Descriptions
(Annotation based on sequence homology with Q08050)
Forkhead transcription factor FoxM1 is an important regulator of gene expression during the G2 phase. Truncated form of FoxM1 that is lacking the N-terminal autorepressor domain (negative regulatory domain) is active throughout the cell cycle and no longer depends on cyclin A for its activation. FoxM1 activity is kept low due to repression by its own N-terminal domain through direct binding to the C-terminal transactivation domain.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O08696
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O08696-F1 | Predicted | AlphaFoldDB |
No variants for O08696
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O08696 | |||||
No associated diseases with O08696
4 regional properties for O08696
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
20 GO annotations of biological process
| Name | Definition |
|---|---|
| cell population proliferation | The multiplication or reproduction of cells, resulting in the expansion of a cell population. |
| DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| G2/M transition of mitotic cell cycle | The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex. |
| liver development | The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| negative regulation of stress-activated MAPK cascade | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of double-strand break repair | Any process that activates or increases the frequency, rate or extent of double-strand break repair. |
| positive regulation of stem cell proliferation | Any process that activates or increases the frequency, rate or extent of stem cell proliferation. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. |
| regulation of cell population proliferation | Any process that modulates the frequency, rate or extent of cell proliferation. |
| regulation of Ras protein signal transduction | Any process that modulates the frequency, rate or extent of Ras protein signal transduction. |
| regulation of reactive oxygen species metabolic process | Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| stem cell proliferation | The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. |
| vasculogenesis | The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32031 | slp2 | Fork head domain transcription factor slp2 | Drosophila melanogaster (Fruit fly) | PR |
| O15353 | FOXN1 | Forkhead box protein N1 | Homo sapiens (Human) | PR |
| Q96NZ1 | FOXN4 | Forkhead box protein N4 | Homo sapiens (Human) | PR |
| Q12948 | FOXC1 | Forkhead box protein C1 | Homo sapiens (Human) | PR |
| Q08050 | FOXM1 | Forkhead box protein M1 | Homo sapiens (Human) | EV |
| Q8K3Q3 | Foxn4 | Forkhead box protein N4 | Mus musculus (Mouse) | PR |
| Q61572 | Foxc1 | Forkhead box protein C1 | Mus musculus (Mouse) | PR |
| P97691 | Foxm1 | Forkhead box protein M1 | Rattus norvegicus (Rat) | PR |
| Q28H65 | foxn5 | Forkhead box protein N5 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| A2BGM5 | foxn4 | Forkhead box protein N4 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRTSPRRPLI | LKRRRLPLPV | QNAPSETSEE | EAKRSPAQPE | PAPAQASQEV | AESSSCKFPA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GIKIINHPTT | PNTQVVAIPS | NADIQSIITA | LTAKGKESGT | SGPNRFILIS | SGGPSSHPSQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PQAHSSRDSK | RAEVITETLG | PKPAAKGVPV | PKPPGAPPRQ | RQESYAGGEA | AGCTLDNSLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NIQWLGKMSS | DGLGPCSVKQ | ELEEKENCHL | EQNRVKVEEP | SGVSTSWQDS | VSERPPYSYM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AMIQFAINST | ERKRMTLKDI | YTWIEDHFPY | FKHIAKPGWK | NSIRHNLSLH | DMFVRETSAN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GKVSFWTIHP | SANRHLTLDQ | VFKPLEPGSP | QSPEHLESQQ | KRPNPELHRN | VTIKTEIPLG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ARRKMKPLLP | RVSSYLEPIQ | FPVNQSLVLQ | PSVKVPFRLA | ASLMSSELAR | HSKRVRIAPK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VLLSSEGIAP | LPATEPPKEE | KPLLGGEGLL | PLLPIQSIKE | EEMQPEEDIA | HLERPIKVES |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PPLEEWPSPC | ASLKEELSNS | WEDSSCSPTP | KPKKSYCGLK | SPTRCVSEML | VTKRREKREV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SRSRRKQHLQ | PPCLDEPDLF | FPEDSSTFRP | AVELLAESSE | PAPHLSCPQE | EGGPFKTPIK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ETLPVSSTPS | KSVLSRDPES | WRLTPPAKVG | GLDFSPVRTP | QGAFGLLPDS | LGLMELNTTP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LKSGPLFDSP | RELLNSEPFD | LASDPFGSPP | PPHVEGPKPG | SPELQIPSLS | ANRSLTEGLV |
| 730 | 740 | 750 | |||
| LDTMNDSLSK | ILLDISFPGL | EEDPLGPDNI | NWSQFIPELR |