O02697

PR
Gene name
PIK3CG
Protein name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Names
PI3-kinase subunit gamma, PI3K-gamma, PI3Kgamma, PtdIns-3-kinase subunit gamma, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, PtdIns-3-kinase subunit p110-gamma, p110gamma, Phosphoinositide-3-kinase catalytic gamma polypeptide, Serine/threonine protein kinase PIK3CG, p120-PI3K
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:396979
EC number
2.7.1.137: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

964-988 (Activation loop from InterPro)

Target domain

797-1094 (Phosphatidylinositol 3-/4-kinase, catalytic domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

7 structures for O02697

Entry ID Method Resolution Chain Position Source
1E7U X-ray 200 A A 144-1102 PDB
1E7V X-ray 240 A A 144-1102 PDB
1E8W X-ray 250 A A 144-1102 PDB
1E8X X-ray 220 A A 144-1102 PDB
1E90 X-ray 270 A A 144-1102 PDB
8AJ8 X-ray 850 A A/C/E/G 1-1102 PDB
AF-O02697-F1 Predicted AlphaFoldDB

No variants for O02697

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O02697

No associated diseases with O02697

8 regional properties for O02697

Type Name Position InterPro Accession
domain Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain 203 - 312 IPR000341
domain Phosphatidylinositol 3-/4-kinase, catalytic domain 797 - 1094 IPR000403
domain Phosphoinositide 3-kinase, accessory (PIK) domain 541 - 733 IPR001263
domain C2 phosphatidylinositol 3-kinase-type domain 349 - 521 IPR002420
domain Phosphatidylinositol 3-kinase, adaptor-binding domain 34 - 141 IPR003113
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 832 - 846 IPR018936-1
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 931 - 951 IPR018936-2
domain PIK3 catalytic subunit gamma, adaptor-binding domain 1 - 192 IPR045580

Functions

Description
EC Number 2.7.1.137 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cytoplasm
  • Cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

7 GO annotations of molecular function

Name Definition
1-phosphatidylinositol-3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).
1-phosphatidylinositol-4-phosphate 3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphatidylinositol-3,4-bisphosphate 5-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).
phosphatidylinositol-4,5-bisphosphate 3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

8 GO annotations of biological process

Name Definition
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
immune system process Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32871 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Bos taurus (Bovine) PR
P42336 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Homo sapiens (Human) PR
P42338 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Homo sapiens (Human) PR
O00329 PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Homo sapiens (Human) PR
P48736 PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (Human) PR
P42337 Pik3ca Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Mus musculus (Mouse) PR
Q8BTI9 Pik3cb Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Mus musculus (Mouse) PR
O35904 Pik3cd Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Mus musculus (Mouse) PR
Q9JHG7 Pik3cg Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Mus musculus (Mouse) PR
Q9Z1L0 Pik3cb Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Rattus norvegicus (Rat) PR
Q94125 age-1 Phosphatidylinositol 3-kinase age-1 Caenorhabditis elegans PR
10 20 30 40 50 60
MELENYEQPV VLREDNRRRR RRMKPRSTAA SLSSMELIPI EFVLPTSQRN TKTPETALLH
70 80 90 100 110 120
VAGHGNVEQM KAQVWLRALE TSVSADFYHR LGPDHFLLLY QKKGQWYEIY DKYQVVQTLD
130 140 150 160 170 180
CLRYWKVLHR SPGQIHVVQR HAPSEETLAF QRQLNALIGY DVTDVSNVHD DELEFTRRRL
190 200 210 220 230 240
VTPRMAEVAG RDPKLYAMHP WVTSKPLPEY LLKKITNNCV FIVIHRSTTS QTIKVSADDT
250 260 270 280 290 300
PGTILQSFFT KMAKKKSLMD IPESQNERDF VLRVCGRDEY LVGETPIKNF QWVRQCLKNG
310 320 330 340 350 360
EEIHLVLDTP PDPALDEVRK EEWPLVDDCT GVTGYHEQLT IHGKDHESVF TVSLWDCDRK
370 380 390 400 410 420
FRVKIRGIDI PVLPRTADLT VFVEANIQYG QQVLCQRRTS PKPFTEEVLW NVWLEFSIKI
430 440 450 460 470 480
KDLPKGALLN LQIYCGKAPA LSGKTSAEMP SPESKGKAQL LYYVNLLLID HRFLLRHGEY
490 500 510 520 530 540
VLHMWQLSGK GEDQGSFNAD KLTSRTNPDK ENSMSISILL DNYCHPIALP KHRPTPDPEG
550 560 570 580 590 600
DRVRAEMPNQ LRKQLEAIIA TDPLNPLTAE DKELLWHFRY ESLKDPKAYP KLFSSVKWGQ
610 620 630 640 650 660
QEIVAKTYQL LAKREVWDQS ALDVGLTMQL LDCNFSDENV RAIAVQKLES LEDDDVLHYL
670 680 690 700 710 720
LQLVQAVKFE PYHDSALARF LLKRGLRNKR IGHFLFWFLR SEIAQSRHYQ QRFAVILEAY
730 740 750 760 770 780
LRGCGTAMLH DFTQQVQVID MLQKVTIDIK SLSAEKYDVS SQVISQLKQK LENLQNLNLP
790 800 810 820 830 840
QSFRVPYDPG LKAGALVIEK CKVMASKKKP LWLEFKCADP TALSNETIGI IFKHGDDLRQ
850 860 870 880 890 900
DMLILQILRI MESIWETESL DLCLLPYGCI STGDKIGMIE IVKDATTIAK IQQSTVGNTG
910 920 930 940 950 960
AFKDEVLSHW LKEKCPIEEK FQAAVERFVY SCAGYCVATF VLGIGDRHND NIMISETGNL
970 980 990 1000 1010 1020
FHIDFGHILG NYKSFLGINK ERVPFVLTPD FLFVMGTSGK KTSLHFQKFQ DVCVKAYLAL
1030 1040 1050 1060 1070 1080
RHHTNLLIIL FSMMLMTGMP QLTSKEDIEY IRDALTVGKS EEDAKKYFLD QIEVCRDKGW
1090 1100
TVQFNWFLHL VLGIKQGEKH SA