O01836
PR
Gene name |
glh-3 |
Protein name |
ATP-dependent RNA helicase glh-3 |
Names |
Germline helicase 3 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_B0414.6 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O01836
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O01836-F1 | Predicted | AlphaFoldDB |
No variants for O01836
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O01836 | |||||
No associated diseases with O01836
8 regional properties for O01836
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 454 - 462 | IPR000629 |
| domain | Helicase, C-terminal | 549 - 698 | IPR001650 |
| domain | Zinc finger, CCHC-type | 202 - 219 | IPR001878-1 |
| domain | Zinc finger, CCHC-type | 223 - 239 | IPR001878-2 |
| domain | DEAD/DEAH box helicase domain | 322 - 501 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 317 - 529 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 298 - 326 | IPR014014 |
| domain | Ded1/Dbp1, DEAD-box helicase domain | 299 - 520 | IPR044763 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| P granule | A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DEAD/H-box RNA helicase binding | Binding to a DEAD/H-box RNA helicase. |
| JUN kinase binding | Binding to JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family. |
| protein self-association | Binding to a domain within the same polypeptide. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| gamete generation | The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. |
18 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5W5U4 | DDX4 | Probable ATP-dependent RNA helicase DDX4 | Bos taurus (Bovine) | SS |
| Q6GVM6 | DDX3Y | ATP-dependent RNA helicase DDX3Y | Pan troglodytes (Chimpanzee) | SS |
| O00571 | DDX3X | ATP-dependent RNA helicase DDX3X | Homo sapiens (Human) | EV |
| Q9NQI0 | DDX4 | Probable ATP-dependent RNA helicase DDX4 | Homo sapiens (Human) | SS |
| O15523 | DDX3Y | ATP-dependent RNA helicase DDX3Y | Homo sapiens (Human) | SS |
| Q62167 | Ddx3x | ATP-dependent RNA helicase DDX3X | Mus musculus (Mouse) | SS |
| P16381 | D1Pas1 | Putative ATP-dependent RNA helicase Pl10 | Mus musculus (Mouse) | SS |
| Q62095 | Ddx3y | ATP-dependent RNA helicase DDX3Y | Mus musculus (Mouse) | SS |
| Q61496 | Ddx4 | ATP-dependent RNA helicase DDX4 | Mus musculus (Mouse) | SS |
| Q6GWX0 | DDX4 | Probable ATP-dependent RNA helicase DDX4 | Sus scrofa (Pig) | SS |
| Q2R1M8 | Os11g0599500 | DEAD-box ATP-dependent RNA helicase 52C | Oryza sativa subsp. japonica (Rice) | SS |
| Q6Z4K6 | PL10B | DEAD-box ATP-dependent RNA helicase 52B | Oryza sativa subsp. japonica (Rice) | SS |
| Q75HJ0 | PL10A | DEAD-box ATP-dependent RNA helicase 37 | Oryza sativa subsp. japonica (Rice) | SS |
| Q18212 | hel-1 | Spliceosome RNA helicase DDX39B homolog | Caenorhabditis elegans | PR |
| D0PV95 | laf-1 | ATP-dependent RNA helicase laf-1 | Caenorhabditis elegans | SS |
| Q84W89 | RH37 | DEAD-box ATP-dependent RNA helicase 37 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8LA13 | RH11 | DEAD-box ATP-dependent RNA helicase 11 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M2F9 | RH52 | DEAD-box ATP-dependent RNA helicase 52 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDKSPTKTSI | RTKFARHQPI | SDVDTTEQSS | SCIKKDDRGL | SSFGVQSSVF | SRRSCRMSEL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EAKPTIISED | QRIAVRSEIG | GSFSGFDDKV | DNVFHSNNNL | HGSPSTTELE | CPGIMNPRFL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VGRSLNSRSR | AVTRGSKRTS | NVKENEGSIH | RSDDQVSTEN | CSAKDEERDR | DSGGVSSYGN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KRSDEFCGTS | PILEAKGFGI | SNTCFNCKKY | GHRATECSAP | QRECANCGDP | NHRANECASW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SKNGVQEPTK | VTYVPVVDKM | EEVFSMLKIN | AGDFFDKFFD | ASVQLVSRGQ | PVTIQPCKSF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SDSDIPQSMR | RNVERAGYTR | TTPIQQYTLP | LVADGKDILA | CAQTGSGKTA | AFLLPIMSRL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ILEKDLNYGA | EGGCYPRCII | LTPTRELADQ | IYNEGRKFSY | QSVMEIKPVY | GGINVGYNKS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QIMKGCTIIV | GTIGRVKHFC | EDGAIKLDKC | RYLVLDEADR | MIDSMGFGPE | IEQIINYKNM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PKNDKRQTMM | FSATFPSSVQ | EAARKLLRED | YTMITIDKIG | AANKCVIQEF | ELCDRTSKVD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KLLKLLGIDI | DTYTTEKNSD | VFVKKTIVFV | AQQKMADTLA | SIMSAAQVPA | ITIHGAREQK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ERSAALKLFR | SGAKPVLIAT | AVVERGLDIK | GVDHVINYDM | PNNIDDYIHR | IGRTGRVGNS |
| 670 | 680 | 690 | 700 | 710 | |
| GRATSFISLA | DDVQILPQLV | RTLADAEQVV | PSWMKEAAGG | TSNPNKFEKS | IDTEEPEEAW |