O08662

PR
Gene name
Pi4ka (Pik4ca)
Protein name
Phosphatidylinositol 4-kinase alpha
Names
PI4-kinase alpha, PI4K-alpha, PtdIns-4-kinase alpha
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:64161
EC number
2.7.1.67: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

157-244 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

1969-1991 (Activation loop from InterPro)

Target domain

1802-2093 (Phosphatidylinositol 3-/4-kinase, catalytic domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for O08662

Entry ID Method Resolution Chain Position Source
AF-O08662-F1 Predicted AlphaFoldDB

No variants for O08662

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O08662

No associated diseases with O08662

5 regional properties for O08662

Type Name Position InterPro Accession
domain Phosphatidylinositol 3-/4-kinase, catalytic domain 1802 - 2093 IPR000403
domain Phosphoinositide 3-kinase, accessory (PIK) domain 1524 - 1723 IPR001263
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 1843 - 1857 IPR018936-1
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 1936 - 1956 IPR018936-2
domain PI4-kinase, N-terminal 372 - 1508 IPR045495

Functions

Description
EC Number 2.7.1.67 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cytoplasm
  • Cell membrane
  • Localization to the plasma membrane is mediated by the PI4K complex and association with EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2)
  • Localization to the plasma membrane is regulated by TMEM150A
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Golgi-associated vesicle membrane The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
1-phosphatidylinositol 4-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
phosphatidylinositol kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate.

8 GO annotations of biological process

Name Definition
biological process involved in interaction with symbiont An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.
modulation by host of viral process A process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected.
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
reorganization of cellular membranes to establish viral sites of replication A process in intracellular membranes are reorganized by viral proteins that perturb membrane integrity and can cause an extensive rearrangement of cellular membranes, forming membranous webs, which are thought to be the site of replication or certain viruses, for example the HPV virus.
viral replication complex formation and maintenance The process of organizing and assembling viral replication proteins in preparation for viral replication.
viral RNA genome replication The replication of a viral RNA genome.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P42356 PI4KA Phosphatidylinositol 4-kinase alpha Homo sapiens (Human) PR
O08561 Pi4kb Phosphatidylinositol 4-kinase beta Rattus norvegicus (Rat) PR
Q9Z1L0 Pik3cb Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Rattus norvegicus (Rat) PR
Q9SXA1 PI4KA1 Phosphatidylinositol 4-kinase alpha 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAAAGARGTG GSGSSSGSST SRGFYFNTVL SLARSLAVQR PASLEKVQKL LCMCPVDFHG
70 80 90 100 110 120
IFQLDERRRD AVIALGIFLI ESDLQHKDCI VPYLLRLLRG LPKVYWVEES TARKGRGNLP
130 140 150 160 170 180
VAESFSFCLV TLLSDVACRD PSLRDEILEA LLQVLHVLLG MCQALEIQEK EYLCKYAIPC
190 200 210 220 230 240
LIGISRSFGR YSNSEESLLS KLFPKVPPHS LRIPEELEGV RRRSFNDFRS ILPSNLLTVC
250 260 270 280 290 300
QEGTLKRKTS SVSSISQVSP ERGMPPPSSP GGSAFHYFEA SCLPDGTTLE PEYYFSTISS
310 320 330 340 350 360
SFSVSPLFNG ITYKEFYIPL EMLRELLNLV KKIVEEPVLK SLDAAVARVM EANPSADLYY
370 380 390 400 410 420
TTFSDPVYLT MFKMLRDTLY YMKDLPTSFV KEIHDFVLEQ FNMSQGELQK ILHDADRIHS
430 440 450 460 470 480
EMSPLKLRCQ ANAACVDLMV WAVKDEQGAE NLCIKLSEKL QSKTSSKVII AHLPLLICCL
490 500 510 520 530 540
QGLGRLCERF PVVVHSVTPS LRDFLVIPSP VLVKLYKYHS QYHTVAGSDI KISVTNEHSE
550 560 570 580 590 600
STLNVLPGKK NQPSMYEQLR DIAIDNICRC LKAGLTVDPV IVEAFLASLS NRLYISQESD
610 620 630 640 650 660
KDAHLIPDHT IRALGHIAVA LRDTPKVMEP ILQILQQKFC QPPSPLDVLI IDQLGCLVIT
670 680 690 700 710 720
GNQYIYQEVW NLFQQISVKA SSVVYSATKD YKDHGYRHCS LAVINALANI AANIQEEHLV
730 740 750 760 770 780
DELLMNLLEL FVQLGLEGKR ASERASEKGP ALKASSSAGN LGVLIPVIAV LTRRLPPIKE
790 800 810 820 830 840
AKPRLQKLFR DFWLYSVLMG FAVEGSGLWP EEWYEGVCEI ATKSPLLTFP SKEPLRSVLQ
850 860 870 880 890 900
YNSAMKNDTV TPAELNELRS TIINLLDPPP EVSALINKLD FAMSTYLLSV YRLEYMRVLR
910 920 930 940 950 960
STDPDRFQVM FCYFEDKAIQ KDKSGMMQCV IAVADKVFDA FLNMMAEKAK TKENEEELER
970 980 990 1000 1010 1020
HAQFLLVNFN HIHKRIRRVA DKYLSGLVDK FPHLLWSGTV LKTMLDILQT LSLSLSADIH
1030 1040 1050 1060 1070 1080
KDQPYYDIPD APYRITVPDT YEARESIVKD FAARCGMILQ EAMKWAPTVT KSHLQEYLNK
1090 1100 1110 1120 1130 1140
HQNWVSGLSQ HTGLAMATES ILHFAGYNKQ NTTLGVTQLT ERPACVKKDY SNFMASLNLR
1150 1160 1170 1180 1190 1200
NRYAGEVHGM IRFSGATGQM SDLNKMMVQD LITALDHSHP QHYTQAMFKL TAMLISSKDC
1210 1220 1230 1240 1250 1260
DPQLLHHLCW GPLRMFNEHG METALACWEW LLAGKNGVEV PFMREMAGAW HMTVEQKFGL
1270 1280 1290 1300 1310 1320
FSAETKEADP LAASEASQPR PCPPEVTPHY IWIDFLVQRF EIAKYCSSDQ VEIFSSLLQR
1330 1340 1350 1360 1370 1380
SMSLHIGGAR GSMNRHVAAI GPRFKLLTLG LSLLHADVVP NATIRNVLRE KIYSTAFDYF
1390 1400 1410 1420 1430 1440
SCPPKFPTQG EKRLREDISI MIKFWTAMFS DKKYLTASQL VPPDNQDTRS NLDITVGSRQ
1450 1460 1470 1480 1490 1500
QATQGWINTY PLSSGMSTIS KKSGMSKKTN RGSQLHKYYM KRRTLLLSLL ATEIERLITW
1510 1520 1530 1540 1550 1560
YNPLSAPELE LDQAGENSVA NWRSKYISLS EKQWKDNVNL AWTISPYLAV QLPARFKNTE
1570 1580 1590 1600 1610 1620
AIGNEVTRLV RLDPGAVSDV PEAIKFLVTW HTIDADAPEL SHVLCWAPTD PPTGLSYFSS
1630 1640 1650 1660 1670 1680
MYPPHPLTAQ YGVKVLRSFP PDAILFYIPQ IVQALRYDKM GYVREYILWA AAKSQLLAHQ
1690 1700 1710 1720 1730 1740
FIWNMKTNIY LDEEGHQKDP DIGDLLEQLV EEITGSLSGP AKDFYQREFD FFNKITNVSA
1750 1760 1770 1780 1790 1800
IIKPYPKGDE RKKACLSALS EVKVQPGCYL PSNPEAIVLD IDYKSGTPMQ SAAKAPYLAK
1810 1820 1830 1840 1850 1860
FKVKRCGVSE LEKEGLQCRS DTEDECRRQE ADGKKICWQA AIFKVGDDCR QDMLALQIID
1870 1880 1890 1900 1910 1920
LFKNIFQLVG LDLFVFPYRV VATAPGCGVI ECIPDCTSRD QLGRQTDFGM YDYFTRQYGD
1930 1940 1950 1960 1970 1980
ESTLAFQQAR YNFIRSMAAY SLLLFLLQIK DRHNGNIMLD KKGHIIHIDF GFMFESSPGG
1990 2000 2010 2020 2030 2040
NLGWEPDIKL TDEMVMIMGG KMEATPFKWF MEMCVRGYLA VRPYMDAVVS LVTLMLDTGL
2050 2060 2070 2080 2090
PCFRGQTIKL LKHRFSPNMT EREAANFIMK IIQNCFLSNR SRTYDMIQYY QNDIPY