O00141
PR
Gene name |
SGK1 (SGK) |
Protein name |
Serine/threonine-protein kinase Sgk1 |
Names |
Serum/glucocorticoid-regulated kinase 1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:6446 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
(Annotation based on sequence homology with P31751)
Akt is a serine/threonine kinase that belongs to a group of proteins called the AGC superfamily. It is involved in various biological responses through the phosphatidylinositol 3-kinase (PI3K) signal transduction pathway. Akt2, in particular, is regulated by different regions of the protein.
The N-terminal PH domain of Akt2 plays a regulatory role in its activation. Phosphorylation of Ser474 in the C-terminal regulatory domain is also necessary for full activation of Akt2. These modifications help activate the kinase and enable it to carry out its functions.
The linker region between the N-lobe and C-lobe of Akt2 occupies the ATP binding site. Additionally, the activation loop within Akt2 aids in autoinhibition by blocking the binding of peptide substrates, while still allowing access to the ATP binding site.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
239-262 (Activation loop from InterPro)
Target domain |
98-355 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
5 structures for O00141
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2R5T | X-ray | 190 A | A | 60-431 | PDB |
| 3HDM | X-ray | 260 A | A | 60-431 | PDB |
| 3HDN | X-ray | 310 A | A | 60-431 | PDB |
| 7PUE | X-ray | 251 A | A | 60-431 | PDB |
| AF-O00141-F1 | Predicted | AlphaFoldDB |
327 variants for O00141
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
RCV000984130 rs1171390403 CA365725596 |
365 | N>S | Multiple myeloma [ClinVar] | Yes |
ClinGen ClinVar TOPMed dbSNP gnomAD |
|
rs772631179 CA4009736 |
2 | T>K | No |
ClinGen ExAC gnomAD |
|
|
rs746423391 CA4009735 |
4 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs1484154404 CA365728227 |
4 | K>N | No |
ClinGen gnomAD |
|
|
CA365728230 rs1203352641 |
4 | K>R | No |
ClinGen gnomAD |
|
|
CA4009734 rs779318781 |
5 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM220576 rs1199671834 CA365728222 |
5 | T>I | haematopoietic_and_lymphoid_tissue [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs757603367 CA4009733 |
6 | E>D | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 6 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1276580422 CA365728213 |
7 | A>T | No |
ClinGen gnomAD |
|
|
CA365728195 rs1459815482 |
9 | K>N | No |
ClinGen TOPMed |
|
|
rs1233847136 CA365728194 |
10 | G>S | No |
ClinGen gnomAD |
|
|
rs1006949921 CA148088988 |
10 | G>V | No |
ClinGen Ensembl |
|
|
CA365728184 rs1455678759 |
11 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA4009731 rs377644080 |
12 | L>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA365728181 rs1411350406 |
12 | L>P | No |
ClinGen gnomAD |
|
|
CA4009730 rs377644080 |
12 | L>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs868675854 CA148088965 |
13 | T>A | No |
ClinGen Ensembl |
|
|
rs1264150205 CA365728167 |
14 | Y>* | No |
ClinGen Ensembl |
|
|
rs765862379 CA365728155 |
16 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365728157 rs1414288034 |
16 | R>T | No |
ClinGen TOPMed gnomAD |
|
|
CA365728134 rs1466992019 |
19 | G>A | No |
ClinGen gnomAD |
|
|
rs762924994 CA4009727 |
19 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs1411409008 CA365728126 |
20 | M>I | No |
ClinGen gnomAD |
|
|
CA365728127 rs1279248030 |
20 | M>R | No |
ClinGen TOPMed |
|
|
CA365728122 rs954154822 |
21 | V>L | No |
ClinGen gnomAD |
|
|
CA148088929 rs954154822 |
21 | V>M | No |
ClinGen gnomAD |
|
|
rs376300142 CA365728111 |
23 | I>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs376300142 CA365728112 |
23 | I>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs376300142 CA4009726 |
23 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 24 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA365727982 rs1363280581 |
26 | A>G | No |
ClinGen gnomAD |
|
|
rs1204071335 CA365728091 |
26 | A>S | No |
ClinGen TOPMed |
|
|
COSM3927938 COSM3927939 rs1363280581 COSM3927941 CA365727981 COSM3927940 COSM3927942 |
26 | A>V | Variant assessed as Somatic; 0.0 impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA365727980 rs1274723620 |
27 | F>I | No |
ClinGen gnomAD |
|
|
rs1351651254 CA365727971 |
28 | M>V | No |
ClinGen gnomAD |
|
|
rs1304030749 CA365727960 |
29 | K>R | No |
ClinGen gnomAD |
|
|
rs371813326 CA4009684 |
30 | Q>* | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1170253783 CA365727950 |
30 | Q>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1222388331 CA365727928 |
33 | M>I | No |
ClinGen TOPMed gnomAD |
|
|
CA365727931 rs1449785461 |
33 | M>T | No |
ClinGen gnomAD |
|
|
CA365727933 rs1240287713 |
33 | M>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA365727902 rs1212498503 |
37 | D>G | No |
ClinGen TOPMed |
|
|
CA148088634 rs144924996 |
38 | F>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs759597764 CA4009680 |
39 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 41 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA365727865 rs1276251144 |
42 | I>S | No |
ClinGen gnomAD |
|
|
CA4009678 rs766612840 |
42 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4009677 rs763520267 |
43 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs147939116 CA4009675 |
44 | N>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs147939116 CA4009676 |
44 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1308402608 CA365727856 |
44 | N>Y | No |
ClinGen gnomAD |
|
|
CA4009674 rs748475349 |
45 | N>H | No |
ClinGen ExAC gnomAD |
|
|
CA365727846 COSM1581716 rs1369891237 COSM1581715 COSM1581717 COSM1581714 COSM1581718 |
45 | N>K | haematopoietic_and_lymphoid_tissue [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs775140587 CA4009673 |
46 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA4009669 rs770469903 |
47 | Y>F | No |
ClinGen ExAC gnomAD |
|
|
CA4009670 rs370109537 |
47 | Y>H | No |
ClinGen ESP ExAC gnomAD |
|
|
CA365727833 rs1358328003 |
48 | A>S | No |
ClinGen gnomAD |
|
|
CA4009668 rs375777416 |
48 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1416089646 CA365727822 |
49 | C>W | No |
ClinGen gnomAD |
|
|
CA365727821 rs1425345145 |
50 | K>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA365727818 rs777715286 |
50 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs777715286 CA4009667 |
50 | K>T | No |
ClinGen ExAC gnomAD |
|
|
rs1471293508 CA365727812 |
51 | H>Y | No |
ClinGen gnomAD |
|
|
rs748176347 CA4009647 |
52 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs1348425907 CA365727779 |
54 | V>F | No |
ClinGen TOPMed |
|
|
CA148088024 rs754591774 |
55 | Q>R | No |
ClinGen Ensembl |
|
|
CA4009646 rs146718518 |
57 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA4009645 rs754829897 |
59 | K>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 62 | Q>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs866870260 CA148088017 |
63 | P>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs751679554 CA4009644 |
63 | P>S | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 65 | E>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4009643 rs780432540 |
65 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA |
| TCGA novel | 68 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs141028225 CA148088003 |
68 | L>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP NCI-TCGA gnomAD |
|
rs1429093341 CA365727682 |
69 | M>K | No |
ClinGen gnomAD |
|
|
COSM3948063 COSM3948060 COSM3948064 COSM3948062 COSM3948061 rs199799473 CA365727684 |
69 | M>L | lung [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC gnomAD |
|
rs199799473 CA4009641 |
69 | M>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA4009639 rs73560810 |
72 | N>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs754411255 CA365727658 CA4009638 |
72 | N>K | No |
ClinGen ExAC gnomAD |
|
|
CA4009640 rs73560810 |
72 | N>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1188548806 CA365727653 |
73 | P>L | No |
ClinGen gnomAD |
|
|
CA148087961 rs1045779430 |
73 | P>T | No |
ClinGen TOPMed gnomAD |
|
| rs1210359128 | 77 | P>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 77 | P>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA148087650 rs960203849 |
77 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
CA365727620 rs1582684432 COSM1161570 COSM1161569 COSM220570 COSM220571 |
77 | P>S | haematopoietic_and_lymphoid_tissue [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
CA365727612 rs1404960034 |
78 | S>I | No |
ClinGen gnomAD |
|
|
rs754250568 CA4009612 |
79 | P>A | No |
ClinGen ExAC gnomAD |
|
|
CA365727600 rs1428257089 |
80 | S>F | No |
ClinGen gnomAD |
|
|
rs764674965 CA4009611 |
80 | S>P | No |
ClinGen ExAC gnomAD |
|
|
rs142541423 CA148087632 |
82 | Q>E | No |
ClinGen ESP |
|
|
CA4009609 rs756371887 |
82 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs767930401 CA4009607 |
83 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365727575 rs1414171967 |
84 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1201698009 CA365727569 |
85 | L>F | No |
ClinGen gnomAD |
|
|
CA365727556 rs764600523 |
87 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs764600523 CA4009604 |
87 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs772880709 CA4009605 |
87 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA |
|
CA4009602 rs200398601 |
88 | S>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 89 | S>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA148087563 rs897488498 |
89 | S>T | No |
ClinGen Ensembl |
|
|
CA4009601 rs768634473 |
90 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365727537 rs747000339 |
91 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs1223620188 COSM221258 COSM221256 COSM221257 CA365727534 |
91 | P>L | Variant assessed as Somatic; 0.0 impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs747000339 CA4009600 |
91 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs1286115564 CA365727530 |
92 | H>P | No |
ClinGen gnomAD |
|
|
CA365727531 rs1327823295 |
92 | H>Y | No |
ClinGen gnomAD |
|
|
CA365727507 rs1411257923 |
95 | P>L | No |
ClinGen gnomAD |
|
| TCGA novel | 97 | D>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs775401710 CA4009599 |
99 | H>N | No |
ClinGen ExAC gnomAD |
|
|
CA4009598 rs772031134 |
100 | F>Y | No |
ClinGen ExAC gnomAD |
|
|
rs145458241 CA148087532 |
103 | V>M | No |
ClinGen ESP TOPMed |
|
|
rs865885065 CA148087514 |
111 | K>N | No |
ClinGen Ensembl |
|
|
CA365727374 rs1480275168 |
113 | L>V | No |
ClinGen TOPMed |
|
|
CA4009579 rs774371346 |
115 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs749535259 CA4009577 |
117 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
rs139961699 CA148087368 |
120 | E>K | No |
ClinGen ESP |
|
| rs776473640 | 121 | E>missing | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 121 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1179302733 CA365727316 |
122 | V>M | No |
ClinGen TOPMed |
|
|
rs1357813926 CA365727299 |
124 | Y>C | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 127 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 127 | K>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs540942171 CA4009571 |
130 | Q>K | No |
ClinGen 1000Genomes ExAC gnomAD |
|
| TCGA novel | 133 | A>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4009568 rs780339116 |
133 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA4009567 rs756911963 |
133 | A>V | Variant assessed as Somatic; 0.0002772 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA4009566 rs753470807 |
134 | I>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 135 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1316224763 CA365727207 |
138 | K>Q | No |
ClinGen gnomAD |
|
|
rs763656632 CA4009565 |
138 | K>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 138 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 140 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4009550 rs758719635 |
141 | K>M | No |
ClinGen ExAC gnomAD |
|
|
CA4009549 rs753483209 |
142 | H>R | No |
ClinGen ExAC gnomAD |
|
|
rs777584139 CA4009548 |
143 | I>V | No |
ClinGen ExAC |
|
| TCGA novel | 144 | M>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1041694995 CA148087139 |
145 | S>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1426526565 CA365727129 |
147 | R>Q | No |
ClinGen gnomAD |
|
|
CA4009546 rs752251897 |
147 | R>W | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 154 | V>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA365727078 rs1360801177 |
155 | K>E | No |
ClinGen TOPMed |
|
|
CA365727070 rs1582683357 |
156 | H>N | No |
ClinGen Ensembl |
|
|
CA365727061 rs1221791686 |
157 | P>A | No |
ClinGen gnomAD |
|
|
CA4009544 rs759499784 |
157 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs751493243 CA4009543 |
158 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA365727023 rs1442590498 |
163 | H>R | No |
ClinGen TOPMed gnomAD |
|
|
CA365727025 rs1299672306 |
163 | H>Y | No |
ClinGen gnomAD |
|
|
CA4009542 rs766160360 |
167 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
CA365726972 CA4009541 rs762665720 |
170 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1429354855 CA365726959 |
172 | L>W | No |
ClinGen gnomAD |
|
| TCGA novel | 177 | D>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs369277962 CA4009539 |
181 | G>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA4009520 rs761992267 |
186 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761992267 CA4009519 |
186 | Y>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365726832 rs1284856974 |
189 | Q>* | No |
ClinGen TOPMed |
|
| TCGA novel | 189 | Q>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 192 | R>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs764183243 CA4009517 |
192 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1320954533 CA365726807 |
192 | R>H | No |
ClinGen gnomAD |
|
| TCGA novel | 192 | R>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA365726803 rs1312642136 |
193 | C>R | No |
ClinGen gnomAD |
|
|
CA4009516 COSM221197 COSM221198 rs760685664 |
193 | C>Y | haematopoietic_and_lymphoid_tissue [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs1383459382 CA365726773 |
197 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA365726771 rs1383459382 |
197 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
rs775999779 CA365726768 |
198 | R>P | No |
ClinGen ExAC TOPMed |
|
|
rs775999779 CA4009515 |
198 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed |
|
rs746446621 CA4009512 |
200 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4009511 rs368296582 |
200 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 200 | R>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 201 | F>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4009510 rs770532033 |
202 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 204 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 207 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA365726709 rs1426890902 |
207 | A>V | No |
ClinGen gnomAD |
|
|
CA365726703 rs1281485901 |
208 | S>I | No |
ClinGen gnomAD |
|
|
rs1380565663 CA365726687 |
211 | G>S | No |
ClinGen TOPMed |
|
|
rs754441749 CA4009507 |
212 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
CA365726664 rs1477465338 |
214 | H>L | No |
ClinGen TOPMed |
|
|
CA365726655 rs1263929752 |
216 | L>M | No |
ClinGen TOPMed gnomAD |
|
|
CA148086802 VAR_041071 rs34133418 |
219 | V>I | No |
ClinGen UniProt TOPMed dbSNP gnomAD |
|
| TCGA novel | 222 | D>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 223 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs150642168 CA4009483 |
223 | L>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 224 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 228 | I>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 229 | L>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA365726541 rs1320758612 |
230 | L>P | No |
ClinGen gnomAD |
|
|
CA4009480 COSM1073542 rs773691115 COSM1073545 COSM1073544 |
231 | D>E | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA4009478 rs746720665 |
232 | S>A | No |
ClinGen ExAC gnomAD |
|
|
CA4009479 rs746720665 |
232 | S>T | No |
ClinGen ExAC gnomAD |
|
|
CA148086478 rs141890757 |
236 | I>V | No |
ClinGen ESP gnomAD |
|
|
CA4009477 rs779399570 |
238 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs778834609 CA148086458 |
247 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365726394 rs143344432 |
251 | N>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA365726392 rs1178929260 |
252 | S>G | No |
ClinGen gnomAD |
|
|
rs1480887123 CA365726390 |
252 | S>N | No |
ClinGen gnomAD |
|
| TCGA novel | 254 | T>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA365726373 rs1179420999 |
255 | S>A | No |
ClinGen gnomAD |
|
|
rs1238761044 CA365726369 |
255 | S>C | No |
ClinGen TOPMed |
|
|
rs752059456 CA4009466 |
261 | P>L | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 263 | Y>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA365726294 rs1184003254 |
265 | A>T | No |
ClinGen gnomAD |
|
|
rs749143110 CA4009433 |
268 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365726273 rs749143110 |
268 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4009432 rs773226787 |
270 | H>N | No |
ClinGen ExAC gnomAD |
|
|
rs747983718 CA4009430 |
273 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 274 | Y>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA365726217 rs1294342693 |
276 | R>K | No |
ClinGen gnomAD |
|
| TCGA novel | 277 | T>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4009428 rs755224811 |
278 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA365726179 rs1338908765 |
281 | W>* | No |
ClinGen gnomAD |
|
|
CA148085937 rs959120223 |
286 | V>I | No |
ClinGen Ensembl |
|
| TCGA novel | 287 | L>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs758571552 CA4009425 |
290 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4009423 rs772928486 |
293 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
| rs190276895 | 295 | P>= | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA148085350 rs1010616694 |
295 | P>L | No |
ClinGen gnomAD |
|
|
CA365726069 rs1173547658 |
296 | P>R | No |
ClinGen gnomAD |
|
|
CA4009408 rs780434638 |
300 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA4009407 rs780434638 |
300 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4009406 rs758343377 |
300 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4009405 rs745955657 |
302 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA4009404 rs778918804 |
303 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA365726025 rs1207089233 |
303 | A>V | No |
ClinGen gnomAD |
|
|
rs778072365 CA4009401 |
307 | D>E | No |
ClinGen ExAC |
|
|
CA4009402 rs569220878 |
307 | D>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs569220878 CA365725998 |
307 | D>Y | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs756495408 CA4009400 |
308 | N>K | No |
ClinGen ExAC gnomAD |
|
|
CA365725989 rs1202079592 |
308 | N>S | No |
ClinGen gnomAD |
|
|
rs751156921 CA4009399 |
309 | I>F | No |
ClinGen ExAC |
|
|
rs766028121 CA4009398 |
309 | I>S | No |
ClinGen ExAC gnomAD |
|
|
CA4009396 rs764689970 |
310 | L>Q | No |
ClinGen ExAC gnomAD |
|
|
CA4009395 rs764689970 |
310 | L>R | No |
ClinGen ExAC gnomAD |
|
|
CA4009392 rs78176488 |
311 | N>K | No |
ClinGen ExAC gnomAD |
|
|
rs1383077781 CA365725928 |
318 | P>A | No |
ClinGen TOPMed |
|
|
rs1359203744 CA365725920 |
319 | N>S | No |
ClinGen gnomAD |
|
|
CA4009389 rs778816776 |
320 | I>N | No |
ClinGen ExAC gnomAD |
|
|
CA4009390 rs768512667 |
320 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA365725910 rs1406438851 |
321 | T>A | No |
ClinGen gnomAD |
|
|
CA148085233 rs945373246 |
323 | S>C | No |
ClinGen TOPMed |
|
|
CA4009387 rs772324787 |
324 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA4009385 rs552502455 |
330 | G>D | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1434104663 CA365725822 |
334 | K>N | No |
ClinGen gnomAD |
|
| TCGA novel | 334 | K>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA148085202 rs1046343840 |
335 | D>V | No |
ClinGen Ensembl |
|
|
rs1362850200 CA365725800 |
338 | K>E | No |
ClinGen gnomAD |
|
|
rs749748729 CA4009383 |
339 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs770948952 CA4009384 |
339 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1286257956 CA365725788 |
340 | L>F | No |
ClinGen gnomAD |
|
|
CA365725780 rs1244978635 |
341 | G>A | No |
ClinGen TOPMed |
|
|
rs1582679491 CA365725784 |
341 | G>R | No |
ClinGen Ensembl |
|
|
rs55932330 CA148085184 VAR_041072 |
342 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen UniProt NCI-TCGA TOPMed dbSNP gnomAD |
|
rs1582679463 CA365725773 |
343 | K>Q | No |
ClinGen Ensembl |
|
|
rs1312697419 CA365725765 |
344 | D>Y | No |
ClinGen gnomAD |
|
|
CA365725750 rs1379470082 |
345 | D>E | No |
ClinGen gnomAD |
|
|
CA365725757 rs1454209800 |
345 | D>N | No |
ClinGen gnomAD |
|
|
CA365725712 rs759265218 |
349 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs759265218 CA4009344 |
349 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA148084966 rs142730531 COSM106371 |
350 | K>E | skin [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
rs768119116 CA148084961 |
351 | S>N | No |
ClinGen Ensembl |
|
|
rs1343173967 CA365725681 |
353 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1343173967 CA365725680 |
353 | V>G | No |
ClinGen TOPMed gnomAD |
|
|
COSM1754530 COSM1754533 rs146674353 CA4009343 COSM1754532 COSM1754531 COSM1754529 |
353 | V>I | urinary_tract [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs1301824075 CA365725677 |
354 | F>V | No |
ClinGen gnomAD |
|
| rs1562235638 | 355 | F>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4009342 rs766509532 |
359 | N>Y | No |
ClinGen ExAC gnomAD |
|
|
CA365725614 rs1270259131 |
362 | D>E | No |
ClinGen TOPMed |
|
|
CA4009341 rs763222529 |
362 | D>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs773258040 CA4009340 |
364 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA365725593 rs1480146288 |
365 | N>K | No |
ClinGen gnomAD |
|
| rs1562235584 | 367 | K>missing | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs769889438 CA4009339 |
368 | I>T | No |
ClinGen ExAC |
|
| TCGA novel | 368 | I>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1163695741 CA365725570 |
369 | T>A | No |
ClinGen TOPMed |
|
|
rs1433736483 CA365725554 |
371 | P>R | No |
ClinGen gnomAD |
|
| TCGA novel | 372 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA365725541 rs1249502084 |
373 | N>I | No |
ClinGen gnomAD |
|
|
CA148084941 rs868814728 |
374 | P>L | No |
ClinGen Ensembl |
|
| TCGA novel | 374 | P>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs199735060 CA365725524 |
375 | N>K | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA365725502 rs1275194860 |
377 | S>N | No |
ClinGen Ensembl |
|
|
rs983335694 CA148084476 |
378 | G>R | No |
ClinGen TOPMed |
|
|
CA148084470 rs1033588661 |
380 | N>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs1135343 CA148084463 |
381 | D>E | No |
ClinGen Ensembl |
|
|
CA4009312 rs146264488 |
383 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA148084457 rs933783252 |
383 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
CA365725464 rs1380877517 |
384 | H>N | No |
ClinGen gnomAD |
|
|
CA4009310 rs754004596 |
384 | H>Q | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 384 | H>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4009308 COSM1595877 COSM1073518 COSM1073520 rs769365074 COSM1073521 COSM1073519 |
388 | E>K | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs754853241 CA4009305 |
391 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4009303 rs779771297 |
392 | E>D | No |
ClinGen ExAC TOPMed |
|
|
CA4009304 rs537795008 |
392 | E>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1162721678 CA365725396 |
393 | P>L | No |
ClinGen gnomAD |
|
|
CA4009302 rs758199341 |
395 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA365725387 rs1442331872 |
395 | P>S | No |
ClinGen gnomAD |
|
|
rs200826380 CA148084375 |
396 | N>D | No |
ClinGen gnomAD |
|
|
CA365725381 rs1445902419 |
396 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
CA4009301 rs750574360 |
397 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA4009300 rs377098755 |
398 | I>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA4009299 rs377098755 |
398 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 399 | G>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs866837614 CA148084347 |
402 | P>S | No |
ClinGen Ensembl |
|
|
rs1340012954 CA365725336 |
403 | D>E | No |
ClinGen gnomAD |
|
|
CA4009295 rs545423314 |
405 | V>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs774925063 CA4009292 |
407 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4009293 rs774925063 |
407 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 409 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs780541198 CA4009289 |
411 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA4009288 rs142645675 |
412 | K>N | No |
ClinGen ESP ExAC gnomAD |
|
|
rs911864362 CA365725272 |
413 | E>D | No |
ClinGen TOPMed |
|
|
CA4009286 rs779967650 |
416 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA4009285 rs764021613 |
417 | A>P | No |
ClinGen ExAC gnomAD |
|
|
rs1562235087 CA365725248 |
417 | A>V | No |
ClinGen Ensembl |
|
|
COSM1073515 COSM1073516 COSM1073517 COSM1073514 rs750204554 COSM1595878 CA4009284 |
424 | A>V | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs1195237711 CA365725196 |
425 | P>L | No |
ClinGen gnomAD |
|
|
CA365725190 rs1204532413 |
426 | P>L | No |
ClinGen TOPMed |
|
|
rs1259532577 CA365725188 |
427 | T>A | No |
ClinGen TOPMed |
|
|
CA365725185 rs144542860 |
427 | T>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs144542860 CA4009282 |
427 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA148084243 rs150018874 |
429 | S>C | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs150018874 CA365725173 |
429 | S>F | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA4009280 rs764031935 |
431 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365725159 rs1229064897 |
431 | L>P | No |
ClinGen gnomAD |
No associated diseases with O00141
1 regional properties for O00141
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 13 - 159 | IPR005225 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calcium channel regulator activity | Modulates the activity of a calcium channel. |
| chloride channel regulator activity | Binds to and modulates the activity of a chloride channel. |
| potassium channel regulator activity | Binds to and modulates the activity of a potassium channel. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| sodium channel regulator activity | Binds to and modulates the activity of a sodium channel. |
20 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| cellular response to aldosterone | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus. |
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| long-term memory | The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation. |
| neuron projection morphogenesis | The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| positive regulation of transporter activity | Any process that activates or increases the activity of a transporter. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of apoptotic process | Any process that modulates the occurrence or rate of cell death by apoptotic process. |
| regulation of blood pressure | Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. |
| regulation of catalytic activity | Any process that modulates the activity of an enzyme. |
| regulation of cell growth | Any process that modulates the frequency, rate, extent or direction of cell growth. |
| regulation of cell migration | Any process that modulates the frequency, rate or extent of cell migration. |
| regulation of cell population proliferation | Any process that modulates the frequency, rate or extent of cell proliferation. |
| regulation of DNA-binding transcription factor activity | Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
| regulation of gastric acid secretion | Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. |
| regulation of signal transduction by p53 class mediator | Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator. |
| renal sodium ion absorption | A renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. |
| sodium ion transport | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
34 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6TJY3 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | Bos taurus (Bovine) | SS |
| P23443 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | Homo sapiens (Human) | EV SS |
| Q9UBS0 | RPS6KB2 | Ribosomal protein S6 kinase beta-2 | Homo sapiens (Human) | PR |
| O15530 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | Homo sapiens (Human) | EV |
| Q05513 | PRKCZ | Protein kinase C zeta type | Homo sapiens (Human) | SS |
| P41743 | PRKCI | Protein kinase C iota type | Homo sapiens (Human) | EV |
| Q16512 | PKN1 | Serine/threonine-protein kinase N1 | Homo sapiens (Human) | EV |
| Q6P5Z2 | PKN3 | Serine/threonine-protein kinase N3 | Homo sapiens (Human) | SS |
| Q16513 | PKN2 | Serine/threonine-protein kinase N2 | Homo sapiens (Human) | EV |
| P24723 | PRKCH | Protein kinase C eta type | Homo sapiens (Human) | SS |
| Q02156 | PRKCE | Protein kinase C epsilon type | Homo sapiens (Human) | SS |
| Q04759 | PRKCQ | Protein kinase C theta type | Homo sapiens (Human) | PR |
| Q05655 | PRKCD | Protein kinase C delta type | Homo sapiens (Human) | SS |
| P17252 | PRKCA | Protein kinase C alpha type | Homo sapiens (Human) | EV |
| P05129 | PRKCG | Protein kinase C gamma type | Homo sapiens (Human) | SS |
| P05771 | PRKCB | Protein kinase C beta type | Homo sapiens (Human) | SS |
| P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens (Human) | EV SS |
| P31749 | AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens (Human) | EV |
| Q9Y243 | AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens (Human) | SS |
| Q96BR1 | SGK3 | Serine/threonine-protein kinase Sgk3 | Homo sapiens (Human) | SS |
| Q9HBY8 | SGK2 | Serine/threonine-protein kinase Sgk2 | Homo sapiens (Human) | SS |
| Q15208 | STK38 | Serine/threonine-protein kinase 38 | Homo sapiens (Human) | EV |
| Q9Y2H1 | STK38L | Serine/threonine-protein kinase 38-like | Homo sapiens (Human) | EV |
| Q6A1A2 | PDPK2P | Putative 3-phosphoinositide-dependent protein kinase 2 | Homo sapiens (Human) | PR |
| Q8QZV4 | Stk32c | Serine/threonine-protein kinase 32C | Mus musculus (Mouse) | PR |
| Q9Z1M4 | Rps6kb2 | Ribosomal protein S6 kinase beta-2 | Mus musculus (Mouse) | SS |
| Q8BSK8 | Rps6kb1 | Ribosomal protein S6 kinase beta-1 | Mus musculus (Mouse) | SS |
| Q9ERE3 | Sgk3 | Serine/threonine-protein kinase Sgk3 | Mus musculus (Mouse) | PR |
| P67999 | Rps6kb1 | Ribosomal protein S6 kinase beta-1 | Rattus norvegicus (Rat) | EV SS |
| Q9SUA3 | D6PKL1 | Serine/threonine-protein kinase D6PKL1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O48963 | PHOT1 | Phototropin-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64682 | PID | Protein kinase PINOID | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUL2 | WAG2 | Serine/threonine-protein kinase WAG2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q5BKK4 | sgk1 | Serine/threonine-protein kinase Sgk1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTVKTEAAKG | TLTYSRMRGM | VAILIAFMKQ | RRMGLNDFIQ | KIANNSYACK | HPEVQSILKI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SQPQEPELMN | ANPSPPPSPS | QQINLGPSSN | PHAKPSDFHF | LKVIGKGSFG | KVLLARHKAE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EVFYAVKVLQ | KKAILKKKEE | KHIMSERNVL | LKNVKHPFLV | GLHFSFQTAD | KLYFVLDYIN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GGELFYHLQR | ERCFLEPRAR | FYAAEIASAL | GYLHSLNIVY | RDLKPENILL | DSQGHIVLTD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FGLCKENIEH | NSTTSTFCGT | PEYLAPEVLH | KQPYDRTVDW | WCLGAVLYEM | LYGLPPFYSR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NTAEMYDNIL | NKPLQLKPNI | TNSARHLLEG | LLQKDRTKRL | GAKDDFMEIK | SHVFFSLINW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DDLINKKITP | PFNPNVSGPN | DLRHFDPEFT | EEPVPNSIGK | SPDSVLVTAS | VKEAAEAFLG |
| 430 | |||||
| FSYAPPTDSF | L |