O00506
PR
Gene name |
STK25 (SOK1, YSK1) |
Protein name |
Serine/threonine-protein kinase 25 |
Names |
Ste20-like kinase, Sterile 20/oxidant stress-response kinase 1, SOK-1, Ste20/oxidant stress response kinase 1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:10494 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
157-180 (Activation loop from InterPro)
Target domain |
15-291 (Catalytic domain of Serine/Threonine Kinase 25, also called Yeast Sps1/Ste20-related kinase 1) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
5 structures for O00506
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2XIK | X-ray | 197 A | A | 1-293 | PDB |
| 3W8H | X-ray | 243 A | B | 355-426 | PDB |
| 4NZW | X-ray | 358 A | B | 1-293 | PDB |
| 7Z4V | X-ray | 164 A | A | 1-294 | PDB |
| AF-O00506-F1 | Predicted | AlphaFoldDB |
284 variants for O00506
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1353339067 CA351401774 |
2 | A>D | No |
ClinGen gnomAD |
|
|
rs1283950323 CA351401764 |
3 | H>Q | No |
ClinGen gnomAD |
|
|
CA351401761 rs1250873205 |
4 | L>F | No |
ClinGen TOPMed |
|
|
CA2219568 rs760290254 |
4 | L>R | No |
ClinGen ExAC gnomAD |
|
|
rs767199180 CA2219566 |
6 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA2219565 rs761455789 |
8 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA2219564 rs774307518 |
9 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA2219563 rs768678275 |
10 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs752551342 CA2219526 |
11 | H>R | No |
ClinGen ExAC gnomAD |
|
|
rs1483098325 CA351400821 |
13 | R>* | No |
ClinGen gnomAD |
|
|
rs1452803016 CA351400818 |
13 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA68508950 rs190697109 |
23 | L>F | No |
ClinGen 1000Genomes |
|
|
rs773352442 CA2219520 |
24 | D>G | No |
ClinGen ExAC gnomAD |
|
|
CA2219521 rs760811061 |
24 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351400648 rs760811061 |
24 | D>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs991514164 CA68508919 |
25 | R>C | No |
ClinGen TOPMed |
|
|
CA351400632 rs991514164 |
25 | R>G | No |
ClinGen TOPMed |
|
|
COSM1406969 rs200593123 CA2219519 |
25 | R>H | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA68508899 rs199874985 |
26 | I>F | No |
ClinGen ExAC gnomAD |
|
|
rs1375522630 CA351400613 |
26 | I>T | No |
ClinGen TOPMed |
|
|
rs199874985 CA2219518 |
26 | I>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 30 | S>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA68508886 rs975236866 |
31 | F>S | No |
ClinGen Ensembl |
|
| TCGA novel | 33 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2219515 rs749783236 |
35 | Y>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1455320125 CA351400438 |
36 | K>E | No |
ClinGen TOPMed |
|
|
CA68508884 rs958674843 |
36 | K>R | No |
ClinGen TOPMed |
|
| TCGA novel | 36 | K>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA351400320 rs1158309041 |
43 | K>E | No |
ClinGen gnomAD |
|
|
rs978879093 CA68508875 |
44 | E>D | No |
ClinGen TOPMed gnomAD |
|
|
CA2219513 rs756826952 |
44 | E>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746522098 CA2219512 |
45 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs965178011 CA68508863 |
48 | I>M | No |
ClinGen gnomAD |
|
|
CA2219510 rs187090685 |
52 | D>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA351400098 rs1265516838 |
56 | A>G | No |
ClinGen gnomAD |
|
|
CA351398984 rs1319907382 |
57 | E>K | No |
ClinGen gnomAD |
|
|
CA351398938 rs1297417339 |
59 | E>D | No |
ClinGen gnomAD |
|
|
rs766308354 CA2219505 |
60 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA351398881 rs1341615730 |
63 | I>V | No |
ClinGen TOPMed |
|
|
VAR_051674 rs34341643 CA68508832 |
64 | Q>H | No |
ClinGen UniProt Ensembl dbSNP |
|
|
CA351398821 rs1297760661 |
66 | E>A | No |
ClinGen gnomAD |
|
|
rs1252961209 CA351398763 |
70 | L>F | No |
ClinGen TOPMed |
|
|
CA2219500 rs774488883 |
71 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA351398725 rs1457820487 |
72 | Q>H | No |
ClinGen gnomAD |
|
|
CA2219497 rs763297657 |
74 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA2219496 rs182512698 |
75 | S>N | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs770438782 CA2219495 |
77 | Y>F | No |
ClinGen ExAC gnomAD |
|
|
CA2219494 rs139615771 |
78 | I>V | No |
ClinGen ESP ExAC TOPMed |
|
|
CA2219493 rs771755240 COSM1669913 |
80 | R>C | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA2219491 rs747821996 |
80 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs771755240 CA2219492 |
80 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1574951706 CA351398550 |
81 | Y>* | No |
ClinGen Ensembl |
|
|
rs113961789 CA68508778 |
82 | F>S | No |
ClinGen Ensembl |
|
|
CA351398516 rs1259860265 |
83 | G>D | No |
ClinGen gnomAD |
|
|
CA351398494 rs754735722 |
84 | S>C | No |
ClinGen ExAC gnomAD |
|
|
rs754735722 CA2219489 |
84 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs1276146701 CA351398436 |
87 | K>E | No |
ClinGen gnomAD |
|
|
CA351397694 rs1484420797 |
88 | S>R | No |
ClinGen gnomAD |
|
|
CA68508033 rs1010272934 |
90 | K>E | No |
ClinGen TOPMed |
|
|
rs1367663279 CA351397604 |
94 | I>T | No |
ClinGen gnomAD |
|
|
rs375673846 CA2219445 |
99 | G>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA68508009 rs933425489 |
101 | G>S | No |
ClinGen TOPMed |
|
|
rs1053822328 CA68507996 |
103 | A>T | No |
ClinGen TOPMed |
|
|
rs1282333039 CA351397458 |
104 | L>M | No |
ClinGen gnomAD |
|
|
CA351397456 rs1282333039 |
104 | L>V | No |
ClinGen gnomAD |
|
|
CA351397448 rs1230517348 |
105 | D>N | No |
ClinGen gnomAD |
|
|
CA351397399 rs1345630363 |
106 | L>F | No |
ClinGen TOPMed |
|
|
CA351397168 rs1574948202 |
108 | K>N | No |
ClinGen Ensembl |
|
|
CA2219416 rs752226810 |
110 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs1465265667 CA351397002 |
116 | Y>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1169754772 CA351397007 |
116 | Y>H | No |
ClinGen gnomAD |
|
| TCGA novel | 117 | I>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs759161532 CA2219414 |
118 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs1193169411 CA351396971 |
118 | A>V | No |
ClinGen gnomAD |
|
|
rs776397129 CA2219413 |
119 | T>M | No |
ClinGen ExAC gnomAD |
|
|
CA2219409 rs772153850 |
122 | R>W | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 125 | L>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA351396807 rs1215967247 |
126 | K>N | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 126 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs373696384 CA2219405 |
129 | D>G | No |
ClinGen ESP ExAC gnomAD |
|
|
CA2219406 rs768905266 |
129 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs756369752 CA2219403 |
134 | E>K | No |
ClinGen ExAC gnomAD |
|
|
COSM1631929 rs146467504 CA2219402 |
135 | R>C | liver [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs781503135 CA2219401 |
135 | R>H | No |
ClinGen ExAC gnomAD |
|
|
CA68507542 rs757792673 |
136 | K>* | No |
ClinGen ExAC gnomAD |
|
|
CA2219400 rs757792673 |
136 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs752104382 CA2219399 |
139 | R>* | No |
ClinGen ExAC TOPMed |
|
|
rs1057064460 CA68507499 |
142 | K>R | No |
ClinGen TOPMed |
|
|
CA351395709 rs1053183334 |
146 | V>L | No |
ClinGen gnomAD |
|
|
rs1053183334 CA68506727 |
146 | V>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA2219344 rs372803868 |
149 | S>L | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1381626538 CA351395689 |
150 | E>K | No |
ClinGen gnomAD |
|
|
rs904250492 CA68506695 |
152 | G>D | No |
ClinGen gnomAD |
|
|
rs772367382 CA2219341 |
154 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA68506690 rs866103467 |
157 | A>V | No |
ClinGen Ensembl |
|
|
COSM1669912 rs745383015 CA2219337 |
160 | G>W | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA2219336 rs780945283 |
162 | A>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 163 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1254685923 CA351395585 |
166 | T>A | No |
ClinGen TOPMed |
|
|
rs555396941 CA351395567 |
168 | T>M | No |
ClinGen gnomAD |
|
|
rs555396941 CA68506668 |
168 | T>R | No |
ClinGen gnomAD |
|
|
CA351395560 rs1288321591 |
169 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1437850863 CA351395484 |
180 | F>L | No |
ClinGen TOPMed |
|
|
CA68506628 rs747009536 |
182 | M>V | No |
ClinGen Ensembl |
|
|
rs1180597435 CA351395463 |
183 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
| TCGA novel | 185 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1360737092 CA351395391 |
193 | D>V | No |
ClinGen TOPMed |
|
|
CA351395282 rs1162574332 |
198 | I>V | No |
ClinGen gnomAD |
|
|
CA2219312 rs752452467 |
199 | W>S | No |
ClinGen ExAC gnomAD |
|
|
CA68506520 rs187446778 |
203 | I>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA2219310 rs370116221 |
206 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1466914104 CA351395123 |
207 | E>G | No |
ClinGen TOPMed |
|
|
CA351395128 COSM1326291 rs1420940006 |
207 | E>K | ovary Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
rs766429147 CA2219308 |
208 | L>M | No |
ClinGen ExAC gnomAD |
|
|
rs1031820919 CA68506478 |
209 | A>T | No |
ClinGen Ensembl |
|
|
CA351395090 rs1201624473 |
210 | K>E | No |
ClinGen gnomAD |
|
|
CA2219307 rs760810895 |
210 | K>N | No |
ClinGen ExAC gnomAD |
|
|
CA2219306 rs139865238 COSM3673668 |
211 | G>W | prostate [Cosmic] | No |
ClinGen cosmic curated ESP ExAC |
|
rs1252732495 CA351395007 |
215 | N>H | No |
ClinGen gnomAD |
|
|
CA2219305 rs767645058 |
216 | S>C | No |
ClinGen ExAC gnomAD |
|
|
CA2219303 rs55762981 |
217 | D>E | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs376988872 CA2219304 |
217 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA351394954 rs1213633563 |
218 | L>F | No |
ClinGen gnomAD |
|
| TCGA novel | 219 | H>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs148589164 CA2219299 |
222 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA351394918 rs1488055406 |
223 | V>L | No |
ClinGen gnomAD |
|
|
rs371394698 CA2219295 |
229 | K>N | No |
ClinGen ESP ExAC gnomAD |
|
| TCGA novel | 234 | T>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1220749208 CA351394842 |
234 | T>I | No |
ClinGen TOPMed |
|
|
rs1559832304 CA351394819 |
238 | Q>* | No |
ClinGen Ensembl |
|
|
rs1454791691 CA351394788 |
242 | P>A | No |
ClinGen gnomAD |
|
|
rs779971431 CA2219290 |
242 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA2219287 rs767740659 |
247 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA68506411 rs767740659 |
247 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1044177388 CA68506410 |
248 | E>Q | No |
ClinGen Ensembl |
|
|
CA2219286 rs757392362 |
249 | A>P | No |
ClinGen ExAC gnomAD |
|
|
CA351394740 rs757392362 |
249 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA2219284 rs764540534 |
252 | N>I | No |
ClinGen ExAC gnomAD |
|
|
CA2219285 rs764540534 |
252 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA2219283 rs763481609 |
254 | D>A | No |
ClinGen ExAC gnomAD |
|
|
CA2219282 rs776078005 |
254 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351394704 rs763481609 |
254 | D>V | No |
ClinGen ExAC gnomAD |
|
|
rs765855970 CA2219281 |
256 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs143937320 CA2219280 |
256 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs772562575 CA2219279 |
257 | F>I | No |
ClinGen ExAC gnomAD |
|
|
rs771658674 CA2219278 |
257 | F>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351394672 COSM1406966 rs1342567968 |
258 | R>Q | large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
CA351394673 COSM1614637 rs1559831628 |
258 | R>W | liver [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
rs769473240 CA2219235 |
259 | P>H | No |
ClinGen ExAC gnomAD |
|
|
rs769473240 CA68506075 |
259 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs199688267 CA2219234 COSM1196293 |
260 | T>M | lung [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
rs200431947 CA351394640 CA2219232 |
263 | E>D | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1371978316 CA351394639 |
264 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
CA2219230 rs777972537 |
267 | H>R | No |
ClinGen ExAC gnomAD |
|
|
CA351394582 rs1466966937 |
272 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
rs995050256 CA68506054 |
274 | T>A | No |
ClinGen TOPMed |
|
|
CA68506032 rs759935751 |
276 | K>T | No |
ClinGen Ensembl |
|
|
rs772331813 CA2219229 |
278 | S>T | No |
ClinGen ExAC gnomAD |
|
|
CA2219226 rs75331794 |
281 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA68505993 rs75331794 |
281 | T>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs780385824 CA2219223 |
283 | L>R | No |
ClinGen ExAC |
|
|
CA351394512 rs1447655305 |
283 | L>V | No |
ClinGen TOPMed |
|
|
CA2219222 rs756612709 |
285 | D>Y | No |
ClinGen ExAC gnomAD |
|
|
rs763580944 CA2219220 |
286 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA2219219 rs762518545 |
286 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs1395271593 CA351394486 |
287 | Y>C | No |
ClinGen gnomAD |
|
| TCGA novel | 288 | K>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1296105536 CA351394475 |
288 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
CA2219218 rs752281908 |
289 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2219217 rs145988240 |
289 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs145988240 CA351394471 |
289 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs759205958 CA2219216 |
290 | W>* | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 291 | K>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1574942828 CA351394452 |
292 | S>A | No |
ClinGen Ensembl |
|
|
CA2219215 rs148061318 |
292 | S>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1237259446 CA351394443 |
293 | E>D | No |
ClinGen Ensembl |
|
|
rs1182205428 CA351394431 |
295 | H>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1418305061 CA351394420 |
297 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
rs1418305061 CA351394421 |
297 | E>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA351394403 rs1574942754 |
299 | S>A | No |
ClinGen Ensembl |
|
|
CA351394351 rs1486694585 |
306 | I>T | No |
ClinGen gnomAD |
|
|
CA351394336 rs1254415947 |
307 | D>N | No |
ClinGen TOPMed |
|
|
CA351394328 rs1350392086 |
308 | G>C | No |
ClinGen gnomAD |
|
|
rs773223727 CA2219193 |
309 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA2219192 rs767581051 |
310 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2219189 rs549756176 |
311 | E>A | No |
ClinGen ExAC gnomAD |
|
|
CA351394306 rs1327688910 |
311 | E>D | No |
ClinGen gnomAD |
|
|
CA351394305 rs749514218 |
312 | D>H | No |
ClinGen ExAC gnomAD |
|
|
CA2219188 COSM2910674 rs749514218 |
312 | D>N | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs1559830500 CA351394296 |
313 | G>A | No |
ClinGen Ensembl |
|
|
rs770079514 CA2219186 |
313 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781629975 CA351394274 |
316 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781629975 CA2219184 |
316 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1243973473 CA351394261 COSM129473 |
318 | I>M | upper_aerodigestive_tract [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
CA2219182 rs747514740 |
318 | I>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs778467600 CA2219181 |
320 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1246756208 CA351394240 |
321 | F>L | No |
ClinGen gnomAD |
|
|
rs1215887800 CA351394236 |
322 | P>S | No |
ClinGen gnomAD |
|
|
CA2219178 rs755920494 |
323 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755920494 CA2219177 |
323 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351394214 rs545943612 |
326 | R>P | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA2219174 rs545943612 |
326 | R>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs750272830 CA2219175 |
326 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2219173 rs761820180 |
327 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA351394203 rs1441292661 |
328 | S>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1441292661 CA351394204 |
328 | S>T | No |
ClinGen TOPMed gnomAD |
|
|
rs764230430 CA2219171 |
329 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA351394197 rs1325894031 |
329 | P>S | No |
ClinGen TOPMed |
|
|
CA68505612 rs1050289380 |
330 | H>R | No |
ClinGen Ensembl |
|
|
CA351394175 rs1403858616 |
332 | K>R | No |
ClinGen gnomAD |
|
|
CA2219169 rs775725677 |
333 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs1257701302 CA351394157 |
335 | K>E | No |
ClinGen TOPMed |
|
|
CA351394155 rs770027770 |
335 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs770027770 CA2219168 |
335 | K>T | No |
ClinGen ExAC gnomAD |
|
|
CA2219167 rs541808347 |
337 | T>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA2219166 rs776951697 |
337 | T>M | No |
ClinGen ExAC gnomAD |
|
|
CA2219163 rs778144128 |
339 | L>M | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 340 | H>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2219162 rs768150187 |
340 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2219160 rs779810460 |
341 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs1251752394 CA351394110 |
343 | Q>* | No |
ClinGen TOPMed |
|
|
rs76250622 CA2219159 |
343 | Q>P | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA351394078 rs1174596222 |
346 | A>P | No |
ClinGen gnomAD |
|
|
rs202072145 CA2219141 |
346 | A>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA2219139 rs769485841 |
348 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351394065 rs769485841 |
348 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs780996627 CA351394060 |
349 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2219137 rs780996627 |
349 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1485066771 CA351394034 |
352 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
CA2219136 rs367677520 |
353 | P>L | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1203575780 CA351394023 CA351394022 |
354 | R>S | No |
ClinGen TOPMed |
|
|
CA351394019 rs1574939236 |
355 | S>A | No |
ClinGen Ensembl |
|
|
rs1317277894 CA351394016 |
355 | S>F | No |
ClinGen gnomAD |
|
|
rs777728525 CA351394003 |
357 | C>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2219134 rs777728525 |
357 | C>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs199529145 CA2219133 |
360 | T>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA351393977 rs1446437605 |
362 | V>F | No |
ClinGen TOPMed |
|
|
CA351393978 rs1446437605 |
362 | V>L | No |
ClinGen TOPMed |
|
|
CA351393972 rs1378542306 |
363 | R>Q | No |
ClinGen gnomAD |
|
|
rs140408761 CA2219130 |
363 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2219127 rs140768011 |
365 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA351393950 rs1394941139 |
367 | G>R | No |
ClinGen TOPMed |
|
|
rs774941275 CA2219103 |
369 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA68504573 rs900002701 |
370 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
CA2219101 rs759077480 |
372 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA68504542 rs17851334 |
374 | K>E | No |
ClinGen Ensembl |
|
|
rs775975388 CA2219100 |
374 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA351393434 rs1373618275 |
376 | S>N | No |
ClinGen gnomAD |
|
|
rs746631738 CA2219098 |
377 | G>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA2219096 rs771701141 |
378 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA68504506 rs868565904 |
378 | G>V | No |
ClinGen Ensembl |
|
|
CA351393425 rs771701141 |
378 | G>W | No |
ClinGen ExAC gnomAD |
|
|
rs747955670 CA2219095 |
379 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs1574934706 CA351393410 |
380 | V>G | No |
ClinGen Ensembl |
|
|
rs372750048 CA2219093 |
380 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs200296448 CA351393399 |
382 | A>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs200296448 CA2219089 |
382 | A>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA351393394 rs1179240161 |
383 | L>R | No |
ClinGen gnomAD |
|
|
rs113126397 CA2219085 |
388 | N>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs763534616 CA2219083 |
389 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA68504428 rs1009102731 |
389 | A>V | No |
ClinGen Ensembl |
|
|
rs201623221 CA2219082 |
392 | L>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA2219080 rs766292763 |
394 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1308694843 CA351393320 |
395 | E>K | No |
ClinGen gnomAD |
|
|
rs1349316463 CA351393293 |
398 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
COSM1406963 rs1416110172 CA351393291 |
399 | G>S | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA351393285 rs1171927771 |
400 | I>V | No |
ClinGen gnomAD |
|
|
CA2219076 rs774108107 |
403 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs372608064 CA68504398 |
403 | K>M | No |
ClinGen ESP TOPMed |
|
|
rs372608064 CA351393262 |
403 | K>R | No |
ClinGen ESP TOPMed |
|
|
rs758121873 CA2219074 |
405 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764399606 CA68504380 |
410 | E>D | No |
ClinGen Ensembl |
|
|
rs769704557 CA2219072 |
410 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs745982508 CA2219071 |
411 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351393166 rs1246625585 |
416 | S>* | No |
ClinGen gnomAD |
|
|
rs995832965 CA68503904 |
417 | H>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1451779032 CA351393142 |
420 | N>D | No |
ClinGen gnomAD |
|
|
CA351393140 rs1451779032 |
420 | N>H | No |
ClinGen gnomAD |
|
|
rs1369853763 CA351393138 |
420 | N>S | No |
ClinGen TOPMed |
|
|
CA68503901 rs747842738 |
421 | H>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs141038876 CA2219038 |
423 | T>I | No |
ClinGen ESP ExAC gnomAD |
|
|
CA2219035 rs558360310 |
426 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200781797 CA2219034 |
426 | R>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2219036 rs558360310 |
426 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
No associated diseases with O00506
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| metal ion binding | Binding to a metal ion. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| axonogenesis | De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. |
| establishment of Golgi localization | The directed movement of the Golgi to a specific location. |
| establishment or maintenance of cell polarity | Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. |
| Golgi localization | Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. |
| Golgi reassembly | The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance. |
| intrinsic apoptotic signaling pathway in response to hydrogen peroxide | The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2). |
| positive regulation of axonogenesis | Any process that activates or increases the frequency, rate or extent of axonogenesis. |
| positive regulation of stress-activated MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| response to hydrogen peroxide | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
| response to oxidative stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
27 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SWY6 | STK25 | Serine/threonine-protein kinase 25 | Bos taurus (Bovine) | PR |
| Q5E9L6 | STK4 | Serine/threonine-protein kinase 4 | Bos taurus (Bovine) | SS |
| P41279 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Homo sapiens (Human) | EV |
| Q9H2G2 | SLK | STE20-like serine/threonine-protein kinase | Homo sapiens (Human) | PR |
| O94804 | STK10 | Serine/threonine-protein kinase 10 | Homo sapiens (Human) | PR |
| O95747 | OXSR1 | Serine/threonine-protein kinase OSR1 | Homo sapiens (Human) | PR |
| Q9UEW8 | STK39 | STE20/SPS1-related proline-alanine-rich protein kinase | Homo sapiens (Human) | PR |
| Q9Y4K4 | MAP4K5 | Mitogen-activated protein kinase kinase kinase kinase 5 | Homo sapiens (Human) | PR |
| Q92918 | MAP4K1 | Mitogen-activated protein kinase kinase kinase kinase 1 | Homo sapiens (Human) | EV |
| Q12851 | MAP4K2 | Mitogen-activated protein kinase kinase kinase kinase 2 | Homo sapiens (Human) | EV |
| Q8IVH8 | MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Homo sapiens (Human) | SS |
| Q9P289 | STK26 | Serine/threonine-protein kinase 26 | Homo sapiens (Human) | PR |
| Q9Y6E0 | STK24 | Serine/threonine-protein kinase 24 | Homo sapiens (Human) | PR |
| Q13188 | STK3 | Serine/threonine-protein kinase 3 | Homo sapiens (Human) | SS |
| Q13043 | STK4 | Serine/threonine-protein kinase 4 | Homo sapiens (Human) | EV |
| Q07174 | Map3k8 | Mitogen-activated protein kinase kinase kinase 8 | Mus musculus (Mouse) | SS |
| Q99JT2 | Stk26 | Serine/threonine-protein kinase 26 | Mus musculus (Mouse) | PR |
| Q99KH8 | Stk24 | Serine/threonine-protein kinase 24 | Mus musculus (Mouse) | PR |
| Q9Z2W1 | Stk25 | Serine/threonine-protein kinase 25 | Mus musculus (Mouse) | PR |
| Q9JI10 | Stk3 | Serine/threonine-protein kinase 3 | Mus musculus (Mouse) | SS |
| Q9JI11 | Stk4 | Serine/threonine-protein kinase 4 | Mus musculus (Mouse) | PR |
| Q63562 | Map3k8 | Mitogen-activated protein kinase kinase kinase 8 | Rattus norvegicus (Rat) | SS |
| B0LT89 | Stk24 | Serine/threonine-protein kinase 24 | Rattus norvegicus (Rat) | PR |
| H2L099 | gck-1 | Germinal center kinase 1 | Caenorhabditis elegans | PR |
| Q9NB31 | cst-1 | Serine/threonine-protein kinase cst-1 | Caenorhabditis elegans | PR |
| Q6P3Q4 | stk4 | Serine/threonine-protein kinase 4 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q7ZUQ3 | stk3 | Serine/threonine-protein kinase 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAHLRGFANQ | HSRVDPEELF | TKLDRIGKGS | FGEVYKGIDN | HTKEVVAIKI | IDLEEAEDEI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EDIQQEITVL | SQCDSPYITR | YFGSYLKSTK | LWIIMEYLGG | GSALDLLKPG | PLEETYIATI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LREILKGLDY | LHSERKIHRD | IKAANVLLSE | QGDVKLADFG | VAGQLTDTQI | KRNTFVGTPF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WMAPEVIKQS | AYDFKADIWS | LGITAIELAK | GEPPNSDLHP | MRVLFLIPKN | SPPTLEGQHS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KPFKEFVEAC | LNKDPRFRPT | AKELLKHKFI | TRYTKKTSFL | TELIDRYKRW | KSEGHGEESS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SEDSDIDGEA | EDGEQGPIWT | FPPTIRPSPH | SKLHKGTALH | SSQKPAEPVK | RQPRSQCLST |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LVRPVFGELK | EKHKQSGGSV | GALEELENAF | SLAEESCPGI | SDKLMVHLVE | RVQRFSHNRN |
| HLTSTR |