O08747
Gene name |
Unc5c (Rcm, Unc5h3) |
Protein name |
Netrin receptor UNC5C |
Names |
Protein unc-5 homolog 3 , Protein unc-5 homolog C , Rostral cerebellar malformation protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:22253 |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
528-928 (ZU5-UPA-DD) |
Relief mechanism |
Ligand binding |
Assay |
|
Target domain |
528-928 (ZU5-UPA-DD) |
Relief mechanism |
Ligand binding |
Assay |
|
Target domain |
528-928 (ZU5-UPA-DD) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O08747
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O08747-F1 | Predicted | AlphaFoldDB |
38 variants for O08747
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388667406 | 18 | Y>N | No | EVA | |
| rs3388667972 | 22 | M>K | No | EVA | |
| rs3388667427 | 35 | G>D | No | EVA | |
| rs3388660334 | 35 | G>S | No | EVA | |
| rs3413122935 | 96 | N>K | No | EVA | |
| rs3388668014 | 118 | I>F | No | EVA | |
| rs3388670550 | 130 | Q>E | No | EVA | |
| rs3388660418 | 170 | E>K | No | EVA | |
| rs3388664389 | 191 | P>S | No | EVA | |
| rs3393621942 | 201 | W>C | No | EVA | |
| rs3388662105 | 204 | N>I | No | EVA | |
| rs3388655929 | 216 | F>L | No | EVA | |
| rs3388661738 | 253 | A>S | No | EVA | |
| rs3541922858 | 303 | S>N | No | EVA | |
| rs3388666773 | 391 | L>Q | No | EVA | |
| rs1132052629 | 481 | V>E | No | EVA | |
| rs1134816930 | 486 | G>A | No | EVA | |
| rs3388655482 | 501 | L>V | No | EVA | |
| rs3388662082 | 520 | Q>L | No | EVA | |
| rs3388670540 | 612 | C>Y | No | EVA | |
| rs3388667385 | 626 | N>K | No | EVA | |
| rs3388660337 | 630 | Q>H | No | EVA | |
| rs215321611 | 641 | E>Q | No | EVA | |
| rs3388662151 | 683 | K>R | No | EVA | |
| rs3388663927 | 686 | I>F | No | EVA | |
| rs3388655967 | 693 | S>F | No | EVA | |
| rs46096264 | 698 | S>N | No | EVA | |
| rs50530384 | 706 | D>N | No | EVA | |
| rs3388663453 | 714 | V>D | No | EVA | |
| rs3388666718 | 716 | Q>H | No | EVA | |
| rs3388663908 | 766 | F>I | No | EVA | |
| rs3388666741 | 770 | W>R | No | EVA | |
| rs3388661714 | 781 | F>L | No | EVA | |
| rs3388666724 | 782 | T>I | No | EVA | |
| rs256113925 | 831 | S>N | No | EVA | |
| rs3388660407 | 840 | S>C | No | EVA | |
| rs3388667961 | 844 | I>F | No | EVA | |
| rs3388670511 | 847 | P>H | No | EVA |
1 associated diseases with O08747
Without disease ID
10 regional properties for O08747
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Death domain | 838 - 929 | IPR000488 |
| repeat | Thrombospondin type-1 (TSP1) repeat | 260 - 314 | IPR000884-1 |
| repeat | Thrombospondin type-1 (TSP1) repeat | 316 - 368 | IPR000884-2 |
| domain | ZU5 domain | 528 - 673 | IPR000906 |
| domain | Immunoglobulin subtype 2 | 179 - 246 | IPR003598 |
| domain | Immunoglobulin subtype | 173 - 258 | IPR003599 |
| domain | Immunoglobulin-like domain | 175 - 256 | IPR007110 |
| domain | Immunoglobulin I-set | 168 - 257 | IPR013098 |
| domain | UPA domain | 678 - 817 | IPR033772 |
| domain | UNC5C, death domain | 844 - 926 | IPR042154 |
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| filopodium | Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. |
| growth cone | The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic. |
| lamellipodium | A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| netrin receptor activity | Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| netrin receptor activity involved in chemorepulsion | Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| tubulin binding | Binding to monomeric or multimeric forms of tubulin, including microtubules. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| anterior/posterior axon guidance | The process in which the migration of an axon growth cone is directed to a specific target site along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. |
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| chemorepulsion of axon | The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. |
| dorsal root ganglion development | The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure. |
| ectopic germ cell programmed cell death | Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo. |
| netrin-activated signaling pathway | The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance. |
| positive regulation of apoptotic process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
| positive regulation of developmental process | Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). |
| positive regulation of reproductive process | Any process that activates or increases the frequency, rate or extent of reproductive process. |
| regulation of cell migration | Any process that modulates the frequency, rate or extent of cell migration. |
| regulation of neuron migration | Any process that modulates the frequency, rate or extent of neuron migration. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q7T2Z5 | UNC5C | Netrin receptor UNC5C | Gallus gallus (Chicken) | SS |
| Q6UXZ4 | UNC5D | Netrin receptor UNC5D | Homo sapiens (Human) | SS |
| Q6ZN44 | UNC5A | Netrin receptor UNC5A | Homo sapiens (Human) | SS |
| Q8IZJ1 | UNC5B | Netrin receptor UNC5B | Homo sapiens (Human) | SS |
| O95185 | UNC5C | Netrin receptor UNC5C | Homo sapiens (Human) | SS |
| Q8K1S4 | Unc5a | Netrin receptor UNC5A | Mus musculus (Mouse) | SS |
| Q8K1S3 | Unc5b | Netrin receptor UNC5B | Mus musculus (Mouse) | SS |
| Q8K1S2 | Unc5d | Netrin receptor UNC5D | Mus musculus (Mouse) | SS |
| F1LW30 | Unc5d | Netrin receptor UNC5D | Rattus norvegicus (Rat) | SS |
| O08721 | Unc5a | Netrin receptor UNC5A | Rattus norvegicus (Rat) | SS |
| O08722 | Unc5b | Netrin receptor UNC5B | Rattus norvegicus (Rat) | EV |
| Q761X5 | Unc5c | Netrin receptor UNC5C | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRKGLRATAA | RCGLGLGYLL | QMLVLPALAL | LSASGTGSAA | QDDEFFHELP | ETFPSDPPEP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LPHFLIEPEE | AYIVKNKPVN | LYCKASPATQ | IYFKCNSEWV | HQKDHVVDER | VDETSGLIVR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EVSIEISRQQ | VEELFGPEDY | WCQCVAWSSA | GTTKSRKAYV | RIAYLRKTFE | QEPLGKEVSL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EQEVLLQCRP | PEGIPVAEVE | WLKNEDIIDP | AEDRNFYITI | DHNLIIKQAR | LSDTANYTCV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AKNIVAKRKS | TTATVIVYVN | GGWSTWTEWS | VCNSRCGRGY | QKRTRTCTNP | APLNGGAFCE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GQSVQKIACT | TLCPVDGRWT | SWSKWSTCGT | ECTHWRRREC | TAPAPKNGGK | DCDGLVLQSK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NCTDGLCMQA | APDSDDVALY | VGIVIAVTVC | LAITVVVALF | VYRKNHRDFE | SDIIDSSALN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GGFQPVNIKA | ARQDLLAVPP | DLTSAAAMYR | GPVYALHDVS | DKIPMTNSPI | LDPLPNLKIK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VYNSSGAVTP | QDDLAEFSSK | LSPQMTQSLL | ENEALNLKNQ | SLARQTDPSC | TAFGTFNSLG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GHLIIPNSGV | SLLIPAGAIP | QGRVYEMYVT | VHRKENMRPP | MEDSQTLLTP | VVSCGPPGAL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LTRPVILTLH | HCADPSTEDW | KIQLKNQAVQ | GQWEDVVVVG | EENFTTPCYI | QLDAEACHIL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TENLSTYALV | GQSTTKAAAK | RLKLAIFGPL | CCSSLEYSIR | VYCLDDTQDA | LKEVLQLERQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| MGGQLLEEPK | ALHFKGSIHN | LRLSIHDIAH | SLWKSKLLAK | YQEIPFYHIW | SGSQRNLHCT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FTLERLSLNT | VELVCKLCVR | QVEGEGQIFQ | LNCTVSEEPT | GIDLPLLDPA | STITTVTGPS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| AFSIPLPIRQ | KLCSSLDAPQ | TRGHDWRMLA | HKLNLDRYLN | YFATKSSPTG | VILDLWEAQN |
| 910 | 920 | 930 | |||
| FPDGNLSMLA | AVLEEMGRHE | TVVSLAAEGQ | Y |