gnomAD
rs1601721271	491	V>A		No	Ensembl
rs1364368096	491	V>F		No	TOPMed gnomAD
rs1364368096	491	V>I		No	TOPMed gnomAD
rs1419000468	492	E>A		No	TOPMed gnomAD
TCGA novel	492	E>D	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs763707512	492	E>K		No	ExAC gnomAD
rs763707512	492	E>Q		No	ExAC gnomAD
rs1191484055	494	R>Q		No	TOPMed gnomAD
rs1204353756	495	C>F		No	TOPMed gnomAD
rs113752649	495	C>G		No	Ensembl
rs1012489724	496	T>A		No	Ensembl
rs371186063	497	R>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs779460198	497	R>Q		No	ExAC TOPMed gnomAD
rs371186063	497	R>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs771412072	498	K>Q		No	ExAC TOPMed gnomAD
rs777192973	500	E>K		No	ExAC TOPMed gnomAD
rs777192973	500	E>Q		No	ExAC TOPMed gnomAD
rs1258262069	501	C>Y		No	gnomAD
rs752246192	502	P>L		No	ExAC TOPMed gnomAD
rs752246192	502	P>R		No	ExAC TOPMed gnomAD
rs755826651	502	P>S		No	ExAC TOPMed gnomAD
rs751397463	503	R>Q		No	ExAC TOPMed gnomAD
rs754771727	503	R>W		No	ExAC TOPMed gnomAD
rs578011591	504	A>T		No	1000Genomes ExAC TOPMed gnomAD
rs558651178 COSM5628653	505	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	506	E>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs760785944	507	A>P		No	ExAC gnomAD
rs1255977405	507	A>V		No	TOPMed gnomAD
rs1321695799	508	S>T		No	TOPMed gnomAD
rs1459003711	509	H>Q		No	gnomAD
rs2066566803	509	H>R		No	TOPMed
rs374467610	514	R>Q		No	ESP ExAC TOPMed gnomAD
rs774637101	516	K>R		No	ExAC gnomAD
rs573977985	517	S>F		No	1000Genomes ExAC gnomAD
rs2066565411	518	C>Y		No	Ensembl
rs370179188	519	V>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1444914291	520	A>S		No	gnomAD
rs930904680	521	V>I		No	1000Genomes TOPMed gnomAD
rs2066564239	522	T>A		No	Ensembl
TCGA novel	522	T>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs375580670	524	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs746814341	527	Q>H		No	ExAC TOPMed gnomAD
rs920837059	528	N>D		No	Ensembl
rs758431542	529	M>I		No	ExAC gnomAD
rs965224973	529	M>L		No	Ensembl
rs2066562655	530	S>T		No	TOPMed
rs1325057484	531	R>Q		No	gnomAD
rs1433414091	531	R>W		No	TOPMed gnomAD
rs866654904	532	R>W		No	TOPMed gnomAD
rs1406198220	533	A>T		No	TOPMed gnomAD
rs2147495501	534	Q>P		No	Ensembl
rs1384857397	535	G>E		No	TOPMed
rs746118447	535	G>R		No	ExAC TOPMed gnomAD
rs746118447	535	G>W		No	ExAC TOPMed gnomAD
TCGA novel	536	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2147495358	536	E>G		No	Ensembl
rs1450215526	536	E>K		No	TOPMed
rs2147488113	538	Q>H		No	Ensembl
rs2066524719	538	Q>R		No	TOPMed
rs923713459	541	V>A		No	Ensembl
rs768199498	541	V>I		No	ExAC TOPMed gnomAD
rs768199498	541	V>L		No	ExAC TOPMed gnomAD
rs746620222	542	S>G		No	ExAC TOPMed gnomAD
rs1697709939	542	S>R		No	TOPMed
rs1353922189	544	L>F		No	gnomAD
rs374129632	544	L>R		No	ESP TOPMed gnomAD
rs1470797614	545	P>L		No	gnomAD
rs2066522892	546	A>V		No	Ensembl
rs758308131	549	E>K		No	ExAC TOPMed gnomAD
rs1472733540	550	E>K		No	TOPMed gnomAD
rs370325511	551	D>E		No	1000Genomes gnomAD
rs745652433	551	D>N		No	ExAC TOPMed gnomAD
rs574088314	551	D>V		No	1000Genomes ExAC gnomAD
rs376816438	552	E>K		No	ESP ExAC TOPMed gnomAD
rs376816438	552	E>Q		No	ESP ExAC TOPMed gnomAD
rs1013266469	556	L>H		No	TOPMed
rs2066520910	556	L>V		No	Ensembl
rs80161851	557	F>L		No	Ensembl
rs781287988	557	F>S		No	ExAC TOPMed gnomAD
rs781287988	557	F>Y		No	ExAC TOPMed gnomAD
rs2066519965	559	E>D		No	TOPMed
rs1223098951	559	E>G		No	TOPMed gnomAD
rs2066519818	560	S>L		No	Ensembl
rs1676455744	560	S>T		No	gnomAD
TCGA novel	560	S>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1309222896	561	P>L		No	TOPMed gnomAD
rs1372707455	562	P>S		No	TOPMed gnomAD
rs1372707455	562	P>T		No	TOPMed gnomAD
rs1601717965	563	H>P		No	Ensembl
rs1284654575	563	H>Y		No	TOPMed gnomAD
rs1476539274	564	P>S		No	TOPMed gnomAD
rs1476539274	564	P>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs750788711	565	A>S		No	ExAC TOPMed gnomAD
rs750788711	565	A>T		No	ExAC TOPMed gnomAD
rs765677296	566	R>C		No	1000Genomes ExAC TOPMed gnomAD
rs762315379	566	R>H		No	ExAC TOPMed gnomAD
rs765677296	566	R>S		No	1000Genomes ExAC TOPMed gnomAD
rs1156496011	567	V>L		No	TOPMed gnomAD
rs1156496011	567	V>M		No	TOPMed gnomAD
rs1601717911	568	E>G		No	Ensembl
rs2147486561	568	E>K		No	Ensembl
rs539598184	569	G>C		No	1000Genomes TOPMed gnomAD
rs539598184	569	G>S		No	1000Genomes TOPMed gnomAD
rs1447016564	570	E>K		No	TOPMed gnomAD
rs994545360	571	A>T		No	TOPMed gnomAD
rs2066516462	571	A>V		No	gnomAD
rs768260684	572	V>I		No	ExAC TOPMed gnomAD
rs1036427656	573	I>M		No	TOPMed gnomAD
rs1262645431	573	I>V		No	gnomAD
TCGA novel	574	C>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1316368705	575	N>H		No	TOPMed gnomAD
rs1601717866	575	N>T		No	Ensembl
rs760231402	577	P>R		No	ExAC TOPMed gnomAD
rs754908392	578	S>G		No	Ensembl
rs1281340664	578	S>N		No	Ensembl
rs1569169738	579	S>N		No	Ensembl
rs771834961	582	V>I		No	ExAC TOPMed gnomAD
rs1363825688	583	T>K		No	gnomAD
rs2066513152	584	P>A		No	Ensembl
rs557311559	584	P>L		No	1000Genomes ExAC TOPMed gnomAD
rs890732555	585	P>L		No	TOPMed gnomAD
rs890732555	585	P>R		No	TOPMed gnomAD
rs749196497	585	P>S		No	ExAC TOPMed gnomAD
rs777552616	586	G>A		No	ExAC TOPMed gnomAD
rs777552616	586	G>V		No	ExAC TOPMed gnomAD
rs1429426396	587	Q>H		No	TOPMed gnomAD
rs755094925	587	Q>L		No	ExAC TOPMed gnomAD
rs755094925	587	Q>R		No	ExAC TOPMed gnomAD
rs201989267	589	H>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs775569687	590	V>M		No	ExAC gnomAD
rs1248248221	592	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs745931051	593	T>I		No	ExAC gnomAD
rs779253388	594	I>F		No	ExAC
rs11547733	594	I>M		No	Ensembl
rs1264811027	594	I>S		No	TOPMed gnomAD
rs779253388	594	I>V		No	ExAC
rs757361795	595	Q>H		No	ExAC TOPMed gnomAD
rs778239432	598	L>F		No	ExAC TOPMed gnomAD
rs1333488993 COSM3065379	600	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1333488993	600	R>G		No	TOPMed gnomAD
rs756708347	600	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs2066448057	601	G>S		No	Ensembl
rs1407258647	602	N>D		No	1000Genomes gnomAD
rs1339160904	604	F>V		No	gnomAD
rs148722170	605	L>F		No	1000Genomes ESP ExAC TOPMed gnomAD
rs751022390	606	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs2066446476	609	Q>R		No	Ensembl
rs2066446041	611	P>R		No	TOPMed
rs200418993	611	P>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2066445908	612	F>S		No	TOPMed gnomAD
rs761575337	614	D>N		No	ExAC gnomAD
rs371223423	616	R>C		No	ESP ExAC TOPMed gnomAD
rs745972033	616	R>H		No	ExAC TOPMed gnomAD
rs1601713769	617	Q>P		No	Ensembl
rs1206548459	618	A>V		No	gnomAD
rs565870583	619	M>I		No	1000Genomes ExAC TOPMed gnomAD
rs2147470624	619	M>R		No	Ensembl
rs1421329356	621	L>Q		No	TOPMed gnomAD
rs961858625	621	L>V		No	Ensembl
rs1384258254	622	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1317605470	623	E>K		No	gnomAD
rs1340264712	624	N>K		No	gnomAD
rs781106994	624	N>S		No	ExAC gnomAD
rs781106994	624	N>T		No	ExAC gnomAD
rs1402694378	626	P>L		No	gnomAD
rs747427027	628	I>M		No	ExAC gnomAD
COSM3555701	629	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1161549412	631	V>L		No	TOPMed gnomAD
rs1161549412	631	V>M		No	TOPMed gnomAD
rs749920297	632	S>N		No	ExAC TOPMed gnomAD
rs749920297	632	S>T		No	ExAC TOPMed gnomAD
rs778550298	633	N>S		No	ExAC TOPMed gnomAD
rs778550298	633	N>T		No	ExAC TOPMed gnomAD
rs756834081	634	R>C		No	ExAC gnomAD
rs144108995	634	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs144108995	634	R>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1199714162	635	W>*		No	gnomAD
rs1199714162	635	W>C		No	gnomAD
rs1601713327	635	W>G		No	Ensembl
rs199698162	636	T>P		No	ExAC gnomAD
rs1045681680	636	T>S		No	TOPMed
rs2066432925	639	W>*		No	TOPMed
rs1445136737	640	D>E		No	gnomAD
rs2066432430	641	L>P		No	TOPMed
rs2066432586	641	L>V		No	Ensembl
rs752612256	642	R>C		No	ExAC TOPMed gnomAD
rs767483052	642	R>H		No	ExAC TOPMed gnomAD
rs190686647	644	H>Q		No	1000Genomes ExAC TOPMed gnomAD
rs2066431676	644	H>R		No	Ensembl
rs2147468241	645	E>*		No	Ensembl
rs1347435068	645	E>D		No	gnomAD
rs369676765	647	R>Q		No	ESP ExAC TOPMed gnomAD
rs371571515	647	R>W		No	ESP ExAC TOPMed gnomAD
TCGA novel	648	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM6095527	650	S>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1004979336	650	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs530363071	651	P>L		No	1000Genomes TOPMed gnomAD
rs2066430031	653	P>R		No	TOPMed
rs375149704	653	P>T		No	ESP ExAC TOPMed gnomAD
rs1269324664	655	D>N		No	Ensembl
rs1176657220	656	G>S		No	gnomAD
rs1197970133	656	G>V		No	TOPMed gnomAD
rs2066429338	657	I>V		No	TOPMed gnomAD
rs745385290	658	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs201060198	658	V>I		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1477987303	659	R>C		No	TOPMed gnomAD
rs778354203	659	R>H		No	ExAC TOPMed gnomAD
rs2066428372	660	A>V		No	gnomAD
rs756924022	661	H>Y		No	ExAC gnomAD
rs1481801278	662	M>T		No	gnomAD
rs748937712	662	M>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs2066419584	663	E>K		No	TOPMed gnomAD
rs1301853661	664	D>E		No	TOPMed gnomAD
rs751596451	664	D>N		No	ExAC gnomAD
rs138005986	665	S>C		No	1000Genomes ExAC gnomAD
rs138005986	665	S>G		No	1000Genomes ExAC gnomAD
rs1346427963	665	S>I		No	gnomAD
rs2066418568	667	P>T		No	TOPMed
COSM4849340	668	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1156385285	668	Q>H		No	gnomAD
rs1010102713	670	L>R		No	TOPMed gnomAD
rs1164785055	671	G>R		No	TOPMed gnomAD
rs1196476125	673	S>G		No	TOPMed gnomAD
rs267606288	676	V>G		No	TOPMed gnomAD
rs753025129	677	I>F		No	ExAC gnomAD
COSM3555700	678	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs774901026	679	M>I		No	ExAC TOPMed gnomAD
rs759858793	679	M>L		No	ExAC TOPMed gnomAD
rs1292339447	680	N>S		No	gnomAD
rs772714834	681	H>Q		No	ExAC TOPMed gnomAD
rs747791337	682	E>A		No	ExAC gnomAD
TCGA novel	682	E>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs769364893	682	E>K		No	ExAC TOPMed gnomAD
rs780970195	683	T>A		No	ExAC gnomAD
rs768612857	683	T>R		No	ExAC gnomAD
TCGA novel	684	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	685	V>D	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs780199079	686	N>K		No	ExAC TOPMed gnomAD
rs758286991	688	Q>E		No	ExAC gnomAD
rs2066414991	689	G>S		No	TOPMed
rs2066414848	690	K>R		No	gnomAD
rs1304165628	693	D>H		No	TOPMed
rs777859721	693	D>V		No	ExAC gnomAD
rs375588549	695	V>M		No	ESP ExAC TOPMed gnomAD
rs1569167906	696	K>E		No	Ensembl
rs200360490	697	G>C		No	ExAC TOPMed gnomAD
rs2066287681	697	G>V		No	Ensembl
rs1266767480	698	S>F		No	TOPMed
rs2066287421	698	S>P		No	Ensembl
rs1184631640	699	S>F		No	TOPMed gnomAD
rs759068611	699	S>T		No	ExAC gnomAD
rs766214363	701	H>R		No	ExAC TOPMed gnomAD
rs769706219	702	V>A		No	ExAC gnomAD
rs773204897	702	V>M		No	ExAC TOPMed gnomAD
TCGA novel	703	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2066285665	704	S>N		No	Ensembl
rs200637738	705	D>E		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM1035414	705	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs772372051	706	L>F		No	ExAC gnomAD
rs1356074125	707	L>F		No	TOPMed gnomAD
rs746123380	707	L>P		No	ExAC TOPMed gnomAD
rs746123380	707	L>R		No	ExAC TOPMed gnomAD
rs1356074125	707	L>V		No	TOPMed gnomAD
rs553785965	709	F>L		No	1000Genomes ExAC TOPMed gnomAD
rs778433550	710	M>R		No	ExAC gnomAD
rs778433550	710	M>T		No	ExAC gnomAD
rs1405492879	710	M>V		No	gnomAD
rs376746165	712	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs752279615	714	T>I		No	ExAC gnomAD
rs1176769334	716	Q>R		No	gnomAD
rs780516842	718	S>C		No	ExAC TOPMed gnomAD
rs780516842	718	S>F		No	ExAC TOPMed gnomAD
rs2066283184	719	G>R		No	TOPMed
rs1476609267	720	T>A		No	gnomAD
TCGA novel	720	T>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs374900808	722	A>S		No	ESP ExAC TOPMed gnomAD
rs374900808	722	A>T		No	ESP ExAC TOPMed gnomAD
rs1481129048	722	A>V		No	gnomAD
COSM1190495 rs762799219	724	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs201521733 COSM3786401	724	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs750161648	726	P>R		No	ExAC gnomAD
rs2066281853	727	K>E		No	TOPMed
rs1274520275	729	S>F		No	TOPMed
rs2066247278	730	H>P		No	Ensembl
rs769168176	731	D>N		No	gnomAD
TCGA novel	733	N>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs200165560	735	T>M		No	ESP ExAC TOPMed gnomAD
rs372542578	736	L>M		No	ESP TOPMed gnomAD
rs777066522	737	P>L		No	ExAC TOPMed gnomAD
rs2066246072	737	P>S		No	TOPMed
rs746527136	740	L>F		No	ExAC gnomAD
rs370061884	742	V>I		No	ESP ExAC TOPMed gnomAD
rs778621151	743	K>M		No	ExAC TOPMed gnomAD
rs757056511	744	S>F		No	ExAC TOPMed gnomAD
TCGA novel rs1749587286	745	Y>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
TCGA novel	745	Y>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs532944576 COSM1035413	746	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs766613051	748	N>S		No	ExAC gnomAD
rs1478212254	749	I>V		No	TOPMed gnomAD
rs1214386254	750	D>E		No	gnomAD
rs1332617247	750	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs867846722	754	H>R		No	TOPMed gnomAD
rs773637239	754	H>Y		No	ExAC gnomAD
rs761021468	756	T>I		No	ExAC TOPMed gnomAD
rs761021468	756	T>N		No	ExAC TOPMed gnomAD
rs1438903009	757	L>V		No	TOPMed gnomAD
rs2147424977	758	Y>C		No	Ensembl
rs79966207	759	N>D		No	1000Genomes ESP ExAC TOPMed gnomAD
rs772506820	759	N>S		No	ExAC gnomAD
rs1304594338	760	C>Y		No	gnomAD
rs1464607448	763	G>D		No	gnomAD
rs1159157606	764	R>C		No	gnomAD
COSM1417072 rs1441358342	764	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1441358342	764	R>L		No	TOPMed gnomAD
rs1159157606	764	R>S		No	gnomAD
rs538514666	765	S>R		No	1000Genomes ExAC TOPMed gnomAD
COSM1035412 rs1442577954	766	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs749018022	769	L>M		No	ExAC gnomAD
rs1456049111	770	C>Y		No	TOPMed
rs1280294689	771	R>L		No	TOPMed gnomAD
rs1280294689	771	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs777258572	771	R>W		No	ExAC TOPMed gnomAD
TCGA novel	771	R>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs781292997	773	A>T		No	ExAC TOPMed gnomAD
rs1238613070	774	N>D		No	TOPMed gnomAD
rs1238613070	774	N>H		No	TOPMed gnomAD
rs1341368423	775	P>L		No	gnomAD
rs374234427	776	D>N		No	ESP ExAC TOPMed gnomAD
rs374234427	776	D>Y		No	ESP ExAC TOPMed gnomAD
rs1421388101	779	C>Y		No	gnomAD
rs534402671	780	A>T		No	1000Genomes ExAC TOPMed gnomAD
rs1157753906	780	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1369893535	781	W>*		No	gnomAD
TCGA novel	781	W>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs752989186	782	C>Y		No	ExAC gnomAD
rs551456267	783	G>R		No	1000Genomes ExAC TOPMed gnomAD
rs774697614	784	G>D		No	ExAC TOPMed gnomAD
rs2066213863	785	Q>H		No	TOPMed gnomAD
rs770513867	785	Q>P		No	ExAC TOPMed gnomAD
rs770513867	785	Q>R		No	ExAC TOPMed gnomAD
rs1204976368	786	S>N		No	gnomAD
rs1204976368	786	S>T		No	gnomAD
rs762363550	787	R>G		No	ExAC TOPMed gnomAD
rs2066213329	787	R>S		No	Ensembl
rs762363550	787	R>W		No	ExAC TOPMed gnomAD
rs2066213180	788	C>Y		No	TOPMed
rs769514548	789	V>L		No	ExAC TOPMed gnomAD
rs769514548	789	V>M		No	ExAC TOPMed gnomAD
rs374465427	790	Y>H		No	ESP ExAC TOPMed gnomAD
rs768741557	791	E>K		No	ExAC TOPMed gnomAD
rs1392574312	792	A>D		No	gnomAD
rs747019847	792	A>T		No	ExAC gnomAD
rs2066211377	795	N>D		No	TOPMed
rs757427704	796	T>I		No	ExAC gnomAD
COSM4105100 rs1476547887	797	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs1261718526	797	T>I		No	gnomAD
rs953636958	799	E>*		No	TOPMed gnomAD
rs953636958	799	E>K		No	TOPMed gnomAD
rs756284707	800	C>*		No	ExAC
TCGA novel	801	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1208299039	801	P>Q		No	gnomAD
rs375572338	802	P>L		No	ESP ExAC TOPMed gnomAD
rs1258944875	802	P>S		No	gnomAD
TCGA novel	802	P>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2066209118	803	P>H		No	TOPMed gnomAD
rs370412897	804	V>I		No	ESP ExAC TOPMed gnomAD
rs370412897	804	V>L		No	ESP ExAC TOPMed gnomAD
rs1212157084	805	I>V		No	TOPMed
rs1332625528	806	T>S		No	gnomAD
rs2066207967	807	R>K		No	TOPMed
rs763643132	808	I>M		No	ExAC gnomAD
rs200426394	809	Q>L		No	ExAC TOPMed gnomAD
rs28470336	812	T>A		No	1000Genomes ESP ExAC TOPMed gnomAD
rs772065446	812	T>M		No	ExAC TOPMed gnomAD
rs28470336	812	T>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs774241133	814	P>S		No	ExAC TOPMed gnomAD
rs774241133	814	P>T		No	ExAC TOPMed gnomAD
rs965072605	815	L>P		No	Ensembl
rs2066197781	816	G>A		No	Ensembl
rs368997252	816	G>R		No	ESP ExAC TOPMed gnomAD
rs368997252	816	G>S		No	ESP ExAC TOPMed gnomAD
rs1372240792	817	G>R		No	gnomAD
rs562878563	818	G>S		No	1000Genomes
rs781408320	819	I>V		No	ExAC gnomAD
rs376548374	820	R>C		No	ESP ExAC TOPMed gnomAD
rs747432493	820	R>H		No	1000Genomes ExAC TOPMed gnomAD
rs747432493	820	R>P		No	1000Genomes ExAC TOPMed gnomAD
rs780232837	821	I>L		No	ExAC TOPMed gnomAD
rs758772028	822	T>A		No	ExAC gnomAD
rs751011693	822	T>I		No	ExAC gnomAD
rs751011693	822	T>S		No	ExAC gnomAD
rs11547731	823	I>F		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2066195066	823	I>T		No	TOPMed gnomAD
VAR_061537 rs11547731	823	I>V		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs2066194014	826	S>F		No	TOPMed
rs534546225	827	N>D		No	1000Genomes ExAC TOPMed gnomAD
COSM1035411	827	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	827	N>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM1308291	828	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1289387729	829	G>S		No	TOPMed gnomAD
rs376293364	830	V>F		No	ESP ExAC TOPMed gnomAD
rs376293364	830	V>I		No	ESP ExAC TOPMed gnomAD
rs770795215	833	G>E		No	ExAC TOPMed gnomAD
rs770795215	833	G>V		No	ExAC TOPMed gnomAD
rs776534685	836	Q>H		No	ExAC TOPMed gnomAD
rs376030784	837	R>K		No	ESP ExAC TOPMed gnomAD
rs2066191856	839	S>F		No	gnomAD
rs1244467691	840	V>A		No	TOPMed
rs1229632135	841	A>S		No	gnomAD
COSM1417071 rs200079670	842	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs772388012	843	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs2066190638	844	N>D		No	TOPMed
rs1300565978	846	S>P		No	gnomAD
rs746223663	849	P>L		No	ExAC gnomAD
rs2066189687	850	E>Q		No	Ensembl
rs1407238581	851	R>C		No	TOPMed gnomAD
rs199926321	851	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs199926321	851	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs199926321	851	R>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1407238581	851	R>S		No	TOPMed gnomAD
COSM326193	852	Y>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs755618323	854	V>M		No	ExAC gnomAD
rs1485437475	855	S>A		No	gnomAD
rs2066188410	855	S>F		No	Ensembl
rs759339200	856	T>I		No	ExAC TOPMed gnomAD
rs759339200	856	T>S		No	ExAC TOPMed gnomAD
rs766337040	857	R>Q		No	ExAC gnomAD
rs751289776	857	R>W		No	ExAC TOPMed gnomAD
TCGA novel	858	I>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1601699924	858	I>V		No	Ensembl
rs780634166	859	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs373347520	862	I>M		No	ESP ExAC TOPMed gnomAD
rs369024095	863	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs369024095	863	E>Q		No	ESP ExAC TOPMed gnomAD
rs758252261 COSM1417070	865	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs2066167309	866	E>*		No	Ensembl
rs2066167165	866	E>G		No	TOPMed
rs2147413465	867	T>A		No	Ensembl
rs200847817	867	T>M		No	ESP ExAC gnomAD
rs141252891	868	P>L		No	Ensembl
rs1275405215	868	P>S		No	TOPMed
rs1432723103	869	F>L		No	TOPMed gnomAD
rs369732594	870	T>M		No	ESP ExAC TOPMed gnomAD
rs1441303500	871	G>E		No	gnomAD
rs763230043	872	G>D		No	ExAC TOPMed gnomAD
rs1180607449	872	G>R		No	TOPMed gnomAD
rs763230043	872	G>V		No	ExAC TOPMed gnomAD
TCGA novel	872	G>V	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM5090428	873	V>C	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2066164664	873	V>I		No	TOPMed
rs372327269	874	E>K		No	ESP ExAC TOPMed gnomAD
rs372327269	874	E>Q		No	ESP ExAC TOPMed gnomAD
rs1217878121	875	V>G		No	gnomAD
rs368564765	877	V>I		No	ESP ExAC TOPMed gnomAD
rs2066163751	878	F>S		No	Ensembl
rs779699565	879	G>R		No	ExAC TOPMed gnomAD
rs1413009020	881	L>P		No	gnomAD
TCGA novel	881	L>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs771691320	881	L>V		No	ExAC gnomAD
rs200111358	883	R>C		No	ESP ExAC TOPMed gnomAD
rs201999293	883	R>H		No	ESP ExAC TOPMed gnomAD
COSM3842936 rs1382460521	884	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1012249197	886	P>L		No	gnomAD
rs1012249197	886	P>R		No	gnomAD
rs200791148	887	N>S		No	ESP ExAC TOPMed gnomAD
rs2066161416	887	N>Y		No	Ensembl
rs1809975386	888	V>A		No	TOPMed
TCGA novel	888	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1474585625	889	Q>*		No	gnomAD
rs766737874	889	Q>H		No	ExAC gnomAD
COSM1035410	890	F>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs769690739	896	K>Q		No	ExAC TOPMed gnomAD
rs1191997177	898	L>F		No	gnomAD
rs1191997177	898	L>V		No	gnomAD
rs1490829903	901	E>G		No	Ensembl
rs748136803	901	E>K		No	1000Genomes ExAC gnomAD
rs780989066	902	P>L		No	ExAC TOPMed gnomAD
rs1436129405	905	G>R		No	TOPMed gnomAD
rs745882011	906	P>L		No	ExAC TOPMed gnomAD
rs745882011	906	P>Q		No	ExAC TOPMed gnomAD
rs1207839574	906	P>S		No	Ensembl
rs995047869	908	A>T		No	Ensembl
rs754227017	908	A>V		No	ExAC TOPMed gnomAD
rs1439447530	910	G>A		No	TOPMed gnomAD
rs1439447530	910	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs753303246	910	G>R		No	ExAC TOPMed gnomAD
rs753303246	910	G>S		No	ExAC TOPMed gnomAD
rs2066140452	911	T>P		No	TOPMed
rs1334623640	912	T>A		No	gnomAD
rs1328796672	912	T>I		No	gnomAD
rs951133275	914	T>A		No	Ensembl
rs951133275	914	T>P		No	Ensembl
rs767850259	914	T>S		No	ExAC gnomAD
rs1166598462	915	I>F		No	TOPMed
COSM1035408	916	H>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1377653283	917	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
TCGA novel	918	T>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2066138586	919	H>Q		No	TOPMed
rs868423887	922	T>M		No	TOPMed gnomAD
rs2066137692	924	S>F		No	Ensembl
rs1468688470	925	Q>R		No	TOPMed gnomAD
TCGA novel	928	V>C	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs769779572	928	V>M		No	ExAC TOPMed gnomAD
rs923565565	929	R>L		No	TOPMed gnomAD
rs923565565	929	R>Q		No	TOPMed gnomAD
rs747944816	929	R>W		No	ExAC TOPMed gnomAD
rs75735238	930	V>L		No	Ensembl
rs2066136321	931	T>A		No	TOPMed
rs201547301	933	N>S		No	1000Genomes ExAC TOPMed gnomAD
rs778814426	934	G>D		No	ExAC
rs141762500	934	G>S		No	1000Genomes ExAC TOPMed gnomAD
rs62621372	935	V>I		No	1000Genomes ESP ExAC TOPMed gnomAD
rs777954936	936	P>L		No	ExAC TOPMed gnomAD
rs375115998	938	K>E		No	ESP gnomAD
rs755337831	940	T>M		No	ExAC TOPMed gnomAD
rs2066116871	942	F>L		No	Ensembl
rs2066116557	943	G>R		No	Ensembl
rs149805063	944	A>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs149805063	944	A>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1392377758	944	A>T		No	gnomAD
rs149805063 RCV000888880	944	A>V		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs749888275	947	Q>R		No	ExAC TOPMed gnomAD
TCGA novel	948	C>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1166985607	950	T>A		No	TOPMed
rs2066115011	952	P>S		No	TOPMed
rs2066114883	953	Q>*		No	TOPMed
rs927746358	953	Q>P		No	gnomAD
rs927746358	953	Q>R		No	gnomAD
rs1364327455	954	A>T		No	TOPMed gnomAD
rs370055566	954	A>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs375999957	956	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs763839691	956	R>W		No	ExAC TOPMed gnomAD
rs775416355	957	G>D		No	ExAC gnomAD
rs2066113215	957	G>S		No	TOPMed
rs1253631236	958	Q>R		No	gnomAD
rs200474256	959	M>I		No	ESP ExAC TOPMed gnomAD
rs62621407	959	M>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2066112175	959	M>R		No	Ensembl
rs62621407	959	M>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1281407079	960	L>F		No	gnomAD
rs1281407079	960	L>V		No	gnomAD
rs773225348	961	L>V		No	ExAC gnomAD
rs1392075655	963	V>F		No	gnomAD
rs1601697169	963	V>G		No	Ensembl
rs2147401738	964	S>F		No	Ensembl
TCGA novel	965	Y>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs558571072	966	G>R		No	1000Genomes ExAC TOPMed gnomAD
rs747342576	967	G>A		No	ExAC TOPMed gnomAD
rs747342576	967	G>E		No	ExAC TOPMed gnomAD
rs745397200 COSM3555696	968	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	968	S>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs569852454	970	V>M		No	1000Genomes ExAC TOPMed gnomAD
rs1007779940	971	P>S		No	Ensembl
rs2147401382	972	N>T		No	Ensembl
rs1420382741	973	P>H		No	TOPMed gnomAD
rs1420382741	973	P>L		No	TOPMed gnomAD
rs1483052137	974	G>D		No	gnomAD
rs201704027	974	G>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs201704027	974	G>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1213523378	976	F>I		No	TOPMed gnomAD
rs767463618	977	F>Y		No	ExAC gnomAD
rs2147400975	978	T>I		No	Ensembl
rs774240975	978	T>P		No	ExAC gnomAD
rs765299932	979	Y>S		No	ExAC gnomAD
rs201751886	980	R>C		No	ESP ExAC TOPMed gnomAD
rs79500228	980	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs79500228	980	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs201751886	980	R>S		No	ESP ExAC TOPMed gnomAD
rs775951287	981	E>K		No	ExAC TOPMed gnomAD
rs202201273	982	N>T		No	ExAC gnomAD
rs748762533	984	V>E		No	ExAC gnomAD
rs200118373	984	V>I		No	1000Genomes ESP ExAC TOPMed gnomAD
rs200118373	984	V>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1258871941	986	R>*		No	TOPMed gnomAD
rs1258871941	986	R>G		No	TOPMed gnomAD
rs201068347	986	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs957289874	987	A>G		No	TOPMed gnomAD
rs957289874	987	A>V		No	TOPMed gnomAD
rs1255836198	988	F>C		No	gnomAD
rs202117989	988	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs754762851	989	E>K		No	ExAC gnomAD
rs754762851	989	E>Q		No	ExAC gnomAD
COSM5859677	990	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM78321	990	P>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs766283296	992	R>*		No	ExAC gnomAD
rs375104267	992	R>Q		No	ESP ExAC TOPMed gnomAD
rs1339663316	995	A>T		No	gnomAD
rs1189271682 COSM1221300	996	S>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed
rs1189271682	996	S>T		No	TOPMed
rs1335784939	999	R>C		No	gnomAD
rs769351345	999	R>H		No	ExAC gnomAD
rs2066051900	1000	S>G		No	gnomAD
rs373694108	1003	V>I		No	ESP ExAC TOPMed gnomAD
rs746803740	1004	T>M		No	ExAC TOPMed gnomAD
rs1392481472	1006	Q>E		No	TOPMed gnomAD
rs2066050953	1009	S>G		No	TOPMed
rs2066050764	1009	S>N		No	TOPMed
rs750444951	1012	Q>H		No	ExAC TOPMed gnomAD
rs1468364555	1012	Q>K		No	TOPMed gnomAD
rs2066049878	1013	R>G		No	Ensembl
rs778706365	1013	R>S		No	ExAC TOPMed gnomAD
rs752781092	1016	M>V		No	ExAC TOPMed gnomAD
rs1569162645	1017	V>A		No	Ensembl
rs767871551	1017	V>M		No	ExAC gnomAD
rs766832996	1019	I>M		No	ExAC TOPMed gnomAD
rs1213702854	1019	I>V		No	Ensembl
rs374289741	1020	A>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs201274338	1020	A>T		No	TOPMed gnomAD
rs374289741	1020	A>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs765665766	1021	E>A		No	ExAC gnomAD
rs1318244384	1021	E>D		No	TOPMed gnomAD
rs761344667	1022	P>S		No	ExAC TOPMed gnomAD
rs1377598598	1024	Q>P		No	gnomAD
rs768134621	1025	S>F		No	ExAC gnomAD
rs1414053033	1026	W>S		No	gnomAD
TCGA novel	1027	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs576902370	1028	P>L		No	1000Genomes ExAC TOPMed gnomAD
rs771965276	1029	P>L		No	ExAC gnomAD
rs368989847	1030	R>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs763070819	1030	R>Q		No	ExAC TOPMed gnomAD
rs368989847	1030	R>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs970801068	1032	A>S		No	Ensembl
rs2066045819	1033	E>K		No	TOPMed
rs543422894	1034	S>C		No	1000Genomes
rs2147389860	1034	S>P		No	Ensembl
rs755001480	1035	L>V		No	1000Genomes ExAC gnomAD
rs1285892314	1036	Q>*		No	gnomAD
rs11547728	1036	Q>H		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM3842935 rs1345121299	1037	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed
rs766445738	1038	M>T		No	ExAC TOPMed gnomAD
COSM5366523 rs372167877	1039	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs865841168	1040	V>M		No	Ensembl
rs914823000	1041	V>A		No	TOPMed gnomAD
rs914823000	1041	V>G		No	TOPMed gnomAD
rs1028659143	1042	G>R		No	TOPMed gnomAD
rs373669856	1045	Y>C		No	ESP ExAC TOPMed gnomAD
rs1292876817	1046	V>L		No	TOPMed gnomAD
rs1292876817	1046	V>M		No	TOPMed gnomAD
rs1356200724	1048	H>L		No	TOPMed gnomAD
rs1166542517	1049	N>D		No	TOPMed gnomAD
rs1428841737	1049	N>S		No	TOPMed gnomAD
rs1292222969	1051	T>S		No	gnomAD
rs534785502	1054	V>F		No	1000Genomes ExAC TOPMed gnomAD
rs534785502	1054	V>I		No	1000Genomes ExAC TOPMed gnomAD
rs2066030629	1055	F>L		No	TOPMed
TCGA novel	1056	L>C	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM3723108	1057	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs773101215	1058	P>L		No	ExAC TOPMed gnomAD
COSM3390305	1058	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2066029700	1059	A>V		No	Ensembl
rs761703447	1061	P>L		No	ExAC gnomAD
rs769599289	1061	P>S		No	ExAC gnomAD
rs1300753731	1066	A>T		No	gnomAD
rs373860676	1067	Y>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs779118429	1069	L>F		No	ExAC TOPMed gnomAD
rs1375773688	1070	T>K		No	TOPMed gnomAD
rs1375773688	1070	T>M		No	TOPMed gnomAD
rs1213754705	1071	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs371203017	1073	I>M		No	ESP ExAC TOPMed gnomAD
rs139926938	1074	E>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2147386428	1075	M>T		No	Ensembl
rs2066026614	1077	G>R		No	TOPMed gnomAD
rs374627819	1079	R>C		No	ESP ExAC TOPMed gnomAD
rs374627819	1079	R>G		No	ESP ExAC TOPMed gnomAD
rs200429266	1079	R>H		No	ESP ExAC TOPMed gnomAD
rs200429266	1079	R>L		No	ESP ExAC TOPMed gnomAD
rs374627819	1079	R>S		No	ESP ExAC TOPMed gnomAD
rs1244302654	1080	A>P		No	TOPMed gnomAD
rs1244302654	1080	A>S		No	TOPMed gnomAD
rs1160131860	1080	A>V		No	gnomAD
rs1258571413	1084	T>P		No	gnomAD
rs1202536398	1085	E>G		No	gnomAD
rs766161309	1086	A>T		No	ExAC gnomAD
rs758165010	1086	A>V		No	ExAC gnomAD
rs534307672	1087	G>R		No	ExAC TOPMed gnomAD
rs946043122	1088	A>D		No	Ensembl
rs373329714	1088	A>T		No	ESP ExAC TOPMed gnomAD
rs946043122	1088	A>V		No	Ensembl
rs759629858	1090	E>K		No	ExAC TOPMed gnomAD
rs759629858	1090	E>Q		No	ExAC TOPMed gnomAD
rs770979139	1092	V>L		No	ExAC TOPMed gnomAD
rs770979139	1092	V>M		No	ExAC TOPMed gnomAD
rs1569162048	1093	P>R		No	Ensembl
rs749573114	1093	P>S		No	ExAC gnomAD
rs372865746	1094	D>E		No	ESP ExAC gnomAD
rs2066022552	1094	D>N		No	TOPMed
rs2066021969	1095	P>S		No	gnomAD
rs1454918774	1096	T>I		No	TOPMed gnomAD
rs1454918774	1096	T>N		No	TOPMed gnomAD
rs530361396	1100	F>L		No	1000Genomes ExAC gnomAD
rs974464419	1102	G>D		No	TOPMed
rs747486856	1104	V>F		No	ExAC TOPMed gnomAD
rs747486856	1104	V>I		No	ExAC TOPMed gnomAD
rs747486856	1104	V>L		No	ExAC TOPMed gnomAD
rs2066020341	1106	K>E		No	Ensembl
rs779759334	1107	Q>R		No	ExAC gnomAD
rs1205890572	1114	A>T		No	TOPMed gnomAD
rs764874526	1115	R>Q		No	ExAC TOPMed gnomAD
rs1266389693	1115	R>W		No	TOPMed gnomAD
rs776979346	1118	N>S		No	ExAC TOPMed gnomAD
rs769207954	1121	K>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
TCGA novel	1122	A>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs375577050	1122	A>G		No	ESP ExAC TOPMed gnomAD
rs375577050	1122	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs1209043498	1123	M>T		No	gnomAD
rs772579863	1124	T>M		No	ExAC TOPMed gnomAD
rs2066004358	1125	L>P		No	TOPMed
rs778521030	1126	Q>P		No	ExAC TOPMed gnomAD
rs749040680	1129	E>K		No	ExAC TOPMed gnomAD
COSM1417067	1132	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs751429886	1135	E>K		No	ExAC gnomAD
TCGA novel	1135	E>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1307657362	1136	R>C		No	gnomAD
rs377737626	1136	R>H		No	ESP ExAC TOPMed gnomAD
rs377737626	1136	R>L		No	ESP ExAC TOPMed gnomAD
rs1170945805	1138	T>I		No	TOPMed gnomAD
rs1312222476	1138	T>S		No	gnomAD
rs1170945805	1138	T>S		No	TOPMed gnomAD
rs374311597	1139	M>I		No	ESP ExAC TOPMed gnomAD
rs1184195892	1139	M>T		No	gnomAD
rs1364345446	1139	M>V		No	gnomAD
rs2066001865	1140	K>*		No	Ensembl
TCGA novel	1141	T>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1250714562	1141	T>M		No	TOPMed gnomAD
COSM1035406 rs1443835685	1143	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs1244964018	1145	T>I		No	TOPMed gnomAD
rs772289683	1146	D>H		No	ExAC gnomAD
rs1230700141	1149	C>Y		No	gnomAD
rs1288185100	1152	P>L		No	gnomAD
rs2065999564	1153	E>G		No	TOPMed
rs777426414	1154	V>L		No	ExAC gnomAD
rs777426414	1154	V>M		No	ExAC gnomAD
COSM3424269	1156	P>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs953456826	1156	P>H		No	Ensembl
rs376149647	1157	P>L		No	ESP ExAC TOPMed gnomAD
rs2065999099	1157	P>S		No	Ensembl
rs1389397362	1159	K>N		No	TOPMed gnomAD
rs1471607896	1160	R>Q		No	TOPMed gnomAD
rs781014569	1160	R>W		No	ExAC TOPMed gnomAD
rs1182273624	1161	R>Q		No	gnomAD
rs754714515	1161	R>W		No	ExAC TOPMed gnomAD
COSM3800286	1162	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2065997243	1163	K>Q		No	TOPMed
rs747034054	1164	R>*		No	ExAC gnomAD
rs373453904	1164	R>Q		No	ESP ExAC TOPMed gnomAD
rs1269542800	1165	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1269542800	1165	D>Y		No	gnomAD
rs2065996335	1167	T>A		No	TOPMed
rs753916806	1167	T>R		No	ExAC gnomAD
rs1381737303	1168	H>R		No	gnomAD
rs1229284132	1168	H>Y		No	gnomAD
rs1282658376	1171	P>L		No	TOPMed gnomAD
rs767996562	1172	E>D		No	ExAC TOPMed gnomAD
rs752942511	1172	E>K		No	ExAC gnomAD
rs2065994792	1173	F>L		No	TOPMed
rs2065994435	1174	I>M		No	gnomAD
rs756696997	1174	I>T		No	ExAC TOPMed gnomAD
rs1431685062	1175	V>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
rs201645775	1177	F>L		No	ESP ExAC TOPMed gnomAD
rs745854880	1178	G>S		No	ExAC gnomAD
rs1192425761	1179	S>A		No	TOPMed gnomAD
rs1601691401	1179	S>F		No	Ensembl
rs372197536	1180	R>C		No	ESP TOPMed gnomAD
rs1455752970	1180	R>H		No	TOPMed gnomAD
rs770010469	1181	E>K		No	ExAC TOPMed gnomAD
rs2065985604	1183	V>M		No	TOPMed
rs375098920	1186	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs755195831	1186	R>H		No	ExAC TOPMed gnomAD
rs1302135367	1187	V>M		No	TOPMed gnomAD
rs2065984513	1188	E>Q		No	Ensembl
rs750933296	1190	D>N		No	ExAC TOPMed gnomAD
rs2065984062	1191	T>A		No	TOPMed
rs1345961455	1191	T>I		No	Ensembl
rs765673534	1192	R>Q		No	ExAC TOPMed gnomAD
rs1372118434	1192	R>W		No	TOPMed gnomAD
rs536523204	1193	V>M		No	1000Genomes ExAC gnomAD
rs763625119	1195	D>N		No	ExAC TOPMed gnomAD
rs751845658	1196	V>E		No	Ensembl
rs1423712452 COSM1035404	1196	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs371055458	1197	P>L		No	ESP ExAC TOPMed gnomAD
rs774456849	1200	L>F		No	ExAC gnomAD
rs190470503	1203	P>L		No	1000Genomes ExAC TOPMed gnomAD
rs1425765342	1204	L>P		No	TOPMed
rs2065981323	1206	I>V		No	Ensembl
rs747263348	1207	V>L		No	ExAC TOPMed gnomAD
rs747263348	1207	V>M		No	ExAC TOPMed gnomAD
rs2065980800	1208	P>R		No	TOPMed
rs1435253814	1211	V>I		No	Ensembl
rs763081231	1212	V>I		No	ExAC TOPMed gnomAD
rs763081231	1212	V>L		No	ExAC TOPMed gnomAD
rs150309152	1213	I>V		No	1000Genomes TOPMed gnomAD
rs370284603	1214	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs754343905	1214	A>V		No	ExAC TOPMed gnomAD
COSM4831460 rs760225048	1215	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD NCI-TCGA Cosmic
rs760225048	1215	V>M		No	ExAC TOPMed gnomAD
rs1320166252	1216	S>A		No	TOPMed
rs1221057887	1216	S>C		No	TOPMed gnomAD
rs1358003534	1217	V>A		No	gnomAD
rs1458279706	1218	Y>N		No	gnomAD
rs371130944	1218	Y>S		No	1000Genomes ExAC TOPMed gnomAD
rs759439955	1219	C>W		No	ExAC TOPMed gnomAD
rs1014538178	1220	Y>F		No	gnomAD
rs1014538178	1220	Y>S		No	gnomAD
rs2065977604	1221	W>R		No	Ensembl
rs778176942	1223	K>R		No	ExAC gnomAD
rs369828232	1227	A>T		No	ESP ExAC gnomAD
rs2065958882	1227	A>V		No	TOPMed
rs1224789123	1231	Y>*		No	TOPMed
rs1192542607	1232	E>K		No	gnomAD
rs888633390	1235	K>N		No	TOPMed gnomAD
rs1207870229	1236	S>F		No	gnomAD
COSM4406268	1237	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM726732	1239	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2065956712	1239	E>Q		No	Ensembl
rs766000331	1240	G>A		No	ExAC gnomAD
rs751262783	1240	G>S		No	ExAC TOPMed gnomAD
rs1452915116	1248	R>C		No	TOPMed gnomAD
rs1332220132	1248	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs750191330	1249	C>F		No	ExAC gnomAD
TCGA novel	1249	C>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1249	C>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM1035403	1250	K>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	1250	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs764910604	1251	K>R		No	ExAC gnomAD
rs2065955362	1252	E>*		No	TOPMed
rs753759595	1255	D>Y		No	ExAC gnomAD
rs1464914163	1256	L>V		No	TOPMed gnomAD
rs750672460	1258	I>M		No	ExAC TOPMed gnomAD
rs2065941858	1258	I>V		No	TOPMed
rs765509654	1259	E>K		No	ExAC gnomAD
rs2065941396	1260	M>I		No	Ensembl
TCGA novel	1261	E>G	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs984384699	1263	Q>H		No	Ensembl
rs777175182	1263	Q>K		No	ExAC gnomAD
TCGA novel	1265	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1245369694 COSM1035402	1266	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs375409236	1267	V>L		No	ESP ExAC TOPMed gnomAD
COSM4855087 rs375409236	1267	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs952926750	1268	H>Y		No	Ensembl
COSM461056	1269	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	1269	E>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2065939253	1270	A>T		No	TOPMed
TCGA novel	1270	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1383023136	1271	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1200162281	1272	I>V		No	gnomAD
rs1601688609	1274	V>A		No	Ensembl
rs1251509632	1274	V>M		No	TOPMed gnomAD
rs748920566	1276	D>G		No	ExAC TOPMed gnomAD
rs771855846	1279	T>I		No	gnomAD
rs1242017173	1281	T>I		No	gnomAD
rs1368129076	1281	T>S		No	TOPMed
rs1453635304	1282	D>N		No	TOPMed gnomAD
rs201960199	1283	R>C		No	ESP ExAC TOPMed gnomAD
rs748120996	1283	R>H		No	ExAC TOPMed gnomAD
TCGA novel rs1212849563	1284	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1212849563	1284	V>L		No	TOPMed gnomAD
TCGA novel	1286	F>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs374108984	1288	P>L		No	ESP ExAC TOPMed gnomAD
rs1361223860	1288	P>S		No	TOPMed gnomAD
TCGA novel	1289	S>I	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs757601022	1292	G>S		No	ExAC TOPMed gnomAD
rs1000095053	1293	D>N		No	gnomAD
rs2065934687	1294	K>E		No	Ensembl
rs2147368973	1296	V>A		No	Ensembl
rs760877226	1296	V>M		No	ExAC TOPMed gnomAD
rs776075016	1297	M>I		No	ExAC gnomAD
rs1601688478	1299	T>P		No	Ensembl
rs2065933545	1300	G>A		No	TOPMed
rs759115091	1300	G>C		No	ExAC TOPMed gnomAD
rs759115091	1300	G>S		No	ExAC TOPMed gnomAD
rs1267280267	1301	K>N		No	gnomAD
rs904437628	1304	I>L		No	Ensembl
rs1601688454	1304	I>T		No	Ensembl
rs559938153	1305	P>S		No	1000Genomes ExAC gnomAD
rs1601688422	1306	E>G		No	Ensembl
rs772789014	1306	E>K		No	ExAC gnomAD
rs772789014	1306	E>Q		No	ExAC gnomAD
rs201378041	1307	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1279245268	1307	P>S		No	TOPMed gnomAD
rs746941566	1308	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs754910456	1308	R>W		No	ExAC TOPMed gnomAD
rs1057253566	1309	R>L		No	gnomAD
rs1057253566	1309	R>Q		No	gnomAD
rs1351986520	1309	R>W		No	TOPMed gnomAD
rs201776829	1310	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs200080652	1310	P>T		No	ESP ExAC TOPMed gnomAD
rs2065930337	1312	V>L		No	Ensembl
TCGA novel	1316	L>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs748354677	1320	S>A		No	Ensembl
COSM1417065	1320	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1601688328	1321	N>T		No	Ensembl
TCGA novel	1322	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs752961600	1325	S>R		No	ExAC TOPMed gnomAD
TCGA novel	1327	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1601688307	1328	F>S		No	Ensembl
rs1175630159	1330	I>V		No	gnomAD
rs2065928453	1331	N>D		No	Ensembl
rs200739841	1331	N>I		No	ExAC TOPMed gnomAD
rs200739841	1331	N>S		No	ExAC TOPMed gnomAD
rs764718458	1334	H>Q		No	ExAC gnomAD
rs1287532583	1335	T>N		No	gnomAD
rs2065917853	1339	Q>H		No	gnomAD
rs1056972715	1340	R>Q		No	gnomAD
rs1453452385	1340	R>W		No	gnomAD
rs753441958	1341	E>D		No	ExAC TOPMed gnomAD
rs2065917287	1341	E>G		No	TOPMed
TCGA novel	1342	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs539295991	1343	S>L		No	1000Genomes TOPMed gnomAD
rs200418278	1344	A>V		No	1000Genomes ExAC TOPMed gnomAD
rs775464863 COSM5859674	1345	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
COSM1417064	1345	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs769778490	1346	A>P		No	ExAC TOPMed gnomAD
rs769778490	1346	A>S		No	ExAC TOPMed gnomAD
rs769778490	1346	A>T		No	ExAC TOPMed gnomAD
rs1259523188	1350	F>L		No	TOPMed gnomAD
COSM3065306 rs1204353997	1351	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs776753345	1351	A>V		No	ExAC TOPMed gnomAD
rs549095175	1355	T>M		No	1000Genomes ExAC TOPMed gnomAD
rs753348363	1357	A>V		No	ExAC TOPMed gnomAD
rs1444434763	1360	G>R		No	Ensembl
TCGA novel	1362	L>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2065914054	1363	E>V		No	Ensembl
rs767425660	1366	T>A		No	ExAC gnomAD
rs759348018	1366	T>M		No	ExAC TOPMed gnomAD
COSM380546	1367	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs28499460	1368	I>T		No	Ensembl
rs762771999	1369	M>I		No	ExAC gnomAD
rs2065913105	1370	H>R		No	Ensembl
rs776823804	1371	T>M		No	ExAC TOPMed gnomAD
TCGA novel	1371	T>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs775620720	1373	F>L		No	ExAC gnomAD
TCGA novel	1373	F>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs772435940	1375	E>D		No	ExAC TOPMed gnomAD
rs1336814368	1378	E>K		No	gnomAD
rs2065911591	1380	Y>*		No	TOPMed
rs755621229	1381	V>L		No	ExAC TOPMed gnomAD
rs755621229	1381	V>M		No	ExAC TOPMed gnomAD
rs1285642310	1382	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1403460980	1383	A>T		No	gnomAD
rs2065910871	1384	K>E		No	Ensembl
rs73891209	1384	K>N		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1411731682	1389	M>L		No	gnomAD
rs1466531970 COSM3694137	1391	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs1431309803	1391	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
COSM4105097	1392	R>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs776342572	1393	S>P		No	ExAC gnomAD
COSM5499451	1396	V>G	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs768048613	1396	V>L		No	ExAC gnomAD
COSM419495	1399	R>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1271811572	1400	M>L		No	TOPMed gnomAD
rs906534424	1402	S>C		No	TOPMed
rs906534424	1402	S>Y		No	TOPMed
rs778648306	1403	N>S		No	ExAC TOPMed gnomAD
rs757234543	1405	M>T		No	ExAC gnomAD
COSM1308290	1407	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1292126822	1409	L>V		No	TOPMed gnomAD
rs2065877859	1411	Q>P		No	TOPMed
rs1474711307	1413	L>V		No	gnomAD
rs1202488608	1415	D>N		No	gnomAD
rs1263627580	1416	S>G		No	gnomAD
rs2147351814	1417	A>T		No	Ensembl
TCGA novel rs2147351798	1417	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs1321070645	1418	G>R		No	gnomAD
COSM6162464	1419	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2065858233	1419	E>D		No	Ensembl
rs1056628857	1419	E>K		No	TOPMed gnomAD
rs1056628857	1419	E>Q		No	TOPMed gnomAD
rs2147351653	1420	P>S		No	Ensembl
rs2065857818	1423	K>R		No	Ensembl
rs374294294	1424	L>V		No	ESP ExAC TOPMed gnomAD
COSM3842932 rs1300644254	1425	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA Cosmic
rs1440787898	1428	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs2147351482	1428	I>T		No	Ensembl
rs766461191	1429	K>R		No	ExAC TOPMed gnomAD
TCGA novel	1430	H>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs758755240	1430	H>N		No	ExAC gnomAD
rs758755240	1430	H>Y		No	ExAC gnomAD
rs2147351385	1431	Q>*		No	Ensembl
rs1471238582	1431	Q>H		No	gnomAD
rs2147351297	1434	K>M		No	Ensembl
rs2147351297	1434	K>R		No	Ensembl
rs2147351297	1434	K>T		No	Ensembl
rs1332845035	1436	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs765703084	1437	V>M		No	ExAC gnomAD
rs906945700	1438	D>G		No	Ensembl
rs2147351169	1438	D>N		No	Ensembl
rs1410388747	1439	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs2147351099	1440	V>I		No	Ensembl
rs1232704305	1441	Q>*		No	TOPMed gnomAD
rs2065855353	1442	K>E		No	TOPMed
rs2065855226	1442	K>R		No	TOPMed
rs370462169	1443	K>*		No	ESP ExAC TOPMed gnomAD
rs370462169	1443	K>E		No	ESP ExAC TOPMed gnomAD
rs764463882	1443	K>M		No	ExAC TOPMed gnomAD
rs764463882	1443	K>T		No	ExAC TOPMed gnomAD
rs761210103	1444	A>V		No	ExAC TOPMed gnomAD
rs1474596231	1446	Y>C		No	Ensembl
rs771557333	1447	T>A		No	ExAC gnomAD
rs376965540 COSM3555685	1448	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs376965540	1448	L>V		No	ESP ExAC TOPMed gnomAD
rs770735940	1450	D>N		No	ExAC TOPMed gnomAD
rs748998767	1451	T>M		No	ExAC TOPMed gnomAD
rs2147350630	1452	G>W		No	Ensembl
rs2147350535	1454	L>R		No	Ensembl
rs2147350468	1455	G>E		No	Ensembl
rs1302662221	1455	G>R		No	gnomAD
rs2147350449	1456	D>N		No	Ensembl
rs2147350449	1456	D>Y		No	Ensembl
rs372967126	1458	V>A		No	ESP ExAC TOPMed gnomAD
rs780069040	1460	Y>*		No	ExAC TOPMed gnomAD
rs758488420	1461	A>T		No	ExAC TOPMed gnomAD
TCGA novel	1463	L>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
rs2065851633	1463	L>V		No	Ensembl
rs764957819	1464	T>M		No	ExAC TOPMed gnomAD
rs2065803638	1464	T>S		No	gnomAD
rs1385164203	1465	V>A		No	gnomAD
rs1305130308	1465	V>L		No	gnomAD
rs768751941	1466	S>C		No	ExAC TOPMed gnomAD
rs1050704647	1466	S>R		No	TOPMed gnomAD
rs1233904904	1466	S>T		No	TOPMed gnomAD
rs1601680133	1467	V>G		No	Ensembl
rs746916579	1467	V>L		No	ExAC TOPMed gnomAD
rs746916579	1467	V>M		No	ExAC TOPMed gnomAD
rs998098306	1468	I>S		No	Ensembl
rs998098306	1468	I>T		No	Ensembl
rs774626695	1468	I>V		No	ExAC TOPMed gnomAD
rs2065801214	1469	V>E		No	TOPMed gnomAD
rs771037434	1469	V>M		No	ExAC TOPMed gnomAD
TCGA novel	1470	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2065800920	1470	Q>H		No	TOPMed
rs1249297625	1470	Q>R		No	TOPMed gnomAD
rs777991567	1472	E>K		No	ExAC gnomAD
rs2065800372	1473	G>E		No	TOPMed
rs748554523	1476	A>T		No	ExAC TOPMed gnomAD
rs1415622042	1478	P>A		No	TOPMed gnomAD
rs200623878 COSM479115	1478	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs375377088	1479	V>L		No	ESP ExAC gnomAD
rs371453551	1480	K>R		No	ESP TOPMed gnomAD
COSM726734	1483	N>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2065798686	1486	T>A		No	TOPMed
rs750949109	1488	S>F		No	TOPMed gnomAD
rs375291732	1490	V>I		No	ESP ExAC TOPMed gnomAD
rs2147341289	1493	K>R		No	Ensembl
COSM1417061	1493	K>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs764907177	1495	I>S		No	ExAC gnomAD
rs764907177	1495	I>T		No	ExAC gnomAD
rs1295164975	1495	I>V		No	TOPMed gnomAD
COSM1417060	1496	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1228305344	1498	V>L		No	TOPMed gnomAD
rs1569158038	1500	R>G		No	gnomAD
rs1470249034	1500	R>H		No	gnomAD
rs2065796632	1501	G>R		No	TOPMed
rs1183386920	1505	S>F		No	gnomAD
rs760760853	1505	S>P		No	ExAC gnomAD
rs1236891672	1507	W>*		No	gnomAD
rs1435511754	1507	W>R		No	gnomAD
COSM4105095	1509	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2065795403	1511	D>E		No	Ensembl
rs770930229	1512	S>R		No	ExAC gnomAD
rs371319008	1513	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs2147338161	1517	W>C		No	Ensembl
rs2065781631 TCGA novel	1518	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1320459935	1518	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs1227731618	1519	P>L		No	gnomAD
rs2147338021	1520	G>C		No	Ensembl
TCGA novel	1520	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1271760642	1521	S>F		No	gnomAD
rs1397852647	1522	T>A		No	gnomAD
TCGA novel	1522	T>G	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2065780810	1525	I>T		No	Ensembl
rs199650688	1527	S>L		No	ESP ExAC TOPMed gnomAD
rs2065779897	1532	T>M		No	TOPMed
rs1173302787	1534	Q>R		No	gnomAD
rs765375689	1535	R>Q		No	ExAC TOPMed gnomAD
rs751388537	1535	R>W		No	ExAC TOPMed gnomAD
rs761835002	1536	E>V		No	ExAC TOPMed gnomAD
rs1253547739	1537	G>D		No	TOPMed gnomAD
rs760860292	1538	R>P		No	ExAC gnomAD
rs760860292	1538	R>Q		No	ExAC gnomAD
rs182970183	1538	R>W		No	1000Genomes ExAC TOPMed gnomAD
rs1274952446	1539	W>*		No	gnomAD
rs2065778164	1540	K>E		No	TOPMed
rs772316395	1540	K>N		No	ExAC gnomAD
rs746387640	1541	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs779228197	1541	R>H		No	ExAC TOPMed gnomAD
rs201459786	1542	V>I		No	ESP ExAC TOPMed gnomAD
rs1355639445	1546	M>L		No	gnomAD
COSM3555683	1546	M>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1020608286	1550	V>A		No	Ensembl
rs746824032	1551	R>Q		No	ExAC TOPMed gnomAD
COSM4388812 rs1252245593	1551	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs2065768959	1553	G>R		No	Ensembl
rs1482115584	1553	G>V		No	gnomAD
rs1333570512	1556	L>F		No	TOPMed
rs750351888	1560	K>*		No	ExAC gnomAD
rs764161574	1560	K>N		No	ExAC gnomAD
rs2065767807	1561	V>L		No	Ensembl
rs2065767807	1561	V>M		No	Ensembl
rs1376846095	1562	G>R		No	TOPMed gnomAD
rs2065767058	1564	S>C		No	TOPMed gnomAD
rs78482989	1565	Q>E		No	TOPMed gnomAD
rs78482989	1565	Q>K		No	TOPMed gnomAD
rs971202428	1566	Q>L		No	TOPMed gnomAD
rs368368664	1567	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs1258381746	1568	E>Q		No	TOPMed
rs1601678196	1569	D>A		No	Ensembl
rs1156953455	1570	S>R		No	TOPMed gnomAD
rs2147334828	1572	Q>H		No	Ensembl
rs2065765441	1573	D>E		No	Ensembl
rs991130214	1575	P>L		No	TOPMed gnomAD
rs2147334729	1575	P>T		No	Ensembl
rs2065764729	1576	G>A		No	TOPMed gnomAD
rs759773127	1578	R>C		No	ExAC TOPMed gnomAD
rs1389925655	1578	R>L		No	TOPMed gnomAD
rs1389925655	1578	R>P		No	TOPMed gnomAD
rs759231441	1579	H>Y		No	Ensembl
rs765707742	1582	L>M		No	ExAC gnomAD
rs2065751238	1583	E>K		No	Ensembl
rs1207476773	1584	E>K		No	TOPMed gnomAD
rs986307397	1584	E>V		No	TOPMed
rs1467120511	1585	E>G		No	gnomAD
rs1464739619	1586	N>K		No	TOPMed gnomAD
TCGA novel	1586	N>T	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs762362721	1587	R>G		No	ExAC gnomAD
rs776067354	1587	R>L		No	ExAC TOPMed gnomAD
rs776067354	1587	R>Q		No	ExAC TOPMed gnomAD
rs762362721	1587	R>W		No	ExAC gnomAD
TCGA novel	1590	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM4105093	1593	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs768203410	1593	R>P		No	ExAC gnomAD
rs1431136184	1594	P>A		No	TOPMed gnomAD
rs760320759	1594	P>L		No	ExAC TOPMed gnomAD
rs2065748835	1595	T>I		No	TOPMed
rs879151685	1595	T>P		No	Ensembl
rs1199898952	1596	D>N		No	TOPMed gnomAD
rs2065748322	1596	D>V		No	TOPMed gnomAD
rs1601677213	1597	E>*		No	Ensembl
TCGA novel rs1601677213	1597	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2065747702	1598	V>L		No	Ensembl
rs1276759347	1599	D>G		No	gnomAD
rs1346012264	1599	D>N		No	gnomAD
rs2065746948	1600	E>Q		No	gnomAD
rs991246172	1601	G>C		No	TOPMed
rs749235325	1604	K>N		No	ExAC gnomAD
rs781136241	1605	R>K		No	ExAC gnomAD
rs966470315	1606	G>V		No	Ensembl
rs201644992	1607	S>R		No	ESP ExAC TOPMed gnomAD
rs574952389	1608	V>M		No	1000Genomes ExAC TOPMed gnomAD
rs1300839153	1610	E>G		No	TOPMed
rs1403924468	1611	K>N		No	gnomAD
rs1170507545	1612	E>D		No	TOPMed gnomAD
rs770516365	1613	R>Q		No	ExAC TOPMed gnomAD
TCGA novel rs1465229293	1613	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs541570546	1614	T>M		No	1000Genomes ExAC TOPMed gnomAD
rs2065743539	1615	K>E		No	Ensembl
rs1232695446	1615	K>T		No	gnomAD
rs762298147	1616	A>S		No	ExAC gnomAD
rs1198992174	1617	I>T		No	gnomAD
rs2065742264	1621	Y>C		No	gnomAD
rs1351428481	1623	T>M		No	gnomAD
rs1448652231	1624	R>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1448652231	1624	R>Q		No	TOPMed gnomAD
rs1275496634 COSM3065270	1624	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed
TCGA novel	1627	S>F	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1627	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1394044690	1629	K>R		No	gnomAD
rs1296480979	1636	V>M		No	TOPMed gnomAD
rs1401533379	1637	D>H		No	gnomAD
rs2065725558	1638	N>S		No	Ensembl
rs1348119470	1639	F>C		No	TOPMed
rs1173243448	1639	F>L		No	gnomAD
rs866299424	1640	F>C		No	Ensembl
rs866299424	1640	F>Y		No	Ensembl
TCGA novel	1641	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1476977067	1642	S>N		No	gnomAD
TCGA novel	1644	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1644	L>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs778176391	1645	A>V		No	ExAC gnomAD
rs762034126	1646	P>L		No	gnomAD
rs762034126	1646	P>R		No	gnomAD
rs748677291	1647	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs2065723269	1648	H>P		No	gnomAD
rs781634312	1649	A>T		No	ExAC TOPMed gnomAD
rs367781721	1649	A>V		No	1000Genomes ExAC TOPMed gnomAD
rs779415007	1650	V>M		No	ExAC TOPMed gnomAD
rs1454891870	1651	P>R		No	TOPMed gnomAD
rs187332808	1652	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs758133473	1652	P>S		No	ExAC gnomAD
COSM3842931	1653	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs765133194	1653	A>V		No	ExAC gnomAD
rs2147326505	1654	V>F		No	Ensembl
COSM6095530	1657	F>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs372267325	1658	F>C		No	ESP ExAC gnomAD
rs774549808	1658	F>L		No	ExAC TOPMed gnomAD
rs1320343171	1659	D>N		No	TOPMed gnomAD
rs1320343171	1659	D>Y		No	TOPMed gnomAD
rs1372120948	1660	F>Y		No	TOPMed
rs1438187906	1661	L>P		No	TOPMed
COSM6162465	1662	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs763241920	1663	E>*		No	ExAC TOPMed gnomAD
rs367804234	1663	E>G		No	ESP ExAC TOPMed gnomAD
rs763241920	1663	E>K		No	ExAC TOPMed gnomAD
rs2065719635	1664	Q>H		No	Ensembl
TCGA novel	1666	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2065719344	1668	H>Y		No	gnomAD
rs1176561848	1669	N>D		No	gnomAD
rs200372648	1670	I>M		No	ESP ExAC TOPMed gnomAD
rs1326950017	1670	I>V		No	TOPMed
rs962147918	1672	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs2147325981	1673	E>A		No	Ensembl
rs781512674	1675	T>P		No	ExAC
rs1201371323	1678	I>V		No	TOPMed gnomAD
rs867242805	1681	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
TCGA novel	1683	S>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs376134467	1685	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	1685	P>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM5808801	1687	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1417059 rs1293031275	1687	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
COSM4396922 rs1219530033	1688	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic gnomAD
rs369909705	1691	N>S		No	ESP ExAC TOPMed gnomAD
rs1428590987	1693	L>F		No	TOPMed gnomAD
rs1271536295	1697	H>Q		No	TOPMed gnomAD
rs747941915	1699	I>V		No	ExAC gnomAD
rs375503886	1701	D>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2147322796	1702	V>M		No	Ensembl
rs751428804	1703	H>N		No	ExAC gnomAD
TCGA novel	1703	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs886094009	1704	V>I		No	TOPMed
rs1433328187 TCGA novel	1706	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1433328187	1706	E>K		No	gnomAD
rs1193468437	1708	V>A		No	gnomAD
rs2065699694	1708	V>M		No	Ensembl
rs1272970809	1710	A>D		No	TOPMed gnomAD
rs1272970809	1710	A>V		No	TOPMed gnomAD
rs1199622252	1711	S>L		No	TOPMed gnomAD
rs764267512	1713	S>L		No	ExAC gnomAD
rs1300156762	1718	T>N		No	TOPMed gnomAD
rs1300156762	1718	T>S		No	TOPMed gnomAD
rs2065697435	1720	M>L		No	TOPMed
rs780142749	1724	T>M		No	ExAC TOPMed gnomAD
rs1466941704	1725	R>C		No	gnomAD
rs772755944	1725	R>H		No	ExAC gnomAD
rs769389364	1726	T>A		No	ExAC TOPMed gnomAD
rs201182504	1726	T>M		No	ExAC TOPMed gnomAD
rs1465673046	1728	H>Y		No	Ensembl
rs768379764	1732	R>H		No	ExAC TOPMed gnomAD
COSM125457	1734	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1601670501	1734	S>P		No	Ensembl
rs1158354478	1736	S>N		No	gnomAD
rs1569155486	1738	K>E		No	Ensembl
TCGA novel	1739	L>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1218834335	1746	S>F		No	gnomAD
rs752886171	1747	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
TCGA novel	1749	K>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs929270769	1753	E>K		No	TOPMed
rs763593218	1754	D>E		No	ExAC gnomAD
rs201613066	1754	D>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs769993436	1754	D>N		No	ExAC TOPMed gnomAD
TCGA novel	1756	Y>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2065623304	1757	K>E		No	TOPMed
rs775068552	1757	K>R		No	ExAC TOPMed gnomAD
rs887763291	1758	G>R		No	TOPMed gnomAD
rs770951350	1760	R>L		No	ExAC TOPMed gnomAD
rs770951350	1760	R>Q		No	ExAC TOPMed gnomAD
rs759338193	1760	R>W		No	ExAC gnomAD
rs1330311129	1761	Q>R		No	TOPMed
rs1440319925	1769	D>E		No	TOPMed gnomAD
rs542604025	1772	T>A		No	1000Genomes ExAC TOPMed gnomAD
rs1334927536	1772	T>R		No	gnomAD
rs1268844021	1773	H>Q		No	Ensembl
rs1047747817	1773	H>R		No	TOPMed
TCGA novel	1774	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs746289473	1775	A>E		No	ExAC TOPMed gnomAD
rs1172981267	1776	E>D		No	gnomAD
rs372200489	1779	R>W		No	ESP ExAC TOPMed gnomAD
COSM1035400 rs372835571	1780	A>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
rs1309378692	1780	A>V		No	TOPMed gnomAD
rs180698014	1781	H>D		No	1000Genomes ESP ExAC TOPMed gnomAD
rs180698014	1781	H>Y		No	1000Genomes ESP ExAC TOPMed gnomAD
rs779890038	1782	T>M		No	ExAC TOPMed gnomAD
rs779890038	1782	T>R		No	ExAC TOPMed gnomAD
rs750299230	1783	D>E		No	ExAC gnomAD
rs376188298	1784	S>F		No	ESP ExAC TOPMed gnomAD
rs376188298	1784	S>Y		No	ESP ExAC TOPMed gnomAD
rs1375725610	1788	L>F		No	TOPMed
rs1370869646	1788	L>H		No	gnomAD
rs763150093 COSM3390302	1789	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs1254116165	1791	L>F		No	gnomAD
COSM4105089	1791	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs748709582	1797	Y>C		No	1000Genomes ExAC gnomAD
rs2065520014	1797	Y>H		No	Ensembl
rs373532871	1798	T>M		No	ESP ExAC TOPMed gnomAD
rs2065519712	1798	T>P		No	Ensembl
rs746546029	1799	Q>R		No	ExAC gnomAD
COSM4105088 rs779693958 COSM4105087	1801	Y>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs778866905	1803	D>E		No	ExAC TOPMed gnomAD
rs1569154158	1804	E>D		No	TOPMed gnomAD
rs149124212	1804	E>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1348330492	1805	I>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1805	I>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel rs2065505648	1806	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
COSM1566390 COSM4782503	1809	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs759161065	1811	E>D		No	ExAC TOPMed gnomAD
rs1569153963	1811	E>K		No	TOPMed
rs1460120176	1812	D>N		No	TOPMed gnomAD
TCGA novel	1814	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs748967251	1815	A>S		No	ExAC TOPMed gnomAD
rs748967251	1815	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs777436314	1815	A>V		No	ExAC gnomAD
rs1319632932	1818	M>R		No	gnomAD
rs769581020	1819	Q>E		No	ExAC gnomAD
rs1383318844	1819	Q>H		No	TOPMed gnomAD
rs2065503091	1821	A>S		No	TOPMed
rs1168942832	1821	A>V		No	TOPMed gnomAD
rs1022211560	1822	F>L		No	TOPMed gnomAD
rs1420220256	1822	F>Y		No	gnomAD
COSM4810844 COSM1308289	1826	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1472547858	1827	I>V		No	TOPMed gnomAD
rs866516387	1828	A>V		No	Ensembl
TCGA novel	1829	A>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs750555906	1829	A>T		No	ExAC gnomAD
rs1445164904	1830	A>T		No	TOPMed gnomAD
rs1363450719	1830	A>V		No	TOPMed gnomAD
rs2065500450	1831	L>V		No	TOPMed
rs2147287143	1834	K>E		No	Ensembl
rs754031063	1835	V>I		No	ExAC TOPMed gnomAD
rs991382066	1836	T>A		No	Ensembl
rs2065499062	1836	T>I		No	Ensembl

No associated diseases with O15031

2 regional properties for O15031

Type	Name	Position	InterPro Accession
domain	Pectinesterase, catalytic	255 - 551	IPR000070
domain	Pectinesterase inhibitor domain	40 - 209	IPR006501

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cell surface	The external part of the cell wall and/or plasma membrane.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
semaphorin receptor complex	A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.

1 GO annotations of molecular function

Name	Definition
semaphorin receptor activity	Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

16 GO annotations of biological process

Name	Definition
brain development	The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
excitatory synapse assembly	The aggregation, arrangement and bonding together of a set of components to form an excitatory synapse.
homophilic cell adhesion via plasma membrane adhesion molecules	The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
negative regulation of cell adhesion	Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
neural tube closure	The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
neuroblast proliferation	The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.
positive regulation of axonogenesis	Any process that activates or increases the frequency, rate or extent of axonogenesis.
positive regulation of neuron projection development	Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
positive regulation of translation	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
regulation of cell migration	Any process that modulates the frequency, rate or extent of cell migration.
regulation of cell shape	Any process that modulates the surface configuration of a cell.
regulation of GTPase activity	Any process that modulates the rate of GTP hydrolysis by a GTPase.
regulation of neuron migration	Any process that modulates the frequency, rate or extent of neuron migration.
regulation of protein phosphorylation	Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
semaphorin-plexin signaling pathway	The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
semaphorin-plexin signaling pathway involved in axon guidance	Any semaphorin-plexin signaling pathway that is involved in axon guidance.

27 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q769I5	MET	Hepatocyte growth factor receptor	Bos taurus (Bovine)	PR
A0M8S8	MET	Hepatocyte growth factor receptor	Felis catus (Cat) (Felis silvestris catus)	PR
Q04912	MST1R	Macrophage-stimulating protein receptor	Homo sapiens (Human)	EV
P08581	MET	Hepatocyte growth factor receptor	Homo sapiens (Human)	EV
P51805	PLXNA3	Plexin-A3	Homo sapiens (Human)	SS
Q9UIW2	PLXNA1	Plexin-A1	Homo sapiens (Human)	EV SS
Q9ULL4	PLXNB3	Plexin-B3	Homo sapiens (Human)	SS
O75051	PLXNA2	Plexin-A2	Homo sapiens (Human)	SS
O43157	PLXNB1	Plexin-B1	Homo sapiens (Human)	EV SS
Q9HCM2	PLXNA4	Plexin-A4	Homo sapiens (Human)	SS
Q9QY40	Plxnb3	Plexin-B3	Mus musculus (Mouse)	SS
P70208	Plxna3	Plexin-A3	Mus musculus (Mouse)	EV SS
Q3UH93	Plxnd1	Plexin-D1	Mus musculus (Mouse)	SS
P70207	Plxna2	Plexin-A2	Mus musculus (Mouse)	SS
Q62190	Mst1r	Macrophage-stimulating protein receptor	Mus musculus (Mouse)	SS
Q8CJH3	Plxnb1	Plexin-B1	Mus musculus (Mouse)	SS
Q9QZC2	Plxnc1	Plexin-C1	Mus musculus (Mouse)	SS
Q80UG2	Plxna4	Plexin-A4	Mus musculus (Mouse)	SS
P16056	Met	Hepatocyte growth factor receptor	Mus musculus (Mouse)	PR
P70206	Plxna1	Plexin-A1	Mus musculus (Mouse)	EV SS
B2RXS4	Plxnb2	Plexin-B2	Mus musculus (Mouse)	SS
Q2QLE0	MET	Hepatocyte growth factor receptor	Sus scrofa (Pig)	PR
P97523	Met	Hepatocyte growth factor receptor	Rattus norvegicus (Rat)	PR
D3ZPX4	Plxna3	Plexin-A3	Rattus norvegicus (Rat)	SS
D3ZLH5	Plxnb3	Plexin-B3	Rattus norvegicus (Rat)	SS
Q6BEA0	plxna4	Plexin-A4	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
B0S5N4	plxna3	Plexin A3	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MALQLWALTL	LGLLGAGASL	RPRKLDFFRS	EKELNHLAVD	EASGVVYLGA	VNALYQLDAK
70	80	90	100	110	120
LQLEQQVATG	PALDNKKCTP	PIEASQCHEA	EMTDNVNQLL	LLDPPRKRLV	ECGSLFKGIC
130	140	150	160	170	180
ALRALSNISL	RLFYEDGSGE	KSFVASNDEG	VATVGLVSST	GPGGDRVLFV	GKGNGPHDNG
190	200	210	220	230	240
IIVSTRLLDR	TDSREAFEAY	TDHATYKAGY	LSTNTQQFVA	AFEDGPYVFF	VFNQQDKHPA
250	260	270	280	290	300
RNRTLLARMC	REDPNYYSYL	EMDLQCRDPD	IHAAAFGTCL	AASVAAPGSG	RVLYAVFSRD
310	320	330	340	350	360
SRSSGGPGAG	LCLFPLDKVH	AKMEANRNAC	YTGTREARDI	FYKPFHGDIQ	CGGHAPGSSK
370	380	390	400	410	420
SFPCGSEHLP	YPLGSRDGLR	GTAVLQRGGL	NLTAVTVAAE	NNHTVAFLGT	SDGRILKVYL
430	440	450	460	470	480
TPDGTSSEYD	SILVEINKRV	KRDLVLSGDL	GSLYAMTQDK	VFRLPVQECL	SYPTCTQCRD
490	500	510	520	530	540
SQDPYCGWCV	VEGRCTRKAE	CPRAEEASHW	LWSRSKSCVA	VTSAQPQNMS	RRAQGEVQLT
550	560	570	580	590	600
VSPLPALSEE	DELLCLFGES	PPHPARVEGE	AVICNSPSSI	PVTPPGQDHV	AVTIQLLLRR
610	620	630	640	650	660
GNIFLTSYQY	PFYDCRQAMS	LEENLPCISC	VSNRWTCQWD	LRYHECREAS	PNPEDGIVRA
670	680	690	700	710	720
HMEDSCPQFL	GPSPLVIPMN	HETDVNFQGK	NLDTVKGSSL	HVGSDLLKFM	EPVTMQESGT
730	740	750	760	770	780
FAFRTPKLSH	DANETLPLHL	YVKSYGKNID	SKLHVTLYNC	SFGRSDCSLC	RAANPDYRCA
790	800	810	820	830	840
WCGGQSRCVY	EALCNTTSEC	PPPVITRIQP	ETGPLGGGIR	ITILGSNLGV	QAGDIQRISV
850	860	870	880	890	900
AGRNCSFQPE	RYSVSTRIVC	VIEAAETPFT	GGVEVDVFGK	LGRSPPNVQF	TFQQPKPLSV
910	920	930	940	950	960
EPQQGPQAGG	TTLTIHGTHL	DTGSQEDVRV	TLNGVPCKVT	KFGAQLQCVT	GPQATRGQML
970	980	990	1000	1010	1020
LEVSYGGSPV	PNPGIFFTYR	ENPVLRAFEP	LRSFASGGRS	INVTGQGFSL	IQRFAMVVIA
1030	1040	1050	1060	1070	1080
EPLQSWQPPR	EAESLQPMTV	VGTDYVFHND	TKVVFLSPAV	PEEPEAYNLT	VLIEMDGHRA
1090	1100	1110	1120	1130	1140
LLRTEAGAFE	YVPDPTFENF	TGGVKKQVNK	LIHARGTNLN	KAMTLQEAEA	FVGAERCTMK
1150	1160	1170	1180	1190	1200
TLTETDLYCE	PPEVQPPPKR	RQKRDTTHNL	PEFIVKFGSR	EWVLGRVEYD	TRVSDVPLSL
1210	1220	1230	1240	1250	1260
ILPLVIVPMV	VVIAVSVYCY	WRKSQQAERE	YEKIKSQLEG	LEESVRDRCK	KEFTDLMIEM
1270	1280	1290	1300	1310	1320
EDQTNDVHEA	GIPVLDYKTY	TDRVFFLPSK	DGDKDVMITG	KLDIPEPRRP	VVEQALYQFS
1330	1340	1350	1360	1370	1380
NLLNSKSFLI	NFIHTLENQR	EFSARAKVYF	ASLLTVALHG	KLEYYTDIMH	TLFLELLEQY
1390	1400	1410	1420	1430	1440
VVAKNPKLML	RRSETVVERM	LSNWMSICLY	QYLKDSAGEP	LYKLFKAIKH	QVEKGPVDAV
1450	1460	1470	1480	1490	1500
QKKAKYTLND	TGLLGDDVEY	APLTVSVIVQ	DEGVDAIPVK	VLNCDTISQV	KEKIIDQVYR
1510	1520	1530	1540	1550	1560
GQPCSCWPRP	DSVVLEWRPG	STAQILSDLD	LTSQREGRWK	RVNTLMHYNV	RDGATLILSK
1570	1580	1590	1600	1610	1620
VGVSQQPEDS	QQDLPGERHA	LLEEENRVWH	LVRPTDEVDE	GKSKRGSVKE	KERTKAITEI
1630	1640	1650	1660	1670	1680
YLTRLLSVKG	TLQQFVDNFF	QSVLAPGHAV	PPAVKYFFDF	LDEQAEKHNI	QDEDTIHIWK
1690	1700	1710	1720	1730	1740
TNSLPLRFWV	NILKNPHFIF	DVHVHEVVDA	SLSVIAQTFM	DACTRTEHKL	SRDSPSNKLL
1750	1760	1770	1780	1790	1800
YAKEISTYKK	MVEDYYKGIR	QMVQVSDQDM	NTHLAEISRA	HTDSLNTLVA	LHQLYQYTQK
1810	1820	1830
YYDEIINALE	EDPAAQKMQL	AFRLQQIAAA	LENKVTDL