O08750
PR
Gene name |
Nfil3 (E4bp4) |
Protein name |
Nuclear factor interleukin-3-regulated protein |
Names |
E4 promoter-binding protein 4, Embryo implantation-related NFIL3/E4BP4-like transcription factor |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:18030 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O08750
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O08750-F1 | Predicted | AlphaFoldDB |
29 variants for O08750
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389285626 | 22 | S>P | No | EVA | |
| rs257828666 | 42 | G>S | No | EVA | |
| rs3389279321 | 52 | M>I | No | EVA | |
| rs3389277009 | 72 | K>I | No | EVA | |
| rs3389241583 | 98 | D>E | No | EVA | |
| rs3389291498 | 107 | A>V | No | EVA | |
| rs3389291492 | 123 | K>I | No | EVA | |
| rs3389277089 | 145 | T>I | No | EVA | |
| rs224450921 | 157 | A>S | No | EVA | |
| rs3389281581 | 184 | Q>R | No | EVA | |
| rs3389291517 | 202 | S>I | No | EVA | |
| rs3389298907 | 215 | F>Y | No | EVA | |
| rs3389282439 | 224 | E>K | No | EVA | |
| rs3404193716 | 230 | R>M* | No | EVA | |
| rs250632346 | 238 | T>A | No | EVA | |
| rs250632346 | 238 | T>P | No | EVA | |
| rs3389258321 | 303 | V>L | No | EVA | |
| rs864282659 | 310 | A>S | No | EVA | |
| rs3389291446 | 342 | D>G | No | EVA | |
| rs249589983 | 356 | D>E | No | EVA | |
| rs230622856 | 357 | A>T | No | EVA | |
| rs3389279310 | 384 | Q>* | No | EVA | |
| rs3389284338 | 393 | L>F | No | EVA | |
| rs3389211120 | 410 | S>I | No | EVA | |
| rs260898871 | 421 | G>S | No | EVA | |
| rs3389285388 | 435 | Q>* | No | EVA | |
| rs242052781 | 437 | I>M | No | EVA | |
| rs3389277073 | 445 | V>I | No | EVA | |
| rs3389284357 | 448 | K>N | No | EVA |
No associated diseases with O08750
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| RNA polymerase II transcription regulator complex | A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| DNA-binding transcription repressor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II. |
| identical protein binding | Binding to an identical protein or proteins. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to interleukin-4 | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. |
| circadian rhythm | Any biological process in an organism that recurs with a regularity of approximately 24 hours. |
| immune response | Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. |
| natural killer cell differentiation | The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| transcription by RNA polymerase II | The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q90Z72 | NFIL3 | Nuclear factor interleukin-3-regulated protein | Gallus gallus (Chicken) | PR |
| P17676 | CEBPB | CCAAT/enhancer-binding protein beta | Homo sapiens (Human) | EV |
| Q16649 | NFIL3 | Nuclear factor interleukin-3-regulated protein | Homo sapiens (Human) | PR |
| P28033 | Cebpb | CCAAT/enhancer-binding protein beta | Mus musculus (Mouse) | SS |
| P21272 | Cebpb | CCAAT/enhancer-binding protein beta | Rattus norvegicus (Rat) | SS |
| Q6IMZ0 | Nfil3 | Nuclear factor interleukin-3-regulated protein | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQLRKMQTIK | KEPAPLDPTS | SSDKMLLLNS | ALAEVAEDLA | SGEDLLLNEG | SMGKNKSSAC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RRKREFIPDE | KKDAMYWEKR | RKNNEAAKRS | REKRRLNDLV | LENKLIALGE | ENATLKAELL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SLKLKFGLIS | STAYAQEIQK | LSNSTAVYFQ | DYQTSKAAVS | SFVDEHEPAM | VAGSCISVIK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HSPQSSLSDV | SEVSSVEHTQ | ESPAQGGCRS | PENKFPVIKQ | EPVELESFAR | EAREERGTYS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TSIYQSYMGS | SFSTYSHSPP | LLQVHGSTSN | SPRTSEADEG | VVGKSSDGED | EQQVPKGPIH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SPVELQRVHA | TVVKVPEVNP | SALPHKLRIK | AKAMQVKVEA | LDSEFEGMQK | LSSPADAIAK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RHFDLEKHGT | SGMAHSSLPP | FSVQVTNIQD | WSLKSEHWHH | KELSSKTQSS | FKTGVVEVKD |
| 430 | 440 | 450 | 460 | ||
| GGYKVSEAEN | LYLKQGIANL | SAEVVSLKRF | IATQPISASD | SR |