AiPD: Autoinhibited Protein Database

O00629

Gene name	KPNA4 (QIP1)
Protein name	Importin subunit alpha-3
Names	Importin alpha Q1, Qip1, Karyopherin subunit alpha-4
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3840
EC number
Protein Class

Descriptions

Importin subunit alpha functions in the nuclear transport of classical nuclear localization signal (cNLS)-containing cargo. The NLS binding site in importin alpha proteins may be autoinhibited by the N-terminal IBB domain.

Autoinhibitory domains (AIDs)

2-58 (IBB domain) SS

Target domain	103-498 (NLS-binding domain comprising armadillo (Arm) repeats)
Relief mechanism	Partner binding
Assay

AID

2-58 (IBB domain)

Target domain

103-498 (NLS-binding domain comprising armadillo (Arm) repeats)

Relief mechanism

Partner binding (importin-beta binding)

Assay

Accessory elements

No accessory elements

References

Kimoto C et al. (2015) "Functional characterization of importin α8 as a classical nuclear localization signal receptor", Biochimica et biophysica acta, 1853, 2676-83

Kobe B (1999) "Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha", Nature structural biology, 6, 388-97

Miyatake H et al. (2015) "Crystal structure of human importin-α1 (Rch1), revealing a potential autoinhibition mode involving homodimerization", PloS one, 10, e0115995

Catimel B et al. (2001) "Biophysical characterization of interactions involving importin-alpha during nuclear import", The Journal of biological chemistry, 276, 34189-98

Autoinhibited structure

Activated structure

18 structures for O00629

Entry ID	Method	Resolution	Chain	Position	Source
4UAE	X-ray	270 A	A	68-487	PDB
5TBK	X-ray	345 A	A/B/C/D/E/F/G/H	1-521	PDB
5XZX	X-ray	300 A	A	70-485	PDB
6BVV	X-ray	230 A	A	64-521	PDB
6BVZ	X-ray	230 A	A	64-521	PDB
6BW9	X-ray	160 A	A	64-521	PDB
6BWA	X-ray	220 A	A	64-521	PDB
6BWB	X-ray	230 A	A	64-521	PDB
6WX8	X-ray	230 A	A/C	64-521	PDB
7JJL	X-ray	260 A	A	64-521	PDB
7LF4	X-ray	285 A	A/C	1-521	PDB
7LFC	X-ray	210 A	A	1-521	PDB
7RFY	X-ray	250 A	A	64-521	PDB
7RG5	X-ray	215 A	A	64-521	PDB
8FUB	X-ray	275 A	A	64-521	PDB
8FZM	X-ray	300 A	A/C	64-521	PDB
8HKW	X-ray	190 A	A/B	70-485	PDB
AF-O00629-F1	Predicted				AlphaFoldDB

212 variants for O00629

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1367519851 CA355249497	3	D>E		No	ClinGen gnomAD
CA355249503 rs1406102421	3	D>H		No	ClinGen TOPMed
CA355249493 rs1424229452	4	N>S		No	ClinGen gnomAD
CA2687661 rs766838806	4	N>Y		No	ClinGen ExAC gnomAD
CA2687660 rs763354313	7	L>V		No	ClinGen ExAC TOPMed gnomAD
rs769450296 CA2687658	11	R>W		No	ClinGen ExAC gnomAD
rs1197206678 CA355249431	13	K>R		No	ClinGen gnomAD
CA87084446 rs1040237186	18	K>R		No	ClinGen TOPMed gnomAD
CA2687657 rs761398564	21	D>N		No	ClinGen ExAC gnomAD
CA355249358 rs1225046707	23	E>A		No	ClinGen TOPMed
CA355246554 rs1428852240	24	T>A		No	ClinGen gnomAD
rs1344861219 CA355246541	25	M>I		No	ClinGen gnomAD
COSM168156 CA355246516 rs1427724913	29	R>Q	large_intestine endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
CA355246510 rs763578522	30	N>S		No	ClinGen ExAC gnomAD
rs763578522 CA2687637	30	N>T		No	ClinGen ExAC gnomAD
rs1286423512 CA355246481	34	V>D		No	ClinGen TOPMed
CA2687601 rs202229297	39	N>K		No	ClinGen ExAC gnomAD
CA2687602 rs556752087	39	N>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1264746384 CA355246421	41	R>I		No	ClinGen TOPMed
rs1264746384 CA355246423	41	R>K		No	ClinGen TOPMed
CA355246402 rs1577056765	44	H>N		No	ClinGen Ensembl
rs536439949 CA2687595	50	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs768954151 CA2687594	55	D>E		No	ClinGen ExAC gnomAD
rs1163721154 CA355246313	56	I>S		No	ClinGen gnomAD
rs747286590 CA2687593	56	I>V		No	ClinGen ExAC gnomAD
CA355246307 rs1426133792	57	C>S		No	ClinGen gnomAD
rs1383026004 CA355246283	60	S>C		No	ClinGen gnomAD
rs1464152104 CA355246277	61	D>G		No	ClinGen TOPMed
CA87077319 rs1042700638	62	I>T		No	ClinGen Ensembl
CA2687592 rs185734795	62	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1419458040 CA355246244	66	Y>D		No	ClinGen gnomAD
rs1268360425 CA355246192	71	T>I		No	ClinGen gnomAD
CA355246191 rs1487000690	72	S>T		No	ClinGen gnomAD
CA355246159 rs1324823911	77	V>I		No	ClinGen gnomAD
CA87077263 rs950642896	83	D>N		No	ClinGen TOPMed gnomAD
CA87077255 rs1013441357	92	V>I		No	ClinGen TOPMed
rs1187253328 CA355246034	93	Q>K		No	ClinGen gnomAD
CA355245968 rs1168082870	101	S>G		No	ClinGen gnomAD
rs1425492517 CA355245961	102	D>N		No	ClinGen gnomAD
rs765202780 COSM3427272 CA2687532	103	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA2687530 rs753529883	118	I>L		No	ClinGen ExAC gnomAD
rs764000281 CA2687529	118	I>S		No	ClinGen ExAC gnomAD
CA355245851 rs753529883	118	I>V		No	ClinGen ExAC gnomAD
rs1248953599 CA355245835	120	V>A		No	ClinGen gnomAD
rs1436628246 CA355245839	120	V>I		No	ClinGen gnomAD
rs1480245609 CA355245754	129	P>L		No	ClinGen gnomAD
CA355245757 rs1435989404	129	P>S		No	ClinGen gnomAD
rs1435989404 CA355245759	129	P>T		No	ClinGen gnomAD
rs951179132 CA87076105	130	S>P		No	ClinGen TOPMed
rs773251897 CA2687492	131	L>S		No	ClinGen ExAC gnomAD
CA355245658 rs1177765457	143	A>V		No	ClinGen TOPMed gnomAD
rs762218544 CA2687490	147	S>C		No	ClinGen ExAC gnomAD
CA87076099 rs202043940	148	E>G		No	ClinGen Ensembl
rs777249403 CA2687489	148	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA355245626 rs1188978419	149	Q>*		No	ClinGen gnomAD
rs769052084 CA2687488	151	Q>E		No	ClinGen ExAC gnomAD
rs747336386 CA2687487	152	A>V		No	ClinGen ExAC gnomAD
CA355208058 rs1247151232	157	N>S		No	ClinGen gnomAD
CA355208054 rs1184006608	158	A>T		No	ClinGen gnomAD
rs764626712 CA2687467	158	A>V		No	ClinGen ExAC gnomAD
CA355208045 rs1376568295	159	V>A		No	ClinGen TOPMed
CA355208022 rs1209429228	163	L>V		No	ClinGen gnomAD
rs1395077312 CA355208013	164	R>S		No	ClinGen TOPMed
CA355207992 rs1308150671	167	H>Q		No	ClinGen gnomAD
CA2687465 rs150568783	169	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1275260385 CA355207983	169	P>S		No	ClinGen gnomAD
rs772606186 CA2687464	170	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1330610882 CA355207980	170	H>Y		No	ClinGen TOPMed
CA2687446 rs753324634	190	Q>H		No	ClinGen ExAC gnomAD
CA355207203 rs1249095296	196	I>L		No	ClinGen TOPMed
rs1249095296 CA355207205	196	I>V		No	ClinGen TOPMed
CA86621401 rs370139032	206	S>F		No	ClinGen ESP
CA86621391 rs1000808863	208	I>V		No	ClinGen Ensembl
rs1487415182 CA355207001	212	I>V		No	ClinGen TOPMed gnomAD
CA355206978 rs1192104737	214	I>V		No	ClinGen TOPMed
CA355206850 rs1577053091	223	V>F		No	ClinGen Ensembl
CA355206836 rs1366463744	224	M>L		No	ClinGen gnomAD
CA86621343 rs937267972	231	K>R		No	ClinGen Ensembl
rs1577053067 CA355206718	232	D>A		No	ClinGen Ensembl
rs1461493964 CA355206725	232	D>N		No	ClinGen TOPMed
CA355206687 rs1165589098	234	P>L		No	ClinGen TOPMed
rs1482767370 CA355206693	234	P>S		No	ClinGen gnomAD
CA2687439 rs769252531	236	P>R		No	ClinGen ExAC gnomAD
rs748061946 CA2687438	237	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1324942616 CA355206649	238	E>*		No	ClinGen TOPMed
CA355206637 rs1216985687	238	E>D		No	ClinGen gnomAD
rs1324942616 CA355206645	238	E>Q		No	ClinGen TOPMed
rs776490692 CA2687437	240	I>T		No	ClinGen ExAC gnomAD
rs965087826 CA86621060	244	L>I		No	ClinGen Ensembl
rs1263161190 CA355206541	246	A>T		No	ClinGen gnomAD
CA355206534 rs1300160067	247	L>H		No	ClinGen gnomAD
rs1328926043 CA355206537	247	L>I		No	ClinGen gnomAD
CA2687408 rs771831969	256	V>I		No	ClinGen ExAC TOPMed gnomAD
rs918558955 CA355205862 COSM729414	259	L>V	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA355205804 rs1445613235	263	V>D		No	ClinGen gnomAD
rs1577051657 CA355205746	268	Y>C		No	ClinGen Ensembl
rs201145280 CA86617616	269	L>P		No	ClinGen 1000Genomes
rs1315891433 CA355205672	274	N>S		No	ClinGen TOPMed
CA2687385 rs770117923	278	Q>R		No	ClinGen ExAC gnomAD
rs748420833 CA2687384	281	I>V		No	ClinGen ExAC gnomAD
CA355205544 rs1272050682	283	S>P		No	ClinGen gnomAD
CA2687382 rs768913542	284	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1357252831 CA355205515	285	I>T		No	ClinGen TOPMed
CA2687381 rs747122090	285	I>V		No	ClinGen ExAC gnomAD
CA86617575 rs938708131	289	L>V		No	ClinGen TOPMed
rs750701279 CA2687379	294	S>R		No	ClinGen ExAC TOPMed gnomAD
CA355205441 rs1264214427	295	H>R		No	ClinGen TOPMed
CA355205422 rs1447932914	296	Q>R		No	ClinGen TOPMed
CA355205414 rs1183421306	297	E>K		No	ClinGen TOPMed
rs1204183968 CA355205370	300	V>A		No	ClinGen gnomAD
CA2687377 rs779386613	300	V>I		No	ClinGen ExAC gnomAD
rs943080085 CA86617510	301	Q>E		No	ClinGen TOPMed gnomAD
CA355204330 rs1351857760	302	T>I		No	ClinGen gnomAD
rs1303147736 CA355204267	307	A>G		No	ClinGen TOPMed gnomAD
CA2687352 rs746430687	310	N>S		No	ClinGen ExAC TOPMed gnomAD
CA355204225 rs1270855670	311	I>V		No	ClinGen TOPMed
rs1803012 CA86611964	317	E>G		No	ClinGen Ensembl
rs1490492007 CA355204143	317	E>K		No	ClinGen TOPMed
rs201026574 CA86611959	318	Q>*		No	ClinGen 1000Genomes
CA86611930 rs866927353	320	Q>K		No	ClinGen Ensembl
rs1577048832 CA355204070	325	C>Y		No	ClinGen Ensembl
rs757679998 CA2687350	327	A>V		No	ClinGen ExAC gnomAD
CA355204016 rs1560046009	333	A>E		No	ClinGen Ensembl
CA355203997 rs1423063138	336	T>I		No	ClinGen TOPMed
CA86610531 rs200557165	347	V>L		No	ClinGen 1000Genomes gnomAD
CA86610510 rs372137958	349	F>I		No	ClinGen ESP
rs1451718394 CA355203872	352	N>S		No	ClinGen gnomAD
rs1388754479 CA355203868	353	I>V		No	ClinGen gnomAD
CA2687257 rs750490892	358	Q>E		No	ClinGen ExAC gnomAD
rs1008667332 CA86610457	359	Q>K		No	ClinGen TOPMed
CA355203801 rs1201686529	361	V>I		No	ClinGen gnomAD
rs1231675291 CA355203771	363	A>T		No	ClinGen TOPMed gnomAD
rs79605817 CA86610450	364	V>G		No	ClinGen Ensembl
CA355203715 rs1335901796	367	A>T		No	ClinGen TOPMed
rs778756891 CA86610438	368	N>S		No	ClinGen TOPMed gnomAD
rs757775746 CA355203672	370	V>I		No	ClinGen ExAC TOPMed gnomAD
CA2687255 rs757775746	370	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1343999714 CA355203658	371	P>S		No	ClinGen gnomAD
CA86610400 rs772773319	372	M>T		No	ClinGen TOPMed
CA355203647 rs1295191903 COSM162043	372	M>V	breast [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA355203608 rs1226539528	374	I>T		No	ClinGen gnomAD
CA2687253 rs764714263	375	H>P		No	ClinGen ExAC gnomAD
CA355203596 rs764714263	375	H>R		No	ClinGen ExAC gnomAD
CA2687254 rs754356894	375	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA2687252 rs761057681	376	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1374983323 CA355203547	379	K>Q		No	ClinGen gnomAD
rs550861164 CA2687235	380	G>E		No	ClinGen 1000Genomes ExAC gnomAD
CA355203228 rs1161945262	381	D>N		No	ClinGen gnomAD
rs867615718 CA86606794	386	K>R		No	ClinGen Ensembl
CA355203156 rs1354483609	391	A>T		No	ClinGen TOPMed
rs1182307627 CA355203144	392	I>M		No	ClinGen gnomAD
rs1484387425 CA355203093	400	R>G		No	ClinGen TOPMed
rs756714453 CA2687232	400	R>K		No	ClinGen ExAC gnomAD
rs1417987387 CA355203073	402	D>E		No	ClinGen TOPMed gnomAD
rs771219076 CA86605371	408	I>M		No	ClinGen ExAC gnomAD
rs1212100950 CA355202861	408	I>T		No	ClinGen gnomAD
rs1210589037 CA355202822	410	Q>H		No	ClinGen TOPMed gnomAD
CA355202795 rs1283712965	412	V>A		No	ClinGen gnomAD
rs548538065 CA2687210	413	I>T		No	ClinGen ExAC TOPMed gnomAD
rs781680930 CA2687209	414	P>S		No	ClinGen ExAC gnomAD
rs755242481 CA2687208	418	N>K		No	ClinGen ExAC gnomAD
rs765898133 CA2687207	422	V>I		No	ClinGen ExAC TOPMed gnomAD
rs765898133 CA2687206	422	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1317065006 CA355202641	423	K>R		No	ClinGen gnomAD
rs1270874980 CA355202617	425	A>T		No	ClinGen TOPMed
rs761722683 CA2687202	435	L>V		No	ClinGen ExAC gnomAD
rs760350615 CA2687199	436	S>I		No	ClinGen ExAC gnomAD
CA2687200 rs760350615	436	S>N		No	ClinGen ExAC gnomAD
CA355202527 rs1210914422	438	I>V		No	ClinGen gnomAD
CA355202416 rs1278438654	445	E>V		No	ClinGen gnomAD
CA2687197 rs771040815	446	A>T		No	ClinGen ExAC TOPMed gnomAD
CA86605246 rs552835008	446	A>V		No	ClinGen 1000Genomes
CA2687196 rs377620884	449	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA2687195 rs777997036	451	N>S		No	ClinGen ExAC gnomAD
rs1361878725 CA355202268	455	E>K		No	ClinGen gnomAD
CA2687194 rs188270862	457	G>E		No	ClinGen 1000Genomes ExAC gnomAD
CA355201896 rs1290927473	459	L>M		No	ClinGen gnomAD
CA2687181 rs775120736	459	L>R		No	ClinGen ExAC gnomAD
CA355201773 rs1577044436	466	Q>H		No	ClinGen Ensembl
CA355201739 rs202065920	468	H>Q		No	ClinGen gnomAD
rs1577044428 CA355201720	471	E>Q		No	ClinGen Ensembl
rs1410418674 CA355201644	475	K>I		No	ClinGen TOPMed
rs1410418674 CA355201648	475	K>T		No	ClinGen TOPMed
CA355201599 rs1353776318	478	Y>C		No	ClinGen gnomAD
rs377517727 CA2687178	480	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1560043293 CA355201558	480	I>M		No	ClinGen Ensembl
rs377517727 CA355201571	480	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs770146744 CA2687177	483	Q>E		No	ClinGen ExAC gnomAD
CA355201492 rs1158549941	484	F>Y		No	ClinGen TOPMed gnomAD
rs1470781479 CA355201423	488	D>G		No	ClinGen gnomAD
rs748187964 CA2687176	489	D>E		No	ClinGen ExAC TOPMed gnomAD
CA2687160 rs767371082	490	I>V		No	ClinGen ExAC gnomAD
CA2687157 rs765532352	491	D>E		No	ClinGen ExAC gnomAD
CA86601112 rs762952711	491	D>N		No	ClinGen Ensembl
rs774307739 CA2687158	491	D>V		No	ClinGen ExAC gnomAD
rs1371458562 CA355201114	493	D>G		No	ClinGen gnomAD
rs1560042642 CA355201090	495	S>G		No	ClinGen Ensembl
CA355201020 rs1262024727	500	A>P		No	ClinGen gnomAD
CA86601090 rs868189726	502	Q>*		No	ClinGen Ensembl
rs140254518 CA2687152	503	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA355200955 rs1325106106	504	G>E		No	ClinGen gnomAD
rs375916985 CA2687150	504	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1167880399 CA355200939	506	F>L		No	ClinGen TOPMed
rs746185517 CA2687149	508	F>L		No	ClinGen ExAC TOPMed gnomAD
CA2687148 rs779302903	509	N>S		No	ClinGen ExAC TOPMed gnomAD
CA2687146 rs749040807	511	S>P		No	ClinGen ExAC TOPMed gnomAD
rs1175824140 CA355200893	512	A>S		No	ClinGen gnomAD
rs1301834466 CA355200882	513	N>D		No	ClinGen TOPMed
rs777134189 CA2687145	513	N>S		No	ClinGen ExAC TOPMed gnomAD
rs755593800 CA2687144	514	V>L		No	ClinGen ExAC TOPMed gnomAD
rs867168198 CA86601043	518	G>V		No	ClinGen Ensembl
rs1189747980 CA355200793	519	F>L		No	ClinGen gnomAD

No associated diseases with O00629

1 regional properties for O00629

Type	Name	Position	InterPro Accession
domain	Small GTP-binding protein domain	75 - 233	IPR005225

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
NLS-dependent protein nuclear import complex	A dimer consisting of an alpha and a beta-subunit that imports proteins with an NLS into the nucleus through a nuclear pore.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
nuclear import signal receptor activity	Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
nuclear localization sequence binding	Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.

2 GO annotations of biological process

Name	Definition
NLS-bearing protein import into nucleus	The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope.
protein import into nucleus	The directed movement of a protein from the cytoplasm to the nucleus.

30 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q02821	SRP1	Importin subunit alpha	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	SS
Q0V7M0	KPNA6	Importin subunit alpha-7	Bos taurus (Bovine)	SS
A2VE08	KPNA1	Importin subunit alpha-5	Bos taurus (Bovine)	SS
C1JZ66	KPNA7	Importin subunit alpha-8	Bos taurus (Bovine)	PR
Q5ZML1	KPNA1	Importin subunit alpha-5	Gallus gallus (Chicken)	SS
P52295	Pen	Importin subunit alpha	Drosophila melanogaster (Fruit fly)	SS
A9QM74	KPNA7	Importin subunit alpha-8	Homo sapiens (Human)	EV
O00505	KPNA3	Importin subunit alpha-4	Homo sapiens (Human)	SS
O15131	KPNA5	Importin subunit alpha-6	Homo sapiens (Human)	SS
O60684	KPNA6	Importin subunit alpha-7	Homo sapiens (Human)	SS
P52292	KPNA2	Importin subunit alpha-1	Homo sapiens (Human)	EV
P52294	KPNA1	Importin subunit alpha-5	Homo sapiens (Human)	SS
Q60960	Kpna1	Importin subunit alpha-5	Mus musculus (Mouse)	SS
O35345	Kpna6	Importin subunit alpha-7	Mus musculus (Mouse)	PR
C0LLJ0	Kpna7	Importin subunit alpha-8	Mus musculus (Mouse)	SS
P52293	Kpna2	Importin subunit alpha-1	Mus musculus (Mouse)	EV
O35343	Kpna4	Importin subunit alpha-3	Mus musculus (Mouse)	SS
O35344	Kpna3	Importin subunit alpha-4	Mus musculus (Mouse)	SS
C6K7I2	KPNA7	Importin subunit alpha-8	Sus scrofa (Pig)	SS
P83953	Kpna1	Importin subunit alpha-5	Rattus norvegicus (Rat)	SS
Q56R16	Kpna5	Importin subunit alpha-6	Rattus norvegicus (Rat)	SS
Q71VM4	Os01g0253300	Importin subunit alpha-1a	Oryza sativa subsp. japonica (Rice)	SS
P91276	ima-2	Importin subunit alpha-2	Caenorhabditis elegans	SS
Q19969	ima-3	Importin subunit alpha-3	Caenorhabditis elegans	SS
O04294	IMPA3	Importin subunit alpha-3	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9FJ09	IMPA5	Importin subunit alpha-5	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9M9X7	IMPA7	Importin subunit alpha-7	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9FWY7	IMPA6	Importin subunit alpha-6	Arabidopsis thaliana (Mouse-ear cress)	SS
O22478		Importin subunit alpha	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)	SS
Q503E9	kpna5	Importin subunit alpha-6	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MADNEKLDNQ	RLKNFKNKGR	DLETMRRQRN	EVVVELRKNK	RDEHLLKRRN	VPHEDICEDS
70	80	90	100	110	120
DIDGDYRVQN	TSLEAIVQNA	SSDNQGIQLS	AVQAARKLLS	SDRNPPIDDL	IKSGILPILV
130	140	150	160	170	180
HCLERDDNPS	LQFEAAWALT	NIASGTSEQT	QAVVQSNAVP	LFLRLLHSPH	QNVCEQAVWA
190	200	210	220	230	240
LGNIIGDGPQ	CRDYVISLGV	VKPLLSFISP	SIPITFLRNV	TWVMVNLCRH	KDPPPPMETI
250	260	270	280	290	300
QEILPALCVL	IHHTDVNILV	DTVWALSYLT	DAGNEQIQMV	IDSGIVPHLV	PLLSHQEVKV
310	320	330	340	350	360
QTAALRAVGN	IVTGTDEQTQ	VVLNCDALSH	FPALLTHPKE	KINKEAVWFL	SNITAGNQQQ
370	380	390	400	410	420
VQAVIDANLV	PMIIHLLDKG	DFGTQKEAAW	AISNLTISGR	KDQVAYLIQQ	NVIPPFCNLL
430	440	450	460	470	480
TVKDAQVVQV	VLDGLSNILK	MAEDEAETIG	NLIEECGGLE	KIEQLQNHEN	EDIYKLAYEI
490	500	510	520
IDQFFSSDDI	DEDPSLVPEA	IQGGTFGFNS	SANVPTEGFQ	F