AiPD: Autoinhibited Protein Database

O00470

Gene name	MEIS1
Protein name	Homeobox protein Meis1
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:4211
EC number
Protein Class

Descriptions

MEIS2 is a homeodomain protein containing a conserved homothorax (Hth) domain that is present in all Meis and Prep family proteins and in the Drosophila Hth protein. The region of MEIS2 is an autoinhibitory region which encompasses homology region 2 (hr2) of the Hth domain. The Hth domain interacts with Pbx proteins, thereby promoting cooperative binding of Meis/Pbx dimers to a composite DNA element, and this interaction facilitates binding of the Pbx partner to DNA.

Autoinhibitory domains (AIDs)

148-191 (hr2 region) SS

Target domain	340-470 (C-terminal transcriptional activation domain)
Relief mechanism	Partner binding
Assay

AID

148-191 (hr2 region)

Target domain

340-470 (C-terminal transcriptional activation domain)

Relief mechanism

Partner binding (Pbx1 homeodomain protein binding)

Assay

Accessory elements

No accessory elements

References

Hyman-Walsh C et al. (2010) "An autoinhibitory effect of the homothorax domain of Meis2", The FEBS journal, 277, 2584-97

Autoinhibited structure

Activated structure

3 structures for O00470

Entry ID	Method	Resolution	Chain	Position	Source
4XRS	X-ray	350 A	A/B	279-336	PDB
5EGO	X-ray	254 A	A	279-333	PDB
AF-O00470-F1	Predicted				AlphaFoldDB

188 variants for O00470

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs371461925 CA347081742	4	R>S		No	ClinGen ESP gnomAD
rs765836809 CA1687818	6	D>E		No	ClinGen ExAC gnomAD
CA347081776 rs1407497093	6	D>N		No	ClinGen gnomAD
CA347081825 rs1310247578	13	G>D		No	ClinGen gnomAD
rs1358497771 CA347081834	14	M>I		No	ClinGen gnomAD
CA347081832 rs1458794651	14	M>T		No	ClinGen TOPMed gnomAD
CA347081841 rs1246939958	15	D>G		No	ClinGen gnomAD
rs1482103507 CA347081849	16	G>A		No	ClinGen gnomAD
CA347081853 rs1203988522	17	V>L		No	ClinGen gnomAD
rs1573113424 CA347081861	18	G>A		No	ClinGen Ensembl
CA1687822 rs752993508	19	I>S		No	ClinGen ExAC TOPMed gnomAD
rs752993508 CA347081867	19	I>T		No	ClinGen ExAC TOPMed gnomAD
COSM221648 CA1687823 rs758777353	20	P>S	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs778204771 CA1687824	23	M>I		No	ClinGen ExAC TOPMed gnomAD
CA347081899 rs1192346220	24	Y>C		No	ClinGen TOPMed
CA347081911 rs1384947428	26	D>A		No	ClinGen gnomAD
rs200427772 CA1687825	26	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1384947428 CA347081913	26	D>G		No	ClinGen gnomAD
CA347081920 rs1163790343	27	P>L		No	ClinGen gnomAD
rs1387711149 CA347081929	29	A>T		No	ClinGen gnomAD
CA1687827 rs781181478	30	A>G		No	ClinGen ExAC
CA347081937 rs1169211246	30	A>S		No	ClinGen gnomAD
CA347081935 rs1169211246	30	A>T		No	ClinGen gnomAD
CA1687832 rs772012473	33	M>I		No	ClinGen ExAC gnomAD
rs780426250 CA1687830	33	M>L		No	ClinGen ExAC gnomAD
CA1687831 rs747890719	33	M>T		No	ClinGen ExAC TOPMed gnomAD
rs565471424 CA1687833	34	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
rs367951046 CA1687834	35	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs776061419 CA1687836	40	N>K		No	ClinGen ExAC
rs922651749 CA347082012	41	H>Q		No	ClinGen TOPMed gnomAD
CA50023085 rs553932802	43	P>L		No	ClinGen Ensembl
CA1687837 rs759092516	45	L>R		No	ClinGen ExAC gnomAD
CA347082030 rs1381550151	45	L>V		No	ClinGen TOPMed gnomAD
rs1243110681 CA347082047	47	S>L		No	ClinGen gnomAD
CA1687839 rs752369772	49	Q>R		No	ClinGen ExAC gnomAD
rs372202666 CA1687840	50	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs865922622 CA50023087	51	P>Q		No	ClinGen Ensembl
CA347082100 rs1419561639	55	H>L		No	ClinGen gnomAD
rs1434738144 CA347082106	56	T>N		No	ClinGen TOPMed
rs934185879 CA50023088	57	N>K		No	ClinGen Ensembl
rs572995046 CA50023089	58	A>G		No	ClinGen Ensembl
rs781330399 CA1687844	58	A>T		No	ClinGen ExAC gnomAD
rs1338382686 CA347082124	59	M>I		No	ClinGen gnomAD
CA50023090 rs985991019	59	M>T		No	ClinGen Ensembl
CA1687846 rs545136188	59	M>V		No	ClinGen ExAC gnomAD
CA1687847 rs780370917	60	A>T		No	ClinGen ExAC TOPMed gnomAD
rs749548319 CA1687848	63	M>K		No	ClinGen ExAC gnomAD
rs1271023233 CA347082148	63	M>L		No	ClinGen TOPMed gnomAD
CA347082146 rs1271023233	63	M>L		No	ClinGen TOPMed gnomAD
CA347082157 rs1217591995	64	G>D		No	ClinGen gnomAD
rs954461904 CA50023091	65	S>F		No	ClinGen TOPMed gnomAD
rs1329905600 CA347082160	65	S>T		No	ClinGen gnomAD
rs954461904 CA347082163	65	S>Y		No	ClinGen TOPMed gnomAD
CA50023092 rs867839014	67	V>I		No	ClinGen gnomAD
CA50023093 rs983085178	68	N>H		No	ClinGen TOPMed gnomAD
CA347082183 rs1266576024	69	D>N		No	ClinGen gnomAD
CA347082193 rs1214596612	70	A>S		No	ClinGen gnomAD
rs1259439788 CA347082194	70	A>V		No	ClinGen TOPMed
rs866533130 CA50023094	72	K>N		No	ClinGen Ensembl
rs1242392477 CA347082213	73	R>K		No	ClinGen gnomAD
rs746949791 CA50023095	74	D>E		No	ClinGen ExAC gnomAD
CA50023096 rs35067867	76	D>G		No	ClinGen Ensembl
rs1196740598 CA347082233	76	D>N		No	ClinGen TOPMed gnomAD
rs1427994283 CA347082245	77	A>V		No	ClinGen gnomAD
CA347082387 rs1573116936	81	H>P		No	ClinGen Ensembl
rs575209192 CA50023291	81	H>Q		No	ClinGen Ensembl
rs1462597071 CA347082390	82	P>A		No	ClinGen TOPMed gnomAD
rs1180830551 CA347082416	86	L>F		No	ClinGen TOPMed
CA347082495 rs1469607061	97	A>T		No	ClinGen gnomAD
rs1458505316 CA347082499	98	T>P		No	ClinGen TOPMed
CA347082501 rs1458505316	98	T>S		No	ClinGen TOPMed
rs756115124 CA1687890	100	T>P		No	ClinGen ExAC gnomAD
CA347082522 rs959662082	101	P>L		No	ClinGen TOPMed
CA50023294 rs959662082	101	P>R		No	ClinGen TOPMed
rs779973733 CA1687891	104	P>R		No	ClinGen ExAC gnomAD
CA347082544 rs1321255208	105	G>E		No	ClinGen gnomAD
rs778385393 CA1687894	105	G>R		No	ClinGen ExAC gnomAD
rs747871060 CA1687895	106	V>L		No	ClinGen ExAC TOPMed gnomAD
rs747871060 CA347082547	106	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1573117062 CA347082574	110	D>G		No	ClinGen Ensembl
rs202151942 CA1687900	118	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1480361314 CA347082653	121	I>T		No	ClinGen TOPMed gnomAD
rs561384504 CA50023295	122	A>V		No	ClinGen Ensembl
CA50023296 rs924602028	123	V>A		No	ClinGen Ensembl
CA347082674 rs752841255	125	A>S		No	ClinGen ExAC TOPMed gnomAD
rs752841255 CA1687903	125	A>T		No	ClinGen ExAC TOPMed gnomAD
CA1687971 rs770272549	129	R>L		No	ClinGen ExAC
rs749342831 CA1687973	133	P>T		No	ClinGen ExAC gnomAD
CA50023368 rs749040629	134	L>P		No	ClinGen Ensembl
CA50023370 rs978219405	138	N>Y		No	ClinGen TOPMed
CA50023371 rs866102870	142	D>N		No	ClinGen Ensembl
rs1183259682 CA347082832	145	M>L		No	ClinGen gnomAD
CA50023438 rs952750461	146	I>V		No	ClinGen TOPMed gnomAD
rs530426329 CA1688004	147	Q>K		No	ClinGen ExAC gnomAD
CA347082910 rs983953932	156	L>V		No	ClinGen TOPMed gnomAD
rs1458376080 CA347083013	168	N>S		No	ClinGen TOPMed
CA347083044 rs1262513073	172	R>Q		No	ClinGen gnomAD
rs1157772342 CA347083063	175	S>C		No	ClinGen TOPMed
rs560708954 CA50023614	175	S>N		No	ClinGen Ensembl
CA1688027 rs760299731	184	D>N		No	ClinGen ExAC gnomAD
rs772211406 CA1688028	187	I>T		No	ClinGen ExAC TOPMed gnomAD
rs755348268 CA1688030	189	D>N		No	ClinGen ExAC gnomAD
rs753232642 CA1688032	190	R>G		No	ClinGen ExAC gnomAD
rs758451287 CA1688034	190	R>K		No	ClinGen ExAC
CA347083191 rs1400145161	193	G>A		No	ClinGen gnomAD
rs777773287 CA1688035	198	S>R		No	ClinGen ExAC gnomAD
CA347083249 rs1301661620	201	I>R		No	ClinGen gnomAD
CA347083245 rs1386155008	201	I>V		No	ClinGen gnomAD
CA50023616 rs892646699	202	T>A		No	ClinGen Ensembl
rs369833361 CA50023617	203	R>G		No	ClinGen ESP gnomAD
rs552329583 CA1688036	204	S>T		No	ClinGen ExAC gnomAD
rs1285636755 CA347083277	206	N>S		No	ClinGen gnomAD
rs554620476 CA1688037	208	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1244933999 CA347083297	209	D>E		No	ClinGen TOPMed
CA347083296 rs1244933999	209	D>E		No	ClinGen TOPMed
rs781493613 CA1688038	209	D>N		No	ClinGen ExAC gnomAD
CA347083300 rs1289683834	210	Q>E		No	ClinGen gnomAD
rs760717673 CA1688039	210	Q>R		No	ClinGen ExAC gnomAD
rs1394137805 CA347083413	211	P>S		No	ClinGen TOPMed gnomAD
CA347083425 rs1487044408	213	W>G		No	ClinGen gnomAD
CA1688072 rs759245209	217	H>D		No	ClinGen ExAC gnomAD
rs1051865597 CA50032007	217	H>Q		No	ClinGen TOPMed
CA1688074 rs376358636	220	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1415220775 CA347083485	221	A>V		No	ClinGen gnomAD
CA347083493 rs1358679652	222	S>F		No	ClinGen gnomAD
rs1399537292 CA347083498	223	T>S		No	ClinGen gnomAD
rs867248211 CA50032010	224	R>C		No	ClinGen TOPMed gnomAD
rs867248211 CA347083501	224	R>G		No	ClinGen TOPMed gnomAD
CA1688077 COSM1214899 rs199516222	224	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1368786744 CA347083514	226	G>A		No	ClinGen gnomAD
CA347083519 rs1280357271	227	G>E		No	ClinGen gnomAD
rs767689616 CA347083556	233	S>I		No	ClinGen ExAC gnomAD
CA1688079 rs767689616	233	S>T		No	ClinGen ExAC gnomAD
CA1688081 rs546155412	234	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs780426099 CA1688082	234	G>V		No	ClinGen ExAC gnomAD
rs562863229 CA1688083	235	G>S		No	ClinGen 1000Genomes ExAC gnomAD
CA347083572 rs1419330027	236	H>L		No	ClinGen gnomAD
CA1688085 rs758233459	237	T>M		No	ClinGen ExAC TOPMed gnomAD
CA50032017 rs531297783	239	H>Y		No	ClinGen Ensembl
CA347083598 rs1404054563	240	S>T		No	ClinGen gnomAD
rs1439134180 CA347083618	243	N>Y		No	ClinGen gnomAD
CA347083646 COSM3714222 rs1135875	246	E>D	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs550508376 CA1688089	246	E>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1290610580 CA347085226	248	G>D		No	ClinGen gnomAD
rs1158933133 CA347085240	250	G>D		No	ClinGen TOPMed
rs61752692 CA1688120	254	S>G		No	ClinGen ExAC gnomAD
CA347085273 rs1386075568	255	V>I		No	ClinGen gnomAD
rs1418535282 CA347085291	258	P>S		No	ClinGen TOPMed
rs1433718684 CA347085339	264	D>E		No	ClinGen TOPMed
CA347085349 rs1266332568	266	P>T		No	ClinGen TOPMed
rs751312385 CA1688125	272	R>C		No	ClinGen ExAC TOPMed gnomAD
VAR_063166 rs61752693 CA1688126	272	R>H	found in a patient with susceptibility to restless legs syndrome [UniProt]	No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs751312385 CA1688124	272	R>S		No	ClinGen ExAC TOPMed gnomAD
rs913781723 CA50041801	276	R>H		No	ClinGen Ensembl
CA1688127 rs750403096	278	I>V		No	ClinGen ExAC gnomAD
CA1688131 rs754588629	282	V>L		No	ClinGen ExAC gnomAD
rs1257858865 COSM371379 CA347083348	289	A>V	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1176438845 CA347083365	292	F>V		No	ClinGen gnomAD
rs1218336141 CA347083812	317	L>I		No	ClinGen gnomAD
rs1259130203 CA347083819	318	Q>E		No	ClinGen gnomAD
CA347083818 rs1259130203	318	Q>K		No	ClinGen gnomAD
CA347083834 rs1235206549	320	N>Y		No	ClinGen gnomAD
rs373420611 CA50053494	334	M>V		No	ClinGen ESP TOPMed
CA50053496 rs926938618	338	S>A		No	ClinGen TOPMed
CA50053497 rs958348230	338	S>F		No	ClinGen TOPMed
CA347083990 rs1345250115	339	N>S		No	ClinGen gnomAD
rs200602768 CA1688218	346	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA347084262 rs1278116603	352	G>E		No	ClinGen TOPMed
CA50053708 rs547262794	353	Q>H		No	ClinGen TOPMed gnomAD
CA1688221 rs758483192	355	M>I		No	ClinGen ExAC gnomAD
rs758483192 CA347084284	355	M>I		No	ClinGen ExAC gnomAD
rs1357930820 CA347084277	355	M>L		No	ClinGen TOPMed
rs371528287 CA1688222	357	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs2901863 CA50053711	358	F>V		No	ClinGen Ensembl
CA1688223 rs144778967	359	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs769670616 CA1688224	360	M>I		No	ClinGen ExAC gnomAD
CA347084312 rs1276022900	360	M>T		No	ClinGen gnomAD
rs373115262 CA50053717	361	D>N		No	ClinGen ESP TOPMed gnomAD
CA347084347 rs1343143228	365	H>Y		No	ClinGen gnomAD
CA1688226 rs570343772	366	M>L		No	ClinGen ExAC gnomAD
rs879112620 CA50053720	371	P>A		No	ClinGen Ensembl
rs904457402 CA50053722	371	P>Q		No	ClinGen Ensembl
CA1688243 rs755959089	373	P>S		No	ClinGen ExAC gnomAD
CA1688245 rs373920993	374	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA50053788 rs753394170	376	G>A		No	ClinGen Ensembl
CA347084500 rs1455640713	378	G>V		No	ClinGen TOPMed
rs1209337277 CA347084512	380	N>H		No	ClinGen TOPMed
COSM1532357 rs1476459091 CA347084524	381	M>I	lung [Cosmic]	No	ClinGen cosmic curated gnomAD

1 associated diseases with O00470

[MIM: 612853]: Restless legs syndrome 7 (RLS7)

A neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep. {ECO:0000305|PubMed:19620614}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.

Without disease ID

A neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep. {ECO:0000305|PubMed:19620614}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.

3 regional properties for O00470

Type	Name	Position	InterPro Accession
domain	Homeobox domain	270 - 337	IPR001356
domain	Homeobox KN domain	290 - 329	IPR008422
domain	Homeobox protein PKNOX/Meis, N-terminal	108 - 192	IPR032453

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription regulator complex	A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

5 GO annotations of molecular function

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription activator activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

15 GO annotations of biological process

Name	Definition
angiogenesis	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
animal organ morphogenesis	Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
brain development	The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
definitive hemopoiesis	A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood.
embryonic pattern specification	The process that results in the patterns of cell differentiation that will arise in an embryo.
eye development	The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
hemopoiesis	The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
lens morphogenesis in camera-type eye	The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
locomotory behavior	The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
megakaryocyte development	The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow.
negative regulation of myeloid cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation.
negative regulation of neuron differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

14 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8MIB7	TGIF2LX	Homeobox protein TGIF2LX	Pan troglodytes (Chimpanzee)	PR
P40424	PBX1	Pre-B-cell leukemia transcription factor 1	Homo sapiens (Human)	PR
P40425	PBX2	Pre-B-cell leukemia transcription factor 2	Homo sapiens (Human)	PR
Q8IUE1	TGIF2LX	Homeobox protein TGIF2LX	Homo sapiens (Human)	PR
O14770	MEIS2	Homeobox protein Meis2	Homo sapiens (Human)	EV
Q99687	MEIS3	Homeobox protein Meis3	Homo sapiens (Human)	SS
A8K0S8	MEIS3P2	Putative homeobox protein Meis3-like 2	Homo sapiens (Human)	PR
A6NDR6	MEIS3P1	Putative homeobox protein Meis3-like 1	Homo sapiens (Human)	PR
P97368	Meis3	Homeobox protein Meis3	Mus musculus (Mouse)	PR
P97367	Meis2	Homeobox protein Meis2	Mus musculus (Mouse)	SS
Q75LX9	Os03g0673500	Putative homeobox protein knotted-1-like 5	Oryza sativa subsp japonica (Rice)	PR
Q75LX7	OSH10	Homeobox protein knotted-1-like 4	Oryza sativa subsp japonica (Rice)	PR
Q1PFD1	BLH11	BEL1-like homeodomain protein 11	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SIW1	BLH7	BEL1-like homeodomain protein 7	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MAQRYDDLPH	YGGMDGVGIP	STMYGDPHAA	RSMQPVHHLN	HGPPLHSHQY	PHTAHTNAMA
70	80	90	100	110	120
PSMGSSVNDA	LKRDKDAIYG	HPLFPLLALI	FEKCELATCT	PREPGVAGGD	VCSSESFNED
130	140	150	160	170	180
IAVFAKQIRA	EKPLFSSNPE	LDNLMIQAIQ	VLRFHLLELE	KVHELCDNFC	HRYISCLKGK
190	200	210	220	230	240
MPIDLVIDDR	EGGSKSDSED	ITRSANLTDQ	PSWNRDHDDT	ASTRSGGTPG	PSSGGHTSHS
250	260	270	280	290	300
GDNSSEQGDG	LDNSVASPST	GDDDDPDKDK	KRHKKRGIFP	KVATNIMRAW	LFQHLTHPYP
310	320	330	340	350	360
SEEQKKQLAQ	DTGLTILQVN	NWFINARRRI	VQPMIDQSNR	AVSQGTPYNP	DGQPMGGFVM
370	380
DGQQHMGIRA	PGPMSGMGMN	MGMEGQWHYM