H2L099

PR
Gene name
gck-1
Protein name
Germinal center kinase 1
Names
Species
Caenorhabditis elegans
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

171-194 (Activation loop from InterPro)

Target domain

34-285 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for H2L099

Entry ID Method Resolution Chain Position Source
AF-H2L099-F1 Predicted AlphaFoldDB

No variants for H2L099

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for H2L099

No associated diseases with H2L099

2 regional properties for H2L099

Type Name Position InterPro Accession
domain Protein kinase domain 34 - 285 IPR000719
binding_site Protein kinase, ATP binding site 40 - 63 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Apical cell membrane ; Peripheral membrane protein
  • Co-localizes with ccm-3 in the apical membrane of the excretory canals
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic side of apical plasma membrane The side (leaflet) of the apical region of the plasma membrane that faces the cytoplasm.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
mitogen-activated protein kinase binding Binding to a mitogen-activated protein kinase.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

10 GO annotations of biological process

Name Definition
epithelial tube morphogenesis The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of MAP kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
oogenesis The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
positive regulation of endocytic recycling Any process that activates or increases the frequency, rate or extent of endocytic recycling.
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of Golgi organization Any process that modulates the frequency, rate or extent of Golgi organization.
regulation of oocyte development Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.

19 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5E9L6 STK4 Serine/threonine-protein kinase 4 Bos taurus (Bovine) SS
Q3SWY6 STK25 Serine/threonine-protein kinase 25 Bos taurus (Bovine) PR
P41279 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Homo sapiens (Human) EV
Q9Y6E0 STK24 Serine/threonine-protein kinase 24 Homo sapiens (Human) PR
Q13188 STK3 Serine/threonine-protein kinase 3 Homo sapiens (Human) SS
O00506 STK25 Serine/threonine-protein kinase 25 Homo sapiens (Human) PR
Q13043 STK4 Serine/threonine-protein kinase 4 Homo sapiens (Human) EV
Q9P289 STK26 Serine/threonine-protein kinase 26 Homo sapiens (Human) PR
Q07174 Map3k8 Mitogen-activated protein kinase kinase kinase 8 Mus musculus (Mouse) SS
Q9Z2W1 Stk25 Serine/threonine-protein kinase 25 Mus musculus (Mouse) PR
Q9JI10 Stk3 Serine/threonine-protein kinase 3 Mus musculus (Mouse) SS
Q9JI11 Stk4 Serine/threonine-protein kinase 4 Mus musculus (Mouse) PR
Q99JT2 Stk26 Serine/threonine-protein kinase 26 Mus musculus (Mouse) PR
Q99KH8 Stk24 Serine/threonine-protein kinase 24 Mus musculus (Mouse) PR
Q63562 Map3k8 Mitogen-activated protein kinase kinase kinase 8 Rattus norvegicus (Rat) SS
B0LT89 Stk24 Serine/threonine-protein kinase 24 Rattus norvegicus (Rat) PR
Q9NB31 cst-1 Serine/threonine-protein kinase cst-1 Caenorhabditis elegans PR
Q6P3Q4 stk4 Serine/threonine-protein kinase 4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q7ZUQ3 stk3 Serine/threonine-protein kinase 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MTTTSSDELP RQADDDSMKW DRIYIQKLDP EVIFTKQERI GRGSFGEVYK GIDNRTGRVV
70 80 90 100 110 120
AIKIIDLEQA EDEIEDIQQE IQVLSQCDSQ YVTKYFGSFL KGSKLWIIME YLGGGSALDL
130 140 150 160 170 180
TKSGKLDESH IAVILREILK GLEYLHSERK IHRDIKAANV LVSEHGDVKV ADFGVAGQLT
190 200 210 220 230 240
ETVKKRITFV GSPFWMAPEL IKQSSYDYKA DIWSLGITAI ELANGEPPHS DLHPMRVLFL
250 260 270 280 290 300
IPKNPPPVLQ GSQWSKPFKE FVEMCLNKDP ENRPSASTLL KHQFIKRAKK NSILVDLIER
310 320 330 340 350 360
AAEYRLRTGV SSDSDLDEDS DGGGGTSKWD YPTVRGPRVS ADDDGTVRQR TDRPRAQVDR
370 380 390 400 410 420
RSPSGSPGGT IVRGSPQVAA VAEQLRNSSV GSSGYGSGGN SASSQYATSS LPQSHTASSG
430 440 450 460 470 480
GATTITLGSP NGSPTSSLAR TQSMVSPSGQ RSGSAQSWEL ERGNRPMSER VSSQVSPSKY
490 500 510 520 530 540
NQHRTSSSNG VQGGSGGRRE YINGSGSGLN GNSSNQNHSE YSDAVRQRGP GGSGGRLDYR
550 560 570 580 590 600
ESHVPTSSQE NLNHGRMYGY GAPPPSREAN NVPMPRVKGA LDCSLLPAIE HLSRTRHATA
610 620 630 640 650
ALDQLRHVFR DVEDSCPGIC NELIEELMQR IAVPQVSQSD LDAAIRRLTT PPS