I3L5V6

SS
Gene name
SARM1
Protein name
NAD
Names
+ hydrolase SARM1 , NADase SARM1 , EC 3.2.2.6 , NADP, + hydrolase SARM1 , EC 3.2.2.- , Sterile alpha and TIR motif-containing protein 1
Species
Sus scrofa (Pig)
KEGG Pathway
EC number
3.2.2.6: Hydrolyzing N-glycosyl compounds
Protein Class

Descriptions

Sterile alpha and Toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) regulates axon degeneration, functioning as a key player in the cellular processes involved in neurodegenerative diseases and nerve injury. The physical interaction between the autoinhibitory Armadillo/HEAT motif (ARM) and catalytic Toll/interleukin-1 receptor (TIR) domains blocks the NAD hydrolase activity of SARM1. The autoinhibited TIR domain is activated upon axon injury, activating its NAD+ hydrolase activity and enabling TIR-dependent neuronal destruction.

Autoinhibitory domains (AIDs)

50-410 (ARM domain) SS

Target domain

561-704 (TIR domain)

Relief mechanism

Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for I3L5V6

Entry ID Method Resolution Chain Position Source
AF-I3L5V6-F1 Predicted AlphaFoldDB

No variants for I3L5V6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for I3L5V6

No associated diseases with I3L5V6

3 regional properties for I3L5V6

Type Name Position InterPro Accession
domain Toll/interleukin-1 receptor homology (TIR) domain 560 - 703 IPR000157
domain Sterile alpha motif domain 409 - 476 IPR001660-1
domain Sterile alpha motif domain 479 - 548 IPR001660-2

Functions

Description
EC Number 3.2.2.6 Hydrolyzing N-glycosyl compounds
Subcellular Localization
  • Cytoplasm
  • Cell projection, axon
  • Cell projection, dendrite
  • Synapse
  • Mitochondrion
  • Associated with microtubules
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

4 GO annotations of molecular function

Name Definition
NAD+ nucleosidase activity Catalysis of the reaction
NAD+ nucleotidase, cyclic ADP-ribose generating Catalysis of the reaction
NADP+ nucleosidase activity Catalysis of the reaction
signaling adaptor activity The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.

9 GO annotations of biological process

Name Definition
cell differentiation The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
NAD catabolic process The chemical reactions and pathways resulting in the breakdown of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; catabolism may be of either the oxidized form, NAD, or the reduced form, NADH.
negative regulation of MyD88-independent toll-like receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
protein localization to mitochondrion A process in which a protein is transported to, or maintained in, a location within the mitochondrion.
regulation of dendrite morphogenesis Any process that modulates the frequency, rate or extent of dendrite morphogenesis.
response to axon injury Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6IDD9 Sarm NAD Drosophila melanogaster (Fruit fly) SS
Q6SZW1 SARM1 NAD hydrolase SARM1 hydrolase SARM1) Homo sapiens (Human) EV
Q6PDS3 Sarm1 NAD Mus musculus (Mouse) SS
D3ZUM2 Sarm1 NAD Rattus norvegicus (Rat) SS
F1QWA8 sarm1 NAD Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MVLTILFSAY KLCRFFAMSS PRPGAERLAV PGPDGGGGAG PWWTAGGRGP REVSPGVGAE
70 80 90 100 110 120
VQGALERALP ELQQALSALK QAGGGRAVGA GLAEVFQLVE EAWLLPAMGR EVAQGLCDAI
130 140 150 160 170 180
RLEGGLDLLL RLLQAPELET RVQAARLLEQ ILVAENRRDR VARIGLGVIL NLAKEREPVE
190 200 210 220 230 240
LARSVAGILE HMFKHSEETC QRLVAAGGLD AVLYWCRRTD PALLRHCALA LANCAMHGGQ
250 260 270 280 290 300
AAQRRMVEKR AAEWLFPLAF SKEDELLRLH ACLAVAVLAT NKEVEREVER SGTLALVEPL
310 320 330 340 350 360
VASLDPGRFA RCLVDASDTS QGRGPDDLQR LVPLLDSSRM EAQCIGAFYL CAEAVIMHIK
370 380 390 400 410 420
NRNKVFSDIG AIQSLKRLVS YSTNGTTSAL AKRALRLLGE EVPRPILPCV ASWKEAEVQT
430 440 450 460 470 480
WLQQIGFSQY CESFREQQVD GDLLLRLTEE ELQTDLGMKS GITRKRFFRE LTELKTFANY
490 500 510 520 530 540
ATCDRSNLAD WLGSLDPRFR QYTYGLVSCG LDRSLLHRVS EQQLLEDCGI RLGVHRVRIL
550 560 570 580 590 600
TAAREMLHSP LPCTGSKPSG DVPDVFISYR RNSGSQLASL LKVHLQLHGF SVFIDVEKLE
610 620 630 640 650 660
AGKFEDKLIQ SIMSARNFVL VLSAGALDKC MQDHDCKDWV HKEIVTALSC GKNIVPVIDG
670 680 690 700 710 720
FEWPEPHTLP EDMQAVLTFN GIKWSHEYQE ATIEKIIRFL QGRSSRDSSA GSDTSLEGAA
PMGPT