O02740
PR
Gene name |
GUCY2F (GUC2F) |
Protein name |
Retinal guanylyl cyclase 2 |
Names |
RETGC-2, Guanylate cyclase 2F, retinal, Guanylate cyclase F, GC-F, Rod outer segment membrane guanylate cyclase 2, ROS-GC2 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:282246 |
EC number |
4.6.1.2: Phosphorus-oxygen lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O02740
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O02740-F1 | Predicted | AlphaFoldDB |
No variants for O02740
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O02740 | |||||
No associated diseases with O02740
6 regional properties for O02740
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 532 - 812 | IPR000719 |
| domain | Adenylyl cyclase class-3/4/guanylyl cyclase | 848 - 1061 | IPR001054 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 595 - 808 | IPR001245 |
| domain | Receptor, ligand binding region | 73 - 413 | IPR001828 |
| domain | Haem NO binding associated | 825 - 869 | IPR011645 |
| conserved_site | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | 991 - 1014 | IPR018297 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.6.1.2 | Phosphorus-oxygen lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| rod photoreceptor outer segment | The outer segment of a vertebrate rod photoreceptor that contains sealed membrane discs that are not connected to the ciliary membrane and containing rhodopsin photoreceptor proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| guanylate cyclase activity | Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| visual perception | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. |
17 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P46197 | NPR2 | Atrial natriuretic peptide receptor 2 | Bos taurus (Bovine) | PR |
| Q02846 | GUCY2D | Retinal guanylyl cyclase 1 | Homo sapiens (Human) | PR |
| P20594 | NPR2 | Atrial natriuretic peptide receptor 2 | Homo sapiens (Human) | PR |
| P51841 | GUCY2F | Retinal guanylyl cyclase 2 | Homo sapiens (Human) | PR |
| P52785 | Gucy2e | Retinal guanylyl cyclase 1 | Mus musculus (Mouse) | PR |
| Q6VVW5 | Npr2 | Atrial natriuretic peptide receptor 2 | Mus musculus (Mouse) | PR |
| Q5SDA5 | Gucy2f | Retinal guanylyl cyclase 2 | Mus musculus (Mouse) | PR |
| P51840 | Gucy2e | Retinal guanylyl cyclase 1 | Rattus norvegicus (Rat) | PR |
| P18910 | Npr1 | Atrial natriuretic peptide receptor 1 | Rattus norvegicus (Rat) | PR |
| P16067 | Npr2 | Atrial natriuretic peptide receptor 2 | Rattus norvegicus (Rat) | PR |
| P51842 | Gucy2f | Retinal guanylyl cyclase 2 | Rattus norvegicus (Rat) | PR |
| Q09435 | gcy-1 | Receptor-type guanylate cyclase gcy-1 | Caenorhabditis elegans | PR |
| O16544 | gcy-19 | Receptor-type guanylate cyclase gcy-19 | Caenorhabditis elegans | PR |
| Q18331 | gcy-11 | Receptor-type guanylate cyclase gcy-11 | Caenorhabditis elegans | PR |
| Q10029 | gcy-2 | Receptor-type guanylate cyclase gcy-2 | Caenorhabditis elegans | PR |
| X5M8U1 | gcy-17 | Receptor-type guanylate cyclase gcy-17 | Caenorhabditis elegans | PR |
| Q23682 | gcy-5 | Receptor-type guanylate cyclase gcy-5 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFLAPWPFSH | LMLWFVTLGR | QRGQHGLASF | KLLWCLWLLV | LMSLPLQVWA | PPYKIGVVGP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WTCDPLFSKA | LPEIAAQLAT | ERINKDPALD | LGHSLEYVIF | NEDCQASRAL | SSFISHHQMA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SGFIGPANPG | YCEAASLLGN | SWDKGIFSWA | CVNYELDSKN | SHPTFSRTLP | SPIRVLLTVM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KYFQWAHAGV | ISSDEDIWVH | TAYRVASALR | SRGLPVGVVL | TTGQDSQSIQ | KALQQIRQAD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RIRIIIMCMH | STLIGGETQT | HLLEWAHDLQ | MTDGTYVFVP | YDTLLYSLPY | KHTPYKVLRN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NPKLREAYDA | VLTITVESQE | KTFYQAFEEA | AARGEIPEKL | ESDQVSPLFG | TIYNSIYFIA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QAMNNAMKEN | GWASAASLVQ | HSRNVQFYGF | NQLIRTDANG | NGISEYVILD | TNWKEWELHS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TYTVDMETEL | LRFGETPIHF | PGGRPPRADA | QCWFADGRIC | QGGINPTFAL | MVCLALLIAL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LSINGFAYFI | RHRINKIQLI | KGPNRILLTL | EDVTFINPHF | GSKRGSHASV | SFQITSEVQS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GRSPRLSFSS | GSLTPATCEN | SNIAIYEGDW | VWLKKFPSGN | FGDIKSVESS | ASDIFEMMKD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LRHENINPLV | GFFYDSGVFA | IVTEFCSRRS | LEDILMNQDV | KLDWMFKSSL | LLDLIKGMKY |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LHHREFAHGR | LKSRNCVVDG | RFVLKVTDYG | FNDILETLRL | SQEEPSAEEL | LWTAPELLRA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PRGSRLRSFA | GDVYSFAIIM | QEVMVRGTPF | CMMDLPAKEI | IERIKKPPPV | YRPVVPPEHA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PPECLQLMKQ | CWAEAAEQRP | TFDEIFNQFK | TFNKGKKTNI | IDSMLRMLEQ | YSSNLEDLIQ |
| 850 | 860 | 870 | 880 | 890 | 900 |
| ERTEELEIEK | QKTEKLLTQM | LPPSVAESLK | KGCTVEPEGF | DLVTLYFSDI | VGFTTISAMS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| EPIEVVDLLN | DLYTLFDAII | GSHDVYKVET | IGDAYMVASG | LPKRNGMRHA | AEIANMSLDI |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LSSVGTFKMR | HMPEVPVRIR | IGLHSGPVVA | GVVGLTMPRY | CLFGDTVNTA | SRMESTGLPY |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| RIHVSHSTVT | ILRTLGEGYE | VELRGRTELK | GKGTEETFWL | VGKKGFTKPL | PVPPPVGKDG |
| 1090 | 1100 | ||||
| QVGHGLQSVE | IAAFQRRKQK | SSW |