O08989

PR
Gene name
Mras (Xras)
Protein name
Ras-related protein M-Ras
Names
Muscle and microspikes Ras, Ras-related protein R-Ras3, X-Ras
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:17532
EC number
3.6.5.2: Acting on GTP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

152-208 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for O08989

Entry ID Method Resolution Chain Position Source
1X1R X-ray 130 A A 1-178 PDB
1X1S X-ray 220 A A 1-178 PDB
3KKO X-ray 190 A A/B/P 1-178 PDB
3KKP X-ray 135 A A 1-178 PDB
3KKQ X-ray 120 A A 1-178 PDB
3PIR X-ray 275 A A 1-178 PDB
3PIT X-ray 155 A A 1-178 PDB
AF-O08989-F1 Predicted AlphaFoldDB

6 variants for O08989

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3411996858 12 P>L No EVA
rs3389045576 15 K>I No EVA
rs3389032742 24 V>M No EVA
rs3389032749 65 V>D No EVA
rs258452296 136 V>I No EVA
rs3389067487 204 Q>* No EVA

No associated diseases with O08989

1 regional properties for O08989

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 13 - 159 IPR005225

Functions

Description
EC Number 3.6.5.2 Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization
  • Cell membrane ; Lipid-anchor ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
G protein activity A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).
GDP binding Binding to GDP, guanosine 5'-diphosphate.
GTP binding Binding to GTP, guanosine triphosphate.
GTP-dependent protein binding Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

2 GO annotations of biological process

Name Definition
cellular response to leukemia inhibitory factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
Ras protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.

34 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P08642 HRAS GTPase HRas Gallus gallus (Chicken) SS
P11233 RALA Ras-related protein Ral-A Homo sapiens (Human) PR
Q6T310 RASL11A Ras-like protein family member 11A Homo sapiens (Human) PR
P01116 KRAS GTPase KRas Homo sapiens (Human) EV
P62070 RRAS2 Ras-related protein R-Ras2 Homo sapiens (Human) PR
Q8IYK8 REM2 GTP-binding protein REM 2 Homo sapiens (Human) PR
P11234 RALB Ras-related protein Ral-B Homo sapiens (Human) PR
P55040 GEM GTP-binding protein GEM Homo sapiens (Human) PR
Q99578 RIT2 GTP-binding protein Rit2 Homo sapiens (Human) PR
Q6IQ22 RAB12 Ras-related protein Rab-12 Homo sapiens (Human) PR
Q9BU20 CPLANE2 Ciliogenesis and planar polarity effector 2 Homo sapiens (Human) PR
Q96HU8 DIRAS2 GTP-binding protein Di-Ras2 Homo sapiens (Human) PR
P01112 HRAS GTPase HRas Homo sapiens (Human) SS
P35283 Rab12 Ras-related protein Rab-12 Mus musculus (Mouse) PR
A2A825 Cplane2 Ciliogenesis and planar polarity effector 2 Mus musculus (Mouse) PR
P55041 Gem GTP-binding protein GEM Mus musculus (Mouse) PR
Q8VEL9 Rem2 GTP-binding protein REM 2 Mus musculus (Mouse) PR
P62071 Rras2 Ras-related protein R-Ras2 Mus musculus (Mouse) PR
P70425 Rit2 GTP-binding protein Rit2 Mus musculus (Mouse) PR
Q08AT1 Rasl12 Ras-like protein family member 12 Mus musculus (Mouse) PR
Q5PR73 Diras2 GTP-binding protein Di-Ras2 Mus musculus (Mouse) PR
Q91Z61 Diras1 GTP-binding protein Di-Ras1 Mus musculus (Mouse) PR
Q9JIW9 Ralb Ras-related protein Ral-B Mus musculus (Mouse) PR
P32883 Kras GTPase KRas Mus musculus (Mouse) SS
Q61411 Hras GTPase HRas Mus musculus (Mouse) SS
P36860 Ralb Ras-related protein Ral-B Rattus norvegicus (Rat) PR
P08644 Kras GTPase KRas Rattus norvegicus (Rat) SS
Q9WTY2 Rem2 GTP-binding protein REM 2 Rattus norvegicus (Rat) PR
P20171 Hras GTPase HRas Rattus norvegicus (Rat) SS
Q5BJQ5 Rit2 GTP-binding protein Rit2 Rattus norvegicus (Rat) PR
P97538 Mras Ras-related protein M-Ras Rattus norvegicus (Rat) PR
B7ZTR0 cplane2 Ciliogenesis and planar polarity effector 2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
P79737 nras GTPase NRas Danio rerio (Zebrafish) (Brachydanio rerio) SS
A1DZY4 zgc:110179 Ras-like protein family member 11A-like Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MATSAVPSEN LPTYKLVVVG DGGVGKSALT IQFFQKIFVP DYDPTIEDSY LKHTEIDNQW
70 80 90 100 110 120
AILDVLDTAG QEEFSAMREQ YMRTGDGFLI VYSVTDKASF EHVDRFHQLI LRVKDRESFP
130 140 150 160 170 180
MILVANKVDL MHLRKVTRDQ GKEMATKYNI PYIETSAKDP PLNVDKTFHD LVRVIRQQVP
190 200
EKNQKKKKKT KWRGDRATGT HKLQCVIL