O04887

SS
Gene name
PECS-2.1
Protein name
Pectinesterase 2
Names
PE 2, Pectin methylesterase
Species
Citrus sinensis (Sweet orange) (Citrus aurantium var sinensis)
KEGG Pathway
cit:102577945
EC number
3.1.1.11: Carboxylic ester hydrolases
Protein Class

Descriptions

(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain and prevent untimely PME activity during transport.

Autoinhibitory domains (AIDs)

26-169 (PMEI region) SS

Target domain

202-496 (Pectinesterase domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O04887

Entry ID Method Resolution Chain Position Source
AF-O04887-F1 Predicted AlphaFoldDB

No variants for O04887

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O04887

No associated diseases with O04887

5 regional properties for O04887

Type Name Position InterPro Accession
domain Pectinesterase, catalytic 202 - 496 IPR000070
domain Pectinesterase inhibitor domain 1 - 172 IPR006501
domain Carbohydrate-binding/sugar hydrolysis domain 235 - 413 IPR006633
active_site Pectinesterase, Tyr active site 227 - 246 IPR018040
active_site Pectinesterase, Asp active site 344 - 353 IPR033131

Functions

Description
EC Number 3.1.1.11 Carboxylic ester hydrolases
Subcellular Localization
  • Secreted, cell wall
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

3 GO annotations of molecular function

Name Definition
aspartyl esterase activity Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue.
enzyme inhibitor activity Binds to and stops, prevents or reduces the activity of an enzyme.
pectinesterase activity Catalysis of the reaction: pectin + n H2O = n methanol + pectate.

2 GO annotations of biological process

Name Definition
cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly.
pectin catabolic process The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALRILITVS LVLFSLSHTS FGYSPEEVKS WCGKTPNPQP CEYFLTQKTD VTSIKQDTDF
70 80 90 100 110 120
YKISLQLALE RATTAQSRTY TLGSKCRNER EKAAWEDCRE LYELTVLKLN QTSNSSPGCT
130 140 150 160 170 180
KVDKQTWLST ALTNLETCRA SLEDLGVPEY VLPLLSNNVT KLISNTLSLN KVPYNEPSYK
190 200 210 220 230 240
DGFPTWVKPG DRKLLQTTPR ANIVVAQDGS GNVKTIQEAV AAASRAGGSR YVIYIKAGTY
250 260 270 280 290 300
NENIEVKLKN IMFVGDGIGK TIITGSKSVG GGATTFKSAT VAVVGDNFIA RDITIRNTAG
310 320 330 340 350 360
PNNHQAVALR SGSDLSVFYR CSFEGYQDTL YVHSQRQFYR ECDIYGTVDF IFGNAAVVLQ
370 380 390 400 410 420
NCNIFARKPP NRTNTLTAQG RTDPNQSTGI IIHNCRVTAA SDLKPVQSSV KTFLGRPWKQ
430 440 450 460 470 480
YSRTVYIKTF LDSLINPAGW MEWSGDFALN TLYYAEYMNT GPGSSTANRV KWRGYHVLTS
490 500
PSQVSQFTVG NFIAGNSWLP ATNVPFTSGL