AiPD: Autoinhibited Protein Database

O00308

Gene name	WWP2
Protein name	NEDD4-like E3 ubiquitin-protein ligase WWP2
Names	Atrophin-1-interacting protein 2, AIP2, HECT-type E3 ubiquitin transferase WWP2, WW domain-containing protein 2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:11060
EC number	2.3.2.26: Aminoacyltransferases
Protein Class	HECT DOMAIN UBIQUITIN-PROTEIN LIGASE (PTHR11254)

Descriptions

The C2-WW-HECT-domain E3 proteins downregulates transforming growth factor-β (TGF-β) signaling by targeting itself, the adaptor protein Smad7, and TGF-β receptor kinases for degradation. Like Smurf2, which exhibits the inhibitory C2 and HECT domain interaction, the full-length WWP2 enzyme shows low ubiquitination levels by the C2 domain. The level is significantly enhanced by deleting C2 domain.

Autoinhibitory domains (AIDs)

Target domain	516-868 (HECT domain)
Relief mechanism	Partner binding
Assay	Deletion assay, Structural analysis

AID

1-117 (C2 domain)

Target domain

516-868 (HECT domain)

Relief mechanism

Partner binding (NDFIP1 and NDFIP2 binding to WW domains)

Assay

Deletion assay, Structural analysis

Accessory elements

No accessory elements

References

Mund T et al. (2009) "Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins", EMBO reports, 10, 501-7

Wiesner S et al. (2007) "Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain", Cell, 130, 651-62

Tsunoda T et al. (2022) "ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer", EMBO reports, 23, e51182

Chen Z et al. (2017) "A Tunable Brake for HECT Ubiquitin Ligases", Molecular cell, 66, 345-357.e6

Riling C et al. (2015) "Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation", The Journal of biological chemistry, 290, 23875-87

Wang Z et al. (2019) "A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases", Nature communications, 10, 3162

Zhu K et al. (2017) "Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch", EMBO reports, 18, 1618-1630

Autoinhibited structure

Activated structure

11 structures for O00308

Entry ID	Method	Resolution	Chain	Position	Source
4Y07	X-ray	251 A	A	492-865	PDB
5TJ7	X-ray	260 A	A/B/C/D	334-865	PDB
5TJ8	X-ray	230 A	A	334-865	PDB
5TJQ	X-ray	275 A	A	334-865	PDB
6J1Z	X-ray	270 A			PDB
6RSS	NMR	-	A	438-480	PDB
8EI5	X-ray	260 A	A/B/C/D	492-865	PDB
8EI6	X-ray	362 A	A/B	492-865	PDB
8EI7	X-ray	222 A	A/B	492-865	PDB
8EI8	X-ray	290 A	A	492-865	PDB
AF-O00308-F1	Predicted				AlphaFoldDB

669 variants for O00308

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1364451433 CA396494357	2	A>V		No	ClinGen TOPMed gnomAD
rs1453271755 CA396494370	3	S>F		No	ClinGen gnomAD
CA8136908 rs778621819	4	A>V		No	ClinGen ExAC gnomAD
rs936547731 CA283364272	5	S>N		No	ClinGen TOPMed gnomAD
CA8136909 rs752367875	6	S>C		No	ClinGen ExAC TOPMed gnomAD
CA8136910 rs752367875	6	S>F		No	ClinGen ExAC TOPMed gnomAD
CA8136913 rs746503953	8	R>L		No	ClinGen ExAC TOPMed gnomAD
rs746503953 CA8136912	8	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs142617495 CA8136911	8	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1353048537 CA396494440	11	V>L		No	ClinGen TOPMed gnomAD
CA396494467 rs1382186978	13	L>P		No	ClinGen TOPMed
CA396494470 rs1337273288	14	P>T		No	ClinGen TOPMed
CA8136914 rs150528209	17	K>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs746313358 CA8136915	19	Q>H		No	ClinGen ExAC gnomAD
rs892120436 CA396494535	19	Q>L		No	ClinGen gnomAD
rs892120436 CA283364322	19	Q>P		No	ClinGen gnomAD
rs770299956 CA8136916	22	L>M		No	ClinGen ExAC gnomAD
rs1185929185 CA396494587	24	V>M		No	ClinGen gnomAD
rs1567671817 CA396496686	25	V>A		No	ClinGen Ensembl
CA396496702 rs1181677264	27	A>T		No	ClinGen TOPMed
rs1480491390 CA396496766	30	K>N		No	ClinGen TOPMed gnomAD
CA396496779 rs1177901288	31	V>E		No	ClinGen gnomAD
rs1597685788 CA396496814	33	N>K		No	ClinGen Ensembl
CA8136930 rs751094487	33	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1036291469 CA283371031 COSM1493757	34	R>C	kidney [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
COSM972945 rs756797873 CA396496823	34	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs756797873 CA8136931	34	R>P		No	ClinGen ExAC gnomAD
CA8136933 rs548693533	37	R>*		No	ClinGen 1000Genomes ExAC gnomAD
rs548693533 CA8136934	37	R>G		No	ClinGen 1000Genomes ExAC gnomAD
rs143303340 CA8136935	37	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8136936 rs143303340	37	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA283371051 rs892638537	38	I>V		No	ClinGen TOPMed gnomAD
CA8136938 rs774635737	40	S>A		No	ClinGen ExAC
rs1312179363 CA396496979	40	S>F		No	ClinGen gnomAD
COSM1168824 rs1011375134 CA283371070	42	V>M	pancreas [Cosmic]	No	ClinGen cosmic curated TOPMed
CA8136940 rs140261430	45	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA8136943 rs765133692	47	D>N		No	ClinGen ExAC gnomAD
rs372438560 CA8136944	49	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA8136945 rs150059700	50	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA283371125 rs764855295	51	S>I		No	ClinGen gnomAD
rs764855295 CA396497256	51	S>T		No	ClinGen gnomAD
rs1432559787 CA396497310	53	T>I		No	ClinGen gnomAD
COSM242274 rs1166415028 CA396497298	53	T>S	prostate [Cosmic]	No	ClinGen cosmic curated TOPMed
rs763732833 CA8136946	54	K>Q		No	ClinGen ExAC gnomAD
CA8136947 rs751241119	58	K>R		No	ClinGen ExAC gnomAD
rs367837270 CA8136948	59	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM435637 rs1029698891 CA396497439	59	R>H	breast [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA283371190 rs1029698891	59	R>L		No	ClinGen TOPMed gnomAD
rs1291907818 CA396497455	60	I>N		No	ClinGen gnomAD
rs1291907818 CA396497458	60	I>T		No	ClinGen gnomAD
rs767090543 CA8136949	60	I>V		No	ClinGen ExAC TOPMed gnomAD
CA396497492 rs1366961267	62	S>I		No	ClinGen TOPMed gnomAD
CA396497490 rs1366961267	62	S>N		No	ClinGen TOPMed gnomAD
rs749921377 CA8136950	64	E>*		No	ClinGen ExAC
rs756734868 CA8136951	68	N>D		No	ClinGen ExAC gnomAD
rs1228136849 CA396497626	70	I>F		No	ClinGen gnomAD
rs780694295 CA8136953	70	I>N		No	ClinGen ExAC gnomAD
rs780694295 CA8136952	70	I>S		No	ClinGen ExAC gnomAD
rs779096737 CA8136955	72	I>N		No	ClinGen ExAC TOPMed gnomAD
rs779096737 CA8136956	72	I>T		No	ClinGen ExAC TOPMed gnomAD
CA8136954 rs755380901	72	I>V		No	ClinGen ExAC gnomAD
CA8136977 rs777963501	74	N>K		No	ClinGen ExAC gnomAD
rs1020613769 CA283371509	74	N>S		No	ClinGen Ensembl
rs375318503 COSM1640539 CA8136978	76	T>M	stomach [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
rs1597686717 CA396497905	77	A>V		No	ClinGen Ensembl
rs1419895221 CA396497926	78	Q>H		No	ClinGen TOPMed gnomAD
CA8136981 rs749282458	79	S>C		No	ClinGen ExAC gnomAD
CA396497950 rs1332710332	80	H>N		No	ClinGen TOPMed
CA396497961 rs1449427768	80	H>R		No	ClinGen TOPMed
CA396498000 rs1386521134	82	D>G		No	ClinGen gnomAD
rs768451025 CA8136982	83	L>*		No	ClinGen ExAC
CA396498063 rs1457217205	86	W>*		No	ClinGen gnomAD
CA283371529 rs74374911	86	W>G		No	ClinGen Ensembl
rs761500926 CA396498072	87	S>G		No	ClinGen ExAC gnomAD
CA8136984 rs761500926	87	S>R		No	ClinGen ExAC gnomAD
rs771918775 CA8136985	87	S>T		No	ClinGen ExAC gnomAD
CA396498141 rs1392761618	91	L>F		No	ClinGen TOPMed
CA8136986 rs773005230	93	N>S		No	ClinGen ExAC gnomAD
rs1378065797 CA396498218	96	L>P		No	ClinGen gnomAD
rs981743053 CA283371535	97	G>R		No	ClinGen Ensembl
rs369381187 CA8136989	99	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA8136990 rs760137313	102	N>S		No	ClinGen ExAC gnomAD
CA396498297 rs1444002159	105	N>S		No	ClinGen TOPMed gnomAD
rs373154084 CA8136991	105	N>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs1236671336 CA396498300	106	V>I		No	ClinGen TOPMed gnomAD
rs758691107 CA8136993	110	N>S		No	ClinGen ExAC gnomAD
rs1466934089 CA396498348	112	G>C		No	ClinGen TOPMed
CA8136995 rs375272256	112	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA8137022 rs377573067	114	M>I		No	ClinGen ESP ExAC gnomAD
rs777756000 CA8137023	115	E>G		No	ClinGen ExAC
CA8137024 rs201858298	117	M>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1466679267 CA396496884	118	Q>P		No	ClinGen gnomAD
CA396496967 rs1207354868	122	N>S		No	ClinGen gnomAD
rs770773964 CA8137025	123	L>M		No	ClinGen ExAC TOPMed gnomAD
CA396496973 rs1445644933	123	L>Q		No	ClinGen gnomAD
rs776151376 CA8137026	124	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA8137027 rs530023292	125	T>M		No	ClinGen ExAC gnomAD
rs189041230 CA8137029	127	N>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8137030 rs763493082	127	N>S		No	ClinGen ExAC gnomAD
CA396497116 rs1313360451	129	G>C		No	ClinGen Ensembl
CA396497119 rs1318486836	129	G>D		No	ClinGen gnomAD
CA8137032 rs143354391	131	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs762164829 CA8137033	133	S>P		No	ClinGen ExAC gnomAD
CA396497242 rs1289114218	135	G>R		No	ClinGen TOPMed gnomAD
rs756318143 CA8137036	138	T>K		No	ClinGen ExAC gnomAD
rs371454354 CA8137037	139	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA283385081 rs1045373180	142	D>H		No	ClinGen TOPMed gnomAD
rs1315198496 CA396497410 COSM95538	143	G>R	breast [Cosmic]	No	ClinGen cosmic curated TOPMed
rs939588067 CA283385087	144	P>A		No	ClinGen TOPMed
CA8137039 rs141633678	147	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1169263013 CA396497596	150	N>I		No	ClinGen TOPMed
rs1028535458 CA283385096	153	N>D		No	ClinGen TOPMed gnomAD
CA396497659 rs1186436635	154	G>D		No	ClinGen gnomAD
rs1412186817 CA396497695	156	A>D		No	ClinGen gnomAD
CA8137041 rs200683787	158	T>K		No	ClinGen ExAC TOPMed gnomAD
rs200683787 CA396497716	158	T>R		No	ClinGen ExAC TOPMed gnomAD
rs757130733 CA8137042	159	D>A		No	ClinGen ExAC TOPMed gnomAD
CA8137043 rs757130733	159	D>G		No	ClinGen ExAC TOPMed gnomAD
CA396497723 rs1473094766	159	D>H		No	ClinGen TOPMed
rs1473094766 CA396497720	159	D>N		No	ClinGen TOPMed
rs759693369 CA8137058	160	G>E		No	ClinGen ExAC TOPMed gnomAD
CA283385695 rs546382050	161	S>L		No	ClinGen 1000Genomes
CA396498392 rs1307538180	164	P>L		No	ClinGen gnomAD
CA8137060 rs751563099	165	S>L		No	ClinGen ExAC TOPMed gnomAD
CA283385708 rs887750271	168	S>A		No	ClinGen Ensembl
CA8137062 rs780890962	168	S>C		No	ClinGen ExAC gnomAD
CA8137063 rs750211901	169	S>G		No	ClinGen ExAC TOPMed gnomAD
CA8137064 rs755782083	170	G>R		No	ClinGen ExAC gnomAD
CA8137065 rs779677207	171	T>R		No	ClinGen ExAC gnomAD
CA8137066 rs147074353	172	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs768171630 CA8137067	172	A>V		No	ClinGen ExAC TOPMed
rs1202553262 CA396498446	174	A>T		No	ClinGen gnomAD
rs1250376496 CA396498456	175	P>L		No	ClinGen TOPMed gnomAD
rs138285985 CA283385737	178	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8137070 rs138285985	178	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs184547498 CA8137069	178	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396498475 rs1432509190	179	H>Y		No	ClinGen gnomAD
rs1391749884 CA396498487	180	Q>R		No	ClinGen gnomAD
CA283385748 rs1030160821	182	P>L		No	ClinGen TOPMed gnomAD
CA8137074 rs768917989	183	S>N		No	ClinGen ExAC gnomAD
rs1390718988 CA396498513	184	T>R		No	ClinGen gnomAD
rs759782275 CA8137075	185	N>D		No	ClinGen ExAC gnomAD
CA396498534 rs765437085	187	F>C		No	ClinGen ExAC TOPMed gnomAD
rs765437085 CA8137076	187	F>Y		No	ClinGen ExAC TOPMed gnomAD
rs1228066849 CA396498547	189	G>A		No	ClinGen gnomAD
rs1301867941 CA396498551	190	R>K		No	ClinGen TOPMed gnomAD
rs752795485 CA8137077	191	S>T		No	ClinGen ExAC gnomAD
CA8137080 rs750253078	192	R>L		No	ClinGen ExAC TOPMed gnomAD
CA8137079 rs201287506	192	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8137100 rs773218849	193	T>M		No	ClinGen ExAC TOPMed gnomAD
rs559742728 CA8137099	193	T>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1457168029 CA396504013	196	H>Y		No	ClinGen gnomAD
RCV000896577 CA8137103 rs143156114	197	S>L		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA8137105 rs764860976	198	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1326512812 CA396504070	200	S>L		No	ClinGen TOPMed
rs1300726872 CA396504087	201	A>P		No	ClinGen gnomAD
CA8137106 rs752219825	203	T>A		No	ClinGen ExAC TOPMed gnomAD
CA396504157 rs1289664104	204	T>I		No	ClinGen gnomAD
CA396504144 rs1597087925	204	T>P		No	ClinGen Ensembl
CA396504164 rs777097298	205	P>A		No	ClinGen ExAC TOPMed gnomAD
CA8137108 rs777097298	205	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1006317101 CA283397418	207	T>A		No	ClinGen TOPMed
rs1381840572 CA396504199	207	T>I		No	ClinGen TOPMed
rs1207691765 CA396504206	208	G>D		No	ClinGen gnomAD
CA8137110 rs757805460	208	G>S		No	ClinGen ExAC gnomAD
CA8137112 rs746223579	209	E>K		No	ClinGen ExAC TOPMed gnomAD
rs770208052 CA8137113	210	Q>H		No	ClinGen ExAC gnomAD
CA396504257 rs1597088014	211	S>G		No	ClinGen Ensembl
CA396504287 rs1192320841	212	P>A		No	ClinGen TOPMed
rs1215595478 CA396504296	213	G>A		No	ClinGen TOPMed
CA283397466 rs371719288	213	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA8137115 rs371719288	213	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA396504614 rs1192305533	214	A>V		No	ClinGen gnomAD
rs139932753 CA396504619	215	R>P		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs139932753 CA8137117	215	R>Q		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs145994314 CA8137116	215	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1374545787 CA396504648	217	R>L		No	ClinGen gnomAD
CA396504646 rs1374545787	217	R>Q		No	ClinGen gnomAD
CA8137118 COSM130234 rs760710036	217	R>W	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1429963947 CA396504658	218	H>P		No	ClinGen gnomAD
CA396504660 rs1429963947	218	H>R		No	ClinGen gnomAD
CA8137119 rs766287861	219	R>C		No	ClinGen ExAC TOPMed gnomAD
rs776475086 CA8137120	219	R>H		No	ClinGen ExAC TOPMed gnomAD
CA396504702 rs755244675	222	V>F		No	ClinGen ExAC TOPMed gnomAD
CA8137122 rs755244675	222	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1454177746 CA396504717	223	K>R		No	ClinGen TOPMed
CA396504732 rs1309427340	224	N>S		No	ClinGen gnomAD
rs113797383 CA8137124	226	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA396504751 rs1343185158	226	G>S		No	ClinGen gnomAD
CA396504759 rs113797383	226	G>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs763698650 CA8137125	227	H>R		No	ClinGen ExAC TOPMed gnomAD
CA396504779 rs1437321375	228	S>N		No	ClinGen gnomAD
CA8137127 rs369812987	229	G>D		No	ClinGen ExAC gnomAD
CA8137126 rs751010011	229	G>S		No	ClinGen ExAC TOPMed gnomAD
CA283397523 rs369812987	229	G>V		No	ClinGen ExAC gnomAD
rs1000823195 CA283397527	230	L>F		No	ClinGen gnomAD
CA396504799 rs1477324474	230	L>M		No	ClinGen TOPMed gnomAD
rs1477324474 CA396504801	230	L>V		No	ClinGen TOPMed gnomAD
rs781763876 CA8137128	231	A>T		No	ClinGen ExAC gnomAD
rs756561198 CA8137130	232	N>K		No	ClinGen ExAC gnomAD
CA8137129 rs568343453	232	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1393786323 CA396504855	234	T>A		No	ClinGen gnomAD
rs1265732945 CA396504860	234	T>I		No	ClinGen TOPMed
rs369653281 CA8137149	236	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs755292551 CA8137150	237	D>V		No	ClinGen ExAC gnomAD
CA8137151 rs779004802	238	E>D		No	ClinGen ExAC gnomAD
rs1008899250 CA283407957	238	E>K		No	ClinGen Ensembl
rs965886448 CA283407958	239	P>L		No	ClinGen TOPMed
rs1269334349 CA396507639	240	T>K		No	ClinGen TOPMed gnomAD
rs1269334349 CA396507641	240	T>R		No	ClinGen TOPMed gnomAD
rs748307426 CA8137152	241	T>P		No	ClinGen ExAC gnomAD
CA8137153 rs182311713	242	A>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs182311713 CA8137154	242	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs745845066 CA8137155	243	T>A		No	ClinGen ExAC gnomAD
CA396507697 rs1446112161	243	T>I		No	ClinGen gnomAD
rs1238783413 CA396507710	244	D>H		No	ClinGen gnomAD
CA8137158 rs762653214	246	E>K		No	ClinGen ExAC TOPMed gnomAD
CA8137159 rs768433959	247	E>A		No	ClinGen ExAC gnomAD
rs1597112421 CA396507802	248	P>L		No	ClinGen Ensembl
CA8137161 COSM435638 rs139052693	250	V>I	breast [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs867582987 CA283408022	251	V>F		No	ClinGen Ensembl
rs910129729 CA396507940	252	G>D		No	ClinGen TOPMed gnomAD
rs910129729 CA283408038	252	G>V		No	ClinGen TOPMed gnomAD
rs143752055 CA283408059	254	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs143752055 CA8137163	254	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1336404262 CA396507988	254	T>S		No	ClinGen gnomAD
rs1289060705 CA396508021	256	P>A		No	ClinGen gnomAD
CA8137165 rs766785766	256	P>L		No	ClinGen ExAC TOPMed gnomAD
rs766785766 CA396508026	256	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs754301169 CA8137166	257	P>S		No	ClinGen ExAC gnomAD
CA283408089 rs937621004	258	A>G		No	ClinGen TOPMed gnomAD
CA396508063 rs937621004	258	A>V		No	ClinGen TOPMed gnomAD
CA8137168 rs765584431	262	S>T		No	ClinGen ExAC TOPMed gnomAD
CA396508171 rs1311491028	263	V>M		No	ClinGen TOPMed
CA396508222 rs1186655507	264	T>N		No	ClinGen gnomAD
COSM1379258 rs78426175 CA8137171	265	P>L	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA283408116 rs950225565	266	N>K		No	ClinGen TOPMed
rs756144699 CA8137173	266	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1400121864 CA396508275	266	N>Y		No	ClinGen TOPMed
CA283408118 rs977924804	268	N>Y		No	ClinGen Ensembl
CA396508355 rs1466372901	269	T>M		No	ClinGen gnomAD
rs1220211533 CA396508396	271	S>F		No	ClinGen gnomAD
CA396508394 rs1220211533	271	S>Y		No	ClinGen gnomAD
rs749192267 CA8137175	272	L>F		No	ClinGen ExAC gnomAD
CA396508406 rs1434304344	272	L>P		No	ClinGen gnomAD
CA283408140 rs1034726261	273	P>H		No	ClinGen Ensembl
rs1177327813 CA396508472	275	P>L		No	ClinGen TOPMed
rs1352426825 CA396508458	275	P>S		No	ClinGen gnomAD
CA8137177 rs199723151	277	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs372589501 CA8137179	278	P>L		No	ClinGen ESP ExAC gnomAD
CA396508521 rs1306936044	278	P>S		No	ClinGen gnomAD
rs777023336 CA8137183	279	A>G		No	ClinGen ExAC gnomAD
rs544471484 CA8137182	279	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs760045066 CA8137184	281	G>R		No	ClinGen ExAC gnomAD
CA396508624 rs1274864425	282	E>G		No	ClinGen gnomAD
CA8137185 rs765629014	283	E>A		No	ClinGen ExAC gnomAD
rs753038154 CA8137186	284	P>S		No	ClinGen ExAC gnomAD
rs201890122 CA8137187	285	S>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1597112795 CA396508713	286	T>P		No	ClinGen Ensembl
rs751715302 CA8137189	287	S>L		No	ClinGen ExAC gnomAD
CA8137188 rs764294633	287	S>P		No	ClinGen ExAC gnomAD
CA396508773 rs1453516649	288	G>V		No	ClinGen gnomAD
CA8137191 rs781284452	289	T>I		No	ClinGen ExAC gnomAD
rs1372582333 CA396508802	290	Q>E		No	ClinGen gnomAD
rs74460098 CA283408203	291	Q>P		No	ClinGen TOPMed gnomAD
rs74460098 CA396508845	291	Q>R		No	ClinGen TOPMed gnomAD
CA8137192 rs749215554	294	A>E		No	ClinGen ExAC TOPMed gnomAD
rs749215554 COSM1232887 CA8137193	294	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1389011806 CA396508953	296	A>D		No	ClinGen TOPMed gnomAD
rs778905446 CA8137196	296	A>P		No	ClinGen ExAC TOPMed gnomAD
rs778905446 CA283408218	296	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1389011806 CA396508949	296	A>V		No	ClinGen TOPMed gnomAD
rs1324411732 CA396508958	297	Q>*		No	ClinGen gnomAD
rs747946536 CA396508959	297	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs747946536 CA8137197	297	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA8137198 rs771920744	298	A>G		No	ClinGen ExAC gnomAD
rs1309973526 CA396508972	298	A>T		No	ClinGen TOPMed
CA8137201 rs770374654	300	D>N		No	ClinGen ExAC TOPMed gnomAD
CA8137202 rs770374654	300	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs770269846 CA8137204	301	A>T		No	ClinGen ExAC gnomAD
rs1567408798 CA396509059	301	A>V		No	ClinGen Ensembl
CA283408246 rs113481675	302	L>P		No	ClinGen Ensembl
rs775898714 CA396509075	302	L>V		No	ClinGen ExAC gnomAD
rs920861841 CA283408255	304	A>P		No	ClinGen Ensembl
rs777668170 CA8137218	308	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA396511038 rs1206211338	309	R>*		No	ClinGen gnomAD
CA8137219 rs746677032	309	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8137222 rs141794731	313	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8137224 rs775990884	314	G>R		No	ClinGen ExAC gnomAD
CA8137225 rs377619443	315	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs769042617 CA8137226	315	R>H		No	ClinGen ExAC TOPMed gnomAD
CA8137227 rs774748100	317	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs774748100 CA396511255	317	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs761993448 CA8137228	322	N>D		No	ClinGen ExAC gnomAD
rs562325074 CA8137229	324	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396511488 rs1307796678	324	K>R		No	ClinGen TOPMed
CA396511506 rs1368724214	325	T>S		No	ClinGen TOPMed
rs1241086924 CA396511594	328	W>C		No	ClinGen gnomAD
rs1290872650 CA396511585	328	W>S		No	ClinGen gnomAD
rs766514705 CA8137233	330	R>L		No	ClinGen ExAC TOPMed gnomAD
rs766514705 COSM1232885 CA8137232	330	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA8137231 rs529312655	330	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs758377169 CA8137234	332	L>F		No	ClinGen ExAC gnomAD
CA396511693 rs1314915081	334	P>A		No	ClinGen gnomAD
rs1206637433 CA396513934 COSM972947	339	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
CA396513936 rs1231745895	339	R>H		No	ClinGen gnomAD
rs755734366 CA8137261	341	D>G		No	ClinGen ExAC gnomAD
CA396513982 rs983095247	343	R>*		No	ClinGen TOPMed gnomAD
rs983095247 CA283382877	343	R>G		No	ClinGen TOPMed gnomAD
rs367812535 CA8137262	343	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA396513991 rs1452919157	344	G>R		No	ClinGen gnomAD
CA396514013 rs1171368651	345	R>S		No	ClinGen TOPMed gnomAD
CA396514057 rs1330302815	348	Y>C		No	ClinGen TOPMed gnomAD
rs1330302815 CA396514056	348	Y>F		No	ClinGen TOPMed gnomAD
CA8137264 rs755506667	348	Y>H		No	ClinGen ExAC gnomAD
rs748549161 CA8137266	349	V>M		No	ClinGen ExAC
CA8137267 rs772514474	352	N>S		No	ClinGen ExAC gnomAD
rs1372947769 CA396514114	354	R>Q		No	ClinGen gnomAD
CA8137268 rs773413103	354	R>W		No	ClinGen ExAC TOPMed gnomAD
CA283382906 rs552329158	356	T>I		No	ClinGen Ensembl
CA8137270 rs371532664	360	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs371532664 CA8137269	360	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs776915745 CA8137271	360	R>H		No	ClinGen ExAC TOPMed gnomAD
rs374069767 CA8137272	361	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8137275 rs761615562	363	A>T		No	ClinGen ExAC gnomAD
rs1222991739 CA396514169	363	A>V		No	ClinGen gnomAD
rs767387248 CA8137276	364	E>D		No	ClinGen ExAC gnomAD
rs147694100 CA8137279	366	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8137280 rs766017753	367	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1416798576 CA396514196	368	N>D		No	ClinGen gnomAD
rs1408819627 CA396514199	368	N>S		No	ClinGen gnomAD
rs1165564009 CA396514204	369	Y>H		No	ClinGen gnomAD
rs1597157907 CA396514246	374	S>A		No	ClinGen Ensembl
rs753426948 CA8137281	374	S>L		No	ClinGen ExAC gnomAD
rs753283106 CA8137284	375	Q>R		No	ClinGen ExAC gnomAD
CA8137286 rs778337264	376	R>Q		No	ClinGen ExAC gnomAD
rs758807244 CA8137285	376	R>W		No	ClinGen ExAC gnomAD
CA8137287 rs372845231	378	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1338830426 CA396514278	379	L>P		No	ClinGen gnomAD
CA396514285 rs1597157960	380	Q>L		No	ClinGen Ensembl
rs771352727 CA8137289	381	G>R		No	ClinGen ExAC TOPMed gnomAD
rs771352727 CA8137288	381	G>W		No	ClinGen ExAC TOPMed gnomAD
CA283382962 rs867498351	382	A>V		No	ClinGen Ensembl
CA396514305 rs1157206656	383	M>I		No	ClinGen TOPMed
rs971014815 CA283382966	384	Q>H		No	ClinGen TOPMed
rs1386239465 CA396514336	387	S>R		No	ClinGen TOPMed
rs1163422954 CA396514343	388	Q>H		No	ClinGen TOPMed
rs746038424 CA8137290	390	F>C		No	ClinGen ExAC gnomAD
CA396514370 rs1213501184	392	Y>F		No	ClinGen gnomAD
CA8137292 rs200857360	393	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1187147018 CA396515126	394	S>F		No	ClinGen gnomAD
rs749326066 CA8137311	394	S>T		No	ClinGen ExAC TOPMed gnomAD
rs773149907 CA8137313	395	S>L		No	ClinGen ExAC TOPMed gnomAD
CA8137312 rs768658691	395	S>P		No	ClinGen ExAC gnomAD
CA283385940 rs891887656 COSM417299	398	S>L	urinary_tract [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1435545957 CA396515193	399	T>I		No	ClinGen gnomAD
CA8137316 rs776384837	400	D>G		No	ClinGen ExAC TOPMed gnomAD
CA8137317 rs143999663	401	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs764790347 CA8137318	403	P>A		No	ClinGen ExAC gnomAD
rs1424717017 CA396515253	403	P>L		No	ClinGen gnomAD
CA8137319 rs752326277	405	G>D		No	ClinGen ExAC gnomAD
CA396515286 rs1237418760	406	P>A		No	ClinGen gnomAD
rs1279302871 CA396515294 COSM1709334	406	P>L	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
rs201105755 CA283385954	407	L>F		No	ClinGen gnomAD
COSM3818382 CA283385957 rs751603209	409	P>A	breast [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1295794733 CA396516290	412	E>V		No	ClinGen gnomAD
rs1566452 CA396516299	413	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA396516300 rs1566452	413	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA396516303 rs1224537283	414	R>K		No	ClinGen gnomAD
CA396516312 rs1334090940	415	Q>R		No	ClinGen TOPMed
CA8137351 rs758404167	416	D>E		No	ClinGen ExAC TOPMed gnomAD
CA8137352 rs199513055	418	G>E		No	ClinGen 1000Genomes ExAC gnomAD
CA8137354 rs769507581	419	R>L		No	ClinGen ExAC gnomAD
CA8137355 rs769507581	419	R>Q		No	ClinGen ExAC gnomAD
rs745580617 CA8137353	419	R>W		No	ClinGen ExAC TOPMed gnomAD
rs768411191 CA8137357	420	V>L		No	ClinGen ExAC TOPMed gnomAD
rs768411191 CA396516338	420	V>M		No	ClinGen ExAC TOPMed gnomAD
rs761414227 CA8137359	422	Y>F		No	ClinGen ExAC gnomAD
CA396516358 rs773617409	423	V>L		No	ClinGen ExAC TOPMed gnomAD
CA8137361 rs773617409	423	V>M		No	ClinGen ExAC TOPMed gnomAD
CA283390575 rs527319187	426	N>S		No	ClinGen 1000Genomes
CA396516394 rs1163346636	428	R>C		No	ClinGen gnomAD
CA8137362 rs779707234	428	R>H		No	ClinGen ExAC TOPMed gnomAD
rs779707234 CA8137363	428	R>L		No	ClinGen ExAC TOPMed gnomAD
CA396516423 rs1289099681	432	W>C		No	ClinGen gnomAD
rs1039810522 CA283390579	433	E>G		No	ClinGen TOPMed
CA8137365 rs759817643	436	R>G		No	ClinGen ExAC TOPMed gnomAD
rs904083638 CA283390581	436	R>Q		No	ClinGen TOPMed gnomAD
rs759817643 CA396516446	436	R>W		No	ClinGen ExAC TOPMed gnomAD
CA396516450 rs1356061661	437	T>A		No	ClinGen gnomAD
CA396516499 rs1297452854	442	Q>*		No	ClinGen TOPMed
rs780046309 CA8137392	445	A>P		No	ClinGen ExAC gnomAD
CA283390811 rs1002396463	448	P>R		No	ClinGen Ensembl
CA8137394 rs754845564	448	P>T		No	ClinGen ExAC gnomAD
rs1215003538 CA396516544	449	G>A		No	ClinGen TOPMed
CA8137395 rs369279393	456	S>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA8137397 rs77786756	457	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8137398 rs777211564	459	V>M		No	ClinGen ExAC TOPMed gnomAD
rs746530540 COSM304460 CA8137399	460	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA8137400 rs770286512	466	N>S		No	ClinGen ExAC gnomAD
rs777143460 CA8137401	468	R>C		No	ClinGen ExAC TOPMed gnomAD
rs759088222 CA8137402	468	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1207279224 CA396516678	469	T>S		No	ClinGen gnomAD
rs1457646885 CA396516727	476	R>C		No	ClinGen gnomAD
rs1194651524 CA396516728	476	R>H		No	ClinGen gnomAD
COSM3795062 rs372517256 CA8137403	477	P>L	urinary_tract [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA8137405 rs762597985	479	F>C		No	ClinGen ExAC gnomAD
rs370457139 CA8137406	480	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA8137408 rs761794916	481	S>L		No	ClinGen ExAC TOPMed gnomAD
rs144932234 CA8137407	481	S>T		No	ClinGen ESP ExAC
rs138661773 CA8137426 COSM435640	483	T>M	breast [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs761550151 CA8137427	485	Q>R		No	ClinGen ExAC gnomAD
rs767519385 CA396516801	486	G>D		No	ClinGen ExAC gnomAD
CA8137428 rs767519385	486	G>V		No	ClinGen ExAC gnomAD
CA396516814 rs1337105711	488	P>R		No	ClinGen gnomAD
CA396516809 rs1333168819	488	P>T		No	ClinGen gnomAD
COSM3771996 rs759626310 CA8137430	490	A>S	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA283391208 rs1035707027	493	R>C		No	ClinGen TOPMed gnomAD
rs752781641 CA8137432	494	S>N		No	ClinGen ExAC gnomAD
CA396516858 rs1260439318	495	F>C		No	ClinGen gnomAD
rs1260439318 CA396516859	495	F>S		No	ClinGen gnomAD
rs758627189 CA8137433	496	R>Q		No	ClinGen ExAC gnomAD
COSM972950 rs1477186513 CA396516863	496	R>W	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1464979922 CA396516879	498	K>R		No	ClinGen TOPMed
rs751914087 CA8137435	501	Q>R		No	ClinGen ExAC gnomAD
CA396516909 rs1402684742	502	F>Y		No	ClinGen gnomAD
CA8137437 rs781621999	503	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1359990568 CA396516916	503	R>H		No	ClinGen gnomAD
CA396516941 rs1415417387	507	H>Y		No	ClinGen gnomAD
CA8137470 rs777692533	509	N>T		No	ClinGen ExAC gnomAD
CA396516978 rs1175703711	510	A>V		No	ClinGen gnomAD
CA283391406 rs985519428	512	P>L		No	ClinGen Ensembl
CA396517006 rs763033318	515	V>L		No	ClinGen ExAC TOPMed gnomAD
rs763033318 CA8137474	515	V>M		No	ClinGen ExAC TOPMed gnomAD
rs774557900 CA8137476	518	S>N		No	ClinGen ExAC TOPMed gnomAD
CA8137475 rs768622976	518	S>R		No	ClinGen ExAC gnomAD
CA8137479 rs750753479	519	V>A		No	ClinGen ExAC gnomAD
CA8137478 rs767774692	519	V>I		No	ClinGen ExAC TOPMed gnomAD
CA283391414 rs111926603 COSM1679231	520	S>F	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated Ensembl
rs761056397 CA8137480	523	T>A		No	ClinGen ExAC TOPMed gnomAD
CA8137481 rs766857670	523	T>M		No	ClinGen ExAC TOPMed gnomAD
rs761056397 CA396517056	523	T>S		No	ClinGen ExAC TOPMed gnomAD
CA8137483 rs754439907	524	L>P		No	ClinGen ExAC gnomAD
rs913146723 CA283391420	526	E>K		No	ClinGen gnomAD
rs945994238 CA283391423	529	F>V		No	ClinGen Ensembl
rs567331277 CA8137485	530	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1567441417 CA396517108	531	Q>*		No	ClinGen Ensembl
rs779996006 CA8137510	532	I>M		No	ClinGen ExAC TOPMed gnomAD
rs748174440 CA8137511	533	M>V		No	ClinGen ExAC TOPMed gnomAD
rs938389762 CA283391542	535	M>T		No	ClinGen TOPMed gnomAD
CA8137512 rs772150301	536	K>*		No	ClinGen ExAC gnomAD
CA396517162 rs1597180587	536	K>N		No	ClinGen Ensembl
CA396517171 rs1372022508	538	Y>H		No	ClinGen Ensembl
rs1487384539 CA396517178	539	D>N		No	ClinGen gnomAD
rs773352487 CA8137514	540	L>M		No	ClinGen ExAC TOPMed gnomAD
rs577656898 CA8137515	541	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs776834403 CA8137516	541	R>H		No	ClinGen ExAC gnomAD
CA396517196 rs1180568357	542	R>C		No	ClinGen TOPMed gnomAD
CA8137517 rs139105338	542	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs139105338 CA396517197	542	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs765616095 CA8137518	543	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1419974931 CA396517200	543	R>W		No	ClinGen gnomAD
CA396517203 rs1417398271	544	L>I		No	ClinGen gnomAD
CA283391566 rs372083781	545	Y>C		No	ClinGen Ensembl
CA396517220 rs1376045181	546	I>N		No	ClinGen gnomAD
rs1157494803 CA396517217	546	I>V		No	ClinGen gnomAD
CA283391567 rs945746204 COSM286553	549	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA8137520 rs762488499	549	R>H		No	ClinGen ExAC TOPMed gnomAD
rs763693568 CA8137521	551	E>K		No	ClinGen ExAC TOPMed gnomAD
CA396517267 rs1184705274	553	G>D		No	ClinGen TOPMed
rs1251666016 CA396517294	557	G>E		No	ClinGen TOPMed
CA8137523 rs756837378	559	I>V		No	ClinGen ExAC gnomAD
rs202095634 COSM1519751 CA8137525	560	A>S	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs202095634 CA8137526	560	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396517315 rs1208639902	561	R>K		No	ClinGen gnomAD
CA396517351 rs1597185119	564	F>V		No	ClinGen Ensembl
rs1018000193 CA283392418	565	F>L		No	ClinGen TOPMed gnomAD
rs2270841 CA396517387	569	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA396517383 rs1466567410	569	H>Y		No	ClinGen gnomAD
CA8137580 rs770525394	575	M>T		No	ClinGen ExAC gnomAD
rs371834471 CA283392421	577	C>S		No	ClinGen ESP gnomAD
rs866546819 CA283392425	582	A>V		No	ClinGen Ensembl
CA8137585 rs775208468	583	G>E		No	ClinGen ExAC gnomAD
CA8137584 rs190041711	583	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs762925299 CA8137586	584	K>R		No	ClinGen ExAC gnomAD
rs1324848295 CA396517502	586	N>D		No	ClinGen TOPMed
rs763978892 CA8137587	586	N>S		No	ClinGen ExAC gnomAD
rs78843422 CA283392432	587	Y>S		No	ClinGen Ensembl
CA396517518 rs1218033615	588	C>Y		No	ClinGen TOPMed
CA283392438 rs201620630	592	N>K		No	ClinGen 1000Genomes
rs1597185294 CA396517546	592	N>T		No	ClinGen Ensembl
rs1430848532 CA396517552	593	P>S		No	ClinGen Ensembl
rs1296550431 CA396517587	598	N>K		No	ClinGen gnomAD
CA8137592 rs755314912 COSM1679232	599	P>L	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA396517591 rs1433908388	599	P>S		No	ClinGen gnomAD
rs748506233 CA8137594	601	H>Q		No	ClinGen ExAC gnomAD
rs758903595 CA8137595	602	L>I		No	ClinGen ExAC gnomAD
CA8137596 rs778168809	604	Y>C		No	ClinGen ExAC gnomAD
rs565065326 CA8137597	606	R>C		No	ClinGen ExAC TOPMed gnomAD
rs565065326 CA396517635	606	R>G		No	ClinGen ExAC TOPMed gnomAD
CA8137599 rs776194189	606	R>H		No	ClinGen ExAC TOPMed gnomAD
rs565065326 CA8137598	606	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1360737507 CA396517672	611	F>L		No	ClinGen gnomAD
rs1324982324 CA396517676	612	I>V		No	ClinGen gnomAD
CA8137600 rs745507601	613	A>T		No	ClinGen ExAC TOPMed gnomAD
rs779594319 CA8137619	615	A>V		No	ClinGen ExAC gnomAD
rs200119284 CA8137623	620	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs776819186 CA8137625	623	D>N		No	ClinGen ExAC TOPMed gnomAD
CA8137627 rs765444857	624	T>M		No	ClinGen ExAC gnomAD
COSM233780 rs764431749 CA8137630	628	L>F	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs746439395 CA396517828	633	R>G		No	ClinGen ExAC gnomAD
rs757731089 CA8137632	633	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8137631 rs746439395	633	R>W		No	ClinGen ExAC gnomAD
rs1160174950 CA396517833	634	M>L		No	ClinGen TOPMed
CA8137634 rs749901201	636	N>S		No	ClinGen ExAC gnomAD
CA8137635 rs755590878	641	L>P		No	ClinGen ExAC gnomAD
rs1382282163 CA396517901	644	L>V		No	ClinGen gnomAD
rs1406329153 CA396517939	649	P>L		No	ClinGen TOPMed
CA8137641 rs747991829	652	Y>F		No	ClinGen ExAC gnomAD
rs1351517836 CA396517957	652	Y>H		No	ClinGen gnomAD
CA396517973 rs1257087320	654	S>P		No	ClinGen gnomAD
CA396518010 rs1484483718	659	K>R		No	ClinGen gnomAD
CA8137662 rs746911936	662	N>H		No	ClinGen ExAC gnomAD
rs1370625621 CA396518046	662	N>S		No	ClinGen TOPMed
rs770953604 CA8137663	663	L>P		No	ClinGen ExAC TOPMed gnomAD
CA8137664 rs775403071	665	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA8137665 rs749418137	665	E>V		No	ClinGen ExAC gnomAD
rs768819897 CA8137666	666	C>R		No	ClinGen ExAC gnomAD
rs774571665 CA8137667	666	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA8137668 rs551616659	667	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1246787362 CA396518077	667	G>V		No	ClinGen TOPMed gnomAD
rs767862694 CA396518113	673	I>F		No	ClinGen ExAC gnomAD
rs767862694 CA396518112	673	I>L		No	ClinGen ExAC gnomAD
rs767862694 CA8137669	673	I>V		No	ClinGen ExAC gnomAD
CA8137671 rs761063633	676	M>I		No	ClinGen ExAC TOPMed gnomAD
CA396518137 rs1478046533	676	M>T		No	ClinGen gnomAD
CA8137670 rs773683409	676	M>V		No	ClinGen ExAC TOPMed gnomAD
CA8137672 rs766945833	677	E>A		No	ClinGen ExAC gnomAD
rs1409644973 CA396518146	677	E>D		No	ClinGen gnomAD
CA8137673 rs753243617	678	I>T		No	ClinGen ExAC gnomAD
CA8137674 rs371214769	683	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs117637107 CA8137678	686	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs117637107 COSM249421 CA8137677	686	E>Q	kidney [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1195214760 CA396518209	688	K>Q		No	ClinGen TOPMed
rs1290128886 CA396518231 COSM1232888	691	G>S	large_intestine breast [Cosmic]	No	ClinGen cosmic curated gnomAD
CA8137683 rs182111599	692	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8137685 rs748356463	693	S>C		No	ClinGen ExAC gnomAD
rs891536959 CA283393912	694	I>M		No	ClinGen Ensembl
CA396518259 rs374450870	695	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA8137686 rs374450870	695	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA396518258 rs1394965484	695	R>W		No	ClinGen gnomAD
rs773414786 CA8137687	697	T>I		No	ClinGen ExAC TOPMed gnomAD
rs771291958 CA8137689	699	E>D		No	ClinGen ExAC TOPMed gnomAD
CA396518291 rs1314202819	700	N>S		No	ClinGen TOPMed
CA283393944 rs1045505545	705	I>V		No	ClinGen Ensembl
CA396518337 rs1422063592	706	M>T		No	ClinGen TOPMed gnomAD
rs936714284 CA283394566	711	W>G		No	ClinGen TOPMed
CA396518390 rs1400536782	712	R>H		No	ClinGen TOPMed gnomAD
CA396518403 rs760810777	714	T>N		No	ClinGen gnomAD
CA283394571 rs760810777	714	T>S		No	ClinGen gnomAD
CA8137720 rs758516062	715	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1567447241 CA396518417	717	V>E		No	ClinGen Ensembl
CA8137722 COSM23456 rs747244483	717	V>M	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA396518428 rs140980306	719	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA8137723 rs140980306	719	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1222637654 CA396518450	722	K>E		No	ClinGen gnomAD
rs746270452 CA8137725	722	K>R		No	ClinGen ExAC gnomAD
CA396518457 rs770375571	723	A>S		No	ClinGen ExAC TOPMed gnomAD
CA8137726 rs770375571	723	A>T		No	ClinGen ExAC TOPMed gnomAD
CA8137727 rs776155666	724	F>L		No	ClinGen ExAC gnomAD
CA283394626 rs918825576	725	L>P		No	ClinGen TOPMed gnomAD
CA283394627 rs930208605	726	D>G		No	ClinGen TOPMed gnomAD
CA283394648 rs573540603	730	E>D		No	ClinGen 1000Genomes gnomAD
CA8137729 rs768209450	732	A>V		No	ClinGen ExAC gnomAD
rs761502608 CA8137731	733	P>L		No	ClinGen ExAC TOPMed gnomAD
rs761502608 CA8137732	733	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs773789065 CA8137730	733	P>S		No	ClinGen ExAC gnomAD
rs766242992 CA8137735	734	L>M		No	ClinGen ExAC gnomAD
CA396518536 rs1597191427	736	W>G		No	ClinGen Ensembl
CA396518544 rs942902245	737	L>V		No	ClinGen Ensembl
rs753776280 CA8137737	738	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8137736 rs753776280	738	R>G		No	ClinGen ExAC TOPMed gnomAD
rs897039134 CA283394679	738	R>H		No	ClinGen TOPMed gnomAD
CA8137739 rs751634416	739	Y>*		No	ClinGen ExAC
CA283394688 rs1039747502	739	Y>C		No	ClinGen gnomAD
rs1567447415 CA396518561	740	F>S		No	ClinGen Ensembl
rs1011526276 CA283394706 COSM248364	742	E>K	prostate [Cosmic]	No	ClinGen cosmic curated Ensembl
rs771571733 CA8137767	748	M>V		No	ClinGen ExAC gnomAD
CA396518646 rs1288097279	751	G>S		No	ClinGen gnomAD
CA8137769 rs571751303	753	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396518668 rs1334898662	754	E>K		No	ClinGen gnomAD
rs1314714691 CA396518682	755	I>M		No	ClinGen Ensembl
CA396518686 rs1382210674	756	D>A		No	ClinGen gnomAD
rs770613073 CA283395049	757	M>L		No	ClinGen ExAC TOPMed gnomAD
CA8137771 rs776450176	757	M>T		No	ClinGen ExAC gnomAD
CA8137770 rs770613073	757	M>V		No	ClinGen ExAC TOPMed gnomAD
CA283395061 rs201469783	758	S>N		No	ClinGen TOPMed gnomAD
rs144843054 CA8137773 COSM1232886	759	D>N	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA8137774 rs775294892	763	S>N		No	ClinGen ExAC gnomAD
rs760947004 CA8137778	767	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8137777 rs370632943	767	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA8137779 rs766540283	768	H>D		No	ClinGen ExAC gnomAD
rs1378003553 CA396518773	768	H>Q		No	ClinGen gnomAD
rs1335017877 CA396518786	770	T>S		No	ClinGen gnomAD
rs1447729912 CA396518799	772	N>S		No	ClinGen gnomAD
CA8137782 rs35059847	777	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1475609729 CA396518898	783	V>A		No	ClinGen gnomAD
CA283396108 rs1047298531	784	K>E		No	ClinGen TOPMed
rs1417602300 CA396518903	784	K>R		No	ClinGen gnomAD
COSM4129250 rs756764558 CA8137805	786	M>I	thyroid [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs751012894 CA8137804	786	M>V		No	ClinGen ExAC gnomAD
CA396518938 rs1303014286	789	E>K		No	ClinGen gnomAD
CA8137807 rs745497802	790	K>R		No	ClinGen ExAC gnomAD
rs1433321532 CA396518955	791	R>K		No	ClinGen gnomAD
rs1271618789 CA396518959	791	R>S		No	ClinGen gnomAD
CA396518962 rs1359454696	792	I>F		No	ClinGen gnomAD
CA8137808 rs562949092	792	I>S		No	ClinGen 1000Genomes ExAC gnomAD
rs138762665 CA8137809	793	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA396518982 rs1360898968	796	Q>*		No	ClinGen gnomAD
CA396518989 rs1597194987	797	F>V		No	ClinGen Ensembl
CA396519002 rs1339911152	799	T>S		No	ClinGen TOPMed gnomAD
rs867930821 CA283396127	800	G>S		No	ClinGen Ensembl
CA396519024 rs1447407789	802	C>Y		No	ClinGen gnomAD
CA8137813 rs747018644	803	R>C		No	ClinGen ExAC gnomAD
rs770910169 CA8137814	803	R>H		No	ClinGen ExAC gnomAD
rs1475229008 CA396519038	805	P>S		No	ClinGen TOPMed gnomAD
CA8137816 rs759653665	806	V>F		No	ClinGen ExAC gnomAD
CA8137817 COSM1270550 rs759653665	806	V>I	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA283396181 rs779760708	807	G>E		No	ClinGen gnomAD
CA8137819 rs763322178	807	G>R		No	ClinGen ExAC TOPMed gnomAD
rs763322178 CA396519047	807	G>W		No	ClinGen ExAC TOPMed gnomAD
rs764519328 CA8137820	808	G>E		No	ClinGen ExAC gnomAD
CA8137821 rs764519328	808	G>V		No	ClinGen ExAC gnomAD
rs1344906971 CA396519065	810	A>D		No	ClinGen TOPMed gnomAD
CA396519064 rs1316720678	810	A>S		No	ClinGen TOPMed gnomAD
CA8137824 rs749992969	811	E>D		No	ClinGen ExAC
COSM972953 CA8137823 rs766917559	811	E>K	endometrium breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1013406445 CA283396194	812	L>I		No	ClinGen TOPMed gnomAD
CA396519082 rs1351344340	813	I>T		No	ClinGen gnomAD
CA8137825 rs150082808	813	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396519085 rs1281894801	814	G>S		No	ClinGen gnomAD
CA283396385 rs376710523	819	Q>H		No	ClinGen ESP TOPMed
CA396519151 rs1396438876	821	F>Y		No	ClinGen TOPMed
CA8137853 rs749493460	824	D>E		No	ClinGen ExAC gnomAD
CA8137852 rs780169440	824	D>N		No	ClinGen ExAC gnomAD
rs1343347600 CA396519179	825	K>R		No	ClinGen gnomAD
rs1597195842 CA396519185	826	V>F		No	ClinGen Ensembl
rs148043506 CA8137854	828	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA396519210 rs1597195867	830	T>P		No	ClinGen Ensembl
rs774661579 CA8137855	831	W>S		No	ClinGen ExAC gnomAD
rs773770913 CA8137858	834	R>K		No	ClinGen ExAC gnomAD
CA8137884 rs763930833	840	N>S		No	ClinGen ExAC gnomAD
rs751355850 CA8137885	841	R>C		No	ClinGen ExAC gnomAD
CA396519300 rs1380761859	841	R>H		No	ClinGen TOPMed gnomAD
CA396519310 rs1403287375	843	D>Y		No	ClinGen TOPMed
CA396519329 rs1445954315	846	P>A		No	ClinGen gnomAD
CA396519343 rs1383706620	848	K>E		No	ClinGen gnomAD
CA8137887 rs574704181	849	S>N		No	ClinGen 1000Genomes ExAC gnomAD
rs1313618431 CA396519356	849	S>R		No	ClinGen gnomAD
rs755052182 CA8137889	851	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1262877955 CA396519374	852	Q>*		No	ClinGen gnomAD
rs1473692136 CA396519394	855	E>K		No	ClinGen TOPMed
rs542326585 CA8137894	861	I>T		No	ClinGen 1000Genomes ExAC gnomAD
CA396519433 rs1253409685	861	I>V		No	ClinGen gnomAD
rs1451359639 CA396519446	863	E>K		No	ClinGen gnomAD
rs769333666 CA396519461	865	E>*		No	ClinGen ExAC TOPMed gnomAD
rs769333666 CA8137898	865	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1392536891 CA396519486	868	G>E		No	ClinGen gnomAD
CA8137900 rs762638597	869	Q>R		No	ClinGen ExAC gnomAD

No associated diseases with O00308

5 regional properties for O00308

Type	Name	Position	InterPro Accession
domain	C2 domain	1 - 117	IPR000008
domain	HECT domain	516 - 870	IPR000569
domain	WW domain	300 - 363	IPR001202-1
domain	WW domain	405 - 437	IPR001202-2
domain	WW domain	444 - 477	IPR001202-3

Functions

		Description
EC Number	2.3.2.26	Aminoacyltransferases
Subcellular Localization	Nucleus
PANTHER Family	PTHR11254	HECT DOMAIN UBIQUITIN-PROTEIN LIGASE
PANTHER Subfamily	PTHR11254:SF396	NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP2
PANTHER Protein Class	ubiquitin-protein ligase
PANTHER Pathway Category	Ubiquitin proteasome pathway E3

6 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ubiquitin ligase complex	A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.

4 GO annotations of molecular function

Name	Definition
RNA polymerase II-specific DNA-binding transcription factor binding	Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.
transcription factor binding	Binding to a transcription factor, a protein required to initiate or regulate transcription.
ubiquitin protein ligase activity	Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
ubiquitin-protein transferase activity	Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

19 GO annotations of biological process

Name	Definition
extracellular transport	The transport of substances that occurs outside cells.
negative regulation of DNA-binding transcription factor activity	Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
negative regulation of gene expression	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of Notch signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
negative regulation of protein transport	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
negative regulation of transcription, DNA-templated	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of transporter activity	Any process that stops or reduces the activity of a transporter.
positive regulation of protein catabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
protein autoubiquitination	The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
protein K63-linked ubiquitination	A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.
protein polyubiquitination	Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
protein ubiquitination	The process in which one or more ubiquitin groups are added to a protein.
regulation of ion transmembrane transport	Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
regulation of membrane potential	Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
regulation of potassium ion transmembrane transporter activity	Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity.
viral entry into host cell	The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.

23 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P39940	RSP5	E3 ubiquitin-protein ligase RSP5	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q9V853	Smurf	E3 ubiquitin-protein ligase Smurf1	Drosophila melanogaster (Fruit fly)	SS
Q9Y0H4	Su(dx)	E3 ubiquitin-protein ligase Su	Drosophila melanogaster (Fruit fly)	SS
O95817	BAG3	BAG family molecular chaperone regulator 3	Homo sapiens (Human)	PR
O60861	GAS7	Growth arrest-specific protein 7	Homo sapiens (Human)	PR
Q9HCE7	SMURF1	E3 ubiquitin-protein ligase SMURF1	Homo sapiens (Human)	PR
Q9HAU4	SMURF2	E3 ubiquitin-protein ligase SMURF2	Homo sapiens (Human)	EV
Q9H0M0	WWP1	NEDD4-like E3 ubiquitin-protein ligase WWP1	Homo sapiens (Human)	EV
Q96J02	ITCH	E3 ubiquitin-protein ligase Itchy homolog	Homo sapiens (Human)	EV
Q96PU5	NEDD4L	E3 ubiquitin-protein ligase NEDD4-like	Homo sapiens (Human)	PR
P46934	NEDD4	E3 ubiquitin-protein ligase NEDD4	Homo sapiens (Human)	EV
Q8IYU2	HACE1	E3 ubiquitin-protein ligase HACE1	Homo sapiens (Human)	EV
P46935	Nedd4	E3 ubiquitin-protein ligase NEDD4	Mus musculus (Mouse)	PR
Q9CUN6	Smurf1	E3 ubiquitin-protein ligase SMURF1	Mus musculus (Mouse)	PR
A2A5Z6	Smurf2	E3 ubiquitin-protein ligase SMURF2	Mus musculus (Mouse)	SS
Q8BZZ3	Wwp1	NEDD4-like E3 ubiquitin-protein ligase WWP1	Mus musculus (Mouse)	SS
Q60780	Gas7	Growth arrest-specific protein 7	Mus musculus (Mouse)	PR
Q8C863	Itch	E3 ubiquitin-protein ligase Itchy	Mus musculus (Mouse)	EV
Q8CFI0	Nedd4l	E3 ubiquitin-protein ligase NEDD4-like	Mus musculus (Mouse)	PR
Q9DBH0	Wwp2	NEDD4-like E3 ubiquitin-protein ligase WWP2	Mus musculus (Mouse)	SS
Q62940	Nedd4	E3 ubiquitin-protein ligase NEDD4	Rattus norvegicus (Rat)	PR
Q9N2Z7	wwp-1	E3 ubiquitin-protein ligase wwp-1	Caenorhabditis elegans	SS
A9JRZ0	smurf2	E3 ubiquitin-protein ligase SMURF2	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MASASSSRAG	VALPFEKSQL	TLKVVSAKPK	VHNRQPRINS	YVEVAVDGLP	SETKKTGKRI
70	80	90	100	110	120
GSSELLWNEI	IILNVTAQSH	LDLKVWSCHT	LRNELLGTAS	VNLSNVLKNN	GGKMENMQLT
130	140	150	160	170	180
LNLQTENKGS	VVSGGELTIF	LDGPTVDLGN	VPNGSALTDG	SQLPSRDSSG	TAVAPENRHQ
190	200	210	220	230	240
PPSTNCFGGR	SRTHRHSGAS	ARTTPATGEQ	SPGARSRHRQ	PVKNSGHSGL	ANGTVNDEPT
250	260	270	280	290	300
TATDPEEPSV	VGVTSPPAAP	LSVTPNPNTT	SLPAPATPAE	GEEPSTSGTQ	QLPAAAQAPD
310	320	330	340	350	360
ALPAGWEQRE	LPNGRVYYVD	HNTKTTTWER	PLPPGWEKRT	DPRGRFYYVD	HNTRTTTWQR
370	380	390	400	410	420
PTAEYVRNYE	QWQSQRNQLQ	GAMQHFSQRF	LYQSSSASTD	HDPLGPLPPG	WEKRQDNGRV
430	440	450	460	470	480
YYVNHNTRTT	QWEDPRTQGM	IQEPALPPGW	EMKYTSEGVR	YFVDHNTRTT	TFKDPRPGFE
490	500	510	520	530	540
SGTKQGSPGA	YDRSFRWKYH	QFRFLCHSNA	LPSHVKISVS	RQTLFEDSFQ	QIMNMKPYDL
550	560	570	580	590	600
RRRLYIIMRG	EEGLDYGGIA	REWFFLLSHE	VLNPMYCLFE	YAGKNNYCLQ	INPASSINPD
610	620	630	640	650	660
HLTYFRFIGR	FIAMALYHGK	FIDTGFTLPF	YKRMLNKRPT	LKDLESIDPE	FYNSIVWIKE
670	680	690	700	710	720
NNLEECGLEL	YFIQDMEILG	KVTTHELKEG	GESIRVTEEN	KEEYIMLLTD	WRFTRGVEEQ
730	740	750	760	770	780
TKAFLDGFNE	VAPLEWLRYF	DEKELELMLC	GMQEIDMSDW	QKSTIYRHYT	KNSKQIQWFW
790	800	810	820	830	840
QVVKEMDNEK	RIRLLQFVTG	TCRLPVGGFA	ELIGSNGPQK	FCIDKVGKET	WLPRSHTCFN
850	860
RLDLPPYKSY	EQLREKLLYA	IEETEGFGQE