O02755

SS
Gene name
CEBPB
Protein name
CCAAT/enhancer-binding protein beta
Names
C/EBP beta
Species
Bos taurus (Bovine)
KEGG Pathway
bta:338319
EC number
Protein Class

Descriptions

CEBPB is a transcription factor that regulates oncogenic H-RasV12-induced senescence and growth arrest. Three distinct N-terminal sequences that are predicted to form secondary structures inhibit CEBPB DNA binding. These include the autoinhibitory domain, which is located within CR5, and two LX motifs (LX1 and LX2). CEBPB is autoinhibited by these multiple elements, which also play a role in mediating interactions with coactivators. The autoinhibitory region physically interacts with the basic region within the DNA-binding domain to achieve autoinhibition.Truncation of the autoinhibitory domain, LX1, and/or LX2 recovered CEBPB DNA binding activity

Autoinhibitory domains (AIDs)

88-165 (N-terminal autoinhibitory region) SS

Target domain

272-337 (DNA-binding domain (bZIP region))

Relief mechanism

Partner binding, PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O02755

Entry ID Method Resolution Chain Position Source
AF-O02755-F1 Predicted AlphaFoldDB

No variants for O02755

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O02755

No associated diseases with O02755

1 regional properties for O02755

Type Name Position InterPro Accession
domain Basic-leucine zipper domain 272 - 337 IPR004827

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Translocates to the nucleus when phosphorylated at Ser-288
  • In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription repressor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
protein homodimerization activity Binding to an identical protein to form a homodimer.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

16 GO annotations of biological process

Name Definition
cell differentiation The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
hepatocyte proliferation The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules.
liver regeneration The regrowth of lost or destroyed liver.
negative regulation of T cell proliferation Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
ovarian follicle development The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
positive regulation of fat cell differentiation Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
positive regulation of interleukin-4 production Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
regulation of cell differentiation Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of odontoblast differentiation Any process that modulates the frequency, rate or extent of odontoblast differentiation.
regulation of osteoclast differentiation Any process that modulates the frequency, rate or extent of osteoclast differentiation.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to endoplasmic reticulum stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P17676 CEBPB CCAAT/enhancer-binding protein beta Homo sapiens (Human) EV
P28033 Cebpb CCAAT/enhancer-binding protein beta Mus musculus (Mouse) SS
P21272 Cebpb CCAAT/enhancer-binding protein beta Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MQRLVVWDPV CLPLPPPPPA FKSMEVANFY YEADCLAAAY GGKAAPAAPP ADRPGPRPPT
70 80 90 100 110 120
GELGSIGEHE RAIDFSPYLE PLGAPQAPAP TTASDTFEAA PSAPAPVPAS SGQHHDFLSD
130 140 150 160 170 180
LFSDDYGGKN CKKAAEYGYV SLGRLGAAKG ALHPGCFAPL HPPPPPPPPP AELKAEPGFE
190 200 210 220 230 240
PADCKRKEEA GAPGGGAAGM AAGFPYALRA YLGYQAVPSG SSGSLSTSSS SSPPGTPSPA
250 260 270 280 290 300
DAKATPAAAA CYAGAAPAPS QVKSKAKKTV DKHSDEYKIR RERNNIAVRK SRDKAKMRNL
310 320 330 340
ETQHKVLELT GENERLQKKV EQLSREVSTL RNLFKTLPEP LLASSGHC