O02810

PR
Gene name
PI4KB (PIK4CB)
Protein name
Phosphatidylinositol 4-kinase beta
Names
PI4K-beta, PI4Kbeta, PtdIns 4-kinase beta
Species
Bos taurus (Bovine)
KEGG Pathway
bta:286846
EC number
2.7.1.67: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-157 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

689-711 (Activation loop from InterPro)

Target domain

529-816 (Catalytic domain of Type III Phosphoinositide 4-kinase beta)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

2 structures for O02810

Entry ID Method Resolution Chain Position Source
5EUQ X-ray 320 A E 288-422 PDB
AF-O02810-F1 Predicted AlphaFoldDB

No variants for O02810

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O02810

No associated diseases with O02810

4 regional properties for O02810

Type Name Position InterPro Accession
domain Phosphatidylinositol 3-/4-kinase, catalytic domain 535 - 814 IPR000403
domain Phosphoinositide 3-kinase, accessory (PIK) domain 29 - 242 IPR001263
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 563 - 577 IPR018936-1
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 656 - 676 IPR018936-2

Functions

Description
EC Number 2.7.1.67 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Endomembrane system
  • Mitochondrion outer membrane ; Peripheral membrane protein
  • Rough endoplasmic reticulum membrane ; Peripheral membrane protein
  • Golgi apparatus
  • Golgi apparatus membrane
  • Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum
  • Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex
  • Recruited to the Golgi apparatus membrane by ACBD3, GGA2 is also involved in the recruitment
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
rough endoplasmic reticulum membrane The lipid bilayer surrounding the rough endoplasmic reticulum.

4 GO annotations of molecular function

Name Definition
1-phosphatidylinositol 4-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).
14-3-3 protein binding Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphatidylinositol kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate.

3 GO annotations of biological process

Name Definition
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P39104 PIK1 Phosphatidylinositol 4-kinase PIK1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P32871 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Bos taurus (Bovine) PR
Q9UBF8 PI4KB Phosphatidylinositol 4-kinase beta Homo sapiens (Human) PR
Q8BKC8 Pi4kb Phosphatidylinositol 4-kinase beta Mus musculus (Mouse) PR
O08561 Pi4kb Phosphatidylinositol 4-kinase beta Rattus norvegicus (Rat) PR
A4IID4 pi4kb Phosphatidylinositol 4-kinase beta Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q49GP3 pi4kb Phosphatidylinositol 4-kinase beta Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MGDTIVEPAP LKPTSEPAPG PPGNNGGSLL SVITEGVGEL SVIDPEVAQK ACQEVLEKVK
70 80 90 100 110 120
LLHGGVAISS RGTPLELVNG DGVDSEIRCL DDPPAQIREE EDEMGATVAS GTAKGARRRR
130 140 150 160 170 180
QNNSAKQSWL LRLFESKLFD ISMAISYLYN SKEPGVQAYI GNRLFCFRNE DVDFYLPQLL
190 200 210 220 230 240
NMYIHMDEDV GDAIKPYIVH RCRQSINFSL QCALLLGAYS SDMHISTQRH SRGTKLRKLI
250 260 270 280 290 300
LSDELKPAHR KRELPSLSPA PDTGLSPSKR THQRSKSDAT ASISLSSNLK RTASNPKVEN
310 320 330 340 350 360
EDEELSSSTE SIDNSFSSPV RLAPEREFIK SLMAIGKRLA TLPTKEQKTQ RLISELSLLN
370 380 390 400 410 420
HKLPARVWLP TAGFDHHVVR VPHTQAVVLN SKDKAPYLIY VEVLECENFD TTSVPARIPE
430 440 450 460 470 480
NRIRSTRSVE NLPECGITHE QRAGSFSTVP NYDNDDEAWS VDDIGELQVE LPEVHTNSCD
490 500 510 520 530 540
NISQFSVDSI TSQESKEPVF IAAGDIRRRL SEQLAHTPTA FKRDPEDPSA VALKEPWQEK
550 560 570 580 590 600
VRRIREGSPY GHLPNWRLLS VIVKCGDDLR QELLAFQVLK QLQSIWEQER VPLWIKPYKI
610 620 630 640 650 660
LVISADSGMI EPVVNAVSIH QVKKQSQLSL LDYFLQEHGS YTTEAFLSAQ RNFVQSCAGY
670 680 690 700 710 720
CLGCYLLQVK DRHNGNILLD AEGHIIHIDF GFILSSSPRN LGFETSAFKL TTEFVDVMGG
730 740 750 760 770 780
LDGDMFNYYK MLMLQGLIAA RKHMDKVVQI VEIMQQGSQL PCFHGSSTIR NLKERFHMSM
790 800 810
TEEQLQLLVE QMVDGSMRSI TTKLYDGFQY LTNGIM