O09127
SS
Gene name |
Epha8 (Eek) |
Protein name |
Ephrin type-A receptor 8 |
Names |
EC 2.7.10.1 , EPH- and ELK-related kinase , Tyrosine-protein kinase receptor EEK |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:13842 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Ephrin type-B receptor 2 is a membrane-associated protein that mediates axon guidance, cell migration and morphogenesis. The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. The structure, supported by mutagenesis data, reveals that the juxtamembrane segment adopts a helical conformation that distorts the small lobe of the kinase domain, and blocks the activation segment from attaining an activated conformation. Phosphorylation of the conserved juxtamembrane tyrosines would relieve this autoinhibition by disturbing the association of the juxtamembrane segment with the kinase domain, while liberating phosphotyrosine sites for binding SH2 domains of target proteins.
Autoinhibitory domains (AIDs)
Target domain |
634-895 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for O09127
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O09127-F1 | Predicted | AlphaFoldDB |
64 variants for O09127
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388729316 | 36 | T>P | No | EVA | |
| rs3388724578 | 42 | D>E | No | EVA | |
| rs3388714153 | 43 | W>R | No | EVA | |
| rs3388720327 | 69 | Y>S | No | EVA | |
| rs3388710094 | 79 | Q>K | No | EVA | |
| rs3388719346 | 82 | W>* | No | EVA | |
| rs3388714188 | 107 | C>* | No | EVA | |
| rs3388723469 | 115 | G>D | No | EVA | |
| rs3388717011 | 122 | N>D | No | EVA | |
| rs3388723082 | 197 | R>Q | No | EVA | |
| rs3388725481 | 211 | A>V | No | EVA | |
| rs3394666449 | 224 | S>* | No | EVA | |
| rs3388729266 | 235 | H>L | No | EVA | |
| rs3388710110 | 244 | M>I | No | EVA | |
| rs3388710126 | 248 | A>V | No | EVA | |
| rs3388717014 | 274 | A>V | No | EVA | |
| rs3388714222 | 277 | L>Q | No | EVA | |
| rs3394836583 | 294 | P>A | No | EVA | |
| rs215614435 | 300 | T>S | No | EVA | |
| rs217801627 | 358 | D>N | No | EVA | |
| rs3388719304 | 361 | Y>* | No | EVA | |
| rs3394984761 | 365 | C>* | No | EVA | |
| rs3394962482 | 366 | R>C | No | EVA | |
| rs3388724302 | 375 | C>G | No | EVA | |
| rs3394962464 | 386 | P>Q | No | EVA | |
| rs3388724551 | 386 | P>S | No | EVA | |
| rs3394665558 | 389 | T>A | No | EVA | |
| rs3395061030 | 390 | S>G | No | EVA | |
| rs3388717006 | 392 | A>T | No | EVA | |
| rs3395061042 | 395 | S>C | No | EVA | |
| rs3542878252 | 508 | V>M | No | EVA | |
| rs3388717051 | 527 | E>D | No | EVA | |
| rs3388719308 | 537 | Y>* | No | EVA | |
| rs3542863381 | 538 | D>N | No | EVA | |
| rs3388723460 | 609 | S>T | No | EVA | |
| rs3388729278 | 646 | G>R | No | EVA | |
| rs3388725422 | 653 | L>M | No | EVA | |
| rs3388725448 | 657 | G>R | No | EVA | |
| rs3388723077 | 674 | E>V | No | EVA | |
| rs3394653638 | 680 | F>I | No | EVA | |
| rs3388723447 | 714 | Y>* | No | EVA | |
| rs3394836590 | 730 | Q>H | No | EVA | |
| rs3394936401 | 730 | Q>K | No | EVA | |
| rs3388708977 | 747 | M>K | No | EVA | |
| rs3388714160 | 780 | L>F | No | EVA | |
| rs3388720310 | 807 | E>Q | No | EVA | |
| rs3388719349 | 852 | E>D | No | EVA | |
| rs3388729331 | 854 | Y>H | No | EVA | |
| rs3388720356 | 864 | R>G | No | EVA | |
| rs3388722581 | 872 | D>E | No | EVA | |
| rs3394983496 | 887 | V>D | No | EVA | |
| rs3394938700 | 888 | V>M | No | EVA | |
| rs3388716643 | 890 | V>I | No | EVA | |
| rs3388729329 | 892 | D>N | No | EVA | |
| rs3388724593 | 896 | H>L | No | EVA | |
| rs3388719312 | 902 | R>M | No | EVA | |
| rs3388725508 | 903 | A>G | No | EVA | |
| rs3388723081 | 931 | D>G | No | EVA | |
| rs3388719379 | 948 | D>Y | No | EVA | |
| rs3388722595 | 960 | M>L | No | EVA | |
| rs3388723008 | 968 | D>N | No | EVA | |
| rs3388719364 | 989 | T>S | No | EVA | |
| rs3388714197 | 991 | R>M | No | EVA | |
| rs3388716651 | 992 | A>G | No | EVA |
No associated diseases with O09127
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| early endosome membrane | The lipid bilayer surrounding an early endosome. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ephrin receptor activity | Combining with an ephrin receptor ligand to initiate a change in cell activity. |
| GPI-linked ephrin receptor activity | Combining with a GPI-anchored ephrin to initiate a change in cell activity. |
| growth factor binding | Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. |
| transmembrane-ephrin receptor activity | Combining with a transmembrane ephrin to initiate a change in cell activity. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| cellular response to follicle-stimulating hormone stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. |
| ephrin receptor signaling pathway | The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| neuron projection development | The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| neuron remodeling | The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development. |
| positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
| positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| regulation of cell adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. |
| regulation of cell adhesion mediated by integrin | Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin. |
| substrate-dependent cell migration | The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate. |
49 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P28693 | EPHB2 | Ephrin type-B receptor 2 | Gallus gallus (Chicken) | PR |
| Q07496 | EPHA4 | Ephrin type-A receptor 4 | Gallus gallus (Chicken) | SS |
| Q07494 | EPHB1 | Ephrin type-B receptor 1 | Gallus gallus (Chicken) | SS |
| Q07497 | EPHB5 | Ephrin type-B receptor 5 | Gallus gallus (Chicken) | PR |
| P29318 | EPHA3 | Ephrin type-A receptor 3 | Gallus gallus (Chicken) | SS |
| O42422 | EPHA7 | Ephrin type-A receptor 7 | Gallus gallus (Chicken) | SS |
| P54755 | EPHA5 | Ephrin type-A receptor 5 | Gallus gallus (Chicken) | SS |
| Q07498 | EPHB3 | Ephrin type-B receptor 3 | Gallus gallus (Chicken) | SS |
| P0C0K6 | EPHB6 | Ephrin type-B receptor 6 | Pan troglodytes (Chimpanzee) | SS |
| P21709 | EPHA1 | Ephrin type-A receptor 1 | Homo sapiens (Human) | SS |
| P54764 | EPHA4 | Ephrin type-A receptor 4 | Homo sapiens (Human) | SS |
| P54753 | EPHB3 | Ephrin type-B receptor 3 | Homo sapiens (Human) | SS |
| P29320 | EPHA3 | Ephrin type-A receptor 3 | Homo sapiens (Human) | PR |
| P54760 | EPHB4 | Ephrin type-B receptor 4 | Homo sapiens (Human) | SS |
| P29317 | EPHA2 | Ephrin type-A receptor 2 | Homo sapiens (Human) | SS |
| Q15375 | EPHA7 | Ephrin type-A receptor 7 | Homo sapiens (Human) | SS |
| Q5JZY3 | EPHA10 | Ephrin type-A receptor 10 | Homo sapiens (Human) | SS |
| P29323 | EPHB2 | Ephrin type-B receptor 2 | Homo sapiens (Human) | EV |
| Q9UF33 | EPHA6 | Ephrin type-A receptor 6 | Homo sapiens (Human) | SS |
| P54762 | EPHB1 | Ephrin type-B receptor 1 | Homo sapiens (Human) | SS |
| P54756 | EPHA5 | Ephrin type-A receptor 5 | Homo sapiens (Human) | SS |
| O15197 | EPHB6 | Ephrin type-B receptor 6 | Homo sapiens (Human) | SS |
| P29322 | EPHA8 | Ephrin type-A receptor 8 | Homo sapiens (Human) | SS |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| P54754 | Ephb3 | Ephrin type-B receptor 3 | Mus musculus (Mouse) | SS |
| Q61772 | Epha7 | Ephrin type-A receptor 7 | Mus musculus (Mouse) | SS |
| Q8CBF3 | Ephb1 | Ephrin type-B receptor 1 | Mus musculus (Mouse) | SS |
| Q03137 | Epha4 | Ephrin type-A receptor 4 | Mus musculus (Mouse) | SS |
| Q8BYG9 | Epha10 | Ephrin type-A receptor 10 | Mus musculus (Mouse) | SS |
| O08644 | Ephb6 | Ephrin type-B receptor 6 | Mus musculus (Mouse) | PR |
| P54763 | Ephb2 | Ephrin type-B receptor 2 | Mus musculus (Mouse) | SS |
| Q62413 | Epha6 | Ephrin type-A receptor 6 | Mus musculus (Mouse) | SS |
| P29319 | Epha3 | Ephrin type-A receptor 3 | Mus musculus (Mouse) | SS |
| P54757 | Epha5 | Ephrin type-A receptor 5 | Rattus norvegicus (Rat) | SS |
| P54759 | Epha7 | Ephrin type-A receptor 7 | Rattus norvegicus (Rat) | SS |
| P09759 | Ephb1 | Ephrin type-B receptor 1 | Rattus norvegicus (Rat) | SS |
| P0C0K7 | Ephb6 | Ephrin type-B receptor 6 | Rattus norvegicus (Rat) | SS |
| O08680 | Epha3 | Ephrin type-A receptor 3 | Rattus norvegicus (Rat) | SS |
| O61460 | vab-1 | Ephrin receptor 1 | Caenorhabditis elegans | SS |
| Q9LMN7 | WAK5 | Wall-associated receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZJ9 | CRCK2 | Calmodulin-binding receptor-like cytoplasmic kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O13147 | ephb3 | Ephrin type-B receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73878 | ephb4b | Ephrin type-B receptor 4b | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPARARLSP | ALWVVTAAAA | ATCVSAGRGE | VNLLDTSTIH | GDWGWLTYPA | HGWDSINEVD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ESFRPIHTYQ | VCNVMSPNQN | NWLRTNWVPR | DGARRVYAEI | KFTLRDCNSI | PGVLGTCKET |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FNLHYLESDR | DLGASTQESQ | FLKIDTIAAD | ESFTGADLGV | RRLKLNTEVR | GVGPLSKRGF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YLAFQDIGAC | LAILSLRIYY | KKCPAMVRNL | AAFSEAVTGA | DSSSLVEVRG | QCVRHSEERD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TPKMYCSAEG | EWLVPIGKCV | CSAGYEERRD | ACMACELGFY | KSAPGDQLCA | RCPPHSHSAT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PAAQTCRCDL | SYYRAALDPP | SAACTRPPSA | PVNLISSVNG | TSVTLEWAPP | LDPGGRSDIT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YNAVCRRCPW | ALSHCEACGS | GTRFVPQQTS | LAQASLLVAN | LLAHMNYSFW | IEAVNGVSNL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SPEPRSAAVV | NITTNQAAPS | QVVVIRQERA | GQTSVSLLWQ | EPEQPNGIIL | EYEIKYYEKD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KEMQSYSTLK | AVTTRATVSG | LKPGTRYVFQ | VRARTSAGCG | RFSQAMEVET | GKPRPRYDTR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TIVWICLTLI | TGLVVLLLLL | ICKKRHCGYS | KAFQDSDEEK | MHYQNGQAPP | PVFLPLNHPP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GKFPETQFSA | EPHTYEEPGR | AGRSFTREIE | ASRIHIEKII | GSGESGEVCY | GRLQVPGQRD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VPVAIKALKA | GYTERQRQDF | LSEAAIMGQF | DHPNIIRLEG | VVTRGRLAMI | VTEYMENGSL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DAFLRTHDGQ | FTIVQLVGML | RGVGAGMRYL | SDLGYIHRDL | AARNVLVDGR | LVCKVSDFGL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SRALEDDPEA | AYTTAGGKIP | IRWTAPEAIA | FRTFSSASDV | WSFGVVMWEV | LAYGERPYWN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| MTNQDVISSV | EEGYRLPAPM | GCPRALHQLM | LDCWHKDRAQ | RPRFAHVVSV | LDALVHSPES |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LRATATVSRC | PPPAFARSCF | DLRAGGSGNG | DLTVGDWLDS | IRMGRYRDHF | AAGGYSSLGM |
| 970 | 980 | 990 | 1000 | ||
| VLRMNAQDVR | ALGITLMGHQ | KKILGSIQTM | RAQLSSTQGP | RRHL |