O08859
PR
Gene name |
Tnfaip6 (Tnfip6, Tsg6) |
Protein name |
Tumor necrosis factor-inducible gene 6 protein |
Names |
TNF-stimulated gene 6 protein, TSG-6, Tumor necrosis factor alpha-induced protein 6, TNF alpha-induced protein 6 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:21930 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O08859
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O08859-F1 | Predicted | AlphaFoldDB |
6 variants for O08859
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs250779697 | 8 | C>F | No | EVA | |
| rs3388553000 | 59 | E>K | No | EVA | |
| rs3388551320 | 94 | Y>C | No | EVA | |
| rs3388553526 | 148 | S>T | No | EVA | |
| rs3388553513 | 203 | H>Y | No | EVA | |
| rs3388551317 | 204 | G>V | No | EVA |
No associated diseases with O08859
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| carboxylic ester hydrolase activity | Catalysis of the hydrolysis of a carboxylic ester bond. |
| fibronectin binding | Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids. |
| hyaluronic acid binding | Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| fibronectin fibril organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a fibronectin fibril. |
| hyaluronan metabolic process | The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. |
| negative regulation of BMP signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway. |
| negative regulation of inflammatory response | Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. |
| negative regulation of neutrophil chemotaxis | Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. |
| negative regulation of osteoblast differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation. |
| negative regulation of osteoclast differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation. |
| ovarian cumulus expansion | Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells. |
| ovulation | The release of a mature ovum/oocyte from an ovary. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| positive regulation of receptor clustering | Any process that activates or increases the frequency, rate or extent of receptor clustering. |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6UC88 | LYVE1 | Lymphatic vessel endothelial hyaluronic acid receptor 1 | Bos taurus (Bovine) | PR |
| Q9DER7 | TLL1 | Tolloid-like protein 1 | Gallus gallus (Chicken) | PR |
| P25723 | tld | Dorsal-ventral patterning protein tolloid | Drosophila melanogaster (Fruit fly) | PR |
| O43897 | TLL1 | Tolloid-like protein 1 | Homo sapiens (Human) | PR |
| P13497 | BMP1 | Bone morphogenetic protein 1 | Homo sapiens (Human) | PR |
| Q9Y6L7 | TLL2 | Tolloid-like protein 2 | Homo sapiens (Human) | PR |
| P98066 | TNFAIP6 | Tumor necrosis factor-inducible gene 6 protein | Homo sapiens (Human) | PR |
| Q9Y5Y7 | LYVE1 | Lymphatic vessel endothelial hyaluronic acid receptor 1 | Homo sapiens (Human) | PR |
| P98063 | Bmp1 | Bone morphogenetic protein 1 | Mus musculus (Mouse) | PR |
| Q9WVM6 | Tll2 | Tolloid-like protein 2 | Mus musculus (Mouse) | PR |
| Q6HA09 | Astl | Astacin-like metalloendopeptidase | Mus musculus (Mouse) | PR |
| Q62381 | Tll1 | Tolloid-like protein 1 | Mus musculus (Mouse) | PR |
| Q8BHC0 | Lyve1 | Lymphatic vessel endothelial hyaluronic acid receptor 1 | Mus musculus (Mouse) | PR |
| P45442 | lag-2 | Protein lag-2 | Caenorhabditis elegans | EV |
| Q9U3S9 | nas-6 | Zinc metalloproteinase nas-6 | Caenorhabditis elegans | PR |
| P55112 | nas-4 | Zinc metalloproteinase nas-4 | Caenorhabditis elegans | PR |
| P55113 | nas-7 | Zinc metalloproteinase nas-7 | Caenorhabditis elegans | PR |
| Q18439 | nas-8 | Zinc metalloproteinase nas-8 | Caenorhabditis elegans | PR |
| Q20176 | nas-39 | Zinc metalloproteinase nas-39 | Caenorhabditis elegans | PR |
| Q20942 | nas-38 | Zinc metalloproteinase nas-38 | Caenorhabditis elegans | PR |
| Q21252 | nas-3 | Zinc metalloproteinase nas-3 | Caenorhabditis elegans | PR |
| P55115 | nas-15 | Zinc metalloproteinase nas-15 | Caenorhabditis elegans | PR |
| O57460 | tll1 | Dorsal-ventral patterning tolloid-like protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVVLLCLCVL | LWEEAHGWGF | KNGIFHNSIW | LEQAAGVYHR | EARAGRYKLT | YAEAKAVCEF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EGGRLATYKQ | LEAARKIGFH | VCAAGWMAKG | RVGYPIVKPG | PNCGFGKTGI | IDYGIRLNRS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ERWDAYCYNP | HAKECGGVFT | DPKRIFKSPG | FPNEYDDNQV | CYWHIRLKYG | QRIHLSFLDF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DLEHDPGCLA | DYVEIYDSYD | DVHGFVGRYC | GDELPEDIIS | TGNVMTLKFL | SDASVTAGGF |
| 250 | 260 | 270 | |||
| QIKYVTVDPA | SKSSQAKNTS | TTGNKKFLPG | RFSHL |