O00194
PR
Gene name |
RAB27B |
Protein name |
Ras-related protein Rab-27B |
Names |
C25KG |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:5874 |
EC number |
3.6.5.2: Acting on GTP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for O00194
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2F7S | X-ray | 270 A | A/B | 4-201 | PDB |
| AF-O00194-F1 | Predicted | AlphaFoldDB |
187 variants for O00194
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1246926975 CA402520864 |
2 | T>A | No |
ClinGen gnomAD |
|
|
rs562881530 CA8969490 |
2 | T>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs183204493 CA8969493 |
3 | D>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1472917397 CA402520896 |
4 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
rs750641827 CA8969495 |
5 | D>H | No |
ClinGen ExAC gnomAD |
|
|
CA8969498 rs749423666 |
11 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA8969499 rs768892870 |
14 | A>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 15 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1333058724 CA402521105 |
16 | G>E | No |
ClinGen gnomAD |
|
|
rs772473656 CA8969502 |
16 | G>R | Variant assessed as Somatic; 9.422e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1333058724 CA402521103 |
16 | G>V | No |
ClinGen gnomAD |
|
|
rs772473656 CA402521101 |
16 | G>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1290124969 CA402521126 |
20 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
rs1356060051 CA402521133 |
21 | G>R | No |
ClinGen TOPMed |
|
| TCGA novel | 22 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs187131898 CA402521186 |
27 | Y>C | No |
ClinGen 1000Genomes gnomAD |
|
|
rs187131898 CA300744253 |
27 | Y>F | No |
ClinGen 1000Genomes gnomAD |
|
|
rs764729616 CA8969508 |
28 | R>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA8969509 rs752620773 |
29 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs1163674381 CA402521301 |
35 | N>H | No |
ClinGen gnomAD |
|
| TCGA novel | 38 | F>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA300744258 rs867368280 |
40 | T>I | No |
ClinGen gnomAD |
|
|
CA402521394 rs1430487758 |
41 | T>I | No |
ClinGen gnomAD |
|
|
rs986190030 CA300744260 |
42 | V>I | No |
ClinGen Ensembl |
|
| TCGA novel | 43 | G>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1445586376 CA402521442 |
45 | D>N | No |
ClinGen TOPMed |
|
|
CA8969515 rs766672373 |
47 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8969514 rs766672373 |
47 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs751512741 CA300744265 COSM1711382 |
47 | R>W | skin [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
rs989535601 CA300744271 |
48 | E>G | No |
ClinGen TOPMed gnomAD |
|
|
rs755053322 CA8969516 |
49 | K>I | No |
ClinGen ExAC gnomAD |
|
|
CA8969517 rs778920751 |
50 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs377291150 CA300744275 |
50 | R>H | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA8969518 rs538294426 |
51 | V>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs757557745 CA8969540 |
52 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM709345 rs757557745 CA402521935 |
52 | V>I | lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs1038468355 CA300744572 |
53 | Y>C | No |
ClinGen TOPMed |
|
|
rs781592469 CA8969541 |
53 | Y>D | No |
ClinGen ExAC gnomAD |
|
|
CA402521965 rs1320351664 |
54 | N>S | No |
ClinGen gnomAD |
|
|
rs779474355 CA8969542 |
55 | A>S | No |
ClinGen ExAC gnomAD |
|
|
rs1323494794 CA402521986 |
56 | Q>* | No |
ClinGen gnomAD |
|
|
rs865964184 CA300744574 |
57 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
COSM563720 CA8969544 rs775038590 |
57 | G>R | lung [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs529722142 CA8969545 |
58 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs529722142 CA300744576 |
58 | P>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1346540708 CA402522037 |
60 | G>E | No |
ClinGen TOPMed |
|
|
CA8969549 rs767419104 |
64 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA300744585 rs1025566149 |
65 | A>E | No |
ClinGen Ensembl |
|
|
CA8969551 rs200080884 |
66 | F>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs200080884 CA8969550 |
66 | F>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA402522149 rs1598989345 |
68 | V>G | No |
ClinGen Ensembl |
|
|
CA8969552 rs765328507 |
69 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA300744590 rs746934226 |
70 | L>F | No |
ClinGen TOPMed gnomAD |
|
|
CA402522194 rs1199734462 |
72 | L>F | No |
ClinGen gnomAD |
|
|
CA402522193 rs1199734462 |
72 | L>V | No |
ClinGen gnomAD |
|
|
rs752994920 CA8969553 |
76 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA300744593 rs752994920 |
76 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402522276 rs1413085158 |
78 | Q>* | No |
ClinGen gnomAD |
|
|
CA8969556 rs370613157 |
80 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs376553954 CA8969555 |
80 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA402523050 rs1340082952 |
82 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs367644272 CA8969576 COSM1287503 |
82 | R>W | autonomic_ganglia [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA8969577 rs767959071 |
83 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs750955967 CA8969578 |
85 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402523097 rs1340086222 |
86 | T>I | No |
ClinGen gnomAD |
|
|
CA8969580 rs780529654 |
88 | F>V | No |
ClinGen ExAC |
|
|
CA8969582 rs754703077 |
89 | F>S | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 91 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA8969586 rs9966265 |
92 | A>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA8969585 VAR_051714 rs9966265 |
92 | A>T | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs867951640 CA300745536 |
93 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA402523185 rs1305888809 |
93 | M>T | No |
ClinGen TOPMed |
|
|
rs770617882 CA8969588 |
93 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA300745538 rs868101938 |
94 | G>S | No |
ClinGen Ensembl |
|
|
CA402523221 rs1464532457 |
96 | L>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1464532457 CA402523223 |
96 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1433553560 CA402523255 |
98 | M>T | No |
ClinGen TOPMed |
|
|
CA402523277 rs1397596051 |
99 | F>L | No |
ClinGen gnomAD |
|
|
CA402523274 rs1402563085 |
99 | F>S | No |
ClinGen gnomAD |
|
|
CA402523306 rs1346285878 |
102 | T>A | No |
ClinGen TOPMed |
|
|
CA8969593 rs761837069 |
105 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA8969592 rs774575893 |
105 | Q>L | No |
ClinGen ExAC gnomAD |
|
|
CA402523359 rs1298340426 |
106 | S>N | No |
ClinGen TOPMed |
|
|
rs767584601 CA8969595 |
106 | S>R | No |
ClinGen ExAC gnomAD |
|
|
CA300745546 rs201355784 |
107 | F>L | No |
ClinGen Ensembl |
|
|
CA402523387 rs1369753377 |
108 | L>F | No |
ClinGen TOPMed gnomAD |
|
|
CA8969596 rs761314668 |
110 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA402523406 rs761314668 |
110 | V>L | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 116 | Q>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA8969616 rs777037766 |
116 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402524473 rs1487335776 |
118 | Q>K | No |
ClinGen TOPMed gnomAD |
|
|
rs1249539796 CA402524526 |
121 | A>G | No |
ClinGen TOPMed gnomAD |
|
|
CA402524533 rs1253089421 |
122 | Y>F | No |
ClinGen TOPMed gnomAD |
|
|
rs1253089421 CA402524532 |
122 | Y>S | No |
ClinGen TOPMed gnomAD |
|
|
rs759912904 CA8969617 |
127 | D>H | No |
ClinGen ExAC gnomAD |
|
|
rs1267929626 CA402524608 |
127 | D>V | No |
ClinGen gnomAD |
|
|
CA402524628 rs1457602591 |
128 | I>M | No |
ClinGen TOPMed gnomAD |
|
|
CA8969618 rs765711010 |
128 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1156664609 CA402524619 |
128 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA8969619 rs372053847 |
129 | V>I | No |
ClinGen ESP ExAC gnomAD |
|
|
CA8969621 rs763664942 |
131 | I>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402524662 rs1368902719 |
131 | I>T | No |
ClinGen gnomAD |
|
|
rs1287005983 CA402524738 |
137 | L>V | No |
ClinGen gnomAD |
|
|
rs77350395 CA8969623 |
138 | P>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs77350395 CA402524753 |
138 | P>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA8969624 rs781142576 |
139 | D>A | No |
ClinGen ExAC gnomAD |
|
|
rs1482845008 CA402524757 |
139 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs150505850 CA8969625 |
140 | Q>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA8969626 rs755843368 |
141 | R>K | No |
ClinGen ExAC gnomAD |
|
|
rs755843368 CA402524787 |
141 | R>T | No |
ClinGen ExAC gnomAD |
|
|
CA402524824 rs1225110886 |
143 | V>I | No |
ClinGen TOPMed |
|
|
rs1265574999 CA402524844 |
144 | N>S | No |
ClinGen gnomAD |
|
|
rs184898936 CA300746243 |
146 | R>P | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA8969628 rs184898936 |
146 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs749772540 CA8969627 |
146 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8969629 rs772332104 |
147 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA402524895 rs1184128382 |
148 | A>D | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs773331315 CA8969630 |
148 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402524897 rs1184128382 |
148 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs148221800 CA8969633 |
149 | R>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA8969634 rs148221800 |
149 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA8969631 rs1410433534 |
149 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
CA8969637 rs770277500 |
151 | L>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760180262 CA402524923 |
151 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA300746254 rs776035357 |
152 | A>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8969638 rs776035357 |
152 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402524933 rs1306664518 |
152 | A>S | No |
ClinGen gnomAD |
|
|
rs1306664518 CA402524930 |
152 | A>T | No |
ClinGen gnomAD |
|
|
CA8969639 rs190794224 |
153 | D>E | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA8969640 rs763749981 |
154 | K>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
| TCGA novel | 154 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs751198891 CA8969641 |
155 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA8969642 rs761316323 |
156 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402525069 rs1276454890 |
157 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA402525083 rs1210615856 |
158 | P>A | No |
ClinGen gnomAD |
|
|
rs1243942301 CA402525112 |
160 | F>S | No |
ClinGen gnomAD |
|
|
rs1277569049 CA402525121 |
161 | E>* | No |
ClinGen TOPMed |
|
|
CA402525147 rs768902755 |
163 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8969658 rs768902755 |
163 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs773994833 CA8969659 |
164 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs767025431 CA8969661 |
166 | T>A | No |
ClinGen ExAC gnomAD |
|
|
rs1331645296 CA402525200 |
168 | Q>R | No |
ClinGen TOPMed |
|
|
rs1414235076 CA402525222 |
170 | V>M | No |
ClinGen gnomAD |
|
|
CA402525263 rs1322861195 |
173 | A>P | No |
ClinGen TOPMed |
|
|
rs1335359282 CA402525275 |
174 | V>I | No |
ClinGen gnomAD |
|
|
CA402525305 rs1321222457 |
176 | T>A | No |
ClinGen TOPMed |
|
|
CA402525313 rs1475732197 |
176 | T>I | No |
ClinGen gnomAD |
|
|
rs1187982493 CA402525380 |
182 | M>V | No |
ClinGen gnomAD |
|
|
CA8969664 rs760204134 |
183 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs766267582 CA8969665 |
184 | R>* | No |
ClinGen ExAC gnomAD |
|
|
CA402525767 rs753780291 |
184 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM225061 rs753780291 CA8969666 |
184 | R>Q | Variant assessed as Somatic; 0.0 impact. large_intestine skin [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 185 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA402525792 rs1411357783 |
186 | E>G | No |
ClinGen gnomAD |
|
|
rs73956736 CA300746490 |
187 | Q>E | No |
ClinGen 1000Genomes TOPMed |
|
|
CA8969668 rs778632811 |
187 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
rs754744114 CA8969667 |
187 | Q>R | No |
ClinGen ExAC |
|
|
CA300746493 rs1004828409 |
188 | C>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1004828409 CA402525809 |
188 | C>S | No |
ClinGen TOPMed gnomAD |
|
|
CA300746494 rs753930771 |
188 | C>Y | No |
ClinGen Ensembl |
|
|
rs751803591 CA8969669 |
190 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs757459786 CA8969670 |
191 | K>N | No |
ClinGen ExAC gnomAD |
|
|
rs745893504 CA8969672 |
192 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs553510372 CA300746500 |
193 | Q>E | No |
ClinGen Ensembl |
|
|
CA8969673 rs201695355 |
193 | Q>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA402525918 rs1165901346 |
195 | P>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1165901346 CA402525924 |
195 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
rs749824892 CA8969675 |
195 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA8969676 rs769049294 |
196 | D>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1177806440 CA402525975 |
198 | V>A | No |
ClinGen gnomAD |
|
|
CA402525988 rs1599000348 |
199 | N>S | No |
ClinGen Ensembl |
|
|
rs867508011 CA300746506 |
201 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA8969677 rs774621967 |
201 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8969678 rs747817691 |
203 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs1157892324 CA402526087 |
206 | L>S | No |
ClinGen gnomAD |
|
|
rs771580227 CA8969679 |
207 | D>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 209 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1437030743 CA402526164 |
211 | P>L | No |
ClinGen gnomAD |
|
|
rs765888700 CA8969682 |
212 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8969684 rs759459653 |
213 | E>V | No |
ClinGen ExAC gnomAD |
|
|
CA8969686 CA300746518 rs374063750 |
215 | K>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA300746515 rs994620598 |
215 | K>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA402526229 rs1351760927 |
216 | C>Y | No |
ClinGen gnomAD |
|
|
CA402526237 rs1206966109 |
217 | I>F | No |
ClinGen TOPMed gnomAD |
|
|
rs1599000450 CA402526247 |
217 | I>M | No |
ClinGen Ensembl |
|
|
rs1206966109 CA402526238 |
217 | I>V | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 218 | C>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
No associated diseases with O00194
1 regional properties for O00194
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 8 - 177 | IPR005225 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.5.2 | Acting on GTP; involved in cellular and subcellular movement |
| Subcellular Localization |
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| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
15 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchored component of synaptic vesicle membrane | The component of the synaptic vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. |
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| axon cytoplasm | Any cytoplasm that is part of a axon. |
| exocytic vesicle | A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. |
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi stack | The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. |
| late endosome | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
| melanosome | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. |
| multivesicular body membrane | The lipid bilayer surrounding a multivesicular body. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| platelet dense granule membrane | The lipid bilayer surrounding the platelet dense granule. |
| secretory granule | A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. |
| trans-Golgi network transport vesicle | A vesicle that mediates transport between the trans-Golgi network and other parts of the cell. |
| zymogen granule membrane | The lipid bilayer surrounding a zymogen granule. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein activity | A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP). |
| GDP binding | Binding to GDP, guanosine 5'-diphosphate. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| myosin V binding | Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. |
| protein domain specific binding | Binding to a specific domain of a protein. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| anterograde axonal protein transport | The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons. |
| exocytosis | A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. |
| multivesicular body sorting pathway | A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded. |
| positive regulation of exocytosis | Any process that activates or increases the frequency, rate or extent of exocytosis. |
| synaptic vesicle endocytosis | A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8HZJ5 | RAB27B | Ras-related protein Rab-27B | Bos taurus (Bovine) | PR |
| Q1HE58 | RAB27A | Ras-related protein Rab-27A | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| Q15771 | RAB30 | Ras-related protein Rab-30 | Homo sapiens (Human) | PR |
| P51159 | RAB27A | Ras-related protein Rab-27A | Homo sapiens (Human) | PR |
| Q9BZG1 | RAB34 | Ras-related protein Rab-34 | Homo sapiens (Human) | PR |
| O95755 | RAB36 | Ras-related protein Rab-36 | Homo sapiens (Human) | PR |
| Q9ERI2 | Rab27a | Ras-related protein Rab-27A | Mus musculus (Mouse) | PR |
| Q99P58 | Rab27b | Ras-related protein Rab-27B | Mus musculus (Mouse) | PR |
| Q4LE85 | RAB27A | Ras-related protein Rab-27A | Sus scrofa (Pig) | PR |
| P23640 | Rab27a | Ras-related protein Rab-27A | Rattus norvegicus (Rat) | PR |
| Q99P74 | Rab27b | Ras-related protein Rab-27B | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTDGDYDYLI | KLLALGDSGV | GKTTFLYRYT | DNKFNPKFIT | TVGIDFREKR | VVYNAQGPNG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SSGKAFKVHL | QLWDTAGQER | FRSLTTAFFR | DAMGFLLMFD | LTSQQSFLNV | RNWMSQLQAN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AYCENPDIVL | IGNKADLPDQ | REVNERQARE | LADKYGIPYF | ETSAATGQNV | EKAVETLLDL |
| 190 | 200 | 210 | |||
| IMKRMEQCVE | KTQIPDTVNG | GNSGNLDGEK | PPEKKCIC |