O12990
PR
Gene name |
jak1 |
Protein name |
Tyrosine-protein kinase JAK1 |
Names |
Janus kinase 1, JAK-1 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
|
EC number |
2.7.10.2: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
(Annotation based on sequence homology with O60674)
JAK2 is tyrosine-protein kinase which mediates essential signaling events in both innate and adaptive immunity. JH2 domain inhibits its partnering JAK2 monomer. V617F substitution and autophosphorylation of Y570, located in the pseudokinase domain, relieves the autoinhibition of JAK2's kinase activity. The JAK2 pseudokinase domain negatively regulates the activity of JAK2. Kinase augments downstream JAK2-STAT signaling pathways are constitutively activated by the autoinhibition.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O12990
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O12990-F1 | Predicted | AlphaFoldDB |
No variants for O12990
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O12990 | |||||
No associated diseases with O12990
15 regional properties for O12990
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | FERM domain | 32 - 416 | IPR000299 |
| domain | Protein kinase domain | 580 - 846 | IPR000719-1 |
| domain | Protein kinase domain | 872 - 1150 | IPR000719-2 |
| domain | SH2 domain | 433 - 528 | IPR000980 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 581 - 843 | IPR001245-1 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 873 - 1145 | IPR001245-2 |
| active_site | Tyrosine-protein kinase, active site | 996 - 1008 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 878 - 905 | IPR017441 |
| domain | FERM central domain | 152 - 275 | IPR019748 |
| domain | Band 4.1 domain | 30 - 284 | IPR019749 |
| domain | Tyrosine-protein kinase, catalytic domain | 580 - 844 | IPR020635-1 |
| domain | Tyrosine-protein kinase, catalytic domain | 872 - 1146 | IPR020635-2 |
| domain | JAK, FERM F2 lobe domain | 145 - 275 | IPR041046 |
| domain | FERM F1 lobe ubiquitin-like domain | 34 - 126 | IPR041155 |
| domain | JAK1-3/TYK2, pleckstrin homology-like domain | 306 - 417 | IPR041381 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.2 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endomembrane system | A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cytokine receptor binding | Binding to a cytokine receptor. |
| growth hormone receptor binding | Binding to a growth hormone receptor. |
| metal ion binding | Binding to a metal ion. |
| non-membrane spanning protein tyrosine kinase activity | Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| cytokine-mediated signaling pathway | The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| growth hormone receptor signaling pathway via JAK-STAT | The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| receptor signaling pathway via JAK-STAT | Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins. |
| T cell differentiation in thymus | The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus. |
| tyrosine phosphorylation of STAT protein | The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. |
80 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A0JNB0 | FYN | Tyrosine-protein kinase Fyn | Bos taurus (Bovine) | SS |
| Q0VBZ0 | CSK | Tyrosine-protein kinase CSK | Bos taurus (Bovine) | SS |
| Q3ZC95 | BTK | Tyrosine-protein kinase | Bos taurus (Bovine) | EV SS |
| P42683 | LCK | Proto-oncogene tyrosine-protein kinase LCK | Gallus gallus (Chicken) | SS |
| P41239 | CSK | Tyrosine-protein kinase CSK | Gallus gallus (Chicken) | SS |
| P00523 | SRC | Proto-oncogene tyrosine-protein kinase Src | Gallus gallus (Chicken) | EV |
| Q02977 | YRK | Proto-oncogene tyrosine-protein kinase Yrk | Gallus gallus (Chicken) | SS |
| Q8JH64 | BTK | Tyrosine-protein kinase BTK | Gallus gallus (Chicken) | SS |
| P09324 | YES1 | Tyrosine-protein kinase Yes | Gallus gallus (Chicken) | SS |
| Q05876 | FYN | Tyrosine-protein kinase Fyn | Gallus gallus (Chicken) | SS |
| Q75R65 | JAK2 | Tyrosine-protein kinase JAK2 | Gallus gallus (Chicken) | SS |
| P08630 | Btk | Tyrosine-protein kinase Btk | Drosophila melanogaster (Fruit fly) | SS |
| Q9V9J3 | Src42A | Tyrosine-protein kinase Src42A | Drosophila melanogaster (Fruit fly) | SS |
| P00528 | Src64B | Tyrosine-protein kinase Src64B | Drosophila melanogaster (Fruit fly) | SS |
| Q24592 | hop | Tyrosine-protein kinase hopscotch | Drosophila melanogaster (Fruit fly) | PR |
| P41240 | CSK | Tyrosine-protein kinase CSK | Homo sapiens (Human) | SS |
| P51451 | BLK | Tyrosine-protein kinase Blk | Homo sapiens (Human) | SS |
| P06239 | LCK | Tyrosine-protein kinase Lck | Homo sapiens (Human) | EV |
| P06241 | FYN | Tyrosine-protein kinase Fyn | Homo sapiens (Human) | SS |
| P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Homo sapiens (Human) | SS |
| P12931 | SRC | Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (Human) | EV |
| P09769 | FGR | Tyrosine-protein kinase Fgr | Homo sapiens (Human) | SS |
| P42680 | TEC | Tyrosine-protein kinase Tec | Homo sapiens (Human) | SS |
| O60674 | JAK2 | Tyrosine-protein kinase JAK2 | Homo sapiens (Human) | EV |
| P42679 | MATK | Megakaryocyte-associated tyrosine-protein kinase | Homo sapiens (Human) | SS |
| P52333 | JAK3 | Tyrosine-protein kinase JAK3 | Homo sapiens (Human) | SS |
| Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Homo sapiens (Human) | EV |
| P07948 | LYN | Tyrosine-protein kinase Lyn | Homo sapiens (Human) | SS |
| P29597 | TYK2 | Non-receptor tyrosine-protein kinase TYK2 | Homo sapiens (Human) | EV |
| Q13882 | PTK6 | Protein-tyrosine kinase 6 | Homo sapiens (Human) | EV |
| P08631 | HCK | Tyrosine-protein kinase HCK | Homo sapiens (Human) | EV |
| P07947 | YES1 | Tyrosine-protein kinase Yes | Homo sapiens (Human) | SS |
| P42685 | FRK | Tyrosine-protein kinase FRK | Homo sapiens (Human) | EV |
| Q06187 | BTK | Tyrosine-protein kinase BTK | Homo sapiens (Human) | EV |
| P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Homo sapiens (Human) | SS |
| Q9R117 | Tyk2 | Non-receptor tyrosine-protein kinase TYK2 | Mus musculus (Mouse) | SS |
| P08103 | Hck | Tyrosine-protein kinase HCK | Mus musculus (Mouse) | SS |
| P16277 | Blk | Tyrosine-protein kinase Blk | Mus musculus (Mouse) | SS |
| Q62270 | Srms | Tyrosine-protein kinase Srms | Mus musculus (Mouse) | SS |
| Q64434 | Ptk6 | Protein-tyrosine kinase 6 | Mus musculus (Mouse) | SS |
| P05480 | Src | Proto-oncogene tyrosine-protein kinase Src | Mus musculus (Mouse) | EV |
| P14234 | Fgr | Tyrosine-protein kinase Fgr | Mus musculus (Mouse) | SS |
| P35991 | Btk | Tyrosine-protein kinase BTK | Mus musculus (Mouse) | EV |
| P41241 | Csk | Tyrosine-protein kinase CSK | Mus musculus (Mouse) | EV |
| P25911 | Lyn | Tyrosine-protein kinase Lyn | Mus musculus (Mouse) | EV |
| Q62137 | Jak3 | Tyrosine-protein kinase JAK3 | Mus musculus (Mouse) | SS |
| Q62120 | Jak2 | Tyrosine-protein kinase JAK2 | Mus musculus (Mouse) | EV |
| P06240 | Lck | Proto-oncogene tyrosine-protein kinase LCK | Mus musculus (Mouse) | SS |
| P24604 | Tec | Tyrosine-protein kinase Tec | Mus musculus (Mouse) | SS |
| Q04736 | Yes1 | Tyrosine-protein kinase Yes | Mus musculus (Mouse) | SS |
| P39688 | Fyn | Tyrosine-protein kinase Fyn | Mus musculus (Mouse) | SS |
| Q03526 | Itk | Tyrosine-protein kinase ITK/TSK | Mus musculus (Mouse) | SS |
| P41242 | Matk | Megakaryocyte-associated tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q922K9 | Frk | Tyrosine-protein kinase FRK | Mus musculus (Mouse) | SS |
| P52332 | Jak1 | Tyrosine-protein kinase JAK1 | Mus musculus (Mouse) | SS |
| A1Y2K1 | FYN | Tyrosine-protein kinase Fyn | Sus scrofa (Pig) | SS |
| O19064 | JAK2 | Tyrosine-protein kinase JAK2 | Sus scrofa (Pig) | SS |
| Q62662 | Frk | Tyrosine-protein kinase FRK | Rattus norvegicus (Rat) | SS |
| Q62844 | Fyn | Tyrosine-protein kinase Fyn | Rattus norvegicus (Rat) | SS |
| Q07014 | Lyn | Tyrosine-protein kinase Lyn | Rattus norvegicus (Rat) | SS |
| P50545 | Hck | Tyrosine-protein kinase HCK | Rattus norvegicus (Rat) | SS |
| Q9WUD9 | Src | Proto-oncogene tyrosine-protein kinase Src | Rattus norvegicus (Rat) | SS |
| Q01621 | Lck | Proto-oncogene tyrosine-protein kinase LCK | Rattus norvegicus (Rat) | SS |
| Q6P6U0 | Fgr | Tyrosine-protein kinase Fgr | Rattus norvegicus (Rat) | SS |
| Q62689 | Jak2 | Tyrosine-protein kinase JAK2 | Rattus norvegicus (Rat) | SS |
| Q63272 | Jak3 | Tyrosine-protein kinase JAK3 | Rattus norvegicus (Rat) | SS |
| P32577 | Csk | Tyrosine-protein kinase CSK | Rattus norvegicus (Rat) | SS |
| P41243 | Matk | Megakaryocyte-associated tyrosine-protein kinase | Rattus norvegicus (Rat) | SS |
| F1LM93 | Yes1 | Tyrosine-protein kinase Yes | Rattus norvegicus (Rat) | SS |
| O45539 | src-2 | Tyrosine protein-kinase src-2 | Caenorhabditis elegans | SS |
| G5ECJ6 | csk-1 | Tyrosine-protein kinase csk-1 | Caenorhabditis elegans | SS |
| G5EE56 | src-1 | Tyrosine protein-kinase src-1 | Caenorhabditis elegans | SS |
| Q94C77 | At4g34220 | Receptor protein kinase-like protein At4g34220 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WR59 | At5g10020 | Probable inactive receptor kinase At5g10020 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E991 | PRK6 | Pollen receptor-like kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGQ4 | MDIS2 | Protein MALE DISCOVERER 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A1A5H8 | yes1 | Tyrosine-protein kinase yes | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| F1RDG9 | fynb | Tyrosine-protein kinase fynb | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q1JPZ3 | src | Proto-oncogene tyrosine-protein kinase Src | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6EWH2 | fyna | Tyrosine-protein kinase fyna | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPELAVMDLG | RQLCVKMKKQ | RKAEMTIPTA | MKGLEIHFYL | ADTHQLEFFK | ACYTAEDLCV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EAAKRCRISP | LCHNLFALYE | ESQDLWYAPN | HVFKVTDETS | IKLHYRMRFY | FTNWHGTSEI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ESPVWRHTLS | KQKSVLNSQK | TTEGTPLLDA | ASLDYLFAQG | QYDFLRGLSP | VRPTQTDEEH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HEIENECLGM | AVLAITHHAK | SNNLPLSGAG | AETSYKRFIP | DSLNRTIKQR | NFLTRIRISN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VFKNFLNEFN | SKTIQDSNIG | LYDLKVKYLS | TLETLTQGVG | REIFKPKNLK | VTGESEGSPA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QMLPLGDNGM | GYEVQVYGTT | GISWRRKPAP | NQLILKDKPK | SKKIKGDKQW | NDKKKDSGWT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LFSDFHEITH | IVIKDCCVTI | YRQDNKTMEL | DLFYRDAALS | FAALVDGYFR | LTVDAHHYLC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TDVAPSSVVQ | NLENGCHGPI | CTEYAIHKLR | QEGNEEGTYV | LRWSCTEYNF | IIMTVVCIEL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DLCESRPVPQ | YKNFQIETSP | QGYRLYGTDT | FRPTLKELLE | HLQGQLLRTD | NLRFQLRRCC |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PPQPREISNL | LVMTTDREPV | PQKKTQVSQL | SFDRILKEEI | VQGEHLGRGT | RTNIYAGILK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PKSDDEDDLG | GYSQEVKVVL | KVLGSGHRDI | SLAFFETASM | MRQISHKHTA | LLYGVCVRHQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ENIMVEEFVQ | YGPLDLFMRR | QTTPLSTAWK | FQVAKQLASA | LSYLEDKKMV | HGYVCSKNIL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VARDGLDGEG | GPFIKLSDPG | IPITVLSREE | CVDRIPWIAP | ECVKDTANLT | IAADKWSFGT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TLWEICYNGE | IPLKDKKLSE | KERFYAAQCQ | LATPDCDELA | KLMTHCMTYD | PRQRLFFRAI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VRDIVMVEKQ | NPSIQPVPML | EVDPTVFEKR | FLKKIRDLGE | GHFGKVELCR | YDPRGDRTGE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LVAVKSLKPE | NREEQSNNLW | REIHILRELY | HENIVKYKGI | CNEEGGRSIK | LIMEFLPAGS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LKEYLPRNKA | HINLKTLHNY | SVQICQGMDY | LGSRNYIHRD | LAARNVLVEN | EGTVKIGDFG |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LTKSIKDNEG | YYTVKDDLDS | PVFWYAPECL | IHCKFYRASD | VWSFGVTMYE | LLTYCDASCS |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| PMSVFLKLIG | PTHGQMTVTR | LVKVLEEGKR | LPRPDDCSEQ | LYNLMRRCWE | ATPEKRIDFK |
| 1150 | |||||
| SLIANFQQML | DNL |