O02697
Gene name |
PIK3CG |
Protein name |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform |
Names |
PI3-kinase subunit gamma, PI3K-gamma, PI3Kgamma, PtdIns-3-kinase subunit gamma, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, PtdIns-3-kinase subunit p110-gamma, p110gamma, Phosphoinositide-3-kinase catalytic gamma polypeptide, Serine/threonine protein kinase PIK3CG, p120-PI3K |
Species |
Sus scrofa (Pig) |
KEGG Pathway |
ssc:396979 |
EC number |
2.7.1.137: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|

Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
964-988 (Activation loop from InterPro)
Target domain |
797-1094 (Phosphatidylinositol 3-/4-kinase, catalytic domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure

Activated structure

7 structures for O02697
No variants for O02697
Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
---|---|---|---|---|---|
No variants for O02697 |
No associated diseases with O02697
8 regional properties for O02697
Type | Name | Position | InterPro Accession |
---|---|---|---|
domain | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain | 203 - 312 | IPR000341 |
domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | 797 - 1094 | IPR000403 |
domain | Phosphoinositide 3-kinase, accessory (PIK) domain | 541 - 733 | IPR001263 |
domain | C2 phosphatidylinositol 3-kinase-type domain | 349 - 521 | IPR002420 |
domain | Phosphatidylinositol 3-kinase, adaptor-binding domain | 34 - 141 | IPR003113 |
conserved_site | Phosphatidylinositol 3/4-kinase, conserved site | 832 - 846 | IPR018936-1 |
conserved_site | Phosphatidylinositol 3/4-kinase, conserved site | 931 - 951 | IPR018936-2 |
domain | PIK3 catalytic subunit gamma, adaptor-binding domain | 1 - 192 | IPR045580 |
Functions
Description | ||
---|---|---|
EC Number | 2.7.1.137 | Phosphotransferases with an alcohol group as acceptor |
Subcellular Localization |
|
|
PANTHER Family | ||
PANTHER Subfamily | ||
PANTHER Protein Class | ||
PANTHER Pathway Category | No pathway information available |
2 GO annotations of cellular component
Name | Definition |
---|---|
cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
7 GO annotations of molecular function
Name | Definition |
---|---|
1-phosphatidylinositol-3-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+). |
1-phosphatidylinositol-4-phosphate 3-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+). |
ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
phosphatidylinositol-3,4-bisphosphate 5-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+). |
phosphatidylinositol-4,5-bisphosphate 3-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+). |
protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
8 GO annotations of biological process
Name | Definition |
---|---|
angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
chemotaxis | The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
immune system process | Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. |
inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
phosphatidylinositol phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. |
phosphatidylinositol-mediated signaling | The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
11 homologous proteins in AiPD
UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
---|---|---|---|---|
P32871 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Bos taurus (Bovine) | PR |
P42336 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Homo sapiens (Human) | PR |
P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Homo sapiens (Human) | PR |
O00329 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | Homo sapiens (Human) | PR |
P48736 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Homo sapiens (Human) | PR |
P42337 | Pik3ca | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Mus musculus (Mouse) | PR |
Q8BTI9 | Pik3cb | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Mus musculus (Mouse) | PR |
O35904 | Pik3cd | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | Mus musculus (Mouse) | PR |
Q9JHG7 | Pik3cg | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Mus musculus (Mouse) | PR |
Q9Z1L0 | Pik3cb | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Rattus norvegicus (Rat) | PR |
Q94125 | age-1 | Phosphatidylinositol 3-kinase age-1 | Caenorhabditis elegans | PR |
10 | 20 | 30 | 40 | 50 | 60 |
MELENYEQPV | VLREDNRRRR | RRMKPRSTAA | SLSSMELIPI | EFVLPTSQRN | TKTPETALLH |
70 | 80 | 90 | 100 | 110 | 120 |
VAGHGNVEQM | KAQVWLRALE | TSVSADFYHR | LGPDHFLLLY | QKKGQWYEIY | DKYQVVQTLD |
130 | 140 | 150 | 160 | 170 | 180 |
CLRYWKVLHR | SPGQIHVVQR | HAPSEETLAF | QRQLNALIGY | DVTDVSNVHD | DELEFTRRRL |
190 | 200 | 210 | 220 | 230 | 240 |
VTPRMAEVAG | RDPKLYAMHP | WVTSKPLPEY | LLKKITNNCV | FIVIHRSTTS | QTIKVSADDT |
250 | 260 | 270 | 280 | 290 | 300 |
PGTILQSFFT | KMAKKKSLMD | IPESQNERDF | VLRVCGRDEY | LVGETPIKNF | QWVRQCLKNG |
310 | 320 | 330 | 340 | 350 | 360 |
EEIHLVLDTP | PDPALDEVRK | EEWPLVDDCT | GVTGYHEQLT | IHGKDHESVF | TVSLWDCDRK |
370 | 380 | 390 | 400 | 410 | 420 |
FRVKIRGIDI | PVLPRTADLT | VFVEANIQYG | QQVLCQRRTS | PKPFTEEVLW | NVWLEFSIKI |
430 | 440 | 450 | 460 | 470 | 480 |
KDLPKGALLN | LQIYCGKAPA | LSGKTSAEMP | SPESKGKAQL | LYYVNLLLID | HRFLLRHGEY |
490 | 500 | 510 | 520 | 530 | 540 |
VLHMWQLSGK | GEDQGSFNAD | KLTSRTNPDK | ENSMSISILL | DNYCHPIALP | KHRPTPDPEG |
550 | 560 | 570 | 580 | 590 | 600 |
DRVRAEMPNQ | LRKQLEAIIA | TDPLNPLTAE | DKELLWHFRY | ESLKDPKAYP | KLFSSVKWGQ |
610 | 620 | 630 | 640 | 650 | 660 |
QEIVAKTYQL | LAKREVWDQS | ALDVGLTMQL | LDCNFSDENV | RAIAVQKLES | LEDDDVLHYL |
670 | 680 | 690 | 700 | 710 | 720 |
LQLVQAVKFE | PYHDSALARF | LLKRGLRNKR | IGHFLFWFLR | SEIAQSRHYQ | QRFAVILEAY |
730 | 740 | 750 | 760 | 770 | 780 |
LRGCGTAMLH | DFTQQVQVID | MLQKVTIDIK | SLSAEKYDVS | SQVISQLKQK | LENLQNLNLP |
790 | 800 | 810 | 820 | 830 | 840 |
QSFRVPYDPG | LKAGALVIEK | CKVMASKKKP | LWLEFKCADP | TALSNETIGI | IFKHGDDLRQ |
850 | 860 | 870 | 880 | 890 | 900 |
DMLILQILRI | MESIWETESL | DLCLLPYGCI | STGDKIGMIE | IVKDATTIAK | IQQSTVGNTG |
910 | 920 | 930 | 940 | 950 | 960 |
AFKDEVLSHW | LKEKCPIEEK | FQAAVERFVY | SCAGYCVATF | VLGIGDRHND | NIMISETGNL |
970 | 980 | 990 | 1000 | 1010 | 1020 |
FHIDFGHILG | NYKSFLGINK | ERVPFVLTPD | FLFVMGTSGK | KTSLHFQKFQ | DVCVKAYLAL |
1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
RHHTNLLIIL | FSMMLMTGMP | QLTSKEDIEY | IRDALTVGKS | EEDAKKYFLD | QIEVCRDKGW |
1090 | 1100 | ||||
TVQFNWFLHL | VLGIKQGEKH | SA |