AiPD: Autoinhibited Protein Database

O00505

Gene name	KPNA3 (QIP2)
Protein name	Importin subunit alpha-4
Names	Importin alpha Q2, Qip2, Karyopherin subunit alpha-3, SRP1-gamma
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3839
EC number
Protein Class

Descriptions

Importin subunit alpha functions in the nuclear transport of classical nuclear localization signal (cNLS)-containing cargo. Autoinhibition by the self-binding of IBB domain inhibits the NLS binding affinity by binding IBB domain to the NLS binding sites. In addition, the closed homodimerization works as an autoinhibition state when the IBB domian dissociates from the NLS binding sites.

Autoinhibitory domains (AIDs)

2-58 (IBB domain) SS

Target domain	103-498 (NLS-binding domain comprising armadillo (Arm) repeats)
Relief mechanism	Partner binding
Assay

AID

2-58 (IBB domain)

Target domain

103-498 (NLS-binding domain comprising armadillo (Arm) repeats)

Relief mechanism

Partner binding (importin-beta binding)

Assay

Accessory elements

No accessory elements

References

Kimoto C et al. (2015) "Functional characterization of importin α8 as a classical nuclear localization signal receptor", Biochimica et biophysica acta, 1853, 2676-83

Kobe B (1999) "Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha", Nature structural biology, 6, 388-97

Miyatake H et al. (2015) "Crystal structure of human importin-α1 (Rch1), revealing a potential autoinhibition mode involving homodimerization", PloS one, 10, e0115995

Catimel B et al. (2001) "Biophysical characterization of interactions involving importin-alpha during nuclear import", The Journal of biological chemistry, 276, 34189-98

Autoinhibited structure

Activated structure

1 structures for O00505

Entry ID	Method	Resolution	Chain	Position	Source
AF-O00505-F1	Predicted				AlphaFoldDB

213 variants for O00505

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA6983899 rs762963084	3	E>G		No	ClinGen ExAC gnomAD
CA6983898 rs775628381	4	N>S		No	ClinGen ExAC gnomAD
CA6983897 rs769361097	5	P>S		No	ClinGen ExAC gnomAD
rs758980433 CA6983896	6	S>T		No	ClinGen ExAC gnomAD
CA388202063 rs1334115992	7	L>F		No	ClinGen TOPMed gnomAD
CA6983895 rs776297939	7	L>V		No	ClinGen ExAC TOPMed gnomAD
rs867589978 CA249379504	8	E>D		No	ClinGen Ensembl
CA388202058 rs1325149401	8	E>G		No	ClinGen gnomAD
CA6983894 rs770519769	8	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1387242197 CA388202043	10	H>R		No	ClinGen gnomAD
CA6983892 rs773540519	13	K>R		No	ClinGen ExAC gnomAD
CA6983890 rs748646892	17	N>K		No	ClinGen ExAC TOPMed gnomAD
rs779399471 CA249379471	18	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1451412824 CA388201898	19	G>D		No	ClinGen gnomAD
rs780286546 CA6983886	23	E>A		No	ClinGen ExAC TOPMed gnomAD
rs1194431142 CA388201835	23	E>D		No	ClinGen gnomAD
CA388201838 rs780286546	23	E>G		No	ClinGen ExAC TOPMed gnomAD
CA388198446 rs1457134228	25	M>T		No	ClinGen gnomAD
rs1302911109 CA388198410	30	N>S		No	ClinGen TOPMed
rs1211666156 CA388197615	42	D>N		No	ClinGen gnomAD
rs780052172 CA6983837	43	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1281537974 CA388197545	51	V>I		No	ClinGen Ensembl
rs907317489 CA249382049	57	L>V		No	ClinGen Ensembl
CA388197496 rs1365951160	58	E>G		No	ClinGen gnomAD
CA6983832 rs10450846	58	E>K		No	ClinGen ExAC
rs751788282 CA249382043	60	S>A		No	ClinGen TOPMed
rs1323172642 CA388197480	60	S>L		No	ClinGen gnomAD
rs10450845 CA249382042	61	D>N		No	ClinGen Ensembl
rs1434877177 CA388197454	64	A>G		No	ClinGen gnomAD
rs1349712682 CA388197432	67	K>R		No	ClinGen gnomAD
rs957243635 CA249381846	69	Q>R		No	ClinGen TOPMed
rs1471491627 CA388197389	70	N>S		No	ClinGen gnomAD
rs1338338105 CA388197360	72	T>N		No	ClinGen TOPMed
CA249381838 rs10450844	74	E>K		No	ClinGen ExAC gnomAD
CA6983812 rs10450844	74	E>Q		No	ClinGen ExAC gnomAD
rs1181926174 CA388197333	75	A>T		No	ClinGen gnomAD
rs1436706898 CA388197227	79	N>K		No	ClinGen TOPMed
rs1361977200 CA388197231	79	N>S		No	ClinGen gnomAD
CA6983793 rs748362913	81	T>A		No	ClinGen ExAC TOPMed gnomAD
rs921469759 CA249381761	83	D>A		No	ClinGen Ensembl
CA388197146 rs1222316990	85	P>L		No	ClinGen TOPMed
rs1566343115 CA388197082	90	S>N		No	ClinGen Ensembl
CA6983789 rs558605678	95	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA249381601 rs536858890	109	D>N		No	ClinGen ExAC TOPMed gnomAD
CA6983768 rs536858890	109	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs1363741876 CA388196763	111	I>L		No	ClinGen TOPMed gnomAD
rs757908201 CA6983766	116	L>S		No	ClinGen ExAC gnomAD
rs1388366106 CA388196689	117	P>S		No	ClinGen gnomAD
rs747735726 CA6983765	118	I>V		No	ClinGen ExAC
CA388196637 rs1362136349	121	K>N		No	ClinGen Ensembl
CA6983763 rs34024081	121	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs34024081 CA388196642	121	K>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs754283691 CA6983762	122	C>Y		No	ClinGen ExAC
rs756623016 CA6983760	125	R>G		No	ClinGen ExAC gnomAD
rs750807231 CA249381576	126	D>E		No	ClinGen TOPMed gnomAD
CA388196556 rs750951118	127	D>N		No	ClinGen ExAC gnomAD
rs750951118 CA6983759	127	D>Y		No	ClinGen ExAC gnomAD
CA6983757 rs1165237949	128	N>H		No	ClinGen TOPMed
CA919269096 rs1594437515	128	N>K		No	ClinGen Ensembl
rs1271435377 CA388195651	129	P>S		No	ClinGen gnomAD
rs1350942003 CA388195612	131	L>V		No	ClinGen gnomAD
rs878936287 CA249377856	142	I>V		No	ClinGen Ensembl
CA6983729 rs766127523	148	A>V		No	ClinGen ExAC gnomAD
CA6983728 rs760399906	151	Q>E		No	ClinGen ExAC gnomAD
CA249377843 rs17855583	152	A>D		No	ClinGen TOPMed
CA388195034 rs17855583	152	A>V		No	ClinGen TOPMed
CA249377838 rs17855584	153	V>I		No	ClinGen Ensembl
CA6983727 rs567901349	156	S>C		No	ClinGen 1000Genomes ExAC gnomAD
CA6983726 rs567901349	156	S>F		No	ClinGen 1000Genomes ExAC gnomAD
CA388193937 rs1392120808	159	V>I		No	ClinGen TOPMed
rs374294300 CA249376068	160	P>L		No	ClinGen ESP TOPMed
rs1236399656 CA388193853	163	L>P		No	ClinGen TOPMed
rs1278538848 CA388193829	165	L>I		No	ClinGen TOPMed
rs1159965706 COSM1706781 CA388193795	167	R>C	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1471595203 CA388193793	167	R>H		No	ClinGen TOPMed gnomAD
rs1471595203 CA388193791	167	R>L		No	ClinGen TOPMed gnomAD
CA388193779 rs1367427471	169	P>S		No	ClinGen gnomAD
rs771348895 CA6983697	172	N>D		No	ClinGen ExAC TOPMed gnomAD
rs771348895 CA388193743	172	N>H		No	ClinGen ExAC TOPMed gnomAD
rs1045600035 CA249376060	173	V>A		No	ClinGen Ensembl
rs1290800128 CA388193727	173	V>I		No	ClinGen gnomAD
CA388193690 rs1253063854	176	Q>*		No	ClinGen TOPMed
rs771224261 CA6983677	190	Q>P		No	ClinGen ExAC gnomAD
CA249375801 rs112989840	196	I>T		No	ClinGen Ensembl
rs1228367748 CA388193381	200	V>A		No	ClinGen gnomAD
CA249375796 rs1045213942	202	K>R		No	ClinGen TOPMed gnomAD
rs1326039478 CA388193348	204	L>V		No	ClinGen TOPMed
CA388193294 rs1434765291	209	S>N		No	ClinGen gnomAD
CA388193244 rs1439407579	214	I>V		No	ClinGen TOPMed
rs1368209197 CA388193234	215	T>A		No	ClinGen gnomAD
rs768849258 CA6983671	215	T>I		No	ClinGen ExAC gnomAD
rs1368209197 CA388193232	215	T>P		No	ClinGen gnomAD
rs930596500 CA249375764	217	L>V		No	ClinGen Ensembl
rs1421586817 COSM1322854 CA388193198	218	R>Q	ovary [Cosmic]	No	ClinGen cosmic curated gnomAD
CA249375760 rs948854845	220	V>I		No	ClinGen TOPMed
CA388193143 rs1189332677	223	V>A		No	ClinGen gnomAD
rs780438441 CA6983669	224	I>V		No	ClinGen ExAC TOPMed gnomAD
CA388192841 rs1305066063	227	L>F		No	ClinGen TOPMed
rs202115978 CA249375749	232	D>E		No	ClinGen TOPMed gnomAD
rs1263437346 CA388192617	234	P>T		No	ClinGen TOPMed gnomAD
CA388192592 rs1275755303	235	P>A		No	ClinGen gnomAD
CA388192581 rs1217923463	235	P>L		No	ClinGen gnomAD
rs1284291647 CA388192495	237	M>T		No	ClinGen gnomAD
rs1406461612 CA388192445	239	T>I		No	ClinGen TOPMed gnomAD
CA388192413 rs1348224162	241	Q>K		No	ClinGen gnomAD
CA6983642 rs778927656	247	L>V		No	ClinGen ExAC gnomAD
rs1566337293 CA388201952	248	C>Y		No	ClinGen Ensembl
rs753314773 CA6983640	250	L>F		No	ClinGen ExAC gnomAD
CA388201872 rs1244296506	256	I>T		No	ClinGen TOPMed gnomAD
rs765921453 CA6983639	256	I>V		No	ClinGen ExAC TOPMed gnomAD
rs778612372 CA6983623	260	V>A		No	ClinGen ExAC gnomAD
rs1414694114 CA388201753	268	Y>C		No	ClinGen TOPMed
CA6983621 rs749279440	274	N>S		No	ClinGen ExAC gnomAD
CA388201692 rs1452521916	277	I>V		No	ClinGen TOPMed
CA388201671 rs1321875567	279	M>I		No	ClinGen TOPMed
rs374261701 CA6983618	283	S>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA388201631 rs1265675572	286	V>M		No	ClinGen TOPMed gnomAD
CA249401412 rs1043015 VAR_014454	291	P>S		No	ClinGen UniProt TOPMed dbSNP
rs1470525099 CA388201505	302	T>I		No	ClinGen gnomAD
CA388201496 rs1224312802	304	A>S		No	ClinGen TOPMed
rs916301724 CA249400282	305	L>P		No	ClinGen TOPMed
CA388201470 rs1469077169	308	V>A		No	ClinGen TOPMed
CA6983599 rs745414229	316	D>N		No	ClinGen ExAC gnomAD
rs1421486079 CA388201385	321	V>L		No	ClinGen gnomAD
CA6983596 rs751231267	324	N>S		No	ClinGen ExAC
CA249400261 rs867554821	329	S>L		No	ClinGen Ensembl
CA6983595 rs764518335	331	F>L		No	ClinGen ExAC gnomAD
rs770745525 CA249400253	332	P>A		No	ClinGen Ensembl
rs17853391 CA249400250	332	P>Q		No	ClinGen Ensembl
COSM947904 rs1566333266 CA388201300	334	L>F	endometrium [Cosmic]	No	ClinGen cosmic curated Ensembl
CA388201289 rs1566333261	336	S>T		No	ClinGen Ensembl
CA249400229 rs564882588	343	N>S		No	ClinGen 1000Genomes
rs755526497 CA6983573	361	V>I		No	ClinGen ExAC gnomAD
rs754370752 CA6983572	363	A>V		No	ClinGen ExAC gnomAD
CA388201055 rs1338735599	367	A>G		No	ClinGen gnomAD
CA388201022 rs1327046102	372	M>I		No	ClinGen TOPMed
CA6983571 rs184001441	372	M>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA388201023 rs1381973441	372	M>R		No	ClinGen TOPMed
CA6983569 rs750609683	373	I>L		No	ClinGen ExAC TOPMed gnomAD
rs750609683 CA6983570	373	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6983567 rs762064071	375	H>L		No	ClinGen ExAC gnomAD
rs1428869155 CA388200941	382	F>C		No	ClinGen gnomAD
CA249397878 rs878886058	387	E>G		No	ClinGen Ensembl
CA388200899 rs1200363113	388	A>G		No	ClinGen gnomAD
CA388200870 rs1204494087	392	I>M		No	ClinGen gnomAD
CA388200875 rs1182508366	392	I>V		No	ClinGen gnomAD
rs1439172535 CA388200866	393	S>N		No	ClinGen TOPMed
rs1325412646 CA388200863	393	S>R		No	ClinGen TOPMed
rs1438882290 CA388200839	397	I>V		No	ClinGen gnomAD
CA388200817 rs1594428029	400	R>K		No	ClinGen Ensembl
CA388200776 rs1209949995	404	V>I		No	ClinGen TOPMed
CA249397607 rs979380995	405	E>D		No	ClinGen gnomAD
CA249397593 rs17853390	411	N>D		No	ClinGen Ensembl
rs758682416 CA6983525	418	N>K		No	ClinGen ExAC gnomAD
CA388200677 rs1185176995	418	N>Y		No	ClinGen TOPMed
CA249397557 rs923844119	422	V>A		No	ClinGen Ensembl
rs923844119 CA249397553	422	V>G		No	ClinGen Ensembl
CA6983524 rs150806977	422	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA388200622 rs1158602481	426	Q>H		No	ClinGen gnomAD
rs1594427813 CA388200526	441	M>T		No	ClinGen Ensembl
rs1454910799 CA388200516	442	A>V		No	ClinGen TOPMed
rs141253451 CA6983522	443	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA249397541 rs866925883	447	S>G		No	ClinGen Ensembl
rs773285455 CA388200486	447	S>N		No	ClinGen ExAC gnomAD
rs773285455 CA6983521	447	S>T		No	ClinGen ExAC gnomAD
rs1183979163 CA388200473	449	I>T		No	ClinGen gnomAD
rs369254638 CA6983520	449	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
COSM147689 CA6983518 rs200666130	451	E>D	stomach [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs553205303 CA6983517	452	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1288924141 CA388200446	453	I>M		No	ClinGen gnomAD
rs79884028 CA6983516	453	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs912792431 CA249397503	454	E>D		No	ClinGen TOPMed
CA388200427 rs1234655238	456	C>Y		No	ClinGen TOPMed
CA249395334 rs971159929	458	G>D		No	ClinGen Ensembl
CA6983496 rs763719209	461	K>N		No	ClinGen ExAC gnomAD
CA6983495 rs762510837	462	I>T		No	ClinGen ExAC gnomAD
CA388200332 rs1225080864	468	H>Y		No	ClinGen gnomAD
CA6983494 rs61750351	470	N>S		No	ClinGen ExAC gnomAD
rs1594425920 CA388200303	472	D>N		No	ClinGen Ensembl
CA6983493 rs769999851	473	I>L		No	ClinGen ExAC TOPMed gnomAD
rs769999851 CA388200294	473	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1404435425 CA388200285	474	Y>C		No	ClinGen gnomAD
CA388200252 rs1295841859	479	E>K		No	ClinGen gnomAD
CA249395298 rs1024486447	481	I>M		No	ClinGen gnomAD
CA388200222 rs1289298016	483	Q>E		No	ClinGen gnomAD
CA249395297 rs1013059900	483	Q>H		No	ClinGen Ensembl
CA6983490 rs148675861	488	D>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1188185296 CA388200186	488	D>N		No	ClinGen TOPMed
CA6983489 rs747569703	489	D>E		No	ClinGen ExAC gnomAD
rs759231150 CA6983473	491	D>G		No	ClinGen ExAC gnomAD
CA6983474 rs759231150	491	D>V		No	ClinGen ExAC gnomAD
CA388200148 rs1417942947	492	E>K		No	ClinGen gnomAD
rs776963664 CA6983472	493	D>V		No	ClinGen ExAC gnomAD
CA388200134 rs1566329545	494	P>T		No	ClinGen Ensembl
rs1200412156 CA388200123	495	C>F		No	ClinGen gnomAD
CA388200128 rs1348916614	495	C>R		No	ClinGen TOPMed gnomAD
CA6983470 rs761101228	497	I>V		No	ClinGen ExAC gnomAD
rs1345968213 CA388200103	498	P>L		No	ClinGen TOPMed gnomAD
rs1345968213 CA388200104	498	P>R		No	ClinGen TOPMed gnomAD
CA388200108 rs1203335315	498	P>T		No	ClinGen gnomAD
rs893918448 CA249395019	499	E>K		No	ClinGen Ensembl
CA388200070 rs1236984146	503	G>E		No	ClinGen gnomAD
CA249394989 rs771402129	504	G>S		No	ClinGen Ensembl
rs377267111 CA6983468	504	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1310685327 CA388200061	505	T>S		No	ClinGen gnomAD
CA6983466 rs778898655	511	T>I		No	ClinGen ExAC TOPMed gnomAD
rs778898655 CA388200018	511	T>K		No	ClinGen ExAC TOPMed gnomAD
rs1403925715 CA388200004	513	N>K		No	ClinGen TOPMed gnomAD
rs1403925715 CA388200003	513	N>K		No	ClinGen TOPMed gnomAD
rs1401563616 CA388200006	513	N>S		No	ClinGen TOPMed
CA6983464 rs143531983	515	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1363839479 CA388199966	519	F>L		No	ClinGen gnomAD
CA6983461 rs751398841	520	N>K		No	ClinGen ExAC gnomAD

No associated diseases with O00505

3 regional properties for O00505

Type	Name	Position	InterPro Accession
conserved_site	14-3-3 protein, conserved site	45 - 55	IPR023409-1
conserved_site	14-3-3 protein, conserved site	217 - 236	IPR023409-2
domain	14-3-3 domain	7 - 248	IPR023410

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
host cell	A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope.
NLS-dependent protein nuclear import complex	A dimer consisting of an alpha and a beta-subunit that imports proteins with an NLS into the nucleus through a nuclear pore.
nuclear pore	A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name	Definition
nuclear import signal receptor activity	Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
nuclear localization sequence binding	Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.
protein C-terminus binding	Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.

4 GO annotations of biological process

Name	Definition
NLS-bearing protein import into nucleus	The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope.
protein-containing complex assembly	The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
viral entry into host cell	The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
viral penetration into host nucleus	The crossing by the virus of the host nuclear membrane, either as naked viral genome or for small viruses as an intact capsid.

30 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q02821	SRP1	Importin subunit alpha	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	SS
Q0V7M0	KPNA6	Importin subunit alpha-7	Bos taurus (Bovine)	SS
A2VE08	KPNA1	Importin subunit alpha-5	Bos taurus (Bovine)	SS
C1JZ66	KPNA7	Importin subunit alpha-8	Bos taurus (Bovine)	PR
Q5ZML1	KPNA1	Importin subunit alpha-5	Gallus gallus (Chicken)	SS
P52295	Pen	Importin subunit alpha	Drosophila melanogaster (Fruit fly)	SS
A9QM74	KPNA7	Importin subunit alpha-8	Homo sapiens (Human)	EV
O00629	KPNA4	Importin subunit alpha-3	Homo sapiens (Human)	SS
O15131	KPNA5	Importin subunit alpha-6	Homo sapiens (Human)	SS
O60684	KPNA6	Importin subunit alpha-7	Homo sapiens (Human)	SS
P52292	KPNA2	Importin subunit alpha-1	Homo sapiens (Human)	EV
P52294	KPNA1	Importin subunit alpha-5	Homo sapiens (Human)	SS
Q60960	Kpna1	Importin subunit alpha-5	Mus musculus (Mouse)	SS
O35343	Kpna4	Importin subunit alpha-3	Mus musculus (Mouse)	SS
O35345	Kpna6	Importin subunit alpha-7	Mus musculus (Mouse)	PR
C0LLJ0	Kpna7	Importin subunit alpha-8	Mus musculus (Mouse)	SS
P52293	Kpna2	Importin subunit alpha-1	Mus musculus (Mouse)	EV
O35344	Kpna3	Importin subunit alpha-4	Mus musculus (Mouse)	SS
C6K7I2	KPNA7	Importin subunit alpha-8	Sus scrofa (Pig)	SS
P83953	Kpna1	Importin subunit alpha-5	Rattus norvegicus (Rat)	SS
Q56R16	Kpna5	Importin subunit alpha-6	Rattus norvegicus (Rat)	SS
Q71VM4	Os01g0253300	Importin subunit alpha-1a	Oryza sativa subsp. japonica (Rice)	SS
P91276	ima-2	Importin subunit alpha-2	Caenorhabditis elegans	SS
Q19969	ima-3	Importin subunit alpha-3	Caenorhabditis elegans	SS
O04294	IMPA3	Importin subunit alpha-3	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9FJ09	IMPA5	Importin subunit alpha-5	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9M9X7	IMPA7	Importin subunit alpha-7	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9FWY7	IMPA6	Importin subunit alpha-6	Arabidopsis thaliana (Mouse-ear cress)	SS
O22478		Importin subunit alpha	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)	SS
Q503E9	kpna5	Importin subunit alpha-6	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MAENPSLENH	RIKSFKNKGR	DVETMRRHRN	EVTVELRKNK	RDEHLLKKRN	VPQEESLEDS
70	80	90	100	110	120
DVDADFKAQN	VTLEAILQNA	TSDNPVVQLS	AVQAARKLLS	SDRNPPIDDL	IKSGILPILV
130	140	150	160	170	180
KCLERDDNPS	LQFEAAWALT	NIASGTSAQT	QAVVQSNAVP	LFLRLLRSPH	QNVCEQAVWA
190	200	210	220	230	240
LGNIIGDGPQ	CRDYVISLGV	VKPLLSFISP	SIPITFLRNV	TWVIVNLCRN	KDPPPPMETV
250	260	270	280	290	300
QEILPALCVL	IYHTDINILV	DTVWALSYLT	DGGNEQIQMV	IDSGVVPFLV	PLLSHQEVKV
310	320	330	340	350	360
QTAALRAVGN	IVTGTDEQTQ	VVLNCDVLSH	FPNLLSHPKE	KINKEAVWFL	SNITAGNQQQ
370	380	390	400	410	420
VQAVIDAGLI	PMIIHQLAKG	DFGTQKEAAW	AISNLTISGR	KDQVEYLVQQ	NVIPPFCNLL
430	440	450	460	470	480
SVKDSQVVQV	VLDGLKNILI	MAGDEASTIA	EIIEECGGLE	KIEVLQQHEN	EDIYKLAFEI
490	500	510	520
IDQYFSGDDI	DEDPCLIPEA	TQGGTYNFDP	TANLQTKEFN	F