O01798

PR
Gene name
spe-8
Protein name
Spermatocyte protein spe-8
Names
Defective spermatogenesis protein spe-8
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_F53G12.6
EC number
2.7.10.2: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-112 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

361-383 (Activation loop from InterPro)

Target domain

217-485 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for O01798

Entry ID Method Resolution Chain Position Source
AF-O01798-F1 Predicted AlphaFoldDB

No variants for O01798

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O01798

No associated diseases with O01798

6 regional properties for O01798

Type Name Position InterPro Accession
domain Chromo/chromo shadow domain 58 - 111 IPR000953
repeat Ankyrin repeat 572 - 665 IPR002110-1
repeat Ankyrin repeat 666 - 698 IPR002110-2
repeat Ankyrin repeat 699 - 728 IPR002110-3
conserved_site Chromo domain, conserved site 76 - 96 IPR023779
domain Chromo domain 59 - 109 IPR023780

Functions

Description
EC Number 2.7.10.2 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
  • Cytoplasm
  • Localizes mainly in the cytoplasm of stage I spermatocytes and at the cell membrane of stage II spermatocytes and spermatids
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extrinsic component of cytoplasmic side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
non-membrane spanning protein tyrosine kinase activity Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

4 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
spermatid development The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P16591 FER Tyrosine-protein kinase Fer Homo sapiens (Human) PR
P70451 Fer Tyrosine-protein kinase Fer Mus musculus (Mouse) PR
P09760 Fer Tyrosine-protein kinase Fer Rattus norvegicus (Rat) PR
Q8I7I5 rol-3 Protein roller-3 Caenorhabditis elegans PR
O45539 src-2 Tyrosine protein-kinase src-2 Caenorhabditis elegans SS
O16262 nipi-4 Protein nipi-4 Caenorhabditis elegans PR
P03949 abl-1 Tyrosine-protein kinase abl-1 Caenorhabditis elegans SS
G5ECJ6 csk-1 Tyrosine-protein kinase csk-1 Caenorhabditis elegans SS
G5EE56 src-1 Tyrosine protein-kinase src-1 Caenorhabditis elegans SS
Q95YD4 kin-32 Inactive tyrosine-protein kinase kin-32 Caenorhabditis elegans PR
Q2MHE4 HT1 Serine/threonine/tyrosine-protein kinase HT1 Arabidopsis thaliana (Mouse-ear cress) PR
O22558 STY8 Serine/threonine-protein kinase STY8 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWL6 STY17 Serine/threonine-protein kinase STY17 Arabidopsis thaliana (Mouse-ear cress) PR
F4JTP5 STY46 Serine/threonine-protein kinase STY46 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MRSKSSEGDL QPEDTQSRED KETTATYSED TKPETQKERN AALDNLAKTP IQLVVQPTPL
70 80 90 100 110 120
TPAITPCEAP PPPPPPKPSS DNNNSKRLKV KDQLIEVPSD EVGRVENNID NFPFYHGFMG
130 140 150 160 170 180
RNECEAMLSN HGDFLIRMTE IGKRVAYVIS IKWKYQNIHV LVKRTKTKKL YWTKKYAFKS
190 200 210 220 230 240
ICELIAYHKR NHKPIYEGMT LICGLARHGW QLNNEQVTLN KKLGEGQFGE VHKGSLKTSV
250 260 270 280 290 300
FAAPVTVAVK TLHQNHLSAN EKILFLREAN VMLTLSHPNV IKFYGVCTMK EPIMIVMEFC
310 320 330 340 350 360
DGKSLEDALL SKEEKVSAED KILYLFHAAC GIDYLHGKQV IHRDIAARNC LLNSKKILKI
370 380 390 400 410 420
SDFGLSVKGV AIKERKGGCL PVKYMAPETL KKGLYSTASD IYSYGALMYE VYTDGKTPFE
430 440 450 460 470 480
TCGLRGNELR KAIIGKRISL AVEVELPVFI ANIFEQSRQY ETEDRISSKQ IIQIFKEEVG
490 500 510
FHEIETSGIL HKLVNSLPRI HNKERKPAAV AV