O04886

SS
Gene name
PECS-1.1
Protein name
Pectinesterase 1
Names
PE 1, Pectin methylesterase
Species
Citrus sinensis (Sweet orange) (Citrus aurantium var sinensis)
KEGG Pathway
cit:102578056
EC number
3.1.1.11: Carboxylic ester hydrolases
Protein Class

Descriptions

(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain and prevent untimely PME activity during transport.

Autoinhibitory domains (AIDs)

67-223 (PMEI region) SS

Target domain

273-569 (Pectinesterase domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O04886

Entry ID Method Resolution Chain Position Source
AF-O04886-F1 Predicted AlphaFoldDB

No variants for O04886

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O04886

No associated diseases with O04886

8 regional properties for O04886

Type Name Position InterPro Accession
domain Dbl homology (DH) domain 216 - 396 IPR000219
domain SH2 domain 620 - 726 IPR000980
domain SH3 domain 726 - 788 IPR001452
domain Calponin homology domain 18 - 137 IPR001715
domain Pleckstrin homology domain 432 - 543 IPR001849
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 552 - 601 IPR002219
domain Vav, SH2 domain, invertebrate 616 - 726 IPR035031
domain Vav, PH domain 416 - 545 IPR037832

Functions

Description
EC Number 3.1.1.11 Carboxylic ester hydrolases
Subcellular Localization
  • Secreted, cell wall
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

3 GO annotations of molecular function

Name Definition
aspartyl esterase activity Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue.
enzyme inhibitor activity Binds to and stops, prevents or reduces the activity of an enzyme.
pectinesterase activity Catalysis of the reaction: pectin + n H2O = n methanol + pectate.

2 GO annotations of biological process

Name Definition
cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly.
pectin catabolic process The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTHIKEFFTK LSESSSNQNI SNIPKKKKKL FLALFATLLV VAAVIGIVAG VNSRKNSGDN
70 80 90 100 110 120
GNEPHHAILK SSCSSTRYPD LCFSAIAAVP EASKKVTSQK DVIEMSLNIT TTAVEHNYFG
130 140 150 160 170 180
IQKLLKRTNL TKREKVALHD CLETIDETLD ELHKAVEDLE EYPNKKSLSQ HADDLKTLMS
190 200 210 220 230 240
AAMTNQGTCL DGFSHDDANK HVRDALSDGQ VHVEKMCSNA LAMIKNMTDT DMMIMRTSNN
250 260 270 280 290 300
RKLTEETSTV DGWPAWLSPG DRRLLQSSSV TPNAVVAADG SGNFKTVAAA VAAAPQGGTK
310 320 330 340 350 360
RYIIRIKAGV YRENVEVTKK HKNIMFIGDG RTRTIITGSR NVVDGSTTFK SATAAVVGEG
370 380 390 400 410 420
FLARDITFQN TAGPSKHQAV ALRVGADLSA FYNCDMLAYQ DTLYVHSNRQ FFVNCLIAGT
430 440 450 460 470 480
VDFIFGNAAA VLQNCDIHAR KPNSGQKNMV TAQGRTDPNQ NTGIVIQKSR IGATSDLKPV
490 500 510 520 530 540
QGSFPTYLGR PWKEYSRTVI MQSSITDLIH PAGWHEWDGN FALNTLFYGE HQNSGAGAGT
550 560 570 580
SGRVKWKGFR VITSATEAQA FTPGSFIAGS SWLGSTGFPF SLGL