H2KZU7
Gene name |
svh-2 (T14E8.1) |
Protein name |
Tyrosine-protein kinase receptor svh-2 |
Names |
EC 2.7.10.1 , Met/Ron-like receptor tyrosine kinase svh-2 , Suppressor of vhp-1 deletion lethality protein svh-2 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_T14E8.1 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Accessory elements
875-882 (Activation loop from InterPro)
Target domain |
735-996 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
895-901 (Activation loop from InterPro)
Target domain |
735-996 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
Autoinhibited structure
Activated structure
1 structures for H2KZU7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-H2KZU7-F1 | Predicted | AlphaFoldDB |
No variants for H2KZU7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for H2KZU7 | |||||
No associated diseases with H2KZU7
5 regional properties for H2KZU7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 735 - 996 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 739 - 991 | IPR001245 |
| active_site | Tyrosine-protein kinase, active site | 854 - 866 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 741 - 767 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 735 - 993 | IPR020635 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| mitogen-activated protein kinase kinase kinase binding | Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase. |
| protein tyrosine kinase activity | Catalysis of the reaction |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| axon regeneration | The regrowth of axons following their loss or damage. |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. |
| peptidyl-tyrosine autophosphorylation | The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein. |
| peptidyl-tyrosine phosphorylation | The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. |
| positive regulation of axon regeneration | Any process that activates, maintains or increases the rate of axon regeneration. |
| positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
35 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q769I5 | MET | Hepatocyte growth factor receptor | Bos taurus (Bovine) | PR |
| A0M8S8 | MET | Hepatocyte growth factor receptor | Felis catus (Cat) (Felis silvestris catus) | PR |
| Q04912 | MST1R | Macrophage-stimulating protein receptor | Homo sapiens (Human) | EV |
| P08581 | MET | Hepatocyte growth factor receptor | Homo sapiens (Human) | EV |
| P14616 | INSRR | Insulin receptor-related protein | Homo sapiens (Human) | SS |
| P08922 | ROS1 | Proto-oncogene tyrosine-protein kinase ROS | Homo sapiens (Human) | SS |
| P34925 | RYK | Tyrosine-protein kinase RYK | Homo sapiens (Human) | PR |
| Q12866 | MERTK | Tyrosine-protein kinase Mer | Homo sapiens (Human) | EV |
| Q06418 | TYRO3 | Tyrosine-protein kinase receptor TYRO3 | Homo sapiens (Human) | SS |
| P30530 | AXL | Tyrosine-protein kinase receptor UFO | Homo sapiens (Human) | PR |
| P29376 | LTK | Leukocyte tyrosine kinase receptor | Homo sapiens (Human) | SS |
| Q9UM73 | ALK | ALK tyrosine kinase receptor | Homo sapiens (Human) | EV |
| Q9WTL4 | Insrr | Insulin receptor-related protein | Mus musculus (Mouse) | SS |
| Q62190 | Mst1r | Macrophage-stimulating protein receptor | Mus musculus (Mouse) | SS |
| P16056 | Met | Hepatocyte growth factor receptor | Mus musculus (Mouse) | PR |
| Q01887 | Ryk | Tyrosine-protein kinase RYK | Mus musculus (Mouse) | PR |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| P55144 | Tyro3 | Tyrosine-protein kinase receptor TYRO3 | Mus musculus (Mouse) | SS |
| Q60805 | Mertk | Tyrosine-protein kinase Mer | Mus musculus (Mouse) | SS |
| P97793 | Alk | ALK tyrosine kinase receptor | Mus musculus (Mouse) | SS |
| Q2QLE0 | MET | Hepatocyte growth factor receptor | Sus scrofa (Pig) | PR |
| P97523 | Met | Hepatocyte growth factor receptor | Rattus norvegicus (Rat) | PR |
| Q64716 | Insrr | Insulin receptor-related protein | Rattus norvegicus (Rat) | SS |
| P57097 | Mertk | Tyrosine-protein kinase Mer | Rattus norvegicus (Rat) | SS |
| Q8I7I5 | rol-3 | Protein roller-3 | Caenorhabditis elegans | PR |
| G5EGK5 | cam-1 | Tyrosine-protein kinase receptor cam-1 | Caenorhabditis elegans | SS |
| O61460 | vab-1 | Ephrin receptor 1 | Caenorhabditis elegans | SS |
| Q95ZV7 | ddr-2 | Discoidin domain-containing receptor tyrosine kinase B | Caenorhabditis elegans | PR |
| Q17833 | old-1 | Tyrosine-protein kinase receptor old-1 | Caenorhabditis elegans | PR |
| P34892 | kin-16 | Receptor-like tyrosine-protein kinase kin-16 | Caenorhabditis elegans | PR |
| G5ED65 | ver-1 | Protein ver-1 | Caenorhabditis elegans | PR |
| Q19238 | F09A5.2 | Putative tyrosine-protein kinase F09A5.2 | Caenorhabditis elegans | SS |
| Q10656 | egl-15 | Myoblast growth factor receptor egl-15 | Caenorhabditis elegans | PR |
| F8W3R9 | alk | ALK tyrosine kinase receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| F1QVU0 | ltk | Tyrosine-protein kinase receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVLGSSQSSA | KELTTQSSIF | RFLVLLLCFT | SATGGQINGK | LLNGNGVFVS | RDELQNKNVL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GVITGFDLLV | VATHSRFQVF | ENNEERRTVG | HVSLDMHPRT | KFLELKLFSK | SEIFYCDESS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CGLCTYSGVT | SSCSTFMLNG | DEPKIQEILS | SSAVKIENLG | QIMLAISFKN | EEDPDNPRTM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ILRYNAQDTG | TVIPTAYHAD | SSFIHNNHAL | TGFEREGFVY | FVMTASQIFE | PEVFLHDQSN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NKVTVTKVIR | FCATDQTADL | ASKISILVGC | DQEFRNISSR | GETAVYDHAN | DLINIVMFNH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TSMNHLMCRF | KMANIEKRFK | TIWSTCQETS | FSGSTAKTTR | CKYPQIFDQM | KVKKGCLTYS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RLDDESSPTL | CVRYGRGDAL | DNCQLHTAKS | NSYRYGWLED | YNVLQGELMM | RIPYPFFGIA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ESLITDGKSY | FAAVSGEFDM | SDVLRFSASE | SADIRPHWRT | NISVVGKFSI | TKTKENQLLY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TTVEGLQSLD | ISCKGLYPNC | QTLRQGGWED | PLECSWCADD | NAQRTITSSE | VSSCKNNLKH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ECPPSMRWIH | KYNNNSGFTA | VVDGFRALKN | PKLNACGTNC | VVTVVDSSSI | QCDTNPDEVI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GDSCKQVFLS | GMIGDKNYSF | PFDYQQADRG | TQTDVKNSQV | DDKKGSSPGW | KIAIAIISVM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TIILIVAIIV | YYMRNRFPRI | KTHVRPPIGQ | RIENEYDMGH | MAGRQAQLAI | NGDNYVKVFR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SMRPDLKVDF | KNLRVDKLDP | IGQGHYGVVY | KAMYSPSKSL | EEKVVCKYLK | EGKISEFYEE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ARTMSEFDHP | NILKLIGVAL | DDSSHLPIII | TEYMAKGDLK | SFIENVENTI | KMRDLFEFAF |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DIAKGMNYMH | SKKFIHRDLA | CRNCLLDEHL | RVKIADFGLC | RKVDIETELY | VQMHERDLPV |
| 910 | 920 | 930 | 940 | 950 | 960 |
| RWFPPEISEQ | GFGITSDIWS | FGVVIWELFT | RGSTPYSNMA | SWILILPWLK | ESETNRLRKP |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| PYCPEKLYTD | VMLACWKANP | AERPQFSDLV | TIIPNVVKYM | EGYDRSQLQA | GYERVSSRFL |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| SLSRHDPAFP | IYQNEMPNTP | LLANCQNDTN | DSKTLAELPS | DSPSTSTAIP | QSTPYQLLSE |
| CSETSV |