AiPD: Autoinhibited Protein Database

O14813

Gene name	PHOX2A (ARIX, PMX2A)
Protein name	Paired mesoderm homeobox protein 2A
Names	ARIX1 homeodomain protein, Aristaless homeobox protein homolog, Paired-like homeobox 2A
Species	Homo sapiens (Human)
KEGG Pathway	hsa:401
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-284 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-284 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for O14813

Entry ID	Method	Resolution	Chain	Position	Source
AF-O14813-F1	Predicted				AlphaFoldDB

204 variants for O14813

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV000007242 VAR_019014 CA253980 rs104894269	72	A>V	Fibrosis of extraocular muscles, congenital, 2 Fibrosis of extraocular muscles, congenital, 2 (cfeom2) CFEOM2 [ClinVar, Ensembl, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
rs1590729728 CA381748258	6	L>P		No	ClinGen Ensembl
CA381748242 rs1411232386	7	N>S		No	ClinGen TOPMed
TCGA novel	8	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762717173 CA6170949	11	S>L		No	ClinGen ExAC TOPMed gnomAD
CA224386690 rs911631321	13	V>L		No	ClinGen Ensembl
CA224386688 rs987010045	14	A>E		No	ClinGen TOPMed
rs987010045 CA224386687	14	A>V		No	ClinGen TOPMed
rs771380172 CA6170943	16	M>I		No	ClinGen ExAC TOPMed gnomAD
CA6170945 rs777047193	16	M>K		No	ClinGen ExAC TOPMed gnomAD
CA381748068 rs1590729705	16	M>L		No	ClinGen Ensembl
rs777047193 CA6170946	16	M>R		No	ClinGen ExAC TOPMed gnomAD
rs777047193 CA6170944	16	M>T		No	ClinGen ExAC TOPMed gnomAD
rs1479879253 CA381747991	18	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA381747949 rs1203339283	20	A>T		No	ClinGen TOPMed
TCGA novel	20	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381747419 rs1443141971	22	G>D		No	ClinGen TOPMed
CA224385911 rs954354297	22	G>R		No	ClinGen Ensembl
CA224385909 rs866212469	26	A>S		No	ClinGen Ensembl
CA381747220 rs1387578668	27	C>R		No	ClinGen gnomAD
CA6170938 rs778949321	30	P>A		No	ClinGen ExAC gnomAD
rs1471742598 CA381747102	30	P>R		No	ClinGen TOPMed
CA6170936 rs750255258	31	G>D		No	ClinGen ExAC TOPMed gnomAD
CA381747046 rs1176426459	32	G>C		No	ClinGen gnomAD
TCGA novel CA381746899 rs1590729630	39	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
rs781012132 CA6170935	40	P>S		No	ClinGen ExAC gnomAD
CA381746846 rs757314327	42	F>L		No	ClinGen ExAC gnomAD
rs757314327 CA6170934	42	F>V		No	ClinGen ExAC gnomAD
rs1253973213 CA381746813	43	P>R		No	ClinGen gnomAD
rs1396118353 CA381746762	46	G>R		No	ClinGen TOPMed
CA224385854 rs962759002	48	P>L		No	ClinGen Ensembl
rs1335560338 CA381746714	48	P>S		No	ClinGen TOPMed
rs1590729608 CA381746657	50	P>A		No	ClinGen Ensembl
CA381746604 rs1447989710	52	L>V		No	ClinGen TOPMed
rs1323014867 CA381746583	53	G>R		No	ClinGen gnomAD
rs1344828352 CA381746541	56	N>D		No	ClinGen TOPMed
CA381746538 rs1226641955	56	N>S		No	ClinGen TOPMed
rs763728508 CA6170932	58	A>S		No	ClinGen ExAC TOPMed gnomAD
CA224385844 rs1004154644	61	A>S		No	ClinGen Ensembl
TCGA novel	62	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA224385838 rs12787525	62	L>V		No	ClinGen Ensembl
CA381746325 rs1284175404	63	R>S		No	ClinGen gnomAD
CA381746246 rs1225639714	65	H>N		No	ClinGen TOPMed gnomAD
CA6170929 rs764865688	68	A>P		No	ClinGen ExAC TOPMed gnomAD
rs1182968835 CA381746160	69	P>R		No	ClinGen TOPMed
CA381746104 rs1248558741	72	A>T		No	ClinGen TOPMed
rs1284011059 CA381745151	73	V>E		No	ClinGen TOPMed gnomAD
CA381745146 rs1284011059	73	V>G		No	ClinGen TOPMed gnomAD
CA381745102 rs1461590608	75	Y>F		No	ClinGen gnomAD
CA381745074 rs1278389052	76	K>T		No	ClinGen TOPMed
TCGA novel	77	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381744961 rs1205778370	79	P>S		No	ClinGen gnomAD
CA224384479 rs1038890031	82	S>A		No	ClinGen TOPMed gnomAD
CA6170883 rs777678122	82	S>C		No	ClinGen ExAC TOPMed gnomAD
rs777678122 CA381744881	82	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1038890031 CA381744888	82	S>T		No	ClinGen TOPMed gnomAD
CA381744868 rs1488036379	83	G>D		No	ClinGen TOPMed
CA6170881 rs148937033	85	H>Y		No	ClinGen ESP ExAC gnomAD
rs145702565 CA6170880	86	E>Q		No	ClinGen ESP ExAC gnomAD
CA224384446 rs941856331	87	K>E		No	ClinGen Ensembl
rs370435269 CA381744778	88	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs370435269 CA6170878	88	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6170879 rs370435269	88	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1238984969 CA381744737	90	Q>*		No	ClinGen gnomAD
TCGA novel	91	R>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381744709 rs1189345596	91	R>Q		No	ClinGen TOPMed
TCGA novel	92	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6170875 rs750831247	93	I>L		No	ClinGen ExAC
rs1015776934 CA224384415	93	I>N		No	ClinGen TOPMed
CA381744658 rs1261137367	94	R>H		No	ClinGen gnomAD
rs1003429384 CA224384410	96	T>A		No	ClinGen TOPMed
CA381744587 rs1329217738	96	T>M		No	ClinGen Ensembl
rs767850424 CA6170874	98	T>A		No	ClinGen ExAC gnomAD
CA381744510 rs1289489074	99	S>R		No	ClinGen gnomAD
rs774881202 CA6170872	103	K>E		No	ClinGen ExAC gnomAD
CA6170869 rs775706276	110	A>V		No	ClinGen ExAC TOPMed gnomAD
CA6170867 rs545021626	111	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA381744291 rs545021626	111	E>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs577206882 CA6170866	112	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771856914 CA6170865	113	H>P		No	ClinGen ExAC TOPMed gnomAD
rs748036118 COSM1676278 CA6170864	116	D>A	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA6170862 rs754855249	119	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1477474721 CA381744068	120	R>C		No	ClinGen gnomAD
CA381744020 rs1353217375	122	E>A		No	ClinGen TOPMed
rs1421335811 CA381743996	123	L>P		No	ClinGen gnomAD
rs559070400 CA6170861	125	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	128	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1219714470 CA381743890	128	D>Y		No	ClinGen gnomAD
rs755816300 CA6170859	133	R>C		No	ClinGen ExAC gnomAD
CA381743818 rs1198361707	133	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs915684860 CA224383895	141	R>H		No	ClinGen TOPMed gnomAD
CA381743498 rs915684860	141	R>P		No	ClinGen TOPMed gnomAD
CA6170841 rs745524146	143	A>S		No	ClinGen ExAC gnomAD
TCGA novel	144	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1382912704 CA381743419	147	K>Q		No	ClinGen gnomAD
rs1280398620 CA381743395	148	Q>E		No	ClinGen gnomAD
rs991221797 CA224383889	149	E>G		No	ClinGen TOPMed gnomAD
CA381743355 rs1350964049	150	R>C		No	ClinGen TOPMed gnomAD
rs1350964049 CA381743352	150	R>S		No	ClinGen TOPMed gnomAD
CA381743332 rs1311222076	151	A>P		No	ClinGen gnomAD
CA381743333 rs1311222076	151	A>T		No	ClinGen gnomAD
rs957558168 CA224383881	151	A>V		No	ClinGen TOPMed
rs1445202690 CA381743291	153	S>R		No	ClinGen TOPMed gnomAD
rs1242525580 CA381743301	153	S>T		No	ClinGen TOPMed
rs1244727938 CA381743288	154	A>S		No	ClinGen TOPMed gnomAD
rs926105577 CA224383877	155	K>E		No	ClinGen TOPMed gnomAD
TCGA novel	156	G>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1301085829 CA381743221	158	A>E		No	ClinGen TOPMed gnomAD
rs1301085829 CA381743216	158	A>V		No	ClinGen TOPMed gnomAD
rs1450109937 CA381743192	160	A>E		No	ClinGen gnomAD
CA381743198 rs1394206962	160	A>P		No	ClinGen TOPMed
rs1160019132 CA381743177	161	A>G		No	ClinGen TOPMed
rs756847839 CA6170839	162	G>S		No	ClinGen ExAC gnomAD
rs965362508 CA224383848	162	G>V		No	ClinGen TOPMed gnomAD
rs1382348317 CA381743154	163	A>S		No	ClinGen TOPMed gnomAD
CA381743158 rs1382348317	163	A>T		No	ClinGen TOPMed gnomAD
rs1324838199 CA381743145	163	A>V		No	ClinGen TOPMed
CA224383835 rs1019376816	164	K>R		No	ClinGen TOPMed gnomAD
CA224383829 rs910787400	165	K>E		No	ClinGen gnomAD
CA224383824 rs749817345	167	E>G		No	ClinGen Ensembl
rs1307339741 CA381743109	167	E>K		No	ClinGen TOPMed
rs751993661 CA6170836	168	A>T		No	ClinGen ExAC gnomAD
CA224383822 rs1008875170	169	R>C		No	ClinGen TOPMed
rs1412078000 CA381743080	170	C>R		No	ClinGen TOPMed gnomAD
CA381743060 rs1184175409	171	S>F		No	ClinGen TOPMed gnomAD
CA381743045 rs1486253537	173	E>K		No	ClinGen gnomAD
rs984798743 CA224383820	174	D>H		No	ClinGen gnomAD
CA381743031 rs984798743	174	D>N		No	ClinGen gnomAD
CA381743010 rs773687701 CA224383817	175	D>E		No	ClinGen TOPMed gnomAD
rs1487117889 CA381742952	179	E>G		No	ClinGen gnomAD
CA381742934 rs1262176473	180	S>C		No	ClinGen gnomAD
rs1262176473 CA381742936	180	S>Y		No	ClinGen gnomAD
rs1239276842 CA381742922	181	T>M		No	ClinGen gnomAD
rs1457992431 CA381742903	182	C>W		No	ClinGen TOPMed
rs1320953420 CA381742868	185	T>A		No	ClinGen gnomAD
CA381742859 rs1310241620	185	T>M		No	ClinGen gnomAD
CA381742849 rs1180189292	186	P>S		No	ClinGen TOPMed
rs1297679762 CA381742828	187	D>G		No	ClinGen gnomAD
rs1355965853 CA381742834	187	D>N		No	ClinGen gnomAD
rs1469218529 CA381742790	189	T>I		No	ClinGen TOPMed
CA381742763 rs1362501840	191	S>*		No	ClinGen gnomAD
CA6170832 rs765408975	193	P>L		No	ClinGen ExAC gnomAD
rs1457587202 CA381742737	193	P>S		No	ClinGen gnomAD
rs953362105 CA224383804	194	P>L		No	ClinGen TOPMed
rs1423476484 CA381742678	197	A>V		No	ClinGen gnomAD
CA381742660 rs1192102188	198	P>L		No	ClinGen gnomAD
rs1476578050 CA381742656	199	G>C		No	ClinGen gnomAD
CA381742653 rs1263202462	199	G>D		No	ClinGen gnomAD
rs1476578050 CA381742658	199	G>S		No	ClinGen gnomAD
CA381742599 rs994875339	202	S>I		No	ClinGen TOPMed gnomAD
rs994875339 CA224383788	202	S>T		No	ClinGen TOPMed gnomAD
rs1263486031 CA381742566	204	R>C		No	ClinGen gnomAD
rs1277530682 CA381742473	209	P>L		No	ClinGen gnomAD
CA224383785 rs993516462	209	P>S		No	ClinGen gnomAD
CA381742426 rs1376394068	211	P>L		No	ClinGen TOPMed
rs1328340353 CA381742432	211	P>S		No	ClinGen gnomAD
rs1436890474 CA381742176	225	Q>L		No	ClinGen TOPMed
CA6170828 rs753951866	226	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1295677456 CA381742039	230	A>T		No	ClinGen gnomAD
CA381741984 rs1399988331	232	W>C		No	ClinGen gnomAD
rs1471522999 CA381742007	232	W>G		No	ClinGen TOPMed
rs760780805 CA6170826	233	A>T		No	ClinGen ExAC TOPMed gnomAD
CA381741940 rs1467545612	235	V>M		No	ClinGen TOPMed
CA381741877 rs1467590627	238	G>C		No	ClinGen gnomAD
rs1415268847 CA381741814	240	G>D		No	ClinGen TOPMed
CA381741823 rs1396164038	240	G>S		No	ClinGen TOPMed
rs1338843952 CA381741789	241	G>A		No	ClinGen TOPMed
rs1195075946 CA381741742	243	P>T		No	ClinGen TOPMed gnomAD
TCGA novel	248	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1411367861 CA381741641	248	A>T		No	ClinGen gnomAD
rs1045829640 CA224383748	249	E>*		No	ClinGen TOPMed
CA381741115 rs1280277327	253	A>G		No	ClinGen TOPMed
rs999870931 CA224383736	253	A>S		No	ClinGen Ensembl
CA6170824 rs768291497	255	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA381741061 rs1041507260	256	P>L		No	ClinGen TOPMed gnomAD
rs1041507260 CA381741065 VAR_019016	256	P>Q	may be involved in congenital central hypoventilation syndrome [UniProt]	No	ClinGen UniProt TOPMed dbSNP gnomAD
CA224383734 rs1041507260	256	P>R		No	ClinGen TOPMed gnomAD
CA6170821 rs769308284	258	E>V		No	ClinGen ExAC gnomAD
rs780563989 CA6170819	260	G>D		No	ClinGen ExAC TOPMed gnomAD
CA6170820 rs745442750	260	G>S		No	ClinGen ExAC TOPMed gnomAD
CA381741018 rs1400298597	261	P>S		No	ClinGen TOPMed
CA381741013 rs1397771255	262	G>R		No	ClinGen TOPMed gnomAD
CA381741001 rs1401776265	263	P>S		No	ClinGen TOPMed
CA6170818 rs770665117	264	F>C		No	ClinGen ExAC gnomAD
rs746592765 CA6170817	265	S>P		No	ClinGen ExAC TOPMed gnomAD
CA224383690 rs867393034	266	G>W		No	ClinGen TOPMed gnomAD
CA6170815 rs758767848	267	V>I		No	ClinGen ExAC gnomAD
CA6170816 rs758767848	267	V>L		No	ClinGen ExAC gnomAD
CA381740942 rs1276286873	269	S>F		No	ClinGen TOPMed
rs1237349515 CA381740905	272	H>Q		No	ClinGen TOPMed gnomAD
rs1590726449 CA381740913	272	H>Y		No	ClinGen Ensembl
rs779617832 CA6170813	273	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs755534664 CA6170812	274	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs1175201206 CA381740863	276	G>D		No	ClinGen TOPMed gnomAD
rs766349697 CA6170810	278	A>T		No	ClinGen ExAC gnomAD
rs1343043756 CA381740845	278	A>V		No	ClinGen TOPMed gnomAD
rs935695907 CA224383677	279	L>P		No	ClinGen TOPMed gnomAD
rs750573956 CA6170808	280	K>*		No	ClinGen ExAC gnomAD
rs763955171 CA6170807	281	T>I		No	ClinGen ExAC gnomAD
CA224383653 rs926116966	282	N>D		No	ClinGen TOPMed
rs576149067 CA6170806	282	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA381740822 rs1590726393	283	L>I		No	ClinGen Ensembl
rs1336693230 CA381740810	284	F>L		No	ClinGen gnomAD
rs1334157215 CA381740807	285	F>Q		No	ClinGen gnomAD

1 associated diseases with O14813

[MIM: 600348]: Band heterotopia (BH)

A brain malformation of the lissencephaly spectrum, resulting from disordered neuronal migration and characterized by bands of gray matter interposed in the central white matter. Disease features include severe developmental delay with intellectual disability, enlarged head circumference, periventricular and ribbon-like subcortical heterotopia, polymicrogyria and agenesis of the corpus callosum. {ECO:0000269|PubMed:24859200, ECO:0000269|PubMed:28556411}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID

A brain malformation of the lissencephaly spectrum, resulting from disordered neuronal migration and characterized by bands of gray matter interposed in the central white matter. Disease features include severe developmental delay with intellectual disability, enlarged head circumference, periventricular and ribbon-like subcortical heterotopia, polymicrogyria and agenesis of the corpus callosum. {ECO:0000269|PubMed:24859200, ECO:0000269|PubMed:28556411}. Note=The disease is caused by variants affecting the gene represented in this entry.

5 regional properties for O14813

Type	Name	Position	InterPro Accession
conserved_site	ATP-dependent RNA helicase DEAD-box, conserved site	227 - 235	IPR000629
domain	Helicase, C-terminal	292 - 456	IPR001650
domain	DEAD/DEAH box helicase domain	101 - 268	IPR011545
domain	Helicase superfamily 1/2, ATP-binding domain	96 - 296	IPR014001
domain	RNA helicase, DEAD-box type, Q motif	77 - 105	IPR014014

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name	Definition
DNA-binding transcription activator activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II transcription regulatory region sequence-specific DNA binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

12 GO annotations of biological process

Name	Definition
dopaminergic neuron differentiation	The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.
enteric nervous system development	The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation.
locus ceruleus development	The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.
midbrain development	The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).
noradrenergic neuron differentiation	The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline.
oculomotor nerve formation	The process that gives rise to the oculomotor nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of respiratory gaseous exchange	Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
somatic motor neuron differentiation	The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
sympathetic nervous system development	The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter.
trochlear nerve formation	The process that gives rise to the trochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle.

11 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8NHV9	RHOXF1	Rhox homeobox family member 1	Homo sapiens (Human)	PR
Q9BQY4	RHOXF2	Rhox homeobox family member 2	Homo sapiens (Human)	PR
O95076	ALX3	Homeobox protein aristaless-like 3	Homo sapiens (Human)	PR
Q99811	PRRX2	Paired mesoderm homeobox protein 2	Homo sapiens (Human)	PR
Q62066	Phox2a	Paired mesoderm homeobox protein 2A	Mus musculus (Mouse)	PR
P63013	Prrx1	Paired mesoderm homeobox protein 1	Mus musculus (Mouse)	PR
Q62782	Phox2a	Paired mesoderm homeobox protein 2A	Rattus norvegicus (Rat)	PR
Q7XUJ5	HOX22	Homeobox-leucine zipper protein HOX22	Oryza sativa subsp japonica (Rice)	PR
Q6H6S3	HOX24	Homeobox-leucine zipper protein HOX24	Oryza sativa subsp japonica (Rice)	PR
A3BYC1	HOX25	Homeobox-leucine zipper protein HOX25	Oryza sativa subsp japonica (Rice)	PR
Q9M276	ATHB-12	Homeobox-leucine zipper protein ATHB-12	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MDYSYLNSYD	SCVAAMEASA	YGDFGACSQP	GGFQYSPLRP	AFPAAGPPCP	ALGSSNCALG
70	80	90	100	110	120
ALRDHQPAPY	SAVPYKFFPE	PSGLHEKRKQ	RRIRTTFTSA	QLKELERVFA	ETHYPDIYTR
130	140	150	160	170	180
EELALKIDLT	EARVQVWFQN	RRAKFRKQER	AASAKGAAGA	AGAKKGEARC	SSEDDDSKES
190	200	210	220	230	240
TCSPTPDSTA	SLPPPPAPGL	ASPRLSPSPL	PVALGSGPGP	GPGPQPLKGA	LWAGVAGGGG
250	260	270	280
GGPGAGAAEL	LKAWQPAESG	PGPFSGVLSS	FHRKPGPALK	TNLF